March, 2024

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ECG Blog #419 — The Cause of ECG #1?

Ken Grauer, MD

I was sent the 2 ECGs shown in Figure-1 — which were recorded from an elderly man whose heart beat "has been irregular for years". No clear history for recent chest pain — but the patient "has not been well" for the previous week. Regarding the 2 ECGs in Figure-1 : ECG #1 is the initial tracing obtained at the scene by the EMS ( E mergency M edical S ystems ) team — in association with an alert but markedly hypotensive patient.

Blog 191
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8-hour time-restricted eating linked to a 91% higher risk of cardiovascular death

American Heart News - Heart News

Research Highlights: A study of over 20,000 adults found that those who followed an 8-hour time-restricted eating schedule, a type of intermittent fasting, had a 91% higher risk of death from cardiovascular disease. People with heart disease or cancer.

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Contemporary approach to cardiogenic shock care: a state-of-the-art review

Frontiers in Cardiovascular Medicine

Cardiogenic shock (CS) is a time-sensitive and hemodynamically complex syndrome with a broad spectrum of etiologies and clinical presentations. Despite contemporary therapies, CS continues to maintain high morbidity and mortality ranging from 35 to 50%. More recently, burgeoning observational research in this field aimed at enhancing the early recognition and characterization of the shock state through standardized team-based protocols, comprehensive hemodynamic profiling, and tailored and selec

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8-hour time-restricted eating linked to a 91% higher risk of cardiovascular death

Science Daily - Heart Disease

A study of over 20,000 adults found that those who followed an 8-hour time-restricted eating schedule, a type of intermittent fasting, had a 91% higher risk of death from cardiovascular disease.

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Early Stroke Scare With Bivalent COVID Vaccines Unsupported by Large Study

Med Page Today

(MedPage Today) -- Investigation of an early signal for stroke associated with COVID-19 bivalent vaccines turned into suspicion of high-dose or adjuvanted flu shots instead, based on a large U.S. population-based study. When researchers inspected.

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Boehringer Ingelheim Announces $35 Monthly Price Cap on Inhalers for Asthma, COPD Patients

HCPLive

On March 07, 2024, Boehringer Ingelheim announced it would be instituting a $35 per month out-of-pocket cost cap for its portfolio of inhaler products, with this cap going into effect on June 01, 2024.

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A humanized IL-2 mutein expands Tregs and prolongs transplant survival in preclinical models

Journal of Clinical Investigation - Cardiology

Long-term organ transplant survival remains suboptimal, and life-long immunosuppression predisposes transplant recipients to an increased risk of infection, malignancy, and kidney toxicity. Promoting the regulatory arm of the immune system by expanding Tregs may allow immunosuppression minimization and improve long-term graft outcomes. While low-dose IL-2 treatment can expand Tregs, it has a short half-life and off-target expansion of NK and effector T cells, limiting its clinical applicability.

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Spontaneous Coronary Artery Dissection: A Focus on Post-Dissection Care for the Vascular Medicine Clinician

Frontiers in Cardiovascular Medicine

Spontaneous coronary artery dissection (SCAD) is an uncommon condition which is increasingly recognized as a cause of significant morbidity. SCAD can cause acute coronary syndrome and myocardial infarction (MI), as well as sudden cardiac death. It presents similarly to atherosclerotic MI although typically in patients with few or no atherosclerotic risk factors, and particularly in women.

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Google Street View reveals how built environment correlates with risk of cardiovascular disease

Medical Xpress - Cardiology

Researchers have used Google Street View to study hundreds of elements of the built environment, including buildings, green spaces, pavements and roads, and how these elements relate to each other and influence coronary artery disease in people living in these neighborhoods.

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Sotatercept's FDA Approval a New Chapter for Pulmonary Arterial Hypertension

Med Page Today

(MedPage Today) -- The FDA approved sotatercept (Winrevair) for treating pulmonary arterial hypertension (PAH) in adults, Merck announced on Tuesday. A novel activin signaling inhibitor, sotatercept is indicated to increase exercise capacity.

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Transcutaneous Pacing: Part I

EMS 12-Lead

TCP In Transit: A case reviewing transcutaneous pacing, false electrical capture, and re-arrest. Josh Kimbrell, NRP @joshkimbre Judah Kreinbrook, EMT-P @JMedic2JDoc This is the first installment of a blog series showing how transcutaneous pacing (TCP) can be difficult, and how you can improve your skills. We will be using redacted information from different cases where paramedics attempted TCP in the field.

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Evidence that tirzepatide protects against diabetes-related cardiac damages

Cardiovascular Diabetology

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are effective antidiabetic drugs with potential cardiovascular benefits. Despite their well-established role in reducing the risk of major adverse cardiovas.

Diabetes 125
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Sweetened drinks linked to atrial fibrillation risk

American Heart News - Heart News

Research Highlights: An analysis of health data in the UK Biobank found a 20% higher risk of irregular heart rhythm, known as atrial fibrillation, among people who said they drank two liters or more per week (about 67 ounces) of artificially sweetened.

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Alcohol raises heart disease risk, particularly among women

Science Daily - Heart Disease

Young to middle-aged women who reported drinking eight or more alcoholic beverages per week--more than one per day, on average--were significantly more likely to develop coronary heart disease compared with those who drank less, finds a study presented at the American College of Cardiology's Annual Scientific Session. The risk was highest among both men and women who reported heavy episodic drinking, or 'binge' drinking, and the link between alcohol and heart disease appears to be especially str

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Semaglutide (Wegovy) Receives FDA Label Expansion to Include Cardiovascular Risk Reduction

HCPLive

On March 08, 2024, the FDA approved semaglutide 2.4 mg (Wegovy) to reduce cardiovascular risk in adults with obesity or overweight and heart disease based on the SELECT trial.

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Our Brains Are Getting Bigger, MRIs Show

Med Page Today

(MedPage Today) -- Human brains appeared to be getting bigger, temporal trends showed. From the 1930s to 1970s, brain volumes and cortical surface area of people who had neither dementia nor stroke became progressively larger, reported Charles.

Dementia 139
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Case report of belt electrode-skeletal muscle electrical stimulation for acute heart failure with severe obesity: a novel therapeutic option for acute phase rehabilitation

Frontiers in Cardiovascular Medicine

Background Belt electrode skeletal muscle electrical stimulation (B-SES) is an emerging therapy anticipated to yield more favorable outcomes than conventional neuromuscular electrical stimulation (NMES), owing to its larger stimulation area. However, information on its efficacy and safety in patients with heart failure remains limited. Case presentation A 43-year-old man with a body mass index of 41 kg/m 2 was admitted to our hospital for acute heart failure due to dilated cardiomyopathy.

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Questioning Intermittent Fasting’s Cardiovascular Impact

CardiacWire

A new AHA study shocked the world this week, suggesting that intermittent fasting might significantly increase people’s risk of cardiovascular death, sparking a wave of media coverage, and a frenzy of criticisms from the cardiologist and scientific communities. Time-restricted eating, which is a type of intermittent fasting, involves limiting eating to a specific number of hours per day (e.g. 4 or 8 hours) and fasting for the rest of the day.

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Young adults with migraine, other nontraditional risk factors may have higher stroke risk

American Heart News - Heart News

Research Highlights: Nontraditional risk factors for stroke were significantly associated with the development of strokes in adults younger than ages 35 to 45. Migraine was the most important nontraditional risk factor for stroke among both men and.

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Eggs may not be bad for your heart after all

Science Daily - Heart Disease

Whether you like your eggs sunny-side up, hard boiled or scrambled, many hesitate to eat them amid concerns that eggs may raise cholesterol levels and be bad for heart health. However, results from a prospective, controlled trial show that over a four-month period cholesterol levels were similar among people who ate fortified eggs most days of the week compared with those who didn't eat eggs.

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FDA Approves Aprocitentan (Tryvio) for Treatment-Resistant Hypertension

HCPLive

Idorsia Ltd. announced the FDA's approval of aprocitentan (Tryvio) for treatment-resistant hypertension on March 20, 2024.

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Wegovy Approved for Heart Disease Prevention

Med Page Today

(MedPage Today) -- The FDA approved semaglutide (Wegovy) to reduce the risk of cardiovascular death, heart attack, and stroke in adults with cardiovascular disease and either obesity or overweight, the agency announced on Friday. A GLP-1 receptor.

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Abbott Announces First Procedures in ENVISION Trial of Navitor TAVI System to Treat Patients With Severe Aortic Stenosis

DAIC

milla1cf Mon, 03/25/2024 - 07:00 March 25, 2024 — Abbott announced the first patient has been enrolled in the ENVISION investigational device exemption (IDE) clinical trial. The global, randomized trial ( envisiontrial.com ) will evaluate the safety and effectiveness of Abbott’s minimally invasive Navitor transcatheter aortic valve implantation (TAVI) system in approximately 1,500 patients at intermediate or low surgical risk with severe aortic stenosis (narrowing of the aortic valve).

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Microplastics, Nanoplastics, and Major Cardiac Events

CardiacWire

A landmark NEJM study revealed that many patients with carotid artery disease might have microplastics and nanoplastics (MNPs) embedded in their carotid plaque, and those patients have a massive 4.5-fold greater risk of heart attack, stroke, or death within three years. The researchers examined carotid plaque specimens from 257 patients with asymptomatic carotid artery disease, analyzing their plaque for the presence of 11 MNPs, and tracking the patients’ cardiovascular outcomes over 34 months.

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Social, environmental factors may raise risk of developing heart disease and stroke

American Heart News - Heart News

Research Highlights: People living in neighborhoods with more environmental adversities, including pollution, toxic sites, high traffic and few parks, had higher rates of cardiovascular disease and cardiovascular disease risk factors. This association.

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Small amounts of licorice raise blood pressure, study finds

Science Daily - Heart Disease

It is known that large amounts of licorice cause high blood pressure. A new study now shows that even small amounts of licorice raise blood pressure. The individuals who react most strongly also show signs of strain on the heart.

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Tapinarof Cream for Atopic Dermatitis: An Interim Analysis of Results in Adults, Children

HCPLive

A new analysis of the phase 3 ADORING 3 extension trial involved a large, diverse population and the analysis showed that 91% of eligible participants from previous phases rolled over into this trial.

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CVD Risks Tied to Teeny-Tiny Plastics Lodged in Atherosclerotic Plaque

Med Page Today

(MedPage Today) -- It was common for tiny plastic particles from the environment to infiltrate people's vascular lesions, foreshadowing future cardiovascular disease in patients who underwent carotid endarterectomy, an observational study showed.

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Microplastics linked to heart attack, stroke: Study

Becker's Hospital Review - Cardiology

We all have microplastics in our bodies , but if they show up in carotid artery tissues, patients are nearly two times as likely to experience a stroke, heart attack or related death, according to a study published March 7 in The New England Journal of Medicine.

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Medtronic Announces FDA Approval of Newest-generation Evolut TAVR System for Treatment of Symptomatic Severe Aortic Stenosis

DAIC

milla1cf Thu, 03/28/2024 - 07:30 March 28, 2024 — Medtronic plc, a global leader in healthcare technology, announced that the United States Food and Drug Administration ( FDA ) has approved the Evolut FX+ transcatheter aortic valve replacement (TAVR) system for the treatment of symptomatic severe aortic stenosis. The latest Evolut FX+ TAVR system maintains the valve performance benefits of the legacy Evolut TAVR platform and is designed to facilitate coronary access.

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More exposure to artificial, bright, outdoor nighttime light linked to higher stroke risk

American Heart News - Heart News

Research Highlights: A large study of residents in Ningbo, China, a major city of more than 8.2 million residents, found that exposure to more artificial, outdoor, nighttime light was associated with a higher risk of conditions that affect brain.

Stroke 116
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Increased LL37 in psoriasis and other inflammatory disorders promotes LDL uptake and atherosclerosis

Journal of Clinical Investigation - Cardiology

Patients with chronic inflammatory disorders such as psoriasis have an increased risk of cardiovascular disease and elevated levels of LL37, a cathelicidin host defense peptide that has both antimicrobial and proinflammatory properties. To explore whether LL37 could contribute to the risk of heart disease, we examined its effects on lipoprotein metabolism and show that LL37 enhanced LDL uptake in macrophages through the LDL receptor (LDLR), scavenger receptor class B member 1 (SR-B1), and CD36.

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SGLT2 Inhibitors Could Play a Role in Treating Gout

HCPLive

A new review considers how SGLT2 inhibitors like dapagliflozin and empagliflozin have been shown to clinically improve gout while reducing its cardiometabolic and renal comorbidities.

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Novel Oral Antihypertensive Gets FDA's Blessing

Med Page Today

(MedPage Today) -- The FDA has approved aprocitentan (Tryvio), making it the first endothelin receptor antagonist for the treatment of high blood pressure (BP), Idorsia Pharmaceuticals announced on Wednesday. The once-daily oral medication is.

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Feds to probe UPMC heart implant practices

Becker's Hospital Review - Cardiology

The House Committee on Energy and Commerce is asking the FDA to investigate whether patients received experimental heart implants at UPMC Children’s Hospital of Pittsburgh without consent or proper information, the Pittsburgh Post-Gazette reported March 24.

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Elixir Medical Receives FDA Breakthrough Device Designation for DynamX BTK System for Below-The-Knee Arterial Disease

DAIC

Elixir Medical has announced it has been granted Breakthrough Device Designation by the U.S. Food and Drug Administration (FDA) for its DynamX BTK System, a novel, adaptive implant for use in the treatment of narrowed or blocked vessels below-the-knee (BTK) in patients with chronic limb-threatening ischemia (CLTI). The company reports this broadens the use of the novel bioadaptor platform technology beyond the treatment of coronary artery disease.

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A rare morphology of the cardiac fibroma in a child: a case report

Frontiers in Cardiovascular Medicine

Here we report a rare morphology of a cardiac fibroma in a child. A 2-year and 8-month-old toddler came for “chronic constipation” and was found to have a heart murmur on cardiac auscultation. Further transthoracic echocardiography suggested “a strong echogenic mass in the left ventricular wall, with some part of “a string of beads” in shape extending into left ventricle outflow tract”, which was atypical for either a tumor, thrombus or vegetation.