Journal of Clinical Investigation - Cardiology

APRIL 15, 2024

Functionally, this interaction heightens HRR, leading to a decrease in residual DNA damage in colon cancer cells. This contributes to chemoresistance in colon cancer cells against cisplatin, camptothecin, and oxaliplatin, eventually promoting tumorigenesis in preclinical colon cancer mouse models.

Cancer 122

Cancer 122

Medical Xpress - Cardiology

JANUARY 24, 2024

Biomedical engineers at Duke University have demonstrated that one of the most dangerous mutations found in skin cancers might moonlight as a pathway to mending a broken heart.

Cancer 124

Cancer 124

Journal of Clinical Investigation - Cardiology

MARCH 15, 2024

Cancer cell plasticity contributes to therapy resistance and metastasis, which represent the main causes of cancer-related death, including in breast cancer. The tumor microenvironment drives cancer cell plasticity and metastasis, and unraveling the underlying cues may provide novel strategies for managing metastatic disease.

Cancer 92

Cancer Education 92

HCPLive

JULY 26, 2024

New research suggests combined treatment with fecal microbiota transplant and anti-PD-1 inhibitors may help overcome immune checkpoint inhibitor resistance in gastrointestinal cancers.

Cancer 52

Cancer Transplant Research 52

Heart BMJ

JULY 25, 2024

Background Data on the management of patients with cancer presenting with sudden cardiac arrest (SCA) are scarce. We aimed to assess the characteristics and outcomes of SCA according to cancer history. Results Out of 4069 patients who had SCA admitted alive in hospital, 207 (5.1%) had current or past medical history of cancer.

Cardiac Arrest 52

Cardiac Arrest Cancer Hospital Embolism 52

HCPLive

JULY 15, 2024

A new study shows RA is linked to an increased risk of hematological tumors and bladder, lung, and liver cancer compared to the general population.

Cancer 64

Cancer 64

Open Heart

FEBRUARY 27, 2024

Objectives The clinical outcomes of transcatheter aortic valve replacement (TAVR) in patients with aortic stenosis (AS) and concomitant active cancer remain insufficiently explored. This study aimed to assess the midterm outcomes of TAVR in patients diagnosed with AS and active cancer. vs 74.7%, p=0.50).

Aortic valve 98

Aortic valve Cancer Aortic TAVR 98

Med Page Today

APRIL 10, 2024

(MedPage Today) -- A Scandinavian cohort study suggested a popular class of diabetes drug did not put patients at an elevated risk for thyroid cancer, a longtime lingering concern with this drug class. Compared with DPP-4 inhibitors, patients.

Cancer 115

Cancer Diabetes 115

HCPLive

JUNE 10, 2024

Study from RAD 2024 finds 36% higher risk of nonmelanoma skin cancer in patients with atopic dermatitis relative to matched controls.

Cancer 111

Cancer 111

CTVS

APRIL 26, 2024

The American Cancer Society estimates that there will be about 22,000 new cases of esophageal cancer diagnosed this year, and more than half of those will result in death. As April is Esophageal Cancer Awareness Month, our team of thoracic surgeons are eager to educate people on the risk… Source

Cancer 52

Cancer Education 52

Journal of Clinical Investigation - Cardiology

DECEMBER 15, 2023

A paucity of chemotherapeutic options for metastatic brain cancer limits patient survival and portends poor clinical outcomes. Metixene, an antiparkinsonian drug, was identified as a top therapeutic agent that was capable of decreasing cellular viability and inducing cell death across different metastatic breast cancer subtypes.

Cancer 133

Cancer Outcomes 133

Med Page Today

JANUARY 24, 2024

(MedPage Today) -- A 4-month-old with congenital hyperinsulinism responded well to off-label treatment with a breast cancer drug, researchers reported. A newborn presented with severe congenital hyperinsulinism due to homozygous deletion of the.

Congenital 119

Congenital Cancer Research 119

HCPLive

FEBRUARY 29, 2024

Cancer patients with behavioral health disorders, such as substance abuse, eating disorders, and sleep disorders have a 7.76% increase in health care costs, a new study found.

Cancer 123

Cancer 123

Med Page Today

JUNE 6, 2024

(MedPage Today) -- The addition of androgen receptor signaling inhibitors (ARSIs) alongside standard androgen deprivation therapy (ADT) in advanced prostate cancer was associated with a significantly increased risk of adverse heart events, a systematic.

Cancer 88

Cancer 88

Journal of Clinical Investigation - Cardiology

DECEMBER 15, 2023

Cell lineage plasticity is one of the major causes for the failure of targeted therapies in various cancers. However, the driver and actionable drug targets in promoting cancer cell lineage plasticity are scarcely identified.

Cancer 113

Cancer Pharmacology Ablation 113

HCPLive

JUNE 21, 2024

In retrospective, observational research at ADA 2024, real-world weight loss was linked to a reduction in the risk of obesity-related cancers.

Obesity 80

Obesity Cancer Research 80

Medical Xpress - Cardiology

JANUARY 11, 2024

Jude LIFE) have revealed that two common biomarkers of cardiac function and damage could better predict cardiomyopathy within five years than routine clinical evaluations in high-risk, asymptomatic childhood cancer survivors.

Biomarkers 116

Biomarkers Cancer Cardiac Function Cardiomyopathy 116

HCPLive

JUNE 26, 2024

Patients with RA had a greater risk of delayed cervical cancer screening, and smoking was associated with a decrease in prostate cancer screening in patients with RA.

Cancer 59

Cancer 59

Med Page Today

JANUARY 9, 2024

(MedPage Today) -- Men treated with androgen deprivation therapy (ADT) for prostate cancer had a significantly higher risk of dementia and other neurocognitive disorders, according to a meta-analysis of more than 2.5 million patients. The magnitude.

Cancer 119

Cancer Dementia 119

Science Daily - Heart Disease

MAY 1, 2024

Researchers have found that cells inside clogged arteries have cancer-like properties that aggravate atherosclerosis, and anticancer drugs could be a new treatment.

Cancer 80

Cancer Atherosclerosis Research 80

Journal of Clinical Investigation - Cardiology

JUNE 17, 2024

Cancer cells exhibit heightened secretory states that drive tumor progression. Here, we identified a chromosome 3q amplicon that serves as a platform for secretory regulation in cancer.

Cancer 98

Cancer 98

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

Several poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) are approved by FDA to treat cancer with BRCA mutations. A high expression level of GSDMC predicted better response to PARPi treatment in patients with triple-negative breast cancer (TNBC). BRCA mutations are considered to fuel a PARPi killing effect by inducing apoptosis.

Cancer 104

Cancer 104

Journal of Clinical Investigation - Cardiology

MARCH 1, 2024

Whether NETs can kill cancer cells is unexplored. Here, we report that a combination of glutaminase inhibitor CB-839 and 5-FU inhibited the growth of PIK3CA-mutant colorectal cancers (CRCs) in xenograft, syngeneic, and genetically engineered mouse models in part through NETs.

Cancer 109

Cancer 109

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

Hormone receptor–positive breast cancer (HR+) is immunologically cold and has not benefited from advances in immunotherapy. In contrast, subsets of triple-negative breast cancer (TNBC) display high leukocytic infiltration and respond to checkpoint blockade. MAP source genes highly overlapped between both subtypes.

Cancer 67

Cancer 67

Journal of Clinical Investigation - Cardiology

JANUARY 2, 2024

Following a period of slow progress, the completion of genome sequencing and the paradigm shift relative to the cell of origin for high grade serous ovarian cancer (HGSOC) led to a new perspective on the biology and therapeutic solutions for this deadly cancer.

Cancer 117

Cancer Research 117

Medical Xpress - Cardiology

FEBRUARY 2, 2024

To help protect the hearts of cancer patients, Cedars-Sinai investigators have created a three-dimensional "heart-on-a-chip" to evaluate drug safety. Chemotherapy can be toxic to heart cells.

Cancer 115

Cancer 115

Journal of Cardiothoracic Surgery

JUNE 23, 2024

The prognostic value of cellular retinoic acid-binding protein 2 (CRABP2), in lung cancer patients remains to be uncertained. Therefore, our research attempted to assess the relationship between CRABP2 and sur.

Cancer 52

Cancer Research 52

HCPLive

MAY 17, 2024

This analysis highlights the various factors influencing preferences in skin cancer detection between smartphone applications using artificial intelligence versus dermatologists.

Cancer 64

Cancer 64

DAIC

FEBRUARY 28, 2024

The findings – published this week in the Journal of the American College of Cardiology — could fuel advocacy for a paradigm shift in clinical heart health guidelines to address cardiovascular risk factors at an earlier age in childhood cancer survivors. “We Wendy Bottinor, MD.

Risk Factors 92

Risk Factors Cancer Cardio Oncology Blood Pressure 92

American College of Cardiology

JUNE 21, 2024

Air pollution can greatly increase the risk of cardiovascular disease and mortality in patients with cancer and can contribute to health disparities related to both conditions,

Cancer 74

Cancer Health Disparities Risk Factors Cardiovascular Disease 74

American College of Cardiology

JULY 2, 2024

One pivotal study, the phase 3 trial known as KEYNOTE-522, focused on previously untreated stage II or stage III triple-negative breast cancer patients.

Cancer 52

Cancer Article 52

DAIC

JANUARY 29, 2024

occurrence of postoperative PE in patients undergoing a first-time pulmonary resection for lung cancer. The researchers found no difference in PE risk based on how well the lungs functioned before surgery, cancer cell type (histology), or whether or not the patients received chemotherapy before surgery.

Cancer 102

Cancer Pulmonary Research Blood Clot 102

Journal of Clinical Investigation - Cardiology

JULY 1, 2024

Using high-throughput sequencing, we found that ubiquitin-conjugating enzyme E2 C (UBE2C) was overexpressed in bladder cancer (BCa) and was strongly associated with an unfavorable prognosis. Overexpression of UBE2C increased BCa lymphangiogenesis and promoted LN metastasis both in vitro and in vivo.

Cancer 96

Cancer Outcomes 96

Journal of Cardiothoracic Surgery

JUNE 5, 2024

The most common type of cancer that leads to death worldwide is lung cancer. Despite significant surgery and chemotherapy improvements, lung cancer patient’s survival rate is still poor. The RNA polymerase I s.

Cancer 52

Cancer Research 52

HCPLive

DECEMBER 12, 2023

In a new study, a subgroup analysis demonstrated a reduced risk of colorectal cancer among patients <65 years old with gout.

Cancer 105

Cancer 105

Medical Xpress - Cardiology

JULY 11, 2024

New research from the University of Alberta offers the hope of better long-term outcomes for survivors of childhood cancer—and the path to those better outcomes is exercise.

Cancer 40

Cancer Research Exercise Outcomes 40

Journal of Clinical Investigation - Cardiology

DECEMBER 15, 2023

Protein synthesis is frequently dysregulated in cancer and selective inhibition of mRNA translation represents an attractive cancer therapy. A similar induction of IFN-stimulated genes was observed in breast cancer patient biopsies following zotatifin treatment.

Cancer 98

Cancer Biomarkers 98