2024

article thumbnail

ECG Blog #419 — The Cause of ECG #1?

Ken Grauer, MD

I was sent the 2 ECGs shown in Figure-1 — which were recorded from an elderly man whose heart beat "has been irregular for years". No clear history for recent chest pain — but the patient "has not been well" for the previous week. Regarding the 2 ECGs in Figure-1 : ECG #1 is the initial tracing obtained at the scene by the EMS ( E mergency M edical S ystems ) team — in association with an alert but markedly hypotensive patient.

Blog 196
article thumbnail

COVID-19 infection appeared to increase risk of heart attack & stroke up to 3 years later

American Heart News - Heart News

Research Highlights: An analysis of UK Biobank health data that included adults who had mild to severe COVID-19 before vaccines were available found an increased risk of heart attack, stroke and death among those adults during the nearly three-year.

COVID-19 145
article thumbnail

Standing more may not reduce cardiovascular disease risk, could increase circulatory issues

Medical Xpress - Cardiology

Standing has gained popularity among people looking to offset the harms of a sedentary lifestyle often caused by spending long days sitting in front of the computer, television or driving wheel. Standing desks have become a popular option among office workers, and in other industries like retail, workers may opt to stand instead of sit.

article thumbnail

Type 2 Diabetes Diagnoses Emerge in Teens Months After COVID

Med Page Today

(MedPage Today) -- Children and teens had an increased risk of being diagnosed with type 2 diabetes after COVID-19 infection, a retrospective cohort study of over 600,000 youth suggested. Adolescents 10 to 19 years old had a 55% higher risk for.

COVID-19 134
article thumbnail

Spatiotemporal transcriptomic mapping of regenerative inflammation in skeletal muscle reveals a dynamic multilayered tissue architecture

Journal of Clinical Investigation - Cardiology

Tissue regeneration is orchestrated by macrophages that clear damaged cells and promote regenerative inflammation. How macrophages spatially adapt and diversify their functions to support the architectural requirements of actively regenerating tissue remains unknown. In this study, we reconstructed the dynamic trajectories of myeloid cells isolated from acutely injured and early stage dystrophic muscles.

131
131
article thumbnail

A Win

Dr. Malcolm Kendrick

21st October 2024 Finally, the dust settles. Zoë and I won our case against the Mail on Sunday. The judgement came out a few weeks ago, but the legal wrangling continued – and still continues. The Mail on Sunday did print an apology. Legally, they do not have to print an apology, but they did, which says something. There is still a statement in open court to come (SIOC).

Article 122
article thumbnail

Data-independent LC-MS/MS analysis of ME/CFS plasma reveals a dysregulated coagulation system, endothelial dysfunction, downregulation of complement machinery

Cardiovascular Diabetology

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic condition that is characterized by unresolved fatigue, post-exertion symptom exacerbation (PESE), cognitive dysfunction, or.

Research 145

More Trending

article thumbnail

Global epidemiology of heart failure

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 26 June 2024; doi:10.1038/s41569-024-01046-6 In this Review, Khan and colleagues explore the evolving global epidemiology of heart failure (HF), focusing on changes in incidence and prevalence across the spectrum of left ventricular ejection fraction. The authors highlight the disparities in our understanding of HF epidemiology in low-income and middle-income countries, affirming the need for improved surveillance and resource allocation in vulnerable

article thumbnail

Contemporary approach to cardiogenic shock care: a state-of-the-art review

Frontiers in Cardiovascular Medicine

Cardiogenic shock (CS) is a time-sensitive and hemodynamically complex syndrome with a broad spectrum of etiologies and clinical presentations. Despite contemporary therapies, CS continues to maintain high morbidity and mortality ranging from 35 to 50%. More recently, burgeoning observational research in this field aimed at enhancing the early recognition and characterization of the shock state through standardized team-based protocols, comprehensive hemodynamic profiling, and tailored and selec

article thumbnail

ESC 2024 Highlights

Cardiology Update

Dr. Chadi Alraies discusses some of the important trials presented at the European Society of Cardiology 2024 congress. Read more about the important ESC 2024 highlights. For more cardiology research news join our newsletter or follow us on Twitter , Facebook , LinkedIn or Instagram. The post ESC 2024 Highlights appeared first on Cardiology Update.

Research 130
article thumbnail

ECG Blog #451 — Premature Closure.

Ken Grauer, MD

I was sent the ECG shown in Figure-1 — told only that the patient was a middle-aged man with septicemia. QUESTIONS: Is this rhythm too fast to be sinus tachycardia? Are flutter waves hidden within the QRS and T waves? Are we seeing the retrograde P waves of AVNRT? Is this ATach ( A trial T achycardia )? Figure-1: The initial ECG in today's case. MY Thoughts on Today’s CASE: In my opinion — none of the above answers are optimal to describe the rhythm in Figure-1.

Blog 166
article thumbnail

Heart failure, atrial fibrillation & coronary heart disease linked to cognitive impairment

American Heart News - Heart News

Statement Highlights: Previous studies have found that 14-81% of patients with heart failure experience some degree of cognitive impairment affecting language, memory or executive function. Evidence also indicates that people with atrial fibrillation.

article thumbnail

History of COVID-19 found to double long-term risk of heart attack, stroke and death

Medical Xpress - Cardiology

A history of COVID-19 can double the risk of heart attack, stroke or death according to new research led by Cleveland Clinic and the University of Southern California.

COVID-19 145
article thumbnail

Presidential Candidates Should Undergo Standardized Cognitive and Physical Testing

Med Page Today

(MedPage Today) -- Health professionals often perform the "eyeball test" when they first meet a patient. Through the power of observation, pixels of information are gathered quickly and often unconsciously to determine whether a patient is unwell.

145
145
article thumbnail

8-hour time-restricted eating linked to a 91% higher risk of cardiovascular death

Science Daily - Heart Disease

A study of over 20,000 adults found that those who followed an 8-hour time-restricted eating schedule, a type of intermittent fasting, had a 91% higher risk of death from cardiovascular disease.

article thumbnail

White adipocytes in subcutaneous fat depots require KLF15 for maintenance in preclinical models

Journal of Clinical Investigation - Cardiology

Healthy adipose tissue is essential for normal physiology. There are 2 broad types of adipose tissue depots: brown adipose tissue (BAT), which contains adipocytes poised to burn energy through thermogenesis, and white adipose tissue (WAT), which contains adipocytes that store lipids. However, within those types of adipose, adipocytes possess depot and cell-specific properties that have important implications.

article thumbnail

Nonpharmacological interventions on glycated haemoglobin in youth with type 1 diabetes: a Bayesian network meta-analysis

Cardiovascular Diabetology

The available evidence on the impact of specific non-pharmacological interventions on glycaemic control is currently limited. Consequently, there is a need to determine which interventions could provide the mo.

article thumbnail

Hospitals with highest, lowest 30-day mortality rates for heart attack patients

Becker's Hospital Review - Cardiology

New York City-based NYU Langone hospital had the lowest 30-day mortality rate for heart attack patients in the U.S. between July 1, 2020 and June 30, 2023, according to CMS data released July 31.

article thumbnail

Ultra-processed foods and cardiovascular disease

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 30 January 2024; doi:10.1038/s41569-024-00990-7 In this Comment, we critically examine the association between the increasing consumption of ultra-processed foods and their negative effect on cardiovascular health. We explore the historical evolution of food processing, the Nova food classification and the epidemiological evidence, and highlight the need for urgent public health interventions.

article thumbnail

Boehringer Ingelheim Announces $35 Monthly Price Cap on Inhalers for Asthma, COPD Patients

HCPLive

On March 07, 2024, Boehringer Ingelheim announced it would be instituting a $35 per month out-of-pocket cost cap for its portfolio of inhaler products, with this cap going into effect on June 01, 2024.

140
140
article thumbnail

Another deadly triage ECG missed, and the waiting patient leaves before being seen. What is this nearly pathognomonic ECG?

Dr. Smith's ECG Blog

Written by Bobby Nicholson, MD 67 year old male with history of hypertension and hyperlipidemia presented to the Emergency Department via ambulance with midsternal nonradiating chest pain and dyspnea on exertion. Pain improved to 1/10 after EMS administers 324 mg aspirin and the following EKG is obtained at triage. What do you think? If this EKG were handed to you to screen from triage without any clinical information, what would you think?

article thumbnail

Spontaneous Coronary Artery Dissection: A Focus on Post-Dissection Care for the Vascular Medicine Clinician

Frontiers in Cardiovascular Medicine

Spontaneous coronary artery dissection (SCAD) is an uncommon condition which is increasingly recognized as a cause of significant morbidity. SCAD can cause acute coronary syndrome and myocardial infarction (MI), as well as sudden cardiac death. It presents similarly to atherosclerotic MI although typically in patients with few or no atherosclerotic risk factors, and particularly in women.

SCAD 137
article thumbnail

8-hour time-restricted eating linked to a 91% higher risk of cardiovascular death

American Heart News - Heart News

Research Highlights: A study of over 20,000 adults found that those who followed an 8-hour time-restricted eating schedule, a type of intermittent fasting, had a 91% higher risk of death from cardiovascular disease. People with heart disease or cancer.

Cancer 145
article thumbnail

Metals in the body from pollutants associated with progression of harmful plaque buildup in the arteries

Medical Xpress - Cardiology

Metal exposure from environmental pollution is associated with increased buildup of calcium in the coronary arteries at a level that is comparable to traditional risk factors like smoking and diabetes, according to a study by Columbia University Mailman School of Public Health.

article thumbnail

Shingles Tied to Long-Term Cognitive Changes

Med Page Today

(MedPage Today) -- Herpes zoster (shingles) was tied to an elevated risk of subjective cognitive decline, an analysis of 150,000 U.S. healthcare professionals showed. "In three large independent cohorts, herpes zoster was associated with an approximately.

145
145
article thumbnail

3D-printed blood vessels bring artificial organs closer to reality

Science Daily - Heart Disease

Lab-grown organs are a long-time 'holy grail' of organ engineering that has yet to be achieved, but new research has brought that goal a big step closer to reality using a new 3D-printing method called co-SWIFT. co-SWIFT prints branching networks of double-layered vessels that are infused with smooth muscle cells and endothelial cells into living human cardiac tissue, and can even replicate patient-specific vascular structures,indicating that it could one day be used for personalized medicine.

Research 132
article thumbnail

Meningeal lymphatic CGRP signaling governs pain via cerebrospinal fluid efflux and neuroinflammation in migraine models

Journal of Clinical Investigation - Cardiology

Recently developed antimigraine therapeutics targeting calcitonin gene–related peptide (CGRP) signaling are effective, though their sites of activity remain elusive. Notably, the lymphatic vasculature is responsive to CGRP signaling, but whether meningeal lymphatic vessels (MLVs) contribute to migraine pathophysiology is unknown. Mice with lymphatic vasculature deficient in the CGRP receptor (CalcrliLEC mice) treated with nitroglycerin-mediated (NTG-mediated) chronic migraine exhibit reduced pai

135
135
article thumbnail

Pentoxifylline ameliorates subclinical atherosclerosis progression in patients with type 2 diabetes and chronic kidney disease: a randomized pilot trial

Cardiovascular Diabetology

Diabetic kidney disease (DKD) is associated with a higher risk of cardiovascular disease (CVD). Pentoxifylline (PTF), a nonselective phosphodiesterase inhibitor with anti-inflammatory, antiproliferative, and a.

article thumbnail

Ep 193 The Crashing Asthmatic – Recognition and Management of Life Threatening Asthma

ECG Cases

In this part 2 of our 2-part podcast on asthma with Dr. Sameer Mal and Dr. Leeor Sommer, we dig into the recognition and management of life-threatening asthma. We answer such questions as: what are the key elements in recognition of threatening asthma? What are the most time-sensitive interventions required to break the vicious cycle of asthma? What are the best options for dosing and administering magnesium sulphate, epinephrine, fentanyl and ketamine in the management of the crashing asthmatic

135
135
article thumbnail

Cardiovascular autonomic dysfunction in post-COVID-19 syndrome: a major health-care burden

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 02 January 2024; doi:10.1038/s41569-023-00962-3 Cardiovascular autonomic dysfunction (CVAD) is a malfunction of the autonomic control of circulatory homeostasis and is an important component of post-COVID-19 syndrome. In this Review, Fedorowski and colleagues define the major forms of CVAD (including postural orthostatic tachycardia syndrome), and discuss the aetiology, diagnosis and management of post-COVID-19 syndrome-associated CVAD.

COVID-19 145
article thumbnail

Generic Liraglutide (Victoza) Becomes First Generic GLP-1 Receptor Agonist

HCPLive

Teva Pharmaceuticals’ launch of an authorized generic of liraglutide injection 1.8 mg (Victoza) for type 2 diabetes makes it the first-ever generic GLP-1.

Diabetes 142
article thumbnail

20 hospitals with highest, lowest heart failure death rates

Becker's Hospital Review - Cardiology

Chicago-based Northwestern Memorial Hospital and VA Boston Healthcare System-Jamaica Plain (Mass.) have the lowest death rate for heart failure patients in the country, according to CMS data.

article thumbnail

Transcutaneous Pacing: Part 2

EMS 12-Lead

TCP in the ROSC Patient: False Electrical Capture at 75mA Josh Kimbrell, NRP @joshkimbre Judah Kreinbrook, EMT-P @JMedic2JDoc This is the second installment of a blog series showing how transcutaneous pacing (TCP) can be difficult and how you can improve your skills. We will be using redacted information from different cases where paramedics attempted TCP in the field.

article thumbnail

Cannabis use linked to increase in heart attack and stroke risk

American Heart News - Heart News

Research Highlights: An analysis of survey data for 430,000 adults in the U.S. found that using cannabis has a significant association with an increased risk of heart attack and stroke, independent of tobacco use, with higher odds among the adults.

article thumbnail

Study identifies 18 proteins linked to heart failure, frailty

Medical Xpress - Cardiology

An analysis of blood samples from thousands of study participants, led by researchers at UT Southwestern Medical Center, revealed 18 proteins associated with both heart failure and frailty, conditions that commonly develop in late life. Their findings, published in JAMA Cardiology, could lead to new strategies to jointly predict risk, administer preventive approaches, or treat these conditions, which often occur together.

article thumbnail

Coffee-Dementia Link Continues to Unfurl

Med Page Today

(MedPage Today) -- PHILADELPHIA -- Coffee and tea intake were associated with long-term cognitive changes in older adults, two prospective studies presented at the Alzheimer's Association International Conference (AAIC) suggested. Among 6,001.

Dementia 145
article thumbnail

Babies born to women consuming a high fat, sugary diet at greater risk of cardiovascular disease and diabetes in later life

Science Daily - Heart Disease

Babies born to pregnant women with obesity are more likely to develop heart problems and diabetes as adults due to fetal damage caused by the high-fat, high-energy diet of their mother.

Diet 127