Medical Xpress - Cardiology

MARCH 7, 2025

Researchers report a discovery in cardiac regeneration that offers new hope for the treatment of ischemic heart failure. Published in npj Regenerative Medicine, the study reveals a novel approach to promoting cardiomyocyte proliferation. The researchers are from the Michael E. DeBakey Department of Surgery at Baylor College of Medicine, the QIMR Berghofer Medical Research Institute in Brisbane, Australia, and collaborating institutions.

Heart Failure 138

Heart Failure Research 138

Science Daily - Heart Disease

JANUARY 2, 2025

Researchers have successfully repaired damaged mouse hearts using a protein from zebrafish. They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing side effects, such as heart enlargement. This study marks an important step toward regenerative therapies to prevent heart failure.

Heart Failure 124

Heart Failure Research 124

Physiologically Speaking

MARCH 30, 2025

This talk dives into the science of cardiovascular fitness, its profound impact on longevity, and how to train smarter without overcomplicating it. I delivered it at the Golden Age Health Summit on March 15, 2025, in Austin, TX. Key Takeaways: Why VO2 max is your longevity superpower How aerobic fitness declines with age—and what to do about it A simplified 3-zone training model: Easy (50-70% HR max), Moderate (70-85% HR max), and Hard (85-100% HR max) Practical tips to train effectively w

Physiology 104

Physiology BMI Cholesterol Risk Factors 104

Dr. Smith's ECG Blog

JANUARY 2, 2025

By Smith with comments from our electrophysiologist, Rehan Karim. (And of course Ken's comments at the bottom) An elderly obese woman with cardiomyopathy, Left bundle branch block, and chronic hypercapnea presented hypoxic with altered mental status. She was intubated. Bedside cardiac ultrasound showed moderately decreased LV function. CT of the chest showed no pulmonary embolism but bibasilar infiltrates.

Tachycardia 116

Tachycardia Cardiomyopathy Blog Bradycardia 116

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

Patient Care

Journal of Clinical Investigation - Cardiology

APRIL 1, 2025

Chimeric antigen receptor (CAR) T cell therapy shows promise for various diseases. Our studies in humanized mice and nonhuman primates demonstrate that hematopoietic stem cells (HSCs) modified with anti-HIV CAR achieve lifelong engraftment, providing functional antiviral CAR-T cells that reduce viral rebound after antiretroviral therapy (ART) withdrawal.

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Open Heart

FEBRUARY 23, 2025

Background Individual cardiometabolic diseases (CMDs) increase atrial fibrillation (AF) risk; however, whether multiple CMDs exert a cumulative effect on AF risk remains unclear. Our objective was to examine the link between coexisting CMDs and AF, as well as their cumulative impact. Methods This UK Biobank-based prospective cohort study included data from participants with information related to CMDs and AF.

Atrial Fibrillation 98

Atrial Fibrillation 98

Circulation

APRIL 17, 2025

Circulation, Ahead of Print. Cardiovascular disease remains a leading cause of morbidity and mortality in adults despite recent scientific advancements. Although people are living longer lives, there may be an adverse impact on quality of life, necessitating a greater need for palliative care services and support. Palliative care for adults with advanced cardiovascular disease has the potential to significantly improve quality of life for individuals living with cardiovascular disease and their

Cardiovascular Disease 81

Cardiovascular Disease Quality of Life Circulation Research 81

Frontiers in Cardiovascular Medicine

JANUARY 28, 2025

IntroductionThere is growing evidence that patients with SARS-CoV-2 (The severe acute respiratory syndrome coronavirus 2) may have a variety of cardiovascular complications in the post-acute phase of COVID-19, but these manifestations have not yet been comprehensively characterized.MethodsWe performed a systematic review and meta-analysis of primary research papers which evaluated individuals at least four weeks after confirmed COVID-19 diagnosis and reported on cardiovascular disease prevalence

COVID-19 95

COVID-19 Cardiogenic Shock Cardiomyopathy Outcomes 95

CardiacWire

FEBRUARY 12, 2025

Just a couple weeks after the full trial results of AZALEA TIMI 71 were released, Novartis agreed to acquire Anthos Therapeutics for $925M upfront and another $2.15B in milestone payments, signaling that the pharma titan may have renewed confidence in abelacimab and the Factor XI inhibition segment. Novartis spun out the testing and development of abelacimab and formed Anthos Therapeutics back in 2019.

AFIB 102

AFIB Embolism Plaque Stroke 102

Heart BMJ

MARCH 26, 2025

Background Pericardial complications following cardiac surgery are common and debilitating, significantly impacting patients’ survival. We performed this network meta-analysis to identify the most effective and safest preventions and treatments for pericardial complications following cardiac surgery. Methods We systematically searched PubMed/MEDLINE, EMBASE and Cochrane CENTRAL from inception to 22 January 2024.

Open-Heart Surgery 85

Open-Heart Surgery Pharmacology Atrial Fibrillation Pericarditis 85

Medical Xpress - Cardiology

JANUARY 24, 2025

Researchers from Mass General Brigham and collaborating institutions have developed a non-invasive approach to manipulate cardiac tissue activity by using light to stimulate an innovative ink incorporated into bioprinted tissue. Their goal is to develop a technique that can be used to repair the heart. Their findings in preclinical models, published in Science Advances, show the transformative potential of non-invasive therapeutic methods to control electrically active tissues.

Innovation 130

Innovation Research 130

Science Daily - Heart Disease

JANUARY 22, 2025

Researchers have developed a way of bioprinting tissues that change shape as a result of cell-generated forces, in the same way that it happens in biological tissues during organ development. The breakthrough science focused on replicating heart tissues, bringing research closer to generating functional, bioprinted organs, which would have broad applications in disease modelling, drug screening and regenerative medicine.

Research 129

Research 129

Physiologically Speaking

MARCH 21, 2025

Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. You can find more products I’m affiliated with on my website. Physiologically Speaking is a reader-supported publication.

Physiology 128

Physiology Exercise Stroke Strokes 128

Nature Reviews - Cardiology

FEBRUARY 27, 2025

Nature Reviews Cardiology, Published online: 28 February 2025; doi:10.1038/s41569-025-01143-0 Epigenetic editing holds great promise for the treatment of many diseases, including cardiovascular disease. However, realizing this potential requires more than developing robust technology and demands a steadfast focus on patient needs and inclusion, to ensure that access to epigenetic medicine will be equitable and will benefit diverse populations worldwide.

Technology 88

Technology Cardiovascular Disease 88

DAIC

MARCH 14, 2025

tim.hodson Fri, 03/14/2025 - 11:42 March 11, 2025 CareDx, Inc. The Transplant Company recently announced that AlloSureis now commercially available for pediatric heart transplant patients of all ages and patients who have received a simultaneous pancreas-kidney (SPK) transplant. Both indications are approved by the New York State Clinical Laboratory Evaluation Program, demonstrating that AlloSure has met the most rigorous validation standards for laboratory developed tests (LDTs).

Heart Transplant 87

Heart Transplant Transplant Pediatrics Quality of Life 87

Open Heart

JANUARY 28, 2025

Introduction ST-elevation myocardial infarction (STEMI) is one of the most prevalent presentations in young patients. It is essential to emphasise that each minute of delay in providing medical care is negatively correlated to the patient’s prognosis. The present study was carried out to evaluate the ischaemia-reperfusion times in patients ≤40 years of age versus individuals >40 years of age and their association with mortality and major adverse cardiac event (MACE) over the long

Myocardial Infarction 95

Myocardial Infarction STEMI Risk Factors Hospital 95

Heart Sisters

JANUARY 19, 2025

If asked about a negative experience like the exact moment you were diagnosed with heart disease, would you be able to accurately recall that moment?

Heart Disease 113

Heart Disease 113

Circulation

APRIL 10, 2025

Circulation, Ahead of Print. The Physical Activity Guidelines for Americans supports sitting less and moving more. Growing evidence suggests that a waking behavior profile with less sedentary behavior and more light-intensity physical activity is associated with more favorable cardiovascular health. Remarkably, little is known about how these behaviors relate to cardiovascular health during pregnancy.

Blood Pressure 83

Blood Pressure Cardiovascular Disease Outcomes Hypertension 83

Society of Thoracic Surgeons - Adult Cardiac

JANUARY 26, 2025

Press Release Patients Who Received Ross Procedure Demonstrate Excellent Survival Rates after 20 Years January 26, 2025 KCummings Sun, 01/26/2025 - 13:40 LOS ANGELES January 26, 2024 Young patients who have undergone the Ross procedure for aortic valve disease have shown excellent long-term survival, the majority without the need for additional surgery two decades later.

Aortic valve 83

Aortic valve Cardiothoracic Congenital Aortic 83

ECG Cases

JANUARY 28, 2025

On this month's EM Quick Hits podcast: Anand Swaminathan on optimizing RSI medication timing, Brittany Ellison ED boarding challenges in older patients and solutions to ED crowding and flow, Dave Jeromeon managing prolonged tourniquet application, Nour Khatib and Phil Gillick on a rural peer support case, Jesse McLaren on ECG reciprocal changes in acute coronary occlusion, and Melody Ngon practical nutrition tips for shift workers.

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Heart BMJ

FEBRUARY 26, 2025

Background Menopause is a timely opportunity to screen for cardiovascular disease (CVD) and intervene with healthier lifestyles. We investigated the association between premature/early menopause and the likelihood of CVD and whether a healthy lifestyle is associated with a lower likelihood of CVD in menopausal woman. Methods The Sax Institute’s 45 and Up Study prospectively recruited participants aged ≥45 years (n=267 357) between 2005 and 2009 (New South Wales, Australia).

Cardiovascular Disease 78

Cardiovascular Disease Diet Heart Disease Stroke 78

Frontiers in Cardiovascular Medicine

FEBRUARY 4, 2025

Dyslipidemia is extensively analyzed in clinical trials investigating its role as a risk factor for coronary artery disease (CAD). However, its definition varies vastly among studies, leading to different attributions to the variable dyslipidemia. The objectives of this study are to verify the hypothesis of a lack of a consensual definition of dyslipidemia in coronary angiography studies and to propose a consensual definition of dyslipidemia, considering the influence of each serum lipid paramet

Coronary Artery Disease 94

Coronary Artery Disease Cholesterol Article Risk Factors 94

Science Daily - Heart Disease

FEBRUARY 4, 2025

Researchers have used mathematical analysis tools to study the effect of classical music on a fetal heartbeat and identify patterns in heart rate variability. They recruited 36 pregnant women and played two classical pieces for their fetuses. By attaching external heart rate monitors, the researchers could measure the fetal heart rate response to both songs, and by employing nonlinear recurrence quantification analysis, they could identify changes in heart rate variability during and after the m

Research 121

Research 121

Journal of Clinical Investigation - Cardiology

FEBRUARY 3, 2025

Understanding cell fate regulation in the liver is necessary to advance cell therapies for hepatic disease. Liver progenitor cells (LPCs) contribute to tissue regeneration after severe hepatic injury, yet signals instructing progenitor cell dynamics and fate are largely unknown. Tissue inhibitor of metalloproteinases 1 (TIMP1) and TIMP3 control the sheddases ADAM10 and ADAM17, key for NOTCH activation.

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Nature Reviews - Cardiology

APRIL 6, 2025

Nature Reviews Cardiology, Published online: 07 April 2025; doi:10.1038/s41569-025-01145-y To regenerate the injured heart, cardiomyocytes must proliferate to replace lost myocardial tissue, but this capacity is largely absent in adult mammals. In this Review, Koopmans and van Rooij explore the key pathways that drive cardiomyocyte maturation after birth and how targeted manipulation might reactivate the cell cycle in adult cardiomyocytes.

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American College of Cardiology

MARCH 30, 2025

Implantation of an intra-aortic balloon pump (IABP) did not improve 60-day survival or bridge to heart replacement (HRT) therapies in patients with heart failure-cardiogenic shock (HF-CS) compared to standard care, according to a study presented during a Featured Clinical Research session at ACC.25 in Chicago and simultaneously published in JACC. The trial was stopped by the Data Safety and Monitoring Board at the prespecified interim analysis due to futility.

Cardiogenic Shock 75

Cardiogenic Shock Heart Failure Outcomes Aortic 75

Open Heart

MARCH 28, 2025

Background The significance of stress-test induced arrhythmias has been examined in prior studies, but there is no clear consensus regarding its significance. Objectives To determine the significance of stress test-induced arrhythmias. Methods Relevant studies examining arrhythmia in both exercise and pharmacological stress testing were searched for in PubMed, Embase and Cochrane databases from inception to 14 June 2023.

Arrhythmia 75

Arrhythmia Coronary Artery Disease Myocardial Infarction Atrial Fibrillation 75

Dr. Paddy Barrett

JANUARY 2, 2025

What is inside the Heart Health Formula? A step-step guide to: - Understanding Heart Disease. - Defining Heart Disease Risk. - Reducing Heart Disease Risk. When I set out on my journey over a decade ago to put together a system to do this comprehensively, it did not exist in a way that I found useful. So, I created a system myself. The Heart Health Formula is made up of 3 main modules.

Cholesterol 88

Cholesterol Heart Disease Blood Pressure Coronary Angiogram 88

Circulation

APRIL 7, 2025

Circulation, Ahead of Print. Populations most affected by cardiovascular health disparities, including underrepresented populations with lower socioeconomic status, people with disabilities, and those living in underserved rural communities, are disproportionately exposed to adverse social determinants of health. Specifically, economic instability and suboptimal living conditions within the neighborhood and built environment directly determine access to resources and opportunities for healthful

Technology 79

Technology Health Disparities Cardiovascular Disease Circulation 79

ECG Guru

JANUARY 30, 2025

In this 12-lead ECG there is a bradycardic rhythm, which is regular, heart rate about 45 bpm. The QRS complexes are narow. What is this rhythm called? There are no P waves present, and no flutter or fibrillation waves can be seen. There are 2 possibilities: 1. There is a sinus arrest with a junctional escape rhythm. The junctional rhythm either cannot conduct retrograde to the atria (therefore no inverted retrograde P wave can be seen) or the retrograde P wave is hidden in the QRS complex (atria

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Physiologically Speaking

JANUARY 31, 2025

Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. You can find more products I’m affiliated with on my website. Physiologically Speaking is a reader-supported publication.

Physiology 85

Physiology Exercise Article Research 85

Heart BMJ

MARCH 13, 2025

Objective To investigate the associations between a comprehensive set of retinal vascular parameters and incident stroke to unveil new associations and explore its predictive power for stroke risk. Methods Retinal vascular parameters were extracted from the UK Biobank fundus images using the Retina-based Microvascular Health Assessment System. We used Cox regression analysis, adjusted for traditional risk factors, to examine the associations, with false discovery rate adjustment for multiple com

Stroke 84

Stroke Strokes Risk Factors Research 84

Frontiers in Cardiovascular Medicine

JANUARY 31, 2025

IntroductionVentricular assist devices (VADs) are lifesavers for people with advanced heart failure. The design of these devices has undergone drastic changes over time with the latest designs being far more efficient, small, lightweight, and more user-friendly. This study aims to analyze publications using bibliometric analysis and see the progress and identify key themes, trends, and collaboration networks.MethodData relevant to this study were obtained from Scopus and Web of Science databases

Document 80

Document Innovation Heart Failure Technology 80

Medical Xpress - Cardiology

MARCH 7, 2025

Teenagers who do not get the recommended amount of sleep may be at an increased risk for high blood pressure, according to preliminary research presented at the American Heart Association's Epidemiology, Prevention, Lifestyle & Cardiometabolic Health Scientific Sessions 2025. The meeting is being held in New Orleans, March 69, 2025, and features the latest science on population-based health and wellness and implications for lifestyle.

Blood Pressure 80

Blood Pressure Research 80

Science Daily - Heart Disease

MARCH 18, 2025

Women with blood pressure levels in a range considered clinically normal during pregnancy but no mid-pregnancy drop in blood pressure face an increased risk of developing hypertension in the five years after giving birth. These women -- about 12% of the population studied -- would not be flagged as high-risk by current medical guidelines, but the new findings could help identify them as candidates for early intervention.

Blood Pressure 70

Blood Pressure Hypertension 70

Nature Reviews - Cardiology

JANUARY 19, 2025

Nature Reviews Cardiology, Published online: 20 January 2025; doi:10.1038/s41569-025-01118-1 The past 20 years have witnessed remarkable progress in the evolution of transcatheter procedures for the treatment of adult patients with congenital heart disease. In this Review, Rods-Cabau and colleagues provide a comprehensive overview of the available transcatheter interventions for these patients, focusing on their current indications and associated outcomes.

Congenital Heart Disease 93

Congenital Heart Disease Congenital Heart Disease Outcomes 93