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Breast Cancer Drug Repurposed for Infant With Congenital Hyperinsulinism

Med Page Today

(MedPage Today) -- A 4-month-old with congenital hyperinsulinism responded well to off-label treatment with a breast cancer drug, researchers reported. A newborn presented with severe congenital hyperinsulinism due to homozygous deletion of the.

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Congenital Heart Futures Reauthorization Act 2024

Conquering CHD

History of the Congenital Heart Futures Act First passed into law in 2010, the bipartisan Congenital Heart Futures Act was groundbreaking legislation authorizing research and data collection specific to Congenital Heart Disease. Raising awareness of CHD through the lifespan.

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Adults with congenital heart disease faced higher risk of abnormal heart rhythms

Science Daily - Heart Disease

Adults with congenital heart defects were more likely to experience an abnormal, irregular heartbeat, finds a new study.

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Heart organoids simulate pregestational diabetes-induced congenital heart disease

Science Daily - Heart Disease

The organoids recapitulate hallmarks of pregestational diabetes-induced congenital heart disease found in mice and humans. An advanced human heart organoid system can be used to model embryonic heart development under pregestational diabetes-like conditions, researchers report.

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A metabolic signature for NADSYN1-dependent congenital NAD deficiency disorder

Journal of Clinical Investigation - Cardiology

To date, biallelic loss-of-function variants in 3 genes encoding nonredundant enzymes of the NAD de novo synthesis pathway — KYNU, HAAO, and NADSYN1 — have been identified in humans with congenital malformations defined as congenital NAD deficiency disorder (CNDD).

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Latest research redefines neurodevelopmental risks, outcomes for congenital heart disease

American Heart News - Heart News

Statement Highlights: A new American Heart Association scientific statement updates more than a decade of research identifying, managing and preventing neurodevelopmental delays and disorders among people with congenital heart disease.

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Exercise and Sports Participation in Complex Congenital Heart Disease in Teenagers and Adults

American College of Cardiology

Developments in cardiovascular (CV) surgery and related care have led to the improved survival of patients with congenital heart disease (CHD) and more teenagers and adults living with congenital heart disease (ACHD).