June, 2024

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ECG Blog #435 — Did Cath Show Acute Ischemia?

Ken Grauer, MD

The ECG in Figure-1 — was obtained from a middle-aged woman with positional tachycardia and diaphoresis with change of position from suprine to sitting. Although CP ( C hest P ain ) was not a prominent symptom — ACS ( A cute C oronary S yndrome ) was suspected from the chest lead T wave inversion seen on this ECG. QUESTIONS: How would YOU interpret the ECG in Figure-1 ?

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Nonpharmacological interventions on glycated haemoglobin in youth with type 1 diabetes: a Bayesian network meta-analysis

Cardiovascular Diabetology

The available evidence on the impact of specific non-pharmacological interventions on glycaemic control is currently limited. Consequently, there is a need to determine which interventions could provide the mo.

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Live Updates from the FDA Psychopharmacologic Advisory Committee Meeting on MDMA for PTSD

HCPLive

Follow HCPLive's coverage of the full-day FDA committee meeting regarding Lykos Therapeutics' application for MDMA-assisted therapy as a novel treatment for patients with PTSD.

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More Evidence That Flu Is Linked to Heart Attacks

Med Page Today

(MedPage Today) -- Influenza infection was associated with an increased risk of acute myocardial infarction (MI), especially for those without a prior hospitalization for coronary artery disease (CAD), according to a Dutch observational case series.

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Population shifts, risk factors may triple U.S. cardiovascular disease costs by 2050

American Heart News - Heart News

Embargoed until 4 a.m. CT/5 a.m. ET Tuesday, June 4, 2024 DALLAS, June 4, 2024 — Driven by an older, more diverse population, along with a significant increase in risk factors including high blood pressure and obesity, total costs related to.

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Global epidemiology of heart failure

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 26 June 2024; doi:10.1038/s41569-024-01046-6 In this Review, Khan and colleagues explore the evolving global epidemiology of heart failure (HF), focusing on changes in incidence and prevalence across the spectrum of left ventricular ejection fraction. The authors highlight the disparities in our understanding of HF epidemiology in low-income and middle-income countries, affirming the need for improved surveillance and resource allocation in vulnerable

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ECG Blog #436 — Bigeminy or Alternans?

Ken Grauer, MD

The ECG in Figure-1 — was obtained from an older man with known coronary disease. He was on a number of medications — including antiplatelet agents, a statin drug and Digoxin. The patient presented to the ED ( E mergency D epartment ) for an episode of syncope. He developed cardiac arrest shortly after the ECG in Figure-1 was recorded. QUESTIONS: How would YOU interpret the ECG in Figure-1 ?

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More Trending

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Generic Liraglutide (Victoza) Becomes First Generic GLP-1 Receptor Agonist

HCPLive

Teva Pharmaceuticals’ launch of an authorized generic of liraglutide injection 1.8 mg (Victoza) for type 2 diabetes makes it the first-ever generic GLP-1.

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Is Cholesterol Denialism Pseudoscience or Appropriate Medical Care?

Med Page Today

(MedPage Today) -- Recently, a cardiologist published a commentary in Medscape arguing that physicians and scientists who challenge the putative clinical benefit of statin medications are pseudoscientists. He claimed, ".somewhere along the way.

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Hot enough for ya? It may be too hot for your heart health!

American Heart News - Heart News

DALLAS, June 20, 2024 — It’s only the first day of summer and record high temperatures are already being reported across much of the U.S. That’s prompted the American Heart Association, celebrating a century of lifesaving service as the world’s leading.

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New heart disease risk tool finds 40% fewer people need statins: Study

Becker's Hospital Review - Cardiology

New study suggests that 40% fewer people may need statins for heart disease prevention, according to a risk assessment published in JAMA Internal Medicine.

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ECG Blog #434 — WHY Did this Patient Arrest?

Ken Grauer, MD

The ECG in Figure-1 — was obtained from a middle-aged man who presented to the ED ( E mergency D epartment ) in cardiac arrest. ROSC ( R eturn O f S pontaneous C irculation ) was obtained — and ECG #1 was recorded. In view of this history — How would YOU interpret the ECG in Figure-1 ? Should you activate the cath lab? Figure-1: The initial ECG in today's case. ( To improve visualization — I've digitized the original ECG using PMcardio ).

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Challenges and opportunities in the management of type 2 diabetes in patients with lower extremity peripheral artery disease: a tailored diagnosis and treatment review

Cardiovascular Diabetology

Lower extremity peripheral artery disease (PAD) often results from atherosclerosis, and is highly prevalent in patients with type 2 diabetes mellitus (T2DM). Individuals with T2DM exhibit a more severe manifes.

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FDA Approves Risankizumab (Skyrizi) for Ulcerative Colitis

HCPLive

The approval is based on data from a pair of phase 3 studies and makes risankizumab-rzaa the first IL-23 specific inhibitor approved for both ulcerative colitis and Crohn’s disease.

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Type 1 Diabetes in Older People Has Nearly Tripled Globally Since the '90s

Med Page Today

(MedPage Today) -- Global prevalence of older people living with type 1 diabetes mellitus jumped 180% in the past 30 years, a population-based study found. This represents an increase from 1.3 million people worldwide in 1990 to 3.7 million in.

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Selected startups will advance technology-driven improvements in heart and brain health

American Heart News - Heart News

DALLAS, June 13, 2024 — The American Heart Association, through its Center for Health Technology and Innovation (the Center), has selected five companies to participate in the American Heart Association Heart and Brain Health Accelerator. The AHA.

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Exploring Potential New Treatment for Ventricular Tachycardia

DAIC

Eugenio Cingolani, MD. Photo by Cedars-Sinai. milla1cf Wed, 06/19/2024 - 20:57 June 19, 2024 — When electrophysiologist Eugenio Cingolani, MD , isn’t seeing patients, he can usually be found in his laboratory, investigating improved treatments for heart rhythm disorders. Cingolani, director of Cardiogenetics and Preclinical Research in the Department of Cardiology in the Smidt Heart Institute at Cedars-Sinai, is exploring new ways to help patients with ventricular tachycardia (VT), a recurrin

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ECG #433 — Which Lead Convinced Me?

Ken Grauer, MD

The ECG in Figure-1 was obtained from a previously healthy older man — who presented to the ED ( E mergency D epartment ) with new but atypical CP ( C hest P ain ) for several hours. QUESTIONS: Given this history — How would YOU interpret this ECG? Which lead is the most concerning? Figure-1: The initial ECG in today's case. ( To improve visualization — I've digitized the original ECG using PMcardio ).

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Over-the-counter supplement found to improve walking for peripheral artery disease patients

Medical Xpress - Cardiology

The over-the-counter supplement nicotinamide riboside, a form of vitamin B3, increased the walking endurance of patients with peripheral artery disease, a chronic leg condition for which there are few effective treatments.

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Women who experience depression during pregnancy or after birth have higher risk of cardiovascular disease

Science Daily - Heart Disease

Women diagnosed with perinatal depression are more likely to develop cardiovascular disease in the following 20 years compared to women who have given birth without experiencing perinatal depression. The study is the first of its kind to look at cardiovascular health after perinatal depression and included data on around 600,000 women. It found the strongest links with risks of high blood pressure, ischemic heart disease and heart failure.

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Amino Acid Infusion Before Cardiac Surgery Reduced Acute Kidney Injury

Med Page Today

(MedPage Today) -- An amino acid infusion reduced the occurrence of acute kidney injury (AKI) in adults undergoing elective cardiac surgery with cardiopulmonary bypass, the randomized PROTECTION trial showed. Among over 3,500 patients, in-hospital.

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Chronic high blood pressure during pregnancy doubled between 2008 and 2021 in the U.S.

American Heart News - Heart News

Research Highlights: The number of individuals in the United States who had chronic hypertension or chronic high blood pressure during pregnancy doubled between 2008 and 2021, according to a nationwide review of private health insurance.

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Diabetes Dialogue: INHALE-3 and Diabetes Tech Updates, with Grazia Aleppo, MD

HCPLive

In this episode, hosts are joined by Grazia Aleppo, MD, for a discussion on the use of inhaled insulin following the INHALE-3 trial and relevant updates in diabetes technology at ADA 2024.

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IgG hexamers initiate complement-dependent acute lung injury

Journal of Clinical Investigation - Cardiology

Antibodies can initiate lung injury in a variety of disease states such as autoimmunity, in reactions to transfusions, or after organ transplantation, but the key factors determining in vivo pathogenicity of injury-inducing antibodies are unclear. Harmful antibodies often activate the complement cascade. A model for how IgG antibodies trigger complement activation involves interactions between IgG Fc domains driving the assembly of IgG hexamer structures that activate C1 complexes.

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61% of US adults will have cardiovascular disease by 2050, American Heart Association says

Becker's Hospital Review - Cardiology

A majority of adults in the U.S. — around 61% — are likely to be diagnosed with a form of cardiovascular disease by 2050, according to new American Heart Association data. The increased burden will cost the U.S. health system $1.8 trillion in the time frame.

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A woman in her 50s with multiple episodes of syncope

Dr. Smith's ECG Blog

By Sofiya Diurba MD, reviewed by Meyers, Grauer A woman in her 50s with PMH known RBBB and prior syncopal events presents to the ED for five syncopal events over the last 24 hours. Each event is associated with a prodrome of mild substernal CP, SOB, and “brain fog.” EMS reports intermittent sinus tachycardia and bradycardia secondary to some type of heart block during transport.

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Sugar Substitute Linked to Heart, Thrombotic Risk

Med Page Today

(MedPage Today) -- The popular low-calorie sweetener xylitol was linked to increased cardiovascular and thrombotic risk, a series of experiments showed. Metabolomic studies linked xylitol intake to higher risk for major adverse cardiovascular.

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NEW DATE! Webinar on Optimizing Structural Heart Workflows

DAIC

tim.hodson Tue, 06/11/2024 - 17:21 On July 16, Diagnostic and Interventional Cardiology will present a webinar on "Maximizing Structural Heart Workflows: Harnessing the Power of CVIS and AI." The webinar will take place at 1 p.m. eastern time and is sponsored by Optum. Omer Schalit–Cohen , chief product officer at Optum’s Healthcare Enterprising Imaging business unit, will be the presenter.

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Robert Gish, MD: Advancements in Therapeutic Development, Combination Therapy in PBC

HCPLive

Gish explains recent developments in the treatment of PBC, highlighting the FDA approval of elafibranor, the anticipated decision for seladelpar, and the growing role of combination therapy.

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NR2E3 loss disrupts photoreceptor cell maturation and fate in human organoid models of retinal development

Journal of Clinical Investigation - Cardiology

While dysfunction and death of light-detecting photoreceptor cells underlie most inherited retinal dystrophies, knowledge of the species-specific details of human rod and cone photoreceptor cell development remains limited. Here, we generated retinal organoids carrying retinal disease–causing variants in NR2E3, as well as isogenic and unrelated controls.

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Population shifts, risk factors may triple U.S. cardiovascular disease costs by 2050

Science Daily - Heart Disease

Driven by an older, more diverse population, along with a significant increase in risk factors including high blood pressure and obesity, total costs related to cardiovascular disease (CVD) conditions are likely to triple by 2050, according to recent projections. At least 6 in 10 U.S. adults (61%), more than 184 million people, are expected to have some type of CVD within the next 30 years, reflecting a disease prevalence that will have a $1.8 trillion price tag in direct and indirect costs.

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Diabetic foot disease carries an intrinsic high risk of mortality and other severe outcomes in type 2 diabetes: a propensity score-matched retrospective population-based study

Cardiovascular Diabetology

To evaluate the association between diabetic foot disease (DFD) and the incidence of fatal and non-fatal events in individuals with type 2 diabetes (T2DM) from primary-care settings.

Diabetes 115
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Better Cognitive Outcomes Tied to Vigorous Exercise in Hypertensive Adults

Med Page Today

(MedPage Today) -- Vigorous exercise appeared to preserve cognitive function in older adults with hypertension, a post hoc analysis of SPRINT MIND trial data showed. At least one vigorous physical activity session per week reduced the risk of.

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AliveCor Announces Dual FDA Clearance of AI Technology That Delivers 35 Cardiac Determinations and First-of-its-Kind Kardia 12L ECG System

DAIC

Pocket-Sized Kardia 12L ECG System milla1cf Tue, 06/25/2024 - 18:55 June 25, 2024 — AliveCor , the global leader in AI -powered cardiology, today announced the U.S. Food and Drug Administration ( FDA ) clearance and commercial launch of KAI 12L AI technology and the Kardia 12L ECG System. This is the world’s first AI that can detect life-threatening cardiac conditions, including heart attacks, using a reduced leadset.

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Risk of Malignancy, Major Adverse Cardiovascular Events in Patients with Atopic Dermatitis

HCPLive

These findings, presented at RAD 2024, highlight risk of atopic dermatitis patients for developing various cancers as well as major adverse cardiovascular events.

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ECG Cases 50 – STEMI: A Failed Paradigm, Enter Occlusion MI

ECG Cases

Dr. Jesse McLaren illustrates the paradigm shift from STEMI to Occlusion MI (OMI) through 9 cases, and drives home the points that if there is STEMI criteria, consider false positives (eg. secondary and proportional to LVH or BER); if there is no STEMI criteria, consider false negatives and look for other signs of occlusion (eg. acute Q waves or loss of R waves, hyperacute T waves, or reciprocal STD/TWI) and if the ECG is nondiagnostic, consider other OMI signs including clinical (refractory isc

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Breakthrough in predicting sudden cardiac death

Science Daily - Heart Disease

A new computational method developed by physicists can be used to estimate the risk of sudden cardiac death from a one-minute heart rate measurement at rest. The study was carried out in interdisciplinary collaboration between cardiology and computational physics.