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Ischemia Related Topics 
Ken Grauer, MD
JUNE 22, 2024
That said — the ECG in Figure-1 should prompt the following considerations: The symmetric chest lead T wave inversion in ECG #1 could be a sign of coronary disease, potentially with acute ischemia.
168 
DAIC
JANUARY 9, 2024
milla1cf Tue, 01/09/2024 - 11:32 January 9, 2024 — Cleerly , the company working to create a new standard of care for the diagnosis of heart disease, announced the launch of Cleerly ISCHEMIA , which recently received U.S. Cleerly ISCHEMIA is a transformative addition poised to reshape the landscape of cardiac care.”
101 
Cardiology Update
MARCH 5, 2024
In the ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive Approaches) trial, researchers examined the risk of ischemic events in patients with stable coronary artery disease. For more cardiology research news join our newsletter or follow us on Twitter , Facebook , LinkedIn or Instagram.
Dr. Smith's ECG Blog
MAY 30, 2024
ischemia) or it can be secondary to abnormal depolarization (e.g Discussion: The ECG in today's case does not have typical ST depression vector of diffuse subendocardial ischemia. The ST vector in subendocardial ischemia (SEI) usually has the largest amount of ST depression in leads II and V5, towards the apex of the heart. (ST
77 
HCPLive
APRIL 12, 2024
Tracy Frech, MD, MSCI, explains what rheumatologists need to know about preventing and management digital ischemia.
98 98 American College of Cardiology
JULY 25, 2024
What is the prognostic impact of peri-infarct ischemia on stress cardiovascular magnetic resonance (CMR) imaging?
43 
NEJM Journal Watch - Cardiology
JULY 24, 2024
Identifying and treating silent myocardial ischemia was associated with decreased cardiovascular mortality and fewer adverse cardiovascular events at 5 years.
45 
Cardiovascular Diabetology
MAY 30, 2024
Ischemia and no obstructive coronary artery disease (INOCA) is increasingly recognized and associated with poor outcomes. The triglyceride-glucose (TyG) index is a reliable alternative measure of insulin resis.
Cardiology Update
JANUARY 14, 2024
As the medical community delves deeper into the intricacies of ANOCA, the study provides a compelling narrative for clinicians and researchers alike, aiming to decipher the complexities of myocardial bridges and their role in exercise-induced ischemia. Original article: Sinha A et al. Circ Cardiovasc Interv.
119 
Journal of Cardiothoracic Surgery
JUNE 30, 2024
Myocardial ischemia-reperfusion injury (MIRI) is defined as the restoration of blood flow to the myocardium after a brief interruption of blood supply, causing more severe damage to the ischemic myocardium.
52 
DAIC
FEBRUARY 23, 2024
Food and Drug Administration ( FDA )-cleared Cleerly ISCHEMIA software device applied to a non-invasive coronary CT angiogram ( CCTA ) can be billed using the new Category I CPT code 75580. Prior studies have demonstrated the independent and incremental benefit of Cleerly ISCHEMIA applied to CCTA beyond traditional assessment.
85 
Medical Xpress - Cardiology
JANUARY 9, 2024
However, reperfusion itself could induce more severe injury, called myocardial ischemia/reperfusion injury (MI/RI). The most effective treatment for MI in clinic is reperfusion, e.g., interventional or thrombolytic therapy.
75 
Science Daily - Heart Disease
APRIL 10, 2024
Over 200 million people around the world experience peripheral artery disease (PAD) -- a condition caused by the narrowing of the blood vessels from the heart to the lower limbs that leads to pain when walking -- and for roughly 1-in-10 this advances to chronic limb-threatening ischemia (CLTI), an advanced form of PAD.
DAIC
MAY 2, 2024
a developer of cellular and cell-derived therapeutics for the treatment of cardiovascular and pulmonary diseases, today announced the primary endpoint results of the open label roll-in cohort of the CardiAMP Cell Therapy in Chronic Myocardial Ischemia Trial. Getty Images milla1cf Thu, 05/02/2024 - 10:12 May 2, 2024 — BioCardia, Inc. ,
66 
Journal of Cardiovascular Pharmacology
JULY 15, 2024
The role of intravenous immunoglobulin in protecting the diabetic heart from ischemia/reperfusion (I/R) injury is unclear. Hearts isolated from adult diabetic and non-diabetic Wistar rats (n=8 per group) were treated with intravenous immunoglobulin (IVIG) either two hours before euthanasia, before ischemia, or at reperfusion.
40 
Frontiers in Cardiovascular Medicine
FEBRUARY 1, 2024
In addition, with the prevalence of COVID-19 infection, more and more studies report that COVID-19 infection may lead to arteriovenous thrombosis, which could cause lower limb ischemia. This case reported that a 31-year-old male amateur football player who developed intermittent claudication after recovering from COVID-19.
64 
Frontiers in Cardiovascular Medicine
FEBRUARY 20, 2024
Introduction Accurate identification of the myocardial texture features of fat around the coronary artery on coronary computed tomography angiography (CCTA) images are crucial to improve clinical diagnostic efficiency of myocardial ischemia (MI).
59 59 
Circulation: Cardiovascular Interventions
DECEMBER 28, 2023
BACKGROUND:Lower-limb amputation rates in patients with chronic limb-threatening ischemia vary across the United States, with marked disparities in amputation rates by gender, race, and income status. Circulation: Cardiovascular Interventions, Ahead of Print. Mean age, 76.6
Medical Xpress - Cardiology
APRIL 10, 2024
A new study reveals diminished quality of life among patients with chronic limb-threatening ischemia, a severe form of peripheral artery disease, and emphasizes the benefits of revascularization on well-being.
The American Journal of Cardiology
JUNE 5, 2024
Berger, ISCHEMIA Biorepository Research Group Hamo, Richard Liu, Wenbo Wu, Rebecca Anthopolos, Sripal Bangalore, Claes Held, Ifitkhar Kullo, Kreton Mavromatis, Bruce McManus, L. Kristin Newby, Harmony R. Reynolds, Kelly V. Ruggles, Lars Wallentin, David J. Maron, Judith S. Hochman, Jonathan D. Newman, Jeffrey S.
40 
American College of Cardiology
JANUARY 2, 2024
The goal of the MINT trial was to compare the effect of a liberal vs. restrictive blood transfusion strategy on acute myocardial infarction (MI) in patients with concomitant anemia.
75 
NEJM Journal Watch - Cardiology
APRIL 10, 2024
In a randomized, controlled trial, the device reduced daily angina but not myocardial ischemia in patients with refractory angina.
45 
All About Cardiovascular System and Disorders
FEBRUARY 9, 2024
Why is left ventricle more prone for ischemia than right ventricle or atria?
52 
Journal of the American Heart Association
FEBRUARY 29, 2024
BackgroundDelayed cerebral ischemia represents a significant contributor to death and disability following aneurysmal subarachnoid hemorrhage. Journal of the American Heart Association, Ahead of Print. Our analysis included 102 eligible studies.
40 
Stroke: Vascular and Interventional Neurology
NOVEMBER 9, 2023
IntroductionAcute spinal cord ischemia syndrome (ASCIS) is a rare disease that is thought to comprise roughly only 1.2% Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. of all strokes [1, 2]. Due to the scarcity of these events, the patient outcomes are unclear.
40 
Cardiovascular Diabetology
MAY 19, 2024
There is conflicting evidence whether prediabetes is associated with adverse clinical outcomes in patients with chronic coronary syndrome. We aimed to assess the effect of prediabetes in patients with chronic.
64 
Cardiovascular Diabetology
JULY 17, 2024
Mitochondria play a central role in cellular energy metabolism, and their dysfunction is increasingly recognized as a critical factor in the pathogenesis of diabetes-related cardiac pathophysiology, including vu.
52 
Frontiers in Cardiovascular Medicine
JANUARY 28, 2024
Background Impaired energy balance caused by lipid metabolism dysregulation is an essential mechanism of myocardial ischemia-reperfusion injury (MI/RI). This study aims to explore the lipid metabolism-related gene (LMRG) expression patterns in MI/RI and to find potential therapeutic agents.
59 59 
Stroke Journal
FEBRUARY 1, 2024
To confirm the time-kinetics of cGK1/2 changes, brain samples were divided ischemia-reperfusion period in SMLC and SMKO mice with and without dipyridamole (60 mg/kg, p.o.).Results:Infarction During the ischemia and reperfusion period, neuronal cGK1 was sustained without protein degradation. Not only SMLC but also SMKO were the same.
40 
Stroke Journal
FEBRUARY 1, 2024
miR-155-5p ASO-treated PBMC administration increased VEGF expression 21 d after administration in ischemic rats (28 d after cerebral ischemia). Moreover, VEGF expression levels in the microglia cocultured with OGD-PBMCs were higher with miR-155-5p ASO than without it (P = 0.049).
40 
Circulation: Cardiovascular Interventions
NOVEMBER 6, 2023
We sought to determine the substrates for ischemia in patients with angina, nonobstructive coronary arteries (ANOCA) and a MB in the left anterior descending artery.Methods:Patients with ANOCA underwent acquisition of intracoronary pressure and flow during rest, supine bicycle exercise and adenosine infusion.
40 
Journal of Cardiovascular Pharmacology
APRIL 1, 2024
Abstract: N-n-butyl haloperidol iodide (F2), a derivative of haloperidol developed by our group, exhibits potent antioxidative properties and confers protection against cardiac ischemia/reperfusion (I/R) injury. The protective mechanisms by which F2 ameliorates I/R injury remain obscure.
40 
ECG Cases
SEPTEMBER 23, 2019
And guess what.they all show acute ischemia! The post ECG Cases 1: Missed Ischemia – Never Trust the ECG Computer Interpretation appeared first on Emergency Medicine Cases.
52 
Stroke Journal
FEBRUARY 1, 2024
This study aims to understand the role of SIRT3 on ischemia and reperfusion-induced neuronal apoptosis. One potential therapeutic target for reperfusion injury is Sirtuin 3 (SIRT3), which mediates the deacetylation of enzymes that are responsible for the reduction of ROS, leading to protection against oxidative stress.
40 
Journal of the American Heart Association
DECEMBER 29, 2023
BackgroundFerroptosis, an iron‐dependent form of regulated cell death, is a major cell death mode in myocardial ischemia reperfusion (I/R) injury, along with mitochondrial permeability transition‐driven necrosis, which is inhibited by cyclosporine A (CsA). Journal of the American Heart Association, Ahead of Print.
40 Stroke Journal
FEBRUARY 1, 2024
Background:Malonate, a competitive inhibitor of succinate dehydrogenase, has shown much promise in ameliorating ischemia/reperfusion injury (IRI) in various diseases, including ischemic stroke. Stroke, Volume 55, Issue Suppl_1 , Page AWMP12-AWMP12, February 1, 2024.
40 Stroke Journal
FEBRUARY 1, 2024
In this study, our hypothesis was that NETs cause vascular occlusion leading to delayed cerebral ischemia (DCI) and worse outcome after SAH. Following ischemic stroke, neutrophils cause vascular occlusion via neutrophil extracellular traps (NETs).
40 
Stroke Journal
FEBRUARY 1, 2024
Background and Purpose:Neutrophils are the first recruited leukocytes following ischemia/reperfusion injury in the brain; however, when and where neutrophils enter the brain parenchyma to exert their effects is controversial. Stroke, Volume 55, Issue Suppl_1 , Page ATP309-ATP309, February 1, 2024.
40 
Dr. Smith's ECG Blog
JULY 30, 2023
The STD maximal in V1-V4 is diagnostic of acute transmural posterior wall ischemia, most likely due to posterior OMI. Subendocardial ischemia does not localize, and subendocardial ischemia presents with STD maximal in V5-6, II, and STE in aVR. Subendocardial ischemia does not localize. AI can do it too.
52 
Dr. Smith's ECG Blog
JULY 25, 2024
The ECG shows severe ischemia, possibly posterior OMI. But cardiac arrest is a period of near zero flow in the coronary arteries and causes SEVERE ischemia. It takes time for that ischemia to resolve. The patient was brought to the ED and had this ECG recorded: What do you think? And what do you want to do?
Cardiovascular Diabetology
JULY 4, 2024
Owing to its unique location and multifaceted metabolic functions, epicardial adipose tissue (EAT) is gradually emerging as a new metabolic target for coronary artery disease risk stratification. Microvascular.
American College of Cardiology
APRIL 8, 2024
The goal of the ORBITA-COSMIC trial was to determine the effects of a coronary sinus reducer (CSR) device versus sham control on both myocardial blood flow (MBF) assessed by stress perfusion cardiac magnetic resonance imaging (CMR) and daily angina burden in patients with refractory angina.
54 
Journal of the American Heart Association
JANUARY 19, 2024
BackgroundLittle is known about treatment variability across US hospitals for patients with chronic limb‐threatening ischemia (CLTI).Methods Journal of the American Heart Association, Ahead of Print. Methods and ResultsData were collected from the 2016 to 2018 National Inpatient Sample.
40 
Dr. Smith's ECG Blog
APRIL 14, 2024
No ischemia. This is a conundrum, because it is clear that the patient is having an acute MI, the ECG is dynamic, but the pain is very mild and there is no ECG evidence of active transmural ischemia. We already know that the ischemia is ongoing, though mild (because of the persistent pain). Q-waves are even more pronounced.
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