Journal of Clinical Investigation - Cardiology

FEBRUARY 1, 2024

Here, we examined the therapeutic potential of itaconate in atherosclerosis. Deletion of Acod1 in myeloid cells exacerbated inflammation and atherosclerosis in vivo and resulted in an elevated frequency of a specific subset of M1-polarized proinflammatory macrophages in the atherosclerotic aorta.

Atherosclerosis 98

Atherosclerosis Cholesterol 98

Nature Reviews - Cardiology

MARCH 11, 2024

Nature Reviews Cardiology, Published online: 12 March 2024; doi:10.1038/s41569-024-01007-z Shoaran and Maffia recount how our understanding of the role of inflammation in atherosclerosis has evolved and highlight the study by Göran Hansson and colleagues that provided the first hint of the involvement of the adaptive immune response in atherosclerosis. (..)

Atherosclerosis 53

Atherosclerosis 53

Medical Xpress - Cardiology

DECEMBER 12, 2023

University of Virginia School of Medicine researchers have created an "atlas of atherosclerosis" that reveals, at the level of individual cells, critical processes responsible for forming the harmful plaque buildup that causes heart attacks, strokes, and coronary artery disease.

Heart Attack 105

Heart Attack Heart attacks Atherosclerosis Coronary Artery Disease 105

Med Page Today

DECEMBER 4, 2023

(MedPage Today) -- The link between childhood blood pressure (BP) and adult atherosclerosis appeared stable going all the way back to infancy, suggesting that efforts to prevent arterial thickening may be beneficial starting at the earliest life.

Blood Pressure 98

Blood Pressure Atherosclerosis 98

Medical Xpress - Cardiology

MARCH 22, 2024

Atherosclerosis is the major contributor to cardiovascular mortality worldwide. Diet-induced metabolic abnormalities including obesity, hyperglycemia, dyslipidemia, insulin resistance (IR), and non-alcoholic fatty liver disease are considered atherogenic risk factors.

Atherosclerosis 88

Atherosclerosis Diet Obesity Risk Factors 88

Medical Xpress - Cardiology

JANUARY 24, 2024

Atherosclerosis, a chronic inflammatory disease of the inner walls of blood vessels, is responsible for many cardiovascular conditions. Dendritic cells, which act to recognize foreign substances in the body and mount an immune response, play an important role in the disease.

Atherosclerosis 102

Atherosclerosis Research 102

Science Daily - Heart Disease

APRIL 30, 2024

Researchers have discovered that the smooth muscle cells that line the arteries of people with atherosclerosis can change into new cell types and develop traits similar to cancer that worsen the disease.

Atherosclerosis 55

Atherosclerosis Cancer Peripheral Arterial Disease Coronary Artery Disease 55

Frontiers in Cardiovascular Medicine

MARCH 21, 2024

Introduction The progression of coronary atherosclerosis is an active and regulated process. The Wnt signaling pathway is thought to play an active role in the pathogenesis of several cardiovascular diseases; however, a better understanding of this system in atherosclerosis is yet to be unraveled.

Atherosclerosis 64

Atherosclerosis Plaque Cholesterol Cardiovascular Disease 64

Science Daily - Stroke

JANUARY 13, 2024

A groundbreaking 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, researchers report.

Atherosclerosis 82

Atherosclerosis Research 82

Nature Reviews - Cardiology

JANUARY 1, 2024

In this Review, De Meyer and colleagues describe the various forms of programmed macrophage death in atherosclerosis and the potential therapeutic implications.

Atherosclerosis 87

Atherosclerosis Plaque 87

Frontiers in Cardiovascular Medicine

APRIL 18, 2024

Inflammation and dyslipidemia are critical inducing factors of atherosclerosis. However, synthesized PPAR agonists exhibit contrary therapeutic effects and various side effects in atherosclerosis therapy. However, synthesized PPAR agonists exhibit contrary therapeutic effects and various side effects in atherosclerosis therapy.

Atherosclerosis 52

Atherosclerosis Article Research 52

Medical Xpress - Cardiology

JANUARY 23, 2024

Scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) in Madrid have found that one of the most potent genetic risk factors for Alzheimer's disease, apolipoprotein E4 (APOE4), is also associated with an increased risk of developing subclinical atherosclerosis in middle age.

Atherosclerosis 81

Atherosclerosis Risk Factors 81

Medical Xpress - Cardiology

JANUARY 15, 2024

A new 3D, three-layer nanomatrix vascular sheet that possesses multiple features of atherosclerosis has been applied for developing a high-throughput functional assay of drug candidates to treat this disease, University of Alabama at Birmingham researchers report in the journal Biomaterials in a paper titled "Atherosclerotic three-layer nanomatrix (..)

Atherosclerosis 85

Atherosclerosis Research 85

Frontiers in Cardiovascular Medicine

JANUARY 9, 2024

Atherosclerosis is a chronic inflammatory disease characterized by endothelial dysfunction and plaque formation. Under pro-inflammatory conditions, endothelial cells can undergo endothelial-to-mesenchymal transition (EndMT), contributing to atherosclerosis development.

Atherosclerosis 59

Atherosclerosis Plaque Cardiovascular Disease 59

Medical Xpress - Cardiology

FEBRUARY 22, 2024

Men who were physically fit when they were young had a lower risk of atherosclerosis almost 40 years later, according to a study led by researchers at Linköping University, Sweden.

Atherosclerosis 45

Atherosclerosis Cardiovascular Disease Research 45

Frontiers in Cardiovascular Medicine

FEBRUARY 29, 2024

So far, researchers have focused on the significance of silicon for the development of bones and connective tissue, and its role in preventing neurodegenerative diseases and atherosclerosis. Despite numerous studies, the role of silicon as an active element in the human body is poorly understood.

Atherosclerosis 64

Atherosclerosis Article Research 64

Journal of Cardiovascular Pharmacology

NOVEMBER 16, 2023

This modification will affect not only the onset of diabetes but also the related onset of atherosclerosis. Therefore, in this review, based on the whole process of atherosclerosis evolution, we explored the possible existence of acetylation/deacetylation caused by diabetes.

Atherosclerosis 40

Atherosclerosis Diabetes Cardiovascular Disease Article 40

Cardiovascular Ultrasound

JANUARY 9, 2024

This study aimed to evaluate atherosclerosis as comorbidity by measuring the carotid (bulb and common carotid artery) Carotid intima-media thickness in COPD-diagnosed patients and to evaluate the relationship.

Atherosclerosis 52

Atherosclerosis Risk Factors Research 52

Cardiovascular Diabetology

JANUARY 8, 2024

Atherosclerosis is one of the leading causes of death worldwide. miR-26 is a potential biomarker of atherosclerosis. Standardized diagnostic tests for miR-26 (MIR26-DX) have been developed, but the fastest pro.

Atherosclerosis 52

Atherosclerosis Biomarkers 52

Frontiers in Cardiovascular Medicine

FEBRUARY 23, 2024

Introduction The presence of non-coronary atherosclerosis (NCA) in patients with coronary artery disease is associated with a poor prognosis. We have studied whether NCA is also a predictor of poorer outcomes in patients undergoing coronary artery bypass grafting (CABG).

Coronary Artery Bypass Graft 64

Coronary Artery Bypass Graft Atherosclerosis Peripheral Arterial Disease Coronary Artery Disease 64

Nature Reviews - Cardiology

DECEMBER 17, 2023

Nature Reviews Cardiology, Published online: 18 December 2023; doi:10.1038/s41569-023-00982-z Author Correction: Optical coherence tomography in coronary atherosclerosis assessment and intervention

Atherosclerosis 40

Atherosclerosis 40

Physiologically Speaking

APRIL 10, 2024

Exercise and Coronary Atherosclerosis | Circulation There are a few pieces of evidence, however, that can give endurance athletes some reassurance that they’re not headed to an early grave. When comparing athletes to control groups (i.e., Among athletes, those who are more active have even higher CACS than those who are less active.

Atherosclerosis 52

Atherosclerosis Plaque Exercise Cardiovascular Disease 52

Journal of the American Heart Association

JANUARY 12, 2024

BackgroundUltraviolet B (UV‐B) irradiation is an effective treatment for human cutaneous disorders and was shown to reduce experimental atherosclerosis by attenuating immunoinflammatory responses. Our findings indicate that a novel 282 nm UV‐B phototherapy could be an attractive approach to treat atherosclerosis.

Atherosclerosis 45

Atherosclerosis Plaque Aortic Technology 45

Science Daily - Stroke

NOVEMBER 2, 2023

Researchers have demonstrated the specific role microRNA plays in atherosclerosis -- and how it manages to intervene in this signaling pathway.

Atherosclerosis 40

Atherosclerosis Research 40

Journal of the American Heart Association

DECEMBER 8, 2023

BackgroundThe relationship between depression and subclinical coronary atherosclerosis in asymptomatic individuals is not clear. The degree and extent of subclinical coronary atherosclerosis were evaluated by coronary computed tomographic angiography, and ≥50% diameter stenosis was defined as significant. 2.03];P=0.450).

Coronary Artery Disease 40

Coronary Artery Disease Atherosclerosis Plaque Stenosis 40

Frontiers in Cardiovascular Medicine

FEBRUARY 15, 2024

Background Inflammation is pivotal to the progression of atherosclerosis. Cholesterol crystals (CCs) that grow and enlarge within the plaque core can cause plaque rupture and trigger inflammation as they deposit into the atherosclerotic bed.

Cholesterol 72

Cholesterol Atherosclerosis Plaque 72

Stroke Journal

FEBRUARY 1, 2024

We hypothesized that intracranial atherosclerosis, which is seen predominantly in older patients, affects vasospasm risk in aSAH. Intracranial atherosclerosis burden was quantified by using modified Woodcock (MW) score on CT angiograms measured by trained assessors. Vasospasm was defined based on transcranial Doppler (TCD) criteria.

Atherosclerosis 40

Atherosclerosis Aneurysm Hemorrhage Outcomes 40

Journal of the American Heart Association

JANUARY 31, 2024

Methods and ResultsWe used data from the MESA (Multi‐Ethnic Study of Atherosclerosis), a prospective cohort study of individuals free of baseline cardiovascular disease. Due to potential confounding by indication, we matched aspirin users to nonusers using a propensity score based on CVD risk factors.

Atherosclerosis 75

Atherosclerosis Risk Factors Myocardial Infarction Cardiovascular Disease 75

Med Page Today

APRIL 29, 2024

(MedPage Today) -- Cardiovascular death had a strong tie to the somatic mutations that often accrue with aging in people with subclinical atherosclerosis, an observational study found. For asymptomatic people who had atherosclerosis detected by.

Atherosclerosis 125

Atherosclerosis 125

HCPLive

APRIL 24, 2024

Patients receiving abatacept experienced smaller increases in mean IMT, max IMT, and plaque score compared with the csDMARD cohorts.

Atherosclerosis 64

Atherosclerosis Plaque 64

Journal of Cardiovascular Pharmacology

NOVEMBER 26, 2023

Nevertheless, the correlation between ISNA and the progression of untreated coronary segments affected by native atherosclerosis remains incompletely investigated. Nevertheless, the correlation between ISNA and the progression of untreated coronary segments affected by native atherosclerosis remains incompletely investigated.

Atherosclerosis 40

Atherosclerosis Stents Stent Plaque 40

Frontiers in Cardiovascular Medicine

MARCH 7, 2024

In addition, the role of the ratio of systolic and diastolic pressure (SDR) in the subclinical atherosclerosis (AS) risk remains unknown. Background Although the impact of hypertension on carotid intima-media thickness (IMT) and plaques has been well established, its association with femoral IMT and plaques has not been extensively examined.

Atherosclerosis 49

Atherosclerosis Plaque Blood Pressure Hypertension 49

Science Daily - Stroke

AUGUST 10, 2023

Nano-sized particles released by red blood cells reduce inflammation and fat deposition in immune cells, potentially paving the way for new methods of treating atherosclerosis.

Atherosclerosis 40

Atherosclerosis 40

Journal of Clinical Investigation - Cardiology

MARCH 1, 2024

Patients with chronic inflammatory disorders such as psoriasis have an increased risk of cardiovascular disease and elevated levels of LL37, a cathelicidin host defense peptide that has both antimicrobial and proinflammatory properties.

Atherosclerosis 120

Atherosclerosis Cholesterol Cardiovascular Disease Plaque 120

Circulation

DECEMBER 28, 2023

Our analyses suggest the interferon-γ–inducible chemokine CXCL10 to be a potentially causal mediator for atherosclerosis in 3 vascular compartments and, as such, could serve as a promising drug target for atheroprotection.

Atherosclerosis 49

Atherosclerosis Peripheral Arterial Disease Coronary Artery Disease Pharmacology 49

Stroke Journal

FEBRUARY 1, 2024

Background:Most ischemic strokes are caused by atherosclerosis. Apolipoprotein E (ApoE) regulates lipid metabolism, and its deficiency is associated with dyslipidemia and atherosclerosis. Poor dietary habits promote the onset of atherosclerosis. Stroke, Volume 55, Issue Suppl_1 , Page ATP300-ATP300, February 1, 2024.

Atherosclerosis 40

Atherosclerosis Risk Factors Diet Plaque 40

Circulation: Heart Failure

MARCH 8, 2024

There is an unmet need to define the prevalence and pathogenesis of early symptomatic HF, which may be undiagnosed and precedes HF hospitalization.Methods:The MESA (Multi-Ethnic Study of Atherosclerosis) Early HF study was conducted during MESA exam 6 to determine the prevalence of early HF and investigate the transition from risk factors to early (..)

Heart Failure 40

Heart Failure Atherosclerosis Kidney Disease Risk Factors 40