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Study reveals mechanism linking heart disease to cancer development

Medical Xpress - Cardiology

Researchers at Tel Aviv University (TAU) and the Leviev Cardiothoracic and Vascular Center at the Sheba Medical Center have found a mechanism responsible for increasing the risk of developing cancer among patients with heart disease: Small extracellular bubbles, or vesicles (sEVs), secreted from the sick heart to heal itself, are released into the (..)

Cancer 108
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Cardiovascular disease and cancer: shared risk factors and mechanisms

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 10 April 2024; doi:10.1038/s41569-024-01017-x Patients with cardiovascular disease (CVD) have an increased risk of cancer, and patients with cancer have an increased risk of CVD.

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Small molecules that disrupt RAD54-BLM interaction hamper tumor proliferation in colon cancer chemoresistance models

Journal of Clinical Investigation - Cardiology

Functionally, this interaction heightens HRR, leading to a decrease in residual DNA damage in colon cancer cells. This contributes to chemoresistance in colon cancer cells against cisplatin, camptothecin, and oxaliplatin, eventually promoting tumorigenesis in preclinical colon cancer mouse models.

Cancer 110
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Study Assuages Thyroid Cancer Fears With GLP-1 Receptor Agonists

Med Page Today

(MedPage Today) -- A Scandinavian cohort study suggested a popular class of diabetes drug did not put patients at an elevated risk for thyroid cancer, a longtime lingering concern with this drug class. Compared with DPP-4 inhibitors, patients.

Cancer 122
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Tumor-educated Gr1+CD11b+ cells drive breast cancer metastasis via OSM/IL-6/JAK–induced cancer cell plasticity

Journal of Clinical Investigation - Cardiology

Cancer cell plasticity contributes to therapy resistance and metastasis, which represent the main causes of cancer-related death, including in breast cancer. The tumor microenvironment drives cancer cell plasticity and metastasis, and unraveling the underlying cues may provide novel strategies for managing metastatic disease.

Cancer 94
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Harnessing skin cancer genes to heal hearts

Medical Xpress - Cardiology

Biomedical engineers at Duke University have demonstrated that one of the most dangerous mutations found in skin cancers might moonlight as a pathway to mending a broken heart.

Cancer 123
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Midterm outcomes of transcatheter aortic valve replacement in patients with active cancer

Open Heart

Objectives The clinical outcomes of transcatheter aortic valve replacement (TAVR) in patients with aortic stenosis (AS) and concomitant active cancer remain insufficiently explored. This study aimed to assess the midterm outcomes of TAVR in patients diagnosed with AS and active cancer. vs 74.7%, p=0.50).