Sat.Jul 13, 2024 - Fri.Jul 19, 2024

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Data-independent LC-MS/MS analysis of ME/CFS plasma reveals a dysregulated coagulation system, endothelial dysfunction, downregulation of complement machinery

Cardiovascular Diabetology

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic condition that is characterized by unresolved fatigue, post-exertion symptom exacerbation (PESE), cognitive dysfunction, or.

Research 145
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COVID May Affect Type 1 Diabetes in Kids, and Not in a Good Way

Med Page Today

(MedPage Today) -- COVID-19 may accelerate progression of presymptomatic type 1 diabetes in youth, a German study suggested. Incidence of clinical type 1 diabetes nearly doubled after the pandemic started among 591 youth ages 1 to 16 known to.

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HeartBeam’s Artificial Intelligence Algorithm Combined with Vectorcardiography (VCG) Outperforms Expert Cardiologists in Detecting Arrhythmias

DAIC

mtaschetta-millane Mon, 07/15/2024 - 11:18 July 15, 2024 — HeartBeam, Inc. , a medical technology company focused on transforming cardiac care through the power of personalized insights, today announced new study data demonstrating that HeartBeam AI combined with vectorcardiography (VCG) outperformed an expert panel of heart rhythm cardiologists in detecting atrial flutter.

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30-year risk of cardiovascular disease may help inform blood pressure treatment decisions

American Heart News - Heart News

Research Highlights: A comparison of two tools for calculating cardiovascular disease risk found that if only the current 10-year risk thresholds are applied, fewer adults may be recommended for blood pressure-lowering medication. The tools, The.

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30-year risk of cardiovascular disease may help inform blood pressure treatment decisions

Science Daily - Heart Disease

According to a new study, both 30-year risk for cardiovascular disease in addition to 10-year risk may be considered in making decisions about when to initiate high blood pressure medication.

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New Alzheimer's Mimic Identified

Med Page Today

(MedPage Today) -- A new memory-loss syndrome that mimics the clinical features of Alzheimer's disease was identified, researchers said. "We propose a set of clinical criteria for a limbic-predominant amnestic neurodegenerative syndrome [LANS.

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Society of Cardiovascular Computed Tomography to Honor Oxford’s Kenneth Chan, MBBS at SCCT2024

DAIC

Kenneth Chan, MBBS, Academic Clinical Research Fellow in the Division of Cardiovascular Medicine at Oxford University Hospitals (UK) will receive the 2024 SCCT Clinical Trials and Registries Award (CTRA) at the opening session of the Society’s 19th Annual Scientific Meeting (SCCT2024) on Friday, July 19 in Washington, DC. christine.book Fri, 07/19/2024 - 09:01 July 18, 2024 — The Society of Cardiovascular Computed Tomography ( SCCT ) has announced it will honor Kenneth Chan, MBBS as recipient of

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Baylor St. Luke’s Settles Concurrent Cardiac Surgery Case

CardiacWire

Cardiac surgeon compensation is generally a numbers game – the more procedures you do, the more you make. However, a Medicare fraud settlement featuring some of Houston’s most prominent institutions and cardiac surgeons reveals the pitfalls of this incentive structure. Allegations claim that between 2013 to 2020 three decorated Baylor St. Luke’s heart surgeons regularly operated in two to three rooms simultaneously, while “delegating key aspects of extremely complicated and risky heart sur

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D.C. Hospital Gets a Wake-Up Call to Chagas Disease

Med Page Today

(MedPage Today) -- Researchers from one Washington, D.C., center confirmed that there was a high prevalence of Chagas disease in a sample of Latin American immigrants hospitalized with cardiac conditions. Of 97 adults who underwent a transthoracic.

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HeartFlow Introduces Next Generation Interactive Plaque Analysis Platform to Assess Patient Risk in Suspected Coronary Artery Disease

DAIC

mtaschetta-millane Thu, 07/18/2024 - 10:00 July 18, 2024 — HeartFlow, Inc. , a leader in non-invasive artificial intelligence (AI) heart care solutions, introduced the next generation HeartFlow Plaque Analysis with an interactive experience. This upgraded platform is the only plaque analysis tool fully integrated with FFR CT (when FFR CT is performed), delivering impactful insights to enhance clinical decision-making and enabling personalized patient treatment plans.

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U.S. News Hospital Rankings Are One Piece of the CHD Care Puzzle

Conquering CHD

Where to receive care is one of the most important decisions a family can make. Conquering CHD has a strong commitment to transparency and ensuring patients and families have essential information at their fingertips when they need it to assist them in making the best choice for their family. With the publishing of this year’s U.S. News & World Hospital Report rankings , we remind you this is only one of many tools you can use to have a conversation with your care team and should not be used

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Circadian disruption, clock genes, and metabolic health

Journal of Clinical Investigation - Cardiology

A growing body of research has identified circadian-rhythm disruption as a risk factor for metabolic health. However, the underlying biological basis remains complex, and complete molecular mechanisms are unknown. There is emerging evidence from animal and human research to suggest that the expression of core circadian genes, such as circadian locomotor output cycles kaput gene (CLOCK), brain and muscle ARNT-Like 1 gene (BMAL1), period (PER), and cyptochrome (CRY), and the consequent expression

Diabetes 145
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Trans People on Hormone Therapy Don't Mind Potential Cardiovascular Side Effects

Med Page Today

(MedPage Today) -- Trans adults using gender-affirming hormone therapy said they were content that it helped their overall well-being and, indirectly, felt it benefited their cardiovascular health, researchers reported. Based on interviews with.

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Circle Cardiovascular Imaging Announces Leadership Transition

DAIC

Circle Cardiovascular Imaging has announced that Erkan Akyuz has been appointed Chief Executive Officer to succeed Circle co-founder and CEO Greg Ogrodnick. Image courtesy: Circle Cardiovascular christine.book Thu, 07/18/2024 - 13:32 July 18, 2024 — Circle Cardiovascular Imaging , a developer of artificial intelligence (AI)-driven cardiovascular imaging solutions, has announced that Erkan Akyuz has been appointed Chief Executive Officer, effective August 5, 2024.

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Association of diabetes with cardiovascular calcification and all-cause mortality in end-stage renal disease in the early stages of hemodialysis: a retrospective cohort study

Cardiovascular Diabetology

The main goal of this study was to examine how diabetes, cardiovascular calcification characteristics and other risk factors affect mortality in end-stage renal disease (ESRD) patients in the early stages of h.

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HBV, HCV Screening Disparities Among Low-Income US Veterans

HCPLive

An analysis of data from the NV-HOPE study calls attention to lower rates of HBV and HCV screening among low-income US veterans versus the general US veteran population.

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The President Was Dying, but His Doctors Zipped Their Lips

Med Page Today

(MedPage Today) -- The patient's blood pressure averaged 209/100 mm Hg, a level now considered to be a medical emergency. His heart was enlarged, his skin was gray due to lack of oxygen in the blood, and an ECG showed signs of terminal cardiac.

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Elucid Commences International PRE-VUE CCT Registry Study

DAIC

mtaschetta-millane Thu, 07/18/2024 - 09:19 July 18, 2024 — Elucid , a pioneering AI medical technology company providing physicians with imaging analysis software based on ground truth histology to support diagnosis and treatment of cardiovascular disease, has initiated site recruitment for its Plaque as a Risk Factor for Evaluation of Vascular Events (PRE-VUE) CT Registry Study.

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Prevalence and incidence of heart failure in type 2 diabetes patients: results from a nationwide prospective cohort—the DIABET-IC study

Cardiovascular Diabetology

Type 2 diabetes (T2D) patients have an increased risk of heart failure (HF). There are limited data on the association between HF and T2D in specific healthcare settings. This study sought to analyse the preva.

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VCP activator reverses nuclear proteostasis defects and enhances TDP-43 aggregate clearance in multisystem proteinopathy models

Journal of Clinical Investigation - Cardiology

Pathogenic variants in valosin-containing protein (VCP) cause multisystem proteinopathy (MSP), a disease characterized by multiple clinical phenotypes including inclusion body myopathy, Paget’s disease of the bone, and frontotemporal dementia (FTD). How such diverse phenotypes are driven by pathogenic VCP variants is not known. We found that these diseases exhibit a common pathologic feature: ubiquitinated intranuclear inclusions affecting myocytes, osteoclasts, and neurons.

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Pemafibrate Takes a Small Step Forward in Diabetic Foot Ulcers After CVD Flop

Med Page Today

(MedPage Today) -- Pemafibrate was tied to potential prevention of leg and foot ulcers in type 2 diabetes, a silver lining to the PROMINENT trial's otherwise disappointing cardiovascular results. In an exploratory analysis, pemafibrate was tied.

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AliveCor's Kardia 12L ECG System Receives Category III CPT Codes

DAIC

mtaschetta-millane Thu, 07/18/2024 - 09:05 July 18, 2024 — AliveCor , a global leader in AI-powered cardiology , today announced that the American Medical Association (AMA) has granted new Category III Current Procedural Terminology (CPT) codes that are applicable to the company's Kardia 12L ECG System , which received FDA clearance in June 2024.

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ECG Blog #439 — How Many Possibilities?

Ken Grauer, MD

How would YOU interpret the rhythm in Figure-1 — if you were sent this tracing without the benefit of any history? Figure-1: How would YOU interpret this rhythm? The "Quick" Answer: My initial thoughts on the rhythm in Figure-1 : The rhythm in Figure-1 is not completely regular. That said — the R-R interval for the first 5 beats looks regular. The R-R interval for the last few beats is shorter than this — but also regular.

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Lipoprotein(a) and Long-Term Plaque Progression, Low-Density Plaque, and Pericoronary Inflammation

JAMA Cardiology

This study investigates the impact of lipoprotein(a) levels on long-term coronary artery plaque progression, high-risk plaque, and pericoronary adipose tissue inflammation.

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Brendon Neuen, MBBS, PhD: Optimizing Cardiorenal Prognosis with GLP-1, SGLT2 Combination

HCPLive

Neuen explains the cardiovascular and kidney benefits of combining SGLT2 inhibitors and GLP-1 receptor agonists in diabetes and the future of combination therapy.

Diabetes 105
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BioCardia Announces United States Patent Issuance on Morph DNA Multi-Directional Steerable Catheter Transseptal Application

DAIC

mtaschetta-millane Wed, 07/17/2024 - 11:06 July 17, 2024 — BioCardia, Inc. , a company focused on cellular and cell-derived therapeutics for the treatment of cardiovascular and pulmonary diseases announced that the Unites States Patent Office has granted Patent No: 12,036,371 titled “Method of Accessing the Left Atrium with a Multi-Directional Steerable Catheter,” with a patent term that will expire in 2035.

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Dietary patterns to promote cardiometabolic health

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 17 July 2024; doi:10.1038/s41569-024-01061-7 Various dietary patterns have been proposed to improve cardiometabolic health. In this Review, Pagidipati et al. emphasize the commonalities between recommendations on what to eat (Mediterranean, Dietary Approaches to Stop Hypertension and low-carbohydrate or ketogenic diets) and the possible benefits of time-restricted eating and intermittent fasting.

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Artificial intelligence-enabled atrial fibrillation detection using smartwatches: current status and future perspectives

Frontiers in Cardiovascular Medicine

Atrial fibrillation (AF) significantly increases the risk of stroke and heart failure, but is frequently asymptomatic and intermittent; therefore, its timely diagnosis poses challenges. Early detection in selected patients may aid in stroke prevention and mitigate structural heart complications through prompt intervention. Smartwatches, coupled with powerful artificial intelligence (AI)-enabled algorithms, offer a promising tool for early detection due to their widespread use, easiness of use, a

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Switching to Faricimab Effective for Treatment-Naive Wet AMD

HCPLive

A case series analysis indicated that switching from aflibercept to faricimab could be a safe and effective option for patients with treatment-resistant nAMD.

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Phoenix Cardiology Practice Installs the First and Fastest Cardiovascular CT Scanner in the State, Arineta’s SpotLight Duo

DAIC

mtaschetta-millane Tue, 07/16/2024 - 09:59 July 16, 2024 — Arineta , a leader in advancing cardiovascular imaging solutions through cutting-edge technology, proudly announces the latest installation of its SpotLight Duo at Cardiovascular Consultants, Ltd. (CVC) in Arizona. This makes CVC the first and only practice in the southwest region to have the world’s first dedicated cardiovascular and thoracic CT scanner.

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Why You Struggle To Lose Weight.

Dr. Paddy Barrett

Over the last few months, I have gained weight, and I needed to lose it. The weight gain was intentional, as I was attempting to add muscle mass. But I overshot. Not by a huge amount, but I ended up about 5 kg (11 lbs) over where I was six months ago. Sure, some of that was muscle mass but by no means all of it. I needed to drop some of that excess weight, so what did I do?

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Functional control of myosin motors in the cardiac cycle

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 19 July 2024; doi:10.1038/s41569-024-01063-5 Contraction of the heart is driven by cyclical interactions between myosin and actin filaments driven by ATP hydrolysis. In this Review, Irving summarizes the basal cardiac cycle of the healthy human heart at the ventricular, cellular, sarcomeric, and molecular levels and the implications for the development of novel therapies for heart disease.

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Sunir J. Garg, MD: Pegcetacoplan Preserves Visual Function on Microperimetry

HCPLive

Pegcetacoplan for 36 months led to fewer absolute scotomatous points on microperimetry than delayed treatment, suggesting its efficacy in preserving vision.

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Edwards Lifesciences to Acquire Innovalve

DAIC

Getty Images mtaschetta-millane Mon, 07/15/2024 - 11:06 July 15, 2024 — Edwards Lifesciences announced it has exercised its option to acquire Innovalve Bio Medical Ltd. , an early-stage transcatheter mitral valve replacement (TMVR) company, following its initial investment in 2017. Since that time, Innovalve has demonstrated progress in its program with promising early clinical experience.

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Subthreshold activation of the melanocortin system causes generalized sensitization to anorectic agents in mice

Journal of Clinical Investigation - Cardiology

The melanocortin-3 receptor (MC3R) regulates GABA release from agouti-related protein (AgRP) nerve terminals and thus tonically suppresses multiple circuits involved in feeding behavior and energy homeostasis. Here, we examined the role of the MC3R and the melanocortin system in regulating the response to various anorexigenic agents. The genetic deletion or pharmacological inhibition of the MC3R, or subthreshold doses of an MC4R agonist, improved the dose responsiveness to glucagon-like peptide

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New study finds cardiovascular outcomes better for patients on home hemodialysis

Medical Xpress - Cardiology

Dialysis patients using a more traditional home hemodialysis procedure have lower incidence of cardiovascular disease than patients using a less invasive peritoneal catheter for dialysis at home, according to a study led by a University of Cincinnati College of Medicine researcher.

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RHONE-X: 90% of Patients Treated with Faricimab Free from DME at 4 Years

HCPLive

New data from RHONE-X at ASRS suggest over 90% of DME patients treated with faricimab (Vabysmo) were DME-free at 4 years, with nearly 80% on 3-4 month dosing intervals.

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