Sat.Jun 15, 2024 - Fri.Jun 21, 2024

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Is Cholesterol Denialism Pseudoscience or Appropriate Medical Care?

Med Page Today

(MedPage Today) -- Recently, a cardiologist published a commentary in Medscape arguing that physicians and scientists who challenge the putative clinical benefit of statin medications are pseudoscientists. He claimed, ".somewhere along the way.

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Another deadly triage ECG missed, and the waiting patient leaves before being seen. What is this nearly pathognomonic ECG?

Dr. Smith's ECG Blog

Written by Bobby Nicholson, MD 67 year old male with history of hypertension and hyperlipidemia presented to the Emergency Department via ambulance with midsternal nonradiating chest pain and dyspnea on exertion. Pain improved to 1/10 after EMS administers 324 mg aspirin and the following EKG is obtained at triage. What do you think? If this EKG were handed to you to screen from triage without any clinical information, what would you think?

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FDA Approves Risankizumab (Skyrizi) for Ulcerative Colitis

HCPLive

The approval is based on data from a pair of phase 3 studies and makes risankizumab-rzaa the first IL-23 specific inhibitor approved for both ulcerative colitis and Crohn’s disease.

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Over-the-counter supplement found to improve walking for peripheral artery disease patients

Medical Xpress - Cardiology

The over-the-counter supplement nicotinamide riboside, a form of vitamin B3, increased the walking endurance of patients with peripheral artery disease, a chronic leg condition for which there are few effective treatments.

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Hot enough for ya? It may be too hot for your heart health!

American Heart News - Heart News

DALLAS, June 20, 2024 — It’s only the first day of summer and record high temperatures are already being reported across much of the U.S. That’s prompted the American Heart Association, celebrating a century of lifesaving service as the world’s leading.

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Women who experience depression during pregnancy or after birth have higher risk of cardiovascular disease

Science Daily - Heart Disease

Women diagnosed with perinatal depression are more likely to develop cardiovascular disease in the following 20 years compared to women who have given birth without experiencing perinatal depression. The study is the first of its kind to look at cardiovascular health after perinatal depression and included data on around 600,000 women. It found the strongest links with risks of high blood pressure, ischemic heart disease and heart failure.

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Exploring Potential New Treatment for Ventricular Tachycardia

DAIC

Eugenio Cingolani, MD. Photo by Cedars-Sinai. milla1cf Wed, 06/19/2024 - 20:57 June 19, 2024 — When electrophysiologist Eugenio Cingolani, MD , isn’t seeing patients, he can usually be found in his laboratory, investigating improved treatments for heart rhythm disorders. Cingolani, director of Cardiogenetics and Preclinical Research in the Department of Cardiology in the Smidt Heart Institute at Cedars-Sinai, is exploring new ways to help patients with ventricular tachycardia (VT), a recurrin

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How Does Heat Kill? It Confuses the Brain, Shuts Down Organs, and Strains the Heart.

Med Page Today

(MedPage Today) -- As temperatures and humidity soar outside, what's happening inside the human body can become a life-or-death battle decided by just a few degrees. The critical danger point outdoors for illness and death from relentless heat.

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Diabetic foot disease carries an intrinsic high risk of mortality and other severe outcomes in type 2 diabetes: a propensity score-matched retrospective population-based study

Cardiovascular Diabetology

To evaluate the association between diabetic foot disease (DFD) and the incidence of fatal and non-fatal events in individuals with type 2 diabetes (T2DM) from primary-care settings.

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ECG Cases 50 – STEMI: A Failed Paradigm, Enter Occlusion MI

ECG Cases

Dr. Jesse McLaren illustrates the paradigm shift from STEMI to Occlusion MI (OMI) through 9 cases, and drives home the points that if there is STEMI criteria, consider false positives (eg. secondary and proportional to LVH or BER); if there is no STEMI criteria, consider false negatives and look for other signs of occlusion (eg. acute Q waves or loss of R waves, hyperacute T waves, or reciprocal STD/TWI) and if the ECG is nondiagnostic, consider other OMI signs including clinical (refractory isc

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Research finds causal evidence tying cerebral small-vessel disease to Alzheimer's, dementia

Science Daily - Heart Disease

While previous studies suggested an association of the most common cerebral small-vessel disease with dementia risk, new research provides evidence of causal link, identifying it as a major vascular factor.

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Tech in Diabetes: What's Going Wrong?

Med Page Today

(MedPage Today) -- ORLANDO -- Technologic advances aren't fulfilling their promise for improving diabetes or overall health outcomes in the U.S., argued FDA Commissioner Robert Califf, MD. "We are wowing the world in technology -- much of.

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Researchers say AI accurately screens heart failure patients for clinical trial eligibility

Medical Xpress - Cardiology

Generative Artificial Intelligence (Gen AI) can rapidly and accurately screen patients for clinical trial eligibility, according to a new study from Mass General Brigham researchers. Such technology could make it faster and cheaper to evaluate new treatments and, ultimately, help bring successful ones to patients.

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Biological Agents Reduce PsA Risk More Than Methotrexate in Psoriasis

HCPLive

Patients with psoriasis on biological agents might have a lower PsA risk than those on methotrexate, but patients on topical therapy have an even lower risk, a study found.

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Intensive Blood Pressure Control in Individuals With Hypertension

JAMA Cardiology

This randomized clinical trial investigates the effectiveness and safety of a nonphysician-led, multifaceted, intensive blood pressure intervention in younger and older individuals with hypertension.

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Lupus Complications Reduced With Common Diabetes Drug

Med Page Today

(MedPage Today) -- People with systemic lupus erythematosus (SLE) had lower rates of lupus nephritis, chronic kidney disease, and other complications when they were taking metformin, an analysis of medical records indicated. Among some 88,000.

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Engineers develop face screening tool that detects stroke in seconds

Medical Xpress - Cardiology

A new smartphone face-screening tool could help paramedics to identify stroke in seconds—much sooner and more accurately than is possible with current technologies.

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Fenofibrate Markedly Lowers Progression of Diabetic Retinopathy

HCPLive

A first-time trial presented at ADA 2024 found the common cholesterol-lowering drug halts vision loss in patients with diabetic eye disease.

Diabetes 115
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Chronic high blood pressure during pregnancy doubled between 2008 and 2021 in the U.S.

American Heart News - Heart News

Research Highlights: The number of individuals in the United States who had chronic hypertension or chronic high blood pressure during pregnancy doubled between 2008 and 2021, according to a nationwide review of private health insurance.

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CYP2C19 Genetic Testing for Oral P2Y12 Inhibitor Therapy: A Scientific Statement From the American Heart Association

Circulation

Circulation, Ahead of Print. There is significant variability in the efficacy and safety of oral P2Y12 inhibitors, which are used to prevent ischemic outcomes in common diseases such as coronary and peripheral arterial disease and stroke. Clopidogrel, a prodrug, is the most used oral P2Y12 inhibitor and is activated primarily after being metabolized by a highly polymorphic hepatic cytochrome CYP2C219 enzyme.

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New therapy shows promise in treating hypertension-induced organ damage

Medical Xpress - Cardiology

A team of researchers led by Monash University and the Baker Heart and Diabetes Institute have published the first compelling evidence of the therapeutic potential of a new therapy to treat hypertension-induced organ damage. The paper appears in the journal Cardiovascular Research.

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Rise in Chronic Hypertension in Pregnancy While Treatment Stagnates

Med Page Today

(MedPage Today) -- There was a steady increase in the prevalence of chronic hypertension in pregnancy over the last two decades, with some accompanying changes in treatment, a nationwide cohort study found. From 2008 to 2021, the prevalence of.

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Novel Tricuspid Valve Procedure Improves Patients' Quality of Life and Health Status

DAIC

milla1cf Fri, 06/21/2024 - 20:10 June 21, 2024 — UC San Francisco interventional cardiologists and interventional echocardiographers recently performed the health system’s first commercial transcatheter tricuspid valve replacement procedure using the Edwards EVOQUE system. The novel and minimally invasive cardiac procedure was recently approved for use within the U.S. by the Food and Drug Administration.

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Over-the-counter supplement improves walking for peripheral artery disease patients

Science Daily - Stroke

The over-the-counter supplement nicotinamide riboside, a form of vitamin B3, increased the walking endurance of patients with peripheral artery disease, a chronic leg condition for which there are few effective treatments.

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Machine Learning Could Offer Noninvasive, Reliable Diagnostic Tool in IgA Nephropathy

HCPLive

Findings suggest machine learning models may have promising utility in IgAN, highlighting the superior diagnostic performance of certain models versus standard logistic regression.

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Perinatal Depression Tied to Increased Risk of Midlife Cardiovascular Disease

Med Page Today

(MedPage Today) -- Women with perinatal depression (PND) had a higher risk of cardiovascular disease (CVD) in middle adulthood than matched parous women without PND, a Swedish nationwide study found. Over a mean of 10.4 years, women with PND had.

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Microbot Medical Partners with Brigham and Women's Hospital for Its Pivotal Human Clinical Trial

DAIC

milla1cf Thu, 06/20/2024 - 19:42 June 20, 2024 — Microbot Medical Inc. announced its agreement with Brigham and Women’s Hospital ( BWH ), a leading academic medical center located in Boston, Massachusetts, to serve as one of the sites to perform the pivotal human clinical trial for its LIBERTY Endovascular Robotic Surgical System , as part of its Investigational Device Exemption (“IDE”) application.

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Chromosomal 3q amplicon encodes essential regulators of secretory vesicles that drive secretory addiction in cancer

Journal of Clinical Investigation - Cardiology

Cancer cells exhibit heightened secretory states that drive tumor progression. Here, we identified a chromosome 3q amplicon that serves as a platform for secretory regulation in cancer. The 3q amplicon encodes multiple Golgi-resident proteins, including the scaffold Golgi integral membrane protein 4 (GOLIM4) and the ion channel ATPase secretory pathway Ca2+ transporting 1 (ATP2C1).

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Karen Costenbader, MD: Data Supports Belimumab as Treatment in Early Lupus

HCPLive

Karen Costenbader, MD, discusses the 2 post hoc analyses that demonstrated treatment with belimumab reduces flares and increases response rates among patients with early active SLE.

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Can gardening ward off heart attacks?

Heart Sisters

This study looked at what gardeners already suspect: "Gardening is associated with better cardiovascular health among older adults compared to older adults who do not garden"

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Study Finds Air Pollution Can Increase Cardiovascular Risk for Cancer Patients

DAIC

Getty Images milla1cf Wed, 06/19/2024 - 20:54 June 19, 2024 — Modern therapies have extended the lives of many cancer patients; however, survivors often live with chronic health conditions, including cardiovascular disease. New research published in JACC: CardioOncology shows that air pollution plays a significant role in increasing cardiovascular disease and mortality in cancer patients and contributes to health disparities related to these conditions.

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Vessel-Level Coronary Atherosclerotic Plaque Activity Predicts Myocardial Infarction Risk

Cardiology Update

Coronary artery disease remains a leading cause of morbidity and mortality worldwide. Recent research has illuminated the role of total coronary atherosclerotic plaque activity across the entire coronary arterial tree in predicting patient-level clinical outcomes. However, the association between vessel-level coronary atherosclerotic plaque activity and the incidence of vessel-level myocardial infarction (MI) has not been fully explored.

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Treatment of Asthma in Pediatric Patients

HCPLive

Robert Sporter, MD, explores the differences in treatment approaches between adult and pediatric populations, focusing on allergy-based asthma treatments such as allergen immunotherapy and biologics, and their specific applications in managing asthma in children.

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Cardiac Shockwave Device Passes Hurdle in Ischemic Cardiomyopathy

Med Page Today

(MedPage Today) -- As an adjunct to bypass surgery for ischemic cardiomyopathy, a cardiac shockwave therapy aimed at regenerating ischemic myocardium boosted left ventricular ejection fraction (LVEF) and physical function at 1 year in a small sham.

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Promising Long- and Short-term Clinical Data Show Potential of First ASD Occluder with a Bioresorbable, Metal-free Frame

DAIC

The reSept ASD Occluder has a bioresorbable, metal-free frame milla1cf Thu, 06/20/2024 - 19:39 June 20, 2024 — atHeart Medical , a medical device company establishing a new standard of care for atrial septal defects (ASDs) closure, announced promising long and short-term clinical outcomes of its reSept ASD occluder , to be presented at the medical conference CSI Frankfurt.

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Crizanlizumab for retinal vasculopathy with cerebral leukoencephalopathy in a phase II clinical study

Journal of Clinical Investigation - Cardiology

Background Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) is a rare, autosomal dominant, universally fatal disease without effective treatment options. This study explores the safety and preliminary efficacy of crizanlizumab, a humanized monoclonal antibody against P-selectin approved for the prevention of sickle cell crises, in slowing retinal nonperfusion and preserving vision in patients with RVCL-S.METHODS Eleven patients with RVCL-S with confirme

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TNX-102 SL Significantly Reduces Daily Pain, Improves Fibromyalgia Symptoms

HCPLive

At EULAR, Tonix Pharmaceuticals presented the phase 3 RESILIENT trial which met the primary endpoint of TNX-102 SL reducing daily pain intensity.

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