Trending Articles

article thumbnail

Only One Harm From mRNA COVID Vaccines, Report Determines

Med Page Today

(MedPage Today) -- Independent reviewers confirmed a causal relationship between the first mRNA COVID-19 vaccines and myocarditis, and also determined that, more broadly, intramuscular shots can cause a series of shoulder injuries. At the same.

COVID-19 145
article thumbnail

Survey Finds Many Fibromyalgia Patients Finding Symptom Relief with Medical Cannabis

HCPLive

Almost 50% of fibromyalgia patients use cannabis for symptom relief, according to new study. Experts suggest results underline need for clinician awareness, further research.

article thumbnail

Physical activity lowers cardiovascular disease risk by reducing stress-related brain activity, study finds

Medical Xpress - Cardiology

New research indicates that physical activity lowers cardiovascular disease risk in part by reducing stress-related signaling in the brain.

article thumbnail

ECG Blog #425 — Are there P Waves?

Ken Grauer, MD

I was sent the ECG in Figure-1 — told only that the patient was 70 years old, and had a history of an ASD ( A trial S eptal D efect ). Serum K+ was normal. The patient was hemodynamically stable with ECG #1. QUESTIONS: How would YOU interpret the rhythm in Figure-1 ? Are there P waves? Figure-1: The initial ECG in today's case. MY Initial Thoughts on Today's CASE: Knowing that today's patient has a history of an ASD ( A trial S eptal D efect ) — is relevant to the interpretation of today's inter

Blog 112
article thumbnail

Small molecules that disrupt RAD54-BLM interaction hamper tumor proliferation in colon cancer chemoresistance models

Journal of Clinical Investigation - Cardiology

RAD54 and BLM helicase play pivotal roles during homologous recombination repair (HRR) to ensure genome maintenance. BLM amino acids (aa 181–212) interact with RAD54 and enhance its chromatin remodeling activity. Functionally, this interaction heightens HRR, leading to a decrease in residual DNA damage in colon cancer cells. This contributes to chemoresistance in colon cancer cells against cisplatin, camptothecin, and oxaliplatin, eventually promoting tumorigenesis in preclinical colon cancer mo

Cancer 110
article thumbnail

Cardiac Events Common in Older, Hospitalized RSV Patients

Med Page Today

(MedPage Today) -- More than one in five older adults hospitalized for respiratory syncytial virus (RSV) infection experienced an acute cardiac event, an observational study found. Among 6,248 hospitalized patients 50 or older with laboratory.

Hospital 117
article thumbnail

Electrocardiographic approach strategies in patients with Parkinson disease treated with deep brain stimulation

Frontiers in Cardiovascular Medicine

Deep brain stimulation (DBS) is an interdisciplinary and reversible therapy that uses high-frequency electrical stimulation to correct aberrant neural pathways in motor and cognitive neurological disorders. However, the high frequency of the waves used in DBS can interfere with electrical recording devices (e.g., electrocardiogram, electroencephalogram, cardiac monitor), creating artifacts that hinder their interpretation.

More Trending

article thumbnail

Analysis Suggests Causal Link Between AMD, Rheumatoid Arthritis

HCPLive

Mendelian randomization analysis demonstrated a direct connection between rheumatoid arthritis and an increased risk of age-related macular degeneration.

105
105
article thumbnail

Ectopic expression of the transcription factor ONECUT3 drives a complex karyotype in myelodysplastic syndromes

Journal of Clinical Investigation - Cardiology

Chromosomal instability is a prominent biological feature of myelodysplastic syndromes (MDS), with over 50% of patients with MDS harboring chromosomal abnormalities or a complex karyotype (CK). Despite this observation, the mechanisms underlying mitotic and chromosomal defects in MDS remain elusive. In this study, we identified ectopic expression of the transcription factor ONECUT3, which is associated with CKs and poorer survival outcomes in MDS.

Outcomes 105
article thumbnail

CPR-Therapeutics, Inc. Names Mike Black as Chief Strategy Officer

DAIC

Mike Black milla1cf Wed, 04/17/2024 - 16:15 April 17, 2024 — CPR Therapeutics, Inc. (CPR-T), an early-stage medtech startup funded by the N.I.H and N.S.F to develop the next generation technology for cardiopulmonary resuscitation, announced today that Mike Black will be advising the Company as its first Chief Strategy Officer. CPR Therapeutics, Inc. is developing multimodal cardiopulmonary resuscitation (CPR), a more effective form of automated mechanical CPR.

article thumbnail

Circulating biomolecules identify patients with atrial fibrillation at high risk of cardiovascular events

Medical Xpress - Cardiology

An analysis of the biomolecule substudy of the EAST–AFNET 4 trial has revealed that biomolecule concentrations in the blood of patients with atrial fibrillation can be used to identify patients at high and low cardiovascular risk. The findings were published in Cardiovascular Research.

article thumbnail

After Adverse Pregnancy Outcomes, Mortality Risk Lingers for Decades

Med Page Today

(MedPage Today) -- Women who experienced major adverse pregnancy outcomes still had increased mortality risks decades later, a population-based cohort study of Swedish data found. Adverse pregnancy outcomes independently associated with increased.

article thumbnail

International Consensus Statement Calls for Prioritization of Kidney Disease by the WHO

HCPLive

The consensus calls for the recognition of kidney disease as a major non-communicable disease driver of premature mortality by the World Health Organization.

article thumbnail

56 year old male had 5/10 chest pain for several hours, then presented to the ED in the middle of the night with 1/10 pain.

Dr. Smith's ECG Blog

A 56 year old male with PMHx significant for hypertension had chest pain for several hours, then presented to the ED in the middle of the night. He reported chest pain that developed several hours prior to arrival and was 5/10 in intensity. The pain was located in the mid to left chest and developed after riding his bike. There was associated fatigue when symptoms developed and mild shortness of breath at onset of chest pain however that has since resolved.

article thumbnail

Around 10% of Deaths from Coronary Stenting, Balloon Angioplasty are Preventable

DAIC

Getty Images milla1cf Tue, 04/16/2024 - 12:43 April 16, 2024 — Each year more than 500,000 Americans undergo percutaneous coronary intervention , or PCI, a minimally invasive procedure to unclog the arteries that feed the heart. While PCI, which includes both angioplasty and stenting, is one of the most common operations in the world, it does carry a small (about 1-2%) but significant risk of death.

article thumbnail

ACC: Ticagrelor monotherapy cuts bleeding risk in acute coronary syndrome

Medical Xpress - Cardiology

Treatment with ticagrelor alone results in a lower rate of clinically relevant bleeding compared with ticagrelor and aspirin among patients with an acute coronary syndrome who had percutaneous coronary intervention and remained event-free for one month on dual antiplatelet therapy, according to a study published online April 7 in The Lancet to coincide with the annual meeting of the American College of Cardiology, held from April 6 to 8 in Atlanta.

95
article thumbnail

Antipsychotics in Dementia Tied to Wider Range of 'Serious Harms'

Med Page Today

(MedPage Today) -- Use of antipsychotics in dementia patients was associated with an increased risk for a wider range of adverse outcomes than previously acknowledged, a population-based matched cohort study from the U.K. showed. In the analysis.

article thumbnail

Ankeet Bhatt, MD, MBA: NUDGE-FLU Analysis in Patients With and Without Myocardial Infarction

HCPLive

Ankeet Bhatt, MD, MBA, discusses a NUDGE-FLU analysis from ACC.24 examining effect of the CV gain-framed nudge in patients with and without history of AMI.

article thumbnail

Talking about women’s heart disease to medical students

Heart Sisters

Can we do a better job teaching medical and nursing students about women’s unique cardiac issues? The answer might be in these nine teaching modules!

article thumbnail

FDA Announces Recalls of Abbott/Thoratec Corp. Heartmate II and Heartmate 3 Left Ventricular Assist System (LVAS) Due to Long-term Buildup of biological material Causing an Obstruction

DAIC

Image courtesy of Abbott mtaschetta-millane Mon, 04/15/2024 - 09:54 April 15, 2024 — The U.S. Food and Drug Administration ( FDA ) announced A bbott/Thoratec Corp. is recalling HeartMate II and HeartMate 3 Left Ventricular Assist System (LVAS) due to an issue called Extrinsic Outflow Graft Obstruction , (EOGO). This occurs when biological material builds up between certain parts of the device, causing a blockage that makes it harder for the heart to pump blood.

article thumbnail

Is OMI an ECG Diagnosis?

Dr. Smith's ECG Blog

Written by Jesse McLaren A 70 year old with prior MIs and stents to LAD and RCA presented to the emergency department with 2 weeks of increasing exertional chest pain radiating to the left arm, associated with nausea. The pain recurred at rest 90 minutes prior to presentation, felt like the patient’s prior MIs, and was not relieved by 6 sprays of nitro.

STEMI 61
article thumbnail

Tirzepatide Improves Sleep Apnea in Patients With Obesity, Drugmaker Says

Med Page Today

(MedPage Today) -- Tirzepatide (Zepbound) injections reduced sleep apnea severity among patients with obesity, regardless of positive airway pressure (PAP) use, according to topline data from two phase III trials. In the SURMOUNT-OSA 1 study.

Obesity 73
article thumbnail

Patients with SCD Face Early Death Despite Improved Survival Rates

HCPLive

A recent multi-center study identified risk factors linked to premature mortality in sickle cell disease, including male gender and hematologic and biochemical parameters.

article thumbnail

American and European HF Guideline Comparison: Key Points

American College of Cardiology

The following are key points to remember from a review comparing contemporary clinical practice recommendations for the management of heart failure (HF) in the American and European guidelines.

article thumbnail

CVRx Announces Availability of Additional Data Supporting Long-term Benefits of Barostim

DAIC

milla1cf Tue, 04/16/2024 - 12:35 April 16, 2024 — CVRx, Inc., a commercial-stage medical device company, announced today the availability of additional data, including the publication of results of the post-market phase of the BeAT-HF trial in the European Journal of Heart Failure. These data highlight long-term sustained benefits of Barostim in heart failure patients with reduced ejection fraction.

article thumbnail

Adults with congenital heart disease faced higher risk of abnormal heart rhythms

Science Daily - Heart Disease

Adults with congenital heart defects were more likely to experience an abnormal, irregular heartbeat, finds a new study.

article thumbnail

No Link Between GLP-1 Drugs and Suicide, Says European Regulator

Med Page Today

(MedPage Today) -- The European Medicines Agency (EMA) found no evidence to support a causal link between GLP-1 receptor agonists and suicidal thoughts, a committee said on Friday following a 9-month review. An investigation was launched in July.

93
article thumbnail

Budesonide Maintains IgA Nephropathy Kidney Failure Reduction, Quality of Life at 2 Years

HCPLive

New phase 3 findings show daily oral budesonide reduces eGFR decline while maintaining patient quality of life over 2 years.

article thumbnail

Aprocitentan, a Newly Approved Drug for Resistant Hypertension

NEJM Journal Watch - Cardiology

This drug is the first endothelin-receptor antagonist approved to treat patients with systemic hypertension.

article thumbnail

Getinge Enters into Commercial Distribution Agreement with Cook Medical for iCast Covered Stent System in the United States

DAIC

milla1cf Wed, 04/17/2024 - 16:18 April 17, 2024 — Getinge and Cook Medical announced an exclusive sales and distribution agreement for the iCast covered stent system, which has been on the market for twenty years and recently received premarket approval for treatment of iliac arterial occlusive disease. The agreement includes a 60-day transition period after which Cook Medical will assume the sales, marketing and distribution rights for the product in the United States.

Stents 75
article thumbnail

Polypills can reduce cardiovascular mortality by 11%: Study

Becker's Hospital Review - Cardiology

Polypills for atherosclerotic cardiovascular disease reduced all-cause mortality by 11% and risk of fatal and nonfatal cardiovascular events by 29%, a recent study found.

article thumbnail

Multidisciplinary Team Intervention Flops for Improving CKD Outcomes

Med Page Today

(MedPage Today) -- A multi-pronged electronic health record-based population health management intervention failed to move the needle for slowing chronic kidney disease (CKD) progression, a cluster randomized trial showed. Over a median follow.

article thumbnail

Extending Postpartum Medicaid Linked to Increased Perinatal Mental Health Care

HCPLive

A new study found extending postpartum Medicaid from 60 days to 12 months is linked to new mothers being more likely to seek mental health care for perinatal mood and anxiety disorders.

Medicaid 105
article thumbnail

GLP1RAs in Clinical Practice: Therapeutic Advances and Safety Perspectives

American College of Cardiology

Glucagon-like peptide-1 is an incretin (gut-derived hormone) that plays a crucial role in glucose homeostasis, linking nutrient absorption to pancreatic hormone secretion.

Article 70
article thumbnail

Shorten the Blanking Period After Atrial Fibrillation Ablation, Experts Say

DAIC

Based on continuous monitoring of early recurrence of atrial tachyarrhythmia immediately after patients have undergone atrial fibrillation ablation, Musat et al. recommend shortening the blanking period from three months to one. Graphic courtesy of Dan Musat milla1cf Thu, 04/18/2024 - 13:32 April 18, 2024 — New evidence-based research calls into question the conventional three-month blanking period immediately after atrial fibrillation (AF) ablation, when early occurrences of AF are thought not

article thumbnail

Complete resection of a giant intrapericardial cardiac synovial sarcoma

Journal of Cardiothoracic Surgery

Synovial sarcoma of the heart is a rare tumor. Herein we would like to report a case of giant intrapericardial cardiac synovial sarcoma that originated from the right ventricle and grew outward near the diaphr.

52
article thumbnail

Persistent Non-HDL-C Dyslipidemia Starting in Childhood Tied to Higher CVD Risk

Med Page Today

(MedPage Today) -- Patients with persistent non-high-density lipoprotein (HDL) cholesterol dyslipidemia from childhood to adulthood had an increased risk of cardiovascular disease (CVD) events, but those who had resolved this by adulthood had a.