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Integrin-mediated mTOR signaling drives TGF-β overactivity and myxomatous mitral valve degeneration in hypomorphic fibrillin-1 mice

Journal of Clinical Investigation - Cardiology

Mitral valve prolapse is often benign, but progression to mitral regurgitation may require invasive intervention and there is no specific medical therapy. mgR mice developed severe myxomatous mitral valve degeneration with mitral regurgitation by 12 weeks of age.

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Foldax’s TRIA Mitral Valve Impresses at NYV

CardiacWire

The valve replacement space keeps adding contenders, and Foldax’s polymer-based TRIA Mitral Valve replacement showed compelling one-year results in its India Clinical Trial presented at New York Valves 2025, suggesting we could soon have an alternative to bovine tissue valves. A >90% increase in effective orifice area (0.9 cm² to 1.5

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New AI-driven Tool Aids in Mitral Valve Assessment

CardiacWire

A new tool, Automated 3D Color Flow Quantification (3D Auto CFQ), removes the reliance on assumptions when quantifying mitral regurgitation and replaces it with a reliable and robust, AI-driven method that delivers precise measurement of mitral valve regurgitant volume (RVol) regardless of orifice shape and size. References: 1.

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Transcatheter bicuspid versus tricuspid aortic valve replacement in patients with a small aortic annulus: an observational study

Open Heart

Objective To compare the clinical outcomes and haemodynamic performance following transcatheter aortic valve replacement (TAVR) in patients with severe bicuspid versus tricuspid aortic stenosis (AS) and small annuli. Design Retrospective analysis based on a prospective observational cohort. mm 2 (IQR 348.0–406.4)),

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Cardiology MCQ: Balloon Mitral Valvuloplasty (BMV)

All About Cardiovascular System and Disorders

Percutaneous balloon mitral valvuloplasty was introduced by: A. Inoue Inoue and team described percutaneous balloon mitral valvuloplasty in 1983 from Japan. Till then mitral stenosis was managed surgically, by closed mitral valvotomy or open mitral valvotomy, with the latter requiring cardiopulmonary bypass.

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Contribution of rare chromosome 22q11.2 copy number variants to non-syndromic bicuspid aortic valve

Heart BMJ

Background Bicuspid aortic valve (BAV) is the most common congenital heart defect in adults, often leading to complications such as thoracic aortic aneurysms and aortic stenosis. While BAV is frequently associated with 22q11.2

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Cardiovascular Magnetic Resonance for Quantification of Mitral Regurgitation

American College of Cardiology

Assessment of mitral regurgitation (MR) has traditionally been performed with echocardiography. However, echocardiography has known limitations including the lack of a single reliable parameter of severity, high inter- and intraobserver variability, and discordance between echocardiographic parameters in a given patient.