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Timely initiation of statin therapy for diabetes shown to dramatically reduce risk of heart attack and stroke

Science Daily - Heart Disease

Despite clinicians recommending that many patients with diabetes take statins, nearly one-fifth of them opt to delay treatment. Taking a statin medication is an effective, safe, and low-cost way to lower cholesterol and reduce risk of cardiovascular events.

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Endothelial dysfunction in patients with type 2 diabetes: the truth is in the blood

Journal of Clinical Investigation - Cardiology

Endothelial dysfunction remains a cornerstone of diabetic vascular complications. EVs derived from RBCs (RBC-EVs) of patients with diabetes were taken up by the endothelium and were able to impair endothelium-dependent relaxation via an EV-mediated transfer of the prooxidant enzyme arginase-1 (Arg1) from RBCs to endothelial cells.

Diabetes 101
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Higher linoleic acid levels linked to lower heart disease and diabetes risk

Medical Xpress - Cardiology

New research that used blood markers to measure linoleic acid levels and their relation to cardiometabolic risk adds evidence that this omega-6 fatty acid may help to lower risks of heart disease and type 2 diabetes. The findings challenge claims that seed oils are harmful to cardiometabolic health.

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Erythrocyte-derived extracellular vesicles induce endothelial dysfunction through arginase-1 and oxidative stress in type 2 diabetes

Journal of Clinical Investigation - Cardiology

Red blood cells (RBCs) induce endothelial dysfunction in type 2 diabetes (T2D), but the mechanism by which RBCs communicate with the endothelium is unknown. This study tested the hypothesis that extracellular vesicles (EVs) secreted by RBCs act as mediators of endothelial dysfunction in T2D.

Diabetes 109
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Diabetes Dialogue: INHALE-3 Trial and Afrezza, With Roy Beck, MD, PhD

HCPLive

In this episode, hosts explore technosphere inhaled insulin (Afrezza) in comparison to standard diabetes therapies in the INHALE-3 trial.

Diabetes 111
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Two Drugs Better Than One for Easing Albuminuria in CKD Patients With Diabetes

Med Page Today

(MedPage Today) -- An SGLT2 inhibitor combined with a nonsteroidal mineralocorticoid receptor antagonist quickly cut urinary albumin-to-creatinine ratio (UACR) in patients with albuminuria and both chronic kidney disease (CKD) and type 2 diabetes.

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Don’t Miss a Beat: CONFIDENCE Trial and Combination T2D, CKD Therapy at Heart in Diabetes 2025

HCPLive

He goes on to explain the design of CONFIDENCE, a phase 2 trial that enrolled 800 patients with CKD and type 2 diabetes who were randomized in a 1:1:1 ratio to receive empagliflozin monotherapy, finerenone monotherapy, or combination therapy with simultaneous initiation. to 0.79; P < 001). New England Journal of Medicine.