July, 2025

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AI spots deadly heart risk most doctors can't see

Science Daily - Heart Disease

An advanced Johns Hopkins AI model called MAARS combs through underused heart MRI scans and complete medical records to spot hidden scar patterns that signal sudden cardiac death, dramatically outperforming current dice-roll clinical guidelines and promising to save lives while sparing patients unnecessary defibrillators.

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Prognostic significance of serum galectin-3 in predicting cardiovascular outcomes after percutaneous coronary intervention with drug-eluting stents

Frontiers in Cardiovascular Medicine

BackgroundGalectin-3 is a well-established biomarker on the predictor of cardiovascular events in patients with heart failure. Its pathophysiologic association with inflammation, cell proliferation, and fibrogenesis may implicate serum galectin-3 as a predictor of clinical outcomes in coronary artery disease (CAD) patients undergoing percutaneous coronary intervention (PCI) with drug-eluting stents (DES).

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Even low levels of air pollution may quietly scar your heart, MRI study finds

Science Daily - Stroke

Breathing polluted air—even at levels considered “safe”—may quietly damage your heart. A new study using advanced MRI scans found that people exposed to more air pollution showed early signs of scarring in their heart muscle, which can lead to heart failure over time. This damage showed up in both healthy individuals and people with heart conditions, and was especially noticeable in women, smokers, and those with high blood pressure.

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Venous Ethanol Infusion for the Ablation of Atrial Fibrillation: A Step‐by‐Step Guide

Journal of Cardiovascular Electrophysiology

ABSTRACT Pulmonary vein isolation (PVI) alone has limited success in treating persistent atrial fibrillation (AF), prompting the use of adjunctive strategies like vein of Marshall (VOM) ethanol infusion to improve outcomes. This step-by-step guide outlines a standardized approach for VOM ethanol infusion, including venous access, coronary sinus cannulation, VOM identification, and ethanol infusion via an over-the-wire balloon catheter.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Researchers take major step toward cuff-free blood pressure monitoring

Medical Xpress - Cardiology

Researchers have shown, for the first time, that speckle contrast optical spectroscopy (SCOS) can be used for cuffless blood pressure monitoring. The new technology could improve early detection and management of hypertension.

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Top 6 Cardiology Trends from 2025’s First Half

CardiacWire

The first half of 2025 is now over, and the world of cardiology keeps expanding. As we do every year, we’ve compiled a list of the top six stories of H1 – one for each month – to recap the big changes and innovations happening in cardiology. AI-ECG’s Hot Start and Fast Expansion 2025 kicked off with plenty of buzz about AI applications for one of cardiology’s oldest diagnostic modalities, ECG.

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More Trending

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Prediction of long-term major adverse cardiac events after myocardial infarction: value of combination of inflammatory biomarkers and GRACE score

Frontiers in Cardiovascular Medicine

ObjectiveThis study aims to investigate the prognostic value of integrating inflammatory biomarkers with the established Global Registry of Acute Coronary Events (GRACE) risk score for predicting clinical outcomes in patients with myocardial infarction (MI).MethodsThis prospective, single-center study enrolled adult MI patients admitted to the coronary care unit at Zhongshan Hospital, Fudan University.

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Cardio‐microcurrent device treatment for heart failure with reduced ejection fraction: Results from the C‐MIC II open‐label randomized controlled trial

European Journal of Heart Failure

Efficacy and Safety of C-MIC Device in Patients with Heart Failure with Reduced Ejection Fraction. 6MWD, 6-min walk distance; CI, confidence interval; KCCQ-OSS, Kansas City Cardiomyopathy Questionnaire overall summary score; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association. Abstract Aims In patients with heart failure, alterations in electrical fields generated within the myocardium have been associated with myocardial oedema which can act as a substrate for left ventri

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Atrial Fibrillation Recurrence Reduction: What Treatments Work Best Postablation? A Network Meta‐Analysis

Journal of Cardiovascular Electrophysiology

ABSTRACT Background Atrial fibrillation (AF) is the most common cardiac arrhythmia, associated with significant morbidity, including increased risks of stroke, heart failure, and mortality. While catheter ablation is an effective rhythm control strategy, high recurrence rates postprocedure remain a major clinical challenge. Inflammation plays a key role in AF pathogenesis, and anti-inflammatory therapies have emerged as potential adjunctive treatments to reduce recurrence.

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Scientists identify why some heart rhythm drugs heighten risks when sodium levels drop

Medical Xpress - Cardiology

New research explains how low levels of the electrolyte sodium in the blood can disrupt the timing of the heartbeat in patients taking widely used rhythm-control medications such as flecainide, which is commonly prescribed for atrial fibrillation and other fast or irregular heart rhythms.

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Heart Failure and Stroke Risk in Atrial Fibrillation: Temporal Trends From a Nationwide Cohort Study

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundHeart failure (HF) is a well‐recognized risk factor for ischemic stroke (IS) in patients with atrial fibrillation (AF). Advancements in medical research have significantly improved the detection and management of both AF and HF. However, limited data are available on whether these changes have modified the stroke risk associated with HF in patients with AF.

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FDA Approvals in Cardiometabolic Health: Highlights from January–July 2025

Cardiometabolic Health Congress

FDA Approvals CMHC (Jan-July 2025) The first half of 2025 has brought an impressive wave of progress in cardiometabolic and renal care, with the U.S. Food and Drug Administration (FDA) granting approvals to several novel therapies and expanded indications. These approvals address a broad spectrum of conditions, including hypertension, diabetes, chronic kidney disease, stroke, and cardiovascular risk reduction—diseases that collectively represent some of the most burdensome and costly challenges

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Advanced ECG feature extraction and SVM classification for predicting defibrillation success in OHCA

Frontiers in Cardiovascular Medicine

Out-of-hospital cardiac arrest (OHCA) represents a critical challenge for emergency medical services, with the necessity for rapid and accurate prediction of defibrillation outcomes to enhance patient survival. This study leverages a dataset of 251 ECG signals from OHCA patients, consisting of 195 unsuccessful and 56 successful resuscitation attempts as categorized by expert cardiologists.

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Heartflow Unveils New Data Showing Impact of Heartflow Plaque Analysis

DAIC

tim.hodson Thu, 07/17/2025 - 14:40 July 17, 2025— Heartflow, Inc. recently announced new data for its AI-enabled Heartflow Plaque Analysis , including final primary endpoint data from the DECIDE Registry. Data from the DECIDE Registry showed Heartflow Plaque Analysis led to medical management change in over half of patients beyond coronary computed tomography angiography (CCTA) alone, regardless of traditional risk factors or CCTA findings.

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Increased Use of Radial Access For PCI in the US, Lower Complication Rates | NCDR Study

American College of Cardiology

PCI with radial access site is associated with lower rates of in-hospital mortality, major access site bleeding and other major vascular complications vs. femoral access site and has increased in use in the U.S. over the past decade, overtaking femoral access site.

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AI predicts patients likely to die of sudden cardiac arrest

Medical Xpress - Cardiology

A new AI model is much better than doctors at identifying patients likely to experience cardiac arrest. The linchpin is the system's ability to analyze long-underused heart imaging, alongside a full spectrum of medical records, to reveal previously hidden information about a patient's heart health.

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Cardiovascular Hospitalizations Burden Following Septal Myectomy for Obstructive Hypertrophic Cardiomyopathy

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundLonger‐term morbidity post septal myectomy (SM) in obstructive hypertrophic cardiomyopathy has not been well characterized at a national level. We aimed to investigate the nonfatal longer‐term post‐SM outcomes from a national all‐payer individual‐level claims.MethodsThe Symphony Health Claims database (2016–2021) was analyzed to identify all adult patients with obstructive hypertrophic cardiomyopathy who underwent SM in the Uni

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The State of Cardiovascular Care in Peru: Needs for System Strengthening

Circulation

Circulation, Volume 152, Issue 1 , Page 7-10, July 8, 2025.

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Unraveling mitochondrial crosstalk: a new frontier in heart failure pathogenesis

Frontiers in Cardiovascular Medicine

Mitochondria play a central role in energy production and signal transduction in cardiomyocytes. Their dysfunction is a key contributor to the development and progression of heart failure (HF). Beyond energy metabolism, mitochondria regulate calcium homeostasis, autophagy, protein synthesis, lipid metabolism, and gene expression through close interactions with other organelles.

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Cleerly to Present New AI-QCT Research at SCCT 2025

DAIC

tim.hodson Tue, 07/15/2025 - 12:00 July 9, 2025 — Cleerly, a leader in advanced cardiovascular imaging, will be presenting new research at the Society of Cardiovascular Computed Tomography (SCCT) Annual Meeting 2025. The conference will take place July 17-20, 2025, at the Palais des Congrès de Montréal in Montreal, Canada. This annual event brings together leading cardiovascular imaging specialists, researchers, and technology innovators from around the world to share the latest advances in card

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Increased Use of Radial Access For PCI in the US, Lower Complication Rates | NCDR Study

American College of Cardiology

PCI with radial access site is associated with lower rates of in-hospital mortality, major access site bleeding and other major vascular complications vs. femoral access site and has increased in use in the U.S. over the past decade, overtaking femoral access site.

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Researchers unlock hidden geometry of the heart to revolutionize ECG interpretation

Medical Xpress - Cardiology

A study led by scientists at King's has revealed how the physical orientation of the heart inside the chest dramatically influences the electrical signals captured in an electrocardiogram (ECG)—a discovery that could pave the way for more personalized and accurate heart diagnostics.

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Left Ventricular Mechanical Dispersion and Its Value in Combination With Global Longitudinal Strain to Predict Reverse Remodeling in Patients With Heart Failure With Reduced Ejection Fraction

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundLeft ventricular mechanical dispersion (LV‐MD), an indicator of LV dyssynchrony, is not well studied in heart failure with reduced ejection fraction (HFrEF). This study aims to investigate the profile of LV‐MD in HFrEF, and evaluate whether it provides predictive information in terms of LV reverse remodeling (LVRR), particularly, on top of LV global longitudinal strain (LV‐GLS).MethodsIn this observational cohort study, 239 con

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The Single‐Delayed‐Phase Contrast Computed Tomography Before Ablation to Reduce Radiation Exposure Without Compromising Diagnostic Pulmonary Vein Accuracy

Journal of Cardiovascular Electrophysiology

The results of analyzing the early and delayed phases of contrast computed tomography (CCT) images showed that the single-delayed-phase was comparable in evaluating the anatomy and diameter of the pulmonary veins to the single-early-phase. The single-delayed-phase CCT was considered to be effective for evaluation before ablation. ABSTRACT Introduction Early-phase contrast-enhanced CT (CCT) is often used to plan and guide catheter ablation for atrial fibrillation (AF), and delayed-phase images ca

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Translation of clinical practice to research: the VETS and ETHOS epidemiologic prospective cohorts

Frontiers in Cardiovascular Medicine

For >30 years, the Exercise Testing and Health Outcomes Study (ETHOS) and the Veterans Exercise Testing Study (VETS) cohorts have contributed significantly to the understanding of the association between cardiorespiratory fitness (CRF), health outcomes, and the prevention of chronic disease. Multiple reports from these studies have consistently shown an inverse and graded association between higher CRF and the incidence of chronic conditions including cardiovascular disease, site-specific cancer

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The PRECISION Trial

HCPLive

Panelists discuss how the PRECISION trial demonstrated aprocitentan’s efficacy in lowering blood pressure by nearly 15 mm Hg within 4 weeks in resistant hypertension patients, including those with advanced chronic kidney disease, with durable effects and minimal adverse effects except for manageable peripheral edema.

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Increased Use of Radial Access For PCI in the US, Lower Complication Rates | NCDR Study

American College of Cardiology

PCI with radial access site is associated with lower rates of in-hospital mortality, major access site bleeding and other major vascular complications vs. femoral access site and has increased in use in the U.S. over the past decade, overtaking femoral access site.

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Optimal heart health in children cuts risk of chronic diseases in adulthood, review indicates

Medical Xpress - Cardiology

Optimal heart health from birth through adolescence, as measured by a combination of metrics, leads to long-lasting cardiovascular and overall physical, cognitive and mental health, according to the systematic review published in the Journal of the American Heart Association.

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Interplay of Acquired Risk Factors, Age, and Genetic Predisposition in Incident Stroke: A Prospective Cohort Study

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundStroke is the leading cause of disability and death worldwide, and its pathogenesis involves various risk factors. This study aimed to investigate the associations between acquired risk factors, age, and genetic predisposition in the incidence of stroke.Methods and ResultsWe analyzed 404 873 participants (age, mean±SD, 56.46±8.10 years; 45.97% men) from the UK Biobank cohort, all without a history of stroke at baseline and with

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Treating the Broken Heart: Role of Stellate Ganglion Block in Takotsubo Syndrome

Journal of Cardiovascular Pharmacology

Takotsubo syndrome (TTS) is an acute stress-induced cardiomyopathy characterized by transient left ventricular dysfunction, often mimicking acute myocardial infarction but without obstructive coronary artery disease. While typically reversible, TTS can be complicated by serious adverse events, including life-threatening ventricular arrhythmias (VAs).

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The therapeutic effects of natural organosulfur compounds on atherosclerosis and their potential mechanisms: a comprehensive review

Frontiers in Cardiovascular Medicine

Atherosclerosis (AS) is a major cause of cardiovascular disease morbidity and mortality, characterized by lipid accumulation, oxidative stress, and chronic inflammation. Natural organic sulfur compounds (OSCs), especially those derived from garlic (Allium sativum), have therapeutic value in slowing the course of AS. We systematically evaluate the mechanisms by which OSCs exert their anti-atherogenic effects, focusing on lipid metabolism regulation, antioxidant defense, anti-inflammatory response

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Access to digital health technologies: personalized framework and global perspectives

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 16 July 2025; doi:10.1038/s41569-025-01184-5 In this Review, Narayan and colleagues discuss global disparities in access to digital health technologies, with a focus on cardiovascular medicine. The authors summarize the factors that affect access at various levels of society and present solutions that target each of these levels, culminating in a personalized framework to improve access to digital health technologies.

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Increased Use of Radial Access For PCI in the US, Lower Complication Rates | NCDR Study

American College of Cardiology

PCI with radial access site is associated with lower rates of in-hospital mortality, major access site bleeding and other major vascular complications vs. femoral access site and has increased in use in the U.S. over the past decade, overtaking femoral access site.

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AI tool spots hidden heart disease using routine electrocardiogram data

Medical Xpress - Cardiology

With the help of artificial intelligence (AI), an inexpensive test found in many doctors' offices may soon be used to screen for hidden heart disease.

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Adventitial Fibroblasts Release Interleukin 6 After Vascular Injury and Induce Smooth Muscle Cell Proliferation and Neointima Formation

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundVascular restenosis resulting from neointima formation significantly limits the efficacy of percutaneous interventional therapies compared with bypass surgery. The adventitial layer is involved in neointima formation, but the detailed pathophysiological interplay of the different cell types in this process is still unclear.MethodsWe analyzed the correlation between adventitial and neointimal tissue size in human postmortem rest

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Instructors' Collection ECG: Anterior-lateral M.I.

ECG Guru

The Patient: This ECG was obtained from a man in his mid-sixties who was complaining of chest pain. The pain had an acute onset and is described as "10" on a 1-10 scale. He has a PMHx of coronary artery disease with stents in his right coronary artery and minimally invasive aortic valve replacement. The ECG: The rate is 86 bpm. The rhythm is normal sinus rhythm with one PAC (10th beat).