January, 2024

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Ultra-processed foods and cardiovascular disease

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 30 January 2024; doi:10.1038/s41569-024-00990-7 In this Comment, we critically examine the association between the increasing consumption of ultra-processed foods and their negative effect on cardiovascular health. We explore the historical evolution of food processing, the Nova food classification and the epidemiological evidence, and highlight the need for urgent public health interventions.

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3 ways to drive awareness of women’s greatest health threat for American Heart Month

American Heart News - Heart News

DALLAS, Feb. 1, 2024 – From news desks to iconic buildings, scores of people and landmarks across the U.S. will once again “go red” on National Wear Red Day, Feb. 2, to raise awareness that cardiovascular disease is the No. 1 killer of women and support.

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Some 'Choosing Wisely' Recs Protect Older Folks From Low-Value Care

Med Page Today

(MedPage Today) -- Getting clinicians to commit to the Choosing Wisely recommendations somewhat reduced low-value care for older adults in common scenarios, a cluster randomized trial found. After primary care clinicians committed in writing to.

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Analysis finds biomarkers that improve prediction accuracy of cardiovascular disease risk in people with type 2 diabetes

Medical Xpress - Cardiology

An international academic consortium has identified 13 biomarkers that significantly improve the ability to accurately predict cardiovascular disease risk in people with type 2 diabetes. The analysis, conducted by 23 experts from 11 countries, was led by The Johns Hopkins University in the United States, the Chinese University of Hong Kong in Hong Kong, and Lund University in Sweden.

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Why Nighttime Light Exposure is So Harmful for Cardiovascular Health

Physiologically Speaking

Our body’s physiological processes oscillate on a 24-hour cycle known as the circadian rhythm. Circadian rhythms in blood pressure and heart rate, among other functions, are crucial for cardiovascular health and preventing cardiovascular disease. Recent evidence indicates that nighttime light exposure impacts melatonin release, the autonomic nervous system, and cortisol — with potentially harmful effects on cardiovascular health.

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MCO-010 Gene Therapy for Retinitis Pigmentosa Receives Regulatory Feedback

HCPLive

Both the FDA and EU regulators indicated visual acuity may serve as primary endpoint to evaluate MCO-010 in the treatment of low-vision retinitis pigmentosa patients.

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Cardiovascular autonomic dysfunction in post-COVID-19 syndrome: a major health-care burden

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 02 January 2024; doi:10.1038/s41569-023-00962-3 Cardiovascular autonomic dysfunction (CVAD) is a malfunction of the autonomic control of circulatory homeostasis and is an important component of post-COVID-19 syndrome. In this Review, Fedorowski and colleagues define the major forms of CVAD (including postural orthostatic tachycardia syndrome), and discuss the aetiology, diagnosis and management of post-COVID-19 syndrome-associated CVAD.

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Ibuprofen Fails Another Crack at Reducing Preemie Lung Issues and Deaths

Med Page Today

(MedPage Today) -- Ibuprofen again failed to improve short-term outcomes when used to close patent ductus arteriosus (PDA) in newborns, the placebo-controlled Baby-OSCAR trial showed. Administered parenterally a few days after infants were born.

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Researchers identify circulating proteins linked to preeclampsia and other hypertensive disorders of pregnancy

Medical Xpress - Cardiology

Preeclampsia and other hypertensive disorders of pregnancy—which are characterized by high blood pressure with or without organ dysfunction during the second half of pregnancy—carry considerable short- and long-term risks for both the mother and child. Treatment options (other than expedited delivery) remain limited.

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Plasma metabolite profile of legume consumption and future risk of type 2 diabetes and cardiovascular disease

Cardiovascular Diabetology

Legume consumption has been linked to a reduced risk of type 2 diabetes (T2D) and cardiovascular disease (CVD), while the potential association between plasma metabolites associated with legume consumption and.

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Literature Review: Fever and ST segment elevation after syncope

ECG Weekly Workout

HPI: A young woman presents to the ED after a syncopal episode. She hit her chest after falling and has reproducible chest wall tenderness on exam. She is also noted to be febrile at triage, with reported malaise, vomiting, and unilateral back ache. The following ECG is obtained on arrival before the patient is hospitalized for pyelonephritis, chest pain, and syncope: Case ECG Before watching this week’s video.

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Atherosclerotic plaque stabilization and regression: a review of clinical evidence

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 04 January 2024; doi:10.1038/s41569-023-00979-8 In this Review, Sarraju and Nissen summarize the clinical trial evidence for coronary atherosclerotic plaque stabilization and regression with plasma LDL-cholesterol-lowering therapy and other treatments. Invasive and non-invasive imaging modalities used to assess plaque burden and composition are discussed.

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Snow shoveling, cold temperatures combine for perfect storm of heart health hazards

American Heart News - Heart News

DALLAS, Jan. 11, 2024 — Weather forecasters may call it ‘white fluffy stuff,’ however, snow can be a bigger danger than many people may realize. According to the American Heart Association, celebrating its Centennial birthday as the world’s leading.

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Caution Raised for Post-TAVR Cardiac Surgeries

Med Page Today

(MedPage Today) -- SAN ANTONIO -- The early experience of patients needing cardiac surgery after transcatheter aortic valve replacement (TAVR) has surgeons raising the alarm about the excess risks of these challenging procedures, based on data.

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Harnessing skin cancer genes to heal hearts

Medical Xpress - Cardiology

Biomedical engineers at Duke University have demonstrated that one of the most dangerous mutations found in skin cancers might moonlight as a pathway to mending a broken heart.

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Physicians Who Take Vacation Time, Avoid Working on Vacation Less Likely to Suffer Burnout

HCPLive

A survey of more than 3000 US physicians is shedding light on the impact of taking vacation time and avoiding physician-related work on vacation can have on burnout and achieving professional fulfillment.

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Physiology Friday #200: Higher Aerobic Fitness is Tied to Slower Biological Aging

Physiologically Speaking

Greetings! Welcome to the Physiology Friday newsletter. This newsletter is brought to you by Examine.com — the best place on the internet for health and nutrition information — and my eBook, “VO2 Max Essentials.” Details can be found at the end of the post! Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

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RNA-binding proteins in cardiovascular biology and disease: the beat goes on

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 02 January 2024; doi:10.1038/s41569-023-00958-z In this Review, the authors discuss the latest insights on RNA-binding proteins and RNA biology and appraise them in the context of cardiovascular research, summarizing the progress in our understanding of the involvement of RNA-binding proteins in cardiac biology and disease.

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New evidence informs risk factors, diagnosis and care of patients with CVT stroke

American Heart News - Stroke News

DALLAS, January 29, 2024 — A new scientific statement from the American Heart Association emphasizes the need to increase patients’ and physicians’ awareness of cerebral venous thrombosis (CVT) to improve the recognition of this condition and initiate.

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More Evidence Linking ADT for Prostate Cancer to Adverse Neurocognitive Effects

Med Page Today

(MedPage Today) -- Men treated with androgen deprivation therapy (ADT) for prostate cancer had a significantly higher risk of dementia and other neurocognitive disorders, according to a meta-analysis of more than 2.5 million patients. The magnitude.

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Truncated titin is structurally integrated into the human dilated cardiomyopathic sarcomere

Journal of Clinical Investigation - Cardiology

Heterozygous (HET) truncating variant mutations in the TTN gene (TTNtvs), encoding the giant titin protein, are the most common genetic cause of dilated cardiomyopathy (DCM). However, the molecular mechanisms by which TTNtv mutations induce DCM are controversial. Here, we studied 127 clinically identified DCM human cardiac samples with next-generation sequencing (NGS), high-resolution gel electrophoresis, Western blot analysis, and super-resolution microscopy in order to dissect the structural a

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E-Cigarettes As Effective as Varenicline, More Effective Than Nicotine Gum in Helping to Quit Smoking

HCPLive

This new research may require additional follow up studies on potential harms, as 63% of those in this study’s electronic cigarette arm continue to use the product at 6 months.

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Heart transplantation and biomarkers: a review about their usefulness in clinical practice

Frontiers in Cardiovascular Medicine

Advanced heart failure (AdvHF) can only be treated definitively by heart transplantation (HTx), yet problems such right ventricle dysfunction (RVD), rejection, cardiac allograft vasculopathy (CAV), and primary graft dysfunction (PGD) are linked to a poor prognosis. As a result, numerous biomarkers have been investigated in an effort to identify and prevent certain diseases sooner.

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Targeted scientific research projects to demonstrate effectiveness of ‘food is medicine’ in health care

American Heart News - Heart News

DALLAS, Jan. 24, 2024 — In an effort to identify effective food is medicine approaches for incorporating healthy food into health care delivery, the American Heart Association, the world’s leading voluntary organization focused on heart and brain health.

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Physiology Friday #199: High-Intensity Interval Training Reduces Coronary Artery Plaque

Physiologically Speaking

Greetings! Welcome to the Physiology Friday newsletter. This newsletter is brought to you by Examine.com — the best place on the internet for health and nutrition information — and my new eBook, “VO2 Max Essentials.” Details can be found at the end of the post! Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

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Breast Cancer Drug Repurposed for Infant With Congenital Hyperinsulinism

Med Page Today

(MedPage Today) -- A 4-month-old with congenital hyperinsulinism responded well to off-label treatment with a breast cancer drug, researchers reported. A newborn presented with severe congenital hyperinsulinism due to homozygous deletion of the.

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Thrombotic microangiopathy following systemic AAV administration is dependent on anti-capsid antibodies

Journal of Clinical Investigation - Cardiology

BACKGROUND Systemic administration of adeno-associated virus (AAV) can trigger life-threatening inflammatory responses, including thrombotic microangiopathy (TMA), acute kidney injury due to atypical hemolytic uremic syndrome–like complement activation, immune-mediated myocardial inflammation, and hepatic toxicity.METHODS We describe the kinetics of immune activation following systemic AAV serotype 9 (AAV9) administration in 38 individuals following 2 distinct prophylactic immunomodulation regim

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Short Sleepers with Pre-Existing Medical Conditions at Higher Risk of Long COVID

HCPLive

A new study found the risk of Long COVID for short sleepers with pre-existing medical conditions was 3-fold higher than average-length sleepers without pre-existing conditions.

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Association of temporal change in body mass index with sudden cardiac arrest in diabetes mellitus

Cardiovascular Diabetology

Underweight imposes significant burden on cardiovascular outcomes in patients with diabetes mellitus. However, less is known about the impact of serial change in body weight status measured as body mass index.

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Childhood stress linked to higher risk of high blood pressure, obesity, diabetes in adults

American Heart News - Heart News

Research Highlights: Consistently high scores of perceived stress during adolescence through adulthood may contribute to worse cardiometabolic health including obesity in young adults. Researchers suggest the adoption of healthy coping strategies.

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Algorithm for predicting valvular heart disease from heart sounds in an unselected cohort

Frontiers in Cardiovascular Medicine

Objective This study aims to assess the ability of state-of-the-art machine learning algorithms to detect valvular heart disease (VHD) from digital heart sound recordings in a general population that includes asymptomatic cases and intermediate stages of disease progression. Methods We trained a recurrent neural network to predict murmurs from heart sound audio using annotated recordings collected with digital stethoscopes from four auscultation positions in 2,124 participants from the Tromsø7 s

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How Cardiac Arrest Became a Household Topic After Damar Hamlin's Collapse

Med Page Today

(MedPage Today) -- In January, we reported on Damar Hamlin's collapse during a televised football game. In this report, we follow up on the resulting public interest on sudden cardiac arrest that made Hamlin the most searched person of 2023. During.

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CDKL5 regulates p62-mediated selective autophagy and confers protection against neurotropic viruses

Journal of Clinical Investigation - Cardiology

Virophagy, the selective autophagosomal engulfment and lysosomal degradation of viral components, is crucial for neuronal cell survival and antiviral immunity. However, the mechanisms leading to viral antigen recognition and capture by autophagic machinery remain poorly understood. Here, we identified cyclin-dependent kinase–like 5 (CDKL5), known to function in neurodevelopment, as an essential regulator of virophagy.

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Mindfulness-Oriented Recovery, Methadone Treatment Linked to Less Drug Use

HCPLive

Mindfulness-Oriented Recovery Enhancement plus methadone treatment is a promising treatment option for patients with opioid use disorder, having been significantly associated with less return to drug use and methadone treatment dropout, a new study found.

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Exposure to even moderate levels of radon linked to increased risk of stroke

Science Daily - Heart Disease

Radon is the second leading cause of lung cancer. Now a new study has found exposure to this invisible, odorless gas is also linked to an increased risk of stroke. The study, which examined exposures in middle age to older female participants, found an increased risk of stroke among those exposed to high and even moderate concentrations of the gas compared to those exposed to the lowest concentrations.

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Drinking camel milk can lead to significant reduction in cholesterol levels among diabetics

Medical Xpress - Cardiology

A new study has hailed camel milk for its ability to lower heart disease risk among diabetics and help in the treatment of dyslipidemia.

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National retailers support heart and stroke health through annual Life is Why™ campaign

American Heart News - Heart News

DALLAS, Jan. 25, 2024 — This February, during American Heart Month and the American Heart Association’s Centennial year, the Association is devoted to a world of healthier lives for all by teaming up with retailers and brands around the country for Life.

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