Integrin-mediated mTOR signaling drives TGF-β overactivity and myxomatous mitral valve degeneration in hypomorphic fibrillin-1 mice
Journal of Clinical Investigation - Cardiology
JULY 16, 2025
Mitral valve prolapse is often benign, but progression to mitral regurgitation may require invasive intervention and there is no specific medical therapy. mgR mice developed severe myxomatous mitral valve degeneration with mitral regurgitation by 12 weeks of age.
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