April, 2024

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Only One Harm From mRNA COVID Vaccines, Report Determines

Med Page Today

(MedPage Today) -- Independent reviewers confirmed a causal relationship between the first mRNA COVID-19 vaccines and myocarditis, and also determined that, more broadly, intramuscular shots can cause a series of shoulder injuries. At the same.

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Ep 193 The Crashing Asthmatic – Recognition and Management of Life Threatening Asthma

ECG Cases

In this part 2 of our 2-part podcast on asthma with Dr. Sameer Mal and Dr. Leeor Sommer, we dig into the recognition and management of life-threatening asthma. We answer such questions as: what are the key elements in recognition of threatening asthma? What are the most time-sensitive interventions required to break the vicious cycle of asthma? What are the best options for dosing and administering magnesium sulphate, epinephrine, fentanyl and ketamine in the management of the crashing asthmatic

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ECG Blog #425 — Are there P Waves?

Ken Grauer, MD

I was sent the ECG in Figure-1 — told only that the patient was 70 years old, and had a history of an ASD ( A trial S eptal D efect ). Serum K+ was normal. The patient was hemodynamically stable with ECG #1. QUESTIONS: How would YOU interpret the rhythm in Figure-1 ? Are there P waves? Figure-1: The initial ECG in today's case. MY Initial Thoughts on Today's CASE: Knowing that today's patient has a history of an ASD ( A trial S eptal D efect ) — is relevant to the interpretation of today's inter

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Physical activity lowers cardiovascular disease risk by reducing stress-related brain activity, study finds

Medical Xpress - Cardiology

New research indicates that physical activity lowers cardiovascular disease risk in part by reducing stress-related signaling in the brain.

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Patients with Fibromyalgia Scored Worse in Memory, Attention, Cognitive Function

HCPLive

Without controlling for the severity of symptoms, patients with either fibromyalgia or RA performed worse when compared with controls in terms of cognitive domains including verbal memory, visual memory, and strategic planning.

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Ventricular Fibrillation, ICD, LBBB, QRS of 210 ms, Positive Smith Modified Sgarbossa Criteria, and Pacemaker-Mediated Tachycardia

Dr. Smith's ECG Blog

An elderly man collapsed. There was no bystander CPR. Medics found him in ventricular fibrillation. He was defibrillated, but they also noticed that he was being internally defibrillated and then found that he had an implantable ICD. He was unidentified and there were no records available After 7 shocks, he was successfully defibrillated and brought to the ED.

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CDC: COVID Vax Not Linked to Sudden Deaths in Young Adults

Med Page Today

(MedPage Today) -- The hunt for a signal of excess sudden cardiac deaths among young people after COVID-19 vaccination left Oregon health officials empty-handed, they reported. Investigators searched death certificates for Oregon residents 16.

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Elder Male with Syncope

EMS 12-Lead

David Didlake @DidlakeDW EMS personnel responded to the residence of an 81 y/o Male with syncope. His spouse had called 911 after she heard a loud “thud” in the adjacent room. He was found altered, hypotensive, and with a large hematoma to the left periorbital region. No 12 Lead ECG was captured, but telemetry did reveal the following: The spouse offers a pertinent medical history to include HTN and HLD, and furthermore states that he hasn’t previously complained of any chest discomfort, or shor

Ischemia 116
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7 Things You Can Do To Reduce Your Risk Even If You Already Have Heart Disease.

Dr. Paddy Barrett

This newsletter focuses on prevention. A common feedback I get is that people with existing coronary artery disease feel like it doesn’t apply to them. They feel like they have ‘ missed the boat ’ They have not. And I will explain why. Arguably, applying the principles of prevention offers more bang for buck in the short term for people WITH coronary artery disease than those without coronary artery disease.

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Around 25% of Mild Asthma Patients Not Given Guideline-Directed Therapy, Despite Updates

HCPLive

This analysis highlights trends following the significant update made to the Global Initiative for Asthma and the National Heart Lung and Blood Institute asthma guidelines.

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ECG Cases 49 – ECG and POCUS for Dyspnea and Chest Pain

ECG Cases

In this ECG Cases blog, Jesse McLaren and Rajiv Thavanathan explore how ECG and POCUS complement each other for patients presenting to the emergency department with shortness of breath or chest pain. They explain complementary diagnostic insights into pericardial effusion and cardiac tamponade, occlusion MI and RV strain. The post ECG Cases 49 – ECG and POCUS for Dyspnea and Chest Pain appeared first on Emergency Medicine Cases.

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5 Dead and Over 100 Hospitalized From Recalled Japanese Health Supplements

Med Page Today

(MedPage Today) -- TOKYO (AP) -- Five people who took a Japanese health supplement have died and more than 100 have been hospitalized as of Friday, a week after a pharmaceutical company issued a recall of the products, officials said. Osaka.

Hospital 145
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10 FDA panel members who voted on heart device connected to Abbott: Report

Becker's Hospital Review - Cardiology

The FDA convened a committee of advisers to assess a cardiac device made by Abbott, but the agency did not disclose that 10 of the 14 members had received payments from the company or conducted research it had funded, KFF Health News reported April 8.

Research 113
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Ectopic expression of the transcription factor ONECUT3 drives a complex karyotype in myelodysplastic syndromes

Journal of Clinical Investigation - Cardiology

Chromosomal instability is a prominent biological feature of myelodysplastic syndromes (MDS), with over 50% of patients with MDS harboring chromosomal abnormalities or a complex karyotype (CK). Despite this observation, the mechanisms underlying mitotic and chromosomal defects in MDS remain elusive. In this study, we identified ectopic expression of the transcription factor ONECUT3, which is associated with CKs and poorer survival outcomes in MDS.

Outcomes 105
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Electrocardiographic approach strategies in patients with Parkinson disease treated with deep brain stimulation

Frontiers in Cardiovascular Medicine

Deep brain stimulation (DBS) is an interdisciplinary and reversible therapy that uses high-frequency electrical stimulation to correct aberrant neural pathways in motor and cognitive neurological disorders. However, the high frequency of the waves used in DBS can interfere with electrical recording devices (e.g., electrocardiogram, electroencephalogram, cardiac monitor), creating artifacts that hinder their interpretation.

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Ankeet Bhatt, MD, MBA: NUDGE-FLU Analysis in Patients With and Without Myocardial Infarction

HCPLive

Ankeet Bhatt, MD, MBA, discusses a NUDGE-FLU analysis from ACC.24 examining effect of the CV gain-framed nudge in patients with and without history of AMI.

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Nasal spray safely treats recurrent abnormal heart rhythms, clinical trial suggests

Science Daily - Heart Disease

A clinical trial showed that a nasal spray that patients administer at home, without a physician, successfully and safely treated recurrent episodes of a condition that causes rapid abnormal heart rhythms. The study provides real-world evidence that a wide range of patients can safely and effectively use the experimental drug, called etripamil, to treat recurrent paroxysmal supraventricular tachycardia (PSVT) episodes at home, potentially sparing them the need for repeated hospital trips for mor

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Cardiac Events Common in Older, Hospitalized RSV Patients

Med Page Today

(MedPage Today) -- More than one in five older adults hospitalized for respiratory syncytial virus (RSV) infection experienced an acute cardiac event, an observational study found. Among 6,248 hospitalized patients 50 or older with laboratory.

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Cardiovascular disease and cancer: shared risk factors and mechanisms

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 10 April 2024; doi:10.1038/s41569-024-01017-x Patients with cardiovascular disease (CVD) have an increased risk of cancer, and patients with cancer have an increased risk of CVD. In this Review, the authors discuss the shared modifiable risk factors and the shared pathophysiological mechanisms underlying the bidirectional relationship between these two prevalent diseases.

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Study Finds Olezarsen Cuts Triglyceride Levels by About Half

DAIC

milla1cf Sun, 04/07/2024 - 18:20 April 7, 2024 — An estimated 1 in 5 U.S. adults—and more than 2 in 5 adults aged 60 years and older—have elevated triglycerides, also known as hypertriglyceridemia , putting them at an increased risk for heart attacks and stroke. However, few treatments are currently available for this patient population, until now. A new investigational drug called olezarsen holds promise for substantially reducing triglyceride levels without significant adverse effects, accordi

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FDA clears 1st AI to detect heart failure

Becker's Hospital Review - Cardiology

The FDA has approved an artificial intelligence algorithm for Eko Health's digital stethoscope that can detect low ejection fraction, a key indicator of heart failure.

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COPD, IPF Linked to More Severe COVID-19 Outcomes, Mortality Risk

HCPLive

New data show COPD and IPF, among other interstitial lung diseases, are more significantly associated with poor 30-day outcomes from COVID-19 than asthma.

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Heart disease, depression linked by inflammation

Science Daily - Heart Disease

Coronary artery disease and major depression may be genetically linked via inflammatory pathways to an increased risk for cardiomyopathy, a degenerative heart muscle disease, researchers have found.

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Study Assuages Thyroid Cancer Fears With GLP-1 Receptor Agonists

Med Page Today

(MedPage Today) -- A Scandinavian cohort study suggested a popular class of diabetes drug did not put patients at an elevated risk for thyroid cancer, a longtime lingering concern with this drug class. Compared with DPP-4 inhibitors, patients.

Cancer 122
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More than half a million global stroke deaths may be tied to climate change

Science Daily - Stroke

A changing climate may be linked to growing death and disability from stroke in regions around the world, according to a new study. Researchers found over three decades that non-optimal temperatures, those above or below temperatures associated with the lowest death rates, were increasingly linked to death and disability due to stroke. The study does not prove that climate change causes stroke.

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Cardiology Team Performs Novel Heart Artery Repair with Newly Approved Device

DAIC

Image courtesy of UC Davis Health milla1cf Tue, 04/09/2024 - 16:47 April 9, 2024 — UC Davis Health cardiology team members are among the first in the country to treat patients with tricuspid regurgitation , or a leaky heart valve, by using a groundbreaking catheter. The minimally invasive procedure, a transcatheter edge-to-edge repair (TEER), is made possible with a new medical device called the Abbott TriClip™ system.

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Association between triglyceride–glucose index trajectories and radiofrequency ablation outcomes in patients with stage 3D atrial fibrillation

Cardiovascular Diabetology

This study investigates the relationship between triglyceride-glucose (TyG) index trajectories and the results of ablation in patients with stage 3D atrial fibrillation (AF).

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Survey Finds Many Fibromyalgia Patients Finding Symptom Relief with Medical Cannabis

HCPLive

Almost 50% of fibromyalgia patients use cannabis for symptom relief, according to new study. Experts suggest results underline need for clinician awareness, further research.

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Unnecessary use of beta-blockers after a heart attack?

Science Daily - Heart Disease

Half of all patients discharged from hospital after a heart attack are treated with beta-blockers unnecessarily, new study suggests.

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Oral Appliance for Sleep Apnea Noninferior to CPAP for Reducing Arterial BP

Med Page Today

(MedPage Today) -- ATLANTA -- An oral appliance for people with obstructive sleep apnea (OSA) was noninferior to continuous positive airway pressure (CPAP) for reducing 24-hour mean arterial blood pressure (BP) in patients with hypertension and.

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Study reveals mechanism linking heart disease to cancer development

Medical Xpress - Cardiology

Researchers at Tel Aviv University (TAU) and the Leviev Cardiothoracic and Vascular Center at the Sheba Medical Center have found a mechanism responsible for increasing the risk of developing cancer among patients with heart disease: Small extracellular bubbles, or vesicles (sEVs), secreted from the sick heart to heal itself, are released into the bloodstream and promote the growth of cancer cells throughout the body.

Cancer 108
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TAVR Found Non-Inferior to SAVR for Low-Risk Patients

DAIC

milla1cf Thu, 04/11/2024 - 20:48 April 11, 2024 — Transcatheter aortic valve replacement (TAVR) was found to bring no increased risks and was associated with substantial decreased rates of death or stroke at one year in lowrisk patients, compared with surgical aortic valve replacement (SAVR), according to findings presented at the American College of Cardiology’s Annual Scientific Session.

TAVR 101
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Electronic sock detects unhealthy walking style linked to cardiovascular and diabetic complications

Medical Xpress - ECG

An electronic sock that detects an unhealthy walking style linked with diabetes and poor circulation shows promise for preventing foot ulcers and amputation. The novel research is set to benefit the many patients with diabetes who have clogged arteries in the legs and is presented for the first time at EHRA 2024.

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Inclisiran First Strategy Safe, Effective for LDL-C Control in ASCVD Patients

HCPLive

New data from a phase 3b trial presented at ACC.24 underlines the potential of inclisiran in reducing LDL-C levels among patients with ASCVD.

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Preventive angioplasty does not improve prognosis

Science Daily - Heart Disease

For heart attack patients, treating only the coronary artery that caused the infarction works just as well as preventive balloon dilation of the other coronary arteries, according to a new large study.

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Early Win for Preemptive Stents on Vulnerable Coronary Plaque

Med Page Today

(MedPage Today) -- ATLANTA -- The concept of using stents to seal off non-flow-limiting vulnerable plaques, before they have a chance to rupture, worked out in the first major trial testing this provocative idea. Compared with standard medical.

Plaque 104
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Review identifies disrupted mitochondrial metabolism as a trigger for diabetic cardiomyopathy

Medical Xpress - Cardiology

Diabetes is a global health burden. A whopping 536 million people worldwide struggle with diabetes. Diabetic cardiomyopathy (DC) is a serious condition characterized by impaired heart function due to diabetes-related metabolic abnormalities.