article thumbnail

Cholesterol may not be the only lipid involved in trans fat-driven cardiovascular disease

Medical Xpress - Cardiology

Excess cholesterol is known to form artery-clogging plaques that can lead to stroke, arterial disease, heart attack, and more, making it the focus of many heart health campaigns. But what if there's more to the picture than just cholesterol?

article thumbnail

Missing in action: the genetic mysteries of extremely low HDL cholesterol

Frontiers in Cardiovascular Medicine

IntroductionHigh-Density Lipoprotein Cholesterol (HDL-C) plays a pivotal role in cardiovascular health, acting as a key component in lipid transport and atheroprotection. 349G>A p.Ala117Thr, rs28940886], and APOA1 [NM_000039.3(APOA1):c.388A>T, 388A>T, p.Lys130*].DiscussionEach

article thumbnail

MAR001 Cuts Remnant Cholesterol, Triglycerides by 50% in Phase 2a Trial

HCPLive

MAR001 significantly lowers remnant cholesterol and triglycerides in Phase 2a data, offering hope for high-risk cardiovascular patients.

article thumbnail

New genetic risk score identifies individuals at risk for heart disease who may benefit most from cholesterol-lowering therapies

Science Daily - Heart Disease

Atherosclerosis, or the buildup of plaque in the arteries, develops when low-density lipoprotein cholesterol (LDL-C) enters the blood vessel walls through dysfunctional endothelial cells (EC), leading to the formation of plaques.

article thumbnail

Fluctuating Cholesterol Tied to Higher Dementia Risk

Med Page Today

(MedPage Today) -- Year-to-year fluctuations in total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels were tied to higher risks of cognitive decline and dementia, a study of nearly 10,000 older adults showed. Participants with.

Dementia 136
article thumbnail

Cholesterol crystals in the pathogenesis of atherosclerosis

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 18 November 2024; doi:10.1038/s41569-024-01100-3 Cholesterol crystals (CCs) have a pathogenic role in various cardiovascular diseases, particularly atherosclerosis.

article thumbnail

Join Me Live: The Cholesterol Secrets Masterclass.

Dr. Paddy Barrett

As a cardiologist with over 20 of experience, I’ve seen how confusing and overwhelming it can be for people to manage their cholesterol. ” While these recommendations can help, they don’t address the root causes of high cholesterol. And they certainly don’t give you a clear, step-by-step plan to follow.