Thu.Sep 19, 2024

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Providence Heart Institute planning $42M renovation

Becker's Hospital Review - Cardiology

Renton, Wash.-based Providence is planning a $42 million renovation of the Providence Heart Institute in Spokane, which will increase its patient capacity by 15%, according to a Sept. 17 report from the Spokane Journal of Business.

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Matthew Zirwas, MD: Discussing Upadacitinib, Other JAK Inhibitors for Atopic Dermatitis

HCPLive

In this segment of his interview, Zirwas highlighted the use of JAK inhibitors such as upadacitinib, discussed safety, and touched on topical options for patients with eczema.

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Genetic testing, AI and PET deserts: 5 cardiology study updates

Becker's Hospital Review - Cardiology

"Stay updated on the latest findings in cardiology, including the use of machine-learning models and genetic testing to improve patient care and outcomes.

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FDA Issues CRL to Vanda Pharmaceuticals’ Tradipitant for Gastroparesis Symptoms

HCPLive

The FDA declined to approve the NDA for tradipitant for the treatment of symptoms of gastroparesis, suggesting that Vanda conduct additional studies.

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Empirical superior vena cava electrical isolation guided by quantitative ablation index improves outcomes of radiofrequency catheter ablation for paroxysmal atrial fibrillation

Open Heart

Background The value of empirical superior vena cava isolation (SVCI) following pulmonary vein isolation (PVI) to improve the efficacy of radiofrequency catheter ablation (RFCA) for paroxysmal atrial fibrillation (PAF) remains controversial. Objective To evaluate the efficacy and safety of quantitative ablation index (AI)-guided empirical SVCI, in addition to PVI, for patients with PAF.

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Gene therapy shows promise in treating heart arrhythmia: Study

Becker's Hospital Review - Cardiology

A pharmaceutical gene therapy has shown promise in treating calmodulinopathy, a rare and hard-to-treat heart arrhythmia, according to a study published Aug. 19 in Circulation.

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Interleukin 6 plasma levels are associated with progression of coronary plaques

Open Heart

Background Inflammation plays a pivotal role in atherogenesis and is a causal risk factor for atherosclerotic cardiovascular disease. Non-invasive coronary CT angiography (CCTA) enables evaluation of coronary plaque phenotype. This study investigates the relationship between a comprehensive panel of inflammatory markers and short-term plaque progression on serial CCTA imaging, hypothesising that inflammation is associated with increased plaque volume.

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FDA Approves Digital Health Solution for Heart Failure Management

DAIC

tim.hodson Thu, 09/19/2024 - 09:42 Sept. 18, 2024 – Astellas Pharma Inc. recently announced that Digitiva, a non-invasive digital health solution for heart failure management, has been listed with the U.S. Food and Drug Administration (FDA). Digitiva is classified as a Class I Software as a Medical Device (SaMD) and is exempt from 510(k) premarket submission*.

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FDA Approves First Year-Long Continuous Glucose Monitoring Sensor for Diabetes

Cardiometabolic Health Congress

The U.S. Food and Drug Administration (FDA) has approved Eversense 365, the first and only continuous glucose monitoring (CGM) system designed to function for an entire year, according to a company press release. Developed by Senseonics and Ascensia Diabetes Care, the device represents a significant advancement in long-term glucose monitoring technology.

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Outcomes of Class Switching vs Cycling TNF Inhibitors

HCPLive

Panelists discuss how switching to a biologic with a different mechanism of action can enhance clinical outcomes in patients with inadequate responses to tumor necrosis factor inhibitors.

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Renal Denervation by Iberis Multi-Electrode Renal Denervation System in Patients With Primary Hypertension

American College of Cardiology

The goal of the Iberis-HTN trial was to assess the efficacy and safety of the multi-electrode, unipolar AngioCare Iberis renal denervation (RDN) system in patients with treatment-resistant primary hypertension (HTN) on a standardized three-drug regimen.

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Cycling Within TNF Inhibitors: Complications and Factors Influencing Treatment Choices

HCPLive

Panelists discuss how continued cycling of tumor necrosis factor inhibitors (TNFis) without achieving remission can lead to complications like irreversible joint erosion, significantly diminishing patient quality of life, and explore why providers may persist with TNFis despite failure, access barriers to switching mechanisms of action, and treatment considerations for patients whose initial positive response to TNFis declines over time.

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Mineralocorticoid Antagonism in HF: Key Points

American College of Cardiology

The following are key points to remember from a state-of-the-art review on the established and emerging therapeutic role of mineralocorticoid antagonism in patients with heart failure (HF).

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Noninvasive SAFE Score Stratifies Long-Term Outcomes in Steatotic Liver Disease

HCPLive

High-risk SAFE scores were linked to increased mortality, especially in participants with alcohol-associated liver disease, as this group demonstrated the worst survival.

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Coronary Artery Calcium Density and Risk of CV Events

American College of Cardiology

Is coronary artery calcium (CAC) density by computed tomography (CT) inversely associated with plaque vulnerability and atherosclerotic cardiovascular disease (ASCVD) events (coronary heart disease [CHD] and stroke)?

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HERALD: ALG-055009 Demonstrates Liver Fat Reduction in Phase 2a MASH Study

HCPLive

Positive topline results from the phase 2a HERALD study of ALG-055009 in MASH highlight the THR-β agonist’s impact on liver fat reduction.

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Disparities in Prehospital Care of Acute Stroke Patients

American College of Cardiology

How do patient-level factors, including race/ethnicity and county-level socioeconomic status (SES) affect inequities in prehospital care of patients with stroke?

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Differentiating Between Different Types of Alopecia, with Jerry Shapiro, MD

HCPLive

Shapiro spoke in his Maui Derm NP+PA Fall conference interview about differentiating between types of alopecia areata and about the potential use of JAK inhibitors.

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Race and Ethnicity, Socioeconomic Status Influence Lp(a) Testing Rates

HCPLive

Lp(a) ordering remains low in patients at risk for ASCVD, particularly non-Hispanic Black or Hispanic individuals in socioeconomically disadvantaged neighborhoods.

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Updates on the Diagnosis of Blistering Diseases, with Donna Culton, MD, PhD

HCPLive

This interview with Culton featured a discussion of key challenges faced when treating patients with blistering diseases such as pemphigus and bullous pemphigoid.

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EDG-7500 Achieves Positive Phase 2 Results in Obstructive HCM

HCPLive

EDG-7500 was well-tolerated in healthy patients in Phase 1 while achieving gradient relief without LVEF reductions in the Phase 2 CIRRUS-HCM trial.

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Migraine Patients Achieve Remission of Medication Overuse Headaches with Erenumab

HCPLive

A study revealed erenumab at 140 mg is effective and safe in achieving remission of headaches caused by non-opioid medication overuse.

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Self-Guided Digital Behavioral Therapy Improved Fibromyalgia Management and Pain

HCPLive

Digital ACT demonstrated superiority over active control in a number of outcomes in a phase 3 trial.

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Gout Prevalence to Increase by More Than 70% by 2050

HCPLive

The increase will largely be driven by population growth and aging.

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New Model Predicts the Hepatocellular Carcinoma Risk in Chronic Hepatitis B

HCPLive

The model Revised REACH-B outperforms an earlier model by incorporating predictors of predictors of age, sex, platelet count, ALT levels, and positive hepatitis B antigen result.

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