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Modulation of NOX2 causes obesity-mediated atrial fibrillation

Journal of Clinical Investigation - Cardiology

Obesity is linked to an increased risk of atrial fibrillation (AF) via increased oxidative stress. Here, we studied NOX2-mediated ROS production in obesity-mediated AF using Nox2-knockout mice and mature human induced pluripotent stem cell–derived atrial cardiomyocytes (hiPSC-aCMs).

Obesity 97
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Obesity Linked to Elevated Gout Risk

HCPLive

Obesity was more prevalent among patients with gout and obesity indicators were significantly higher in this group.

Obesity 119
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ASN Releases New Guidance on Obesity Management in Kidney Disease

HCPLive

The new guidance reviews existing tools for weight management and provides recommendations for their use in clinical practice in patients with obesity and kidney disease.

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Connections between obesity and heart failure

Science Daily - Heart Disease

A new small study has revealed the impact of obesity on muscle structure in patients having a form of heart failure called heart failure with a preserved ejection fraction (HFpEF).

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Have We Turned The Tide On Obesity?

Dr. Paddy Barrett

Obesity is one of the world’s biggest health crisis and only seems to be getting worse. For over 50 years, the rates of obesity have continued to rise worldwide 1. The most recent data on obesity has shown a decline for the first time in a very long time. Between 2020 and 2023, the rates of obesity dropped by about 2% 2.

Obesity 52
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Metabolic Accelerator Shows Promise for Weight Loss Side of Obesity-HFpEF Equation

Med Page Today

(MedPage Today) -- The novel investigational weight loss agent HU6 had mixed results specifically targeting obesity-related heart failure with preserved ejection fraction (HFpEF), based on the small HuMain-HFpEF trial. After 19 weeks on daily.

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Need 10,000 Daily Steps to Prevent Obesity? It May Depend on Genetics

Med Page Today

(MedPage Today) -- The daily step count needed to reduce the risk of obesity may be largely dependent on genetics, a retrospective cohort study indicated. adults without obesity in the All of Us Research Program, incidence of obesity.

Obesity 114