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The relationships between inflammatory biomarkers, plaque characteristics, and macrophage clusters in coronary plaque: a quantitative assessment of macrophages based on optical coherence tomography

Frontiers in Cardiovascular Medicine

BackgroundQuantitative assessment of macrophage accumulation is appealing in evaluating plaque inflammation. Patients with macrophage clusters showed markedly higher levels of inflammatory biomarkers and plaque vulnerability. Large macrophage clusters were independently associated with high MHR and high lipid plaque burden.

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Heartflow Unveils New Data Showing Impact of Heartflow Plaque Analysis

DAIC

recently announced new data for its AI-enabled Heartflow Plaque Analysis , including final primary endpoint data from the DECIDE Registry. Additionally, 30% of patients with a calcified plaque volume of zero had a change in management. tim.hodson Thu, 07/17/2025 - 14:40 July 17, 2025— Heartflow, Inc.

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Link between low-fiber diet and more dangerous type of atherosclerotic plaque in the coronary arteries

Medical Xpress - Cardiology

A Swedish multi-center study led by researchers at Lund University shows a link between low fiber consumption and the presence of unstable or high-risk plaque in coronary arteries—the type of plaque that can trigger blood clots and cause heart attacks.

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Does Number of CVD Risk Factors Influence Plaque Vulnerability in ACS?

American College of Cardiology

The number of cardiovascular risk factors was strongly associated with greater plaque vulnerability, especially for culprit lesions, in patients with acute coronary syndromes (ACS), according to new research published in JACC.

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EviCore Adds Heartflow's Plaque Analysis to Updated Cardiac Imaging Guidelines

DAIC

has announced that its Heartflow Plaque Analysis will be included in updated cardiac imaging guidelines by radiology benefit manager EviCore, which provides coverage guidelines to leading commercial health insurers. This milestone follows Medicare’s positive coverage of artificial intelligence-enabled coronary plaque analysis (AI-CPA).

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Nomogram for predicting the severity of high-risk plaques in acute coronary syndrome

Frontiers in Cardiovascular Medicine

BackgroundThe CLIMA study [Relationship between Optical Coherence Tomography (OCT) Coronary Plaque Morphology and Clinical Outcome; NCT02883088] introduced the concept of high-risk plaque (HRP) and demonstrated that HRP was associated with a high risk of major coronary events.

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What have we learnt from histology about the efficacy of coronary imaging modalities in assessing plaque composition?

Frontiers in Cardiovascular Medicine

Intravascular imaging was introduced for this purpose 40 years ago enabling for the first time in vivo plaque characterization.

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