article thumbnail

Efferocytosis in atherosclerosis

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 15 May 2024; doi:10.1038/s41569-024-01037-7 In this Review, Adkar and Leeper describe the mechanisms of programmed cell death and efferocytosis, discuss how efferocytosis becomes impaired in atherosclerosis and other cardiometabolic diseases, and suggest potential strategies to target these pathways for (..)

article thumbnail

Autoimmune Diseases and Coronary Atherosclerosis

American College of Cardiology

Do autoimmune diseases independently correlate with coronary atherosclerosis and atherosclerotic cardiovascular disease (ASCVD) risk, and do traditional cardiovascular risk factors modulate the risk?

article thumbnail

Dynamic metabolism of endothelial triglycerides protects against atherosclerosis in mice

Journal of Clinical Investigation - Cardiology

Blood vessels are continually exposed to circulating lipids, and elevation of ApoB-containing lipoproteins causes atherosclerosis. Consistent with this mechanism, deletion of endothelial ATGL markedly increased lesion size in a model of atherosclerosis.

article thumbnail

Early insulin resistance in normoglycemic low-risk individuals is associated with subclinical atherosclerosis

Cardiovascular Diabetology

Elevated glycated hemoglobin (HbA1c) is associated with a higher burden of subclinical atherosclerosis (SA). However, the association with SA of earlier insulin resistance markers is poorly understood. The stu.

article thumbnail

Atherosclerosis Updates from the 92nd EAS Congress

Cardiometabolic Health Congress

The EAS 2024 Congress (May 26-29, 2024) has concluded, providing critical insights into atherosclerosis and related vascular disease. Shapiro (United States of America) focused on preventing atherosclerosis over myocardial infarction, suggesting that CAC’s late-stage detection does not fit classic definitions of primary prevention.

article thumbnail

Targeting immune cell recruitment in atherosclerosis

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 25 April 2024; doi:10.1038/s41569-024-01023-z In this Review, the authors discuss the receptors, ligands and interactors that regulate immune cell recruitment in atherosclerosis, describe mechanisms that promote the resolution of inflammation in atherosclerotic lesions, and highlight potential strategies (..)

article thumbnail

Canonical and non-canonical roles of complement in atherosclerosis

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 10 April 2024; doi:10.1038/s41569-024-01016-y In this Review, Kemper and colleagues discuss the canonical and non-canonical roles of the complement system in the pathogenesis of atherosclerosis and discuss potential new therapeutic strategies targeting the complement system for the prevention and treatment (..)