Frontiers in Cardiovascular Medicine

MARCH 26, 2024

Introduction This study evaluated the hypothesis that vascular aging (VA) reduces ventricular contractile function and mechanical efficiency (ME) using the left ventricular pressure-volume (PV) construct. Methods A previously published in-silico computational model (CM) was modified to evaluate the hypothesis in two phases.

Cardiac Function 64

Cardiac Function Aortic Stroke Strokes 64

HCPLive

MARCH 14, 2024

The AccuCinch® System, utilized by Allegheny General Hospital, offers a breakthrough approach to treating heart failure by targeting the left ventricle.

Quality of Life 52

Quality of Life Heart Failure Cardiac Function Innovation 52

HeartRhythm

APRIL 30, 2024

Whether and how STIM1 expression in cardiomyocytes (CM) impacts cardiac remodeling in response to I/R injury is unclear. Loss of stromal interaction molecule 1 (STIM1) expression in smooth muscle cells protects against ischemia reperfusion (I/R) injury.

Cardiac Function 40

Cardiac Function Ischemia 40

Medical Xpress - Cardiology

JANUARY 11, 2024

Jude LIFE) have revealed that two common biomarkers of cardiac function and damage could better predict cardiomyopathy within five years than routine clinical evaluations in high-risk, asymptomatic childhood cancer survivors. Data from the St. Jude lifetime cohort study (St.

Biomarkers 116

Biomarkers Cancer Cardiac Function Cardiomyopathy 116

Medical Xpress - Cardiology

JANUARY 19, 2024

The study, published in the journal Science Advances, identifies the first therapeutic target that can be modulated to preserve cardiac function in pulmonary hypertension, providing hope in the fight against this rare but fatal disease for which there is currently no cure.

Pulmonary 101

Pulmonary Hypertension Cardiac Function Research 101

HeartRhythm

APRIL 30, 2024

Cardiac Contractility Modulation (CCM) is a non-excitatory electrical stimulation for improving cardiac function. However, the effect of CCM on metabolic remodeling of heart failure is unknown.

Heart Failure 40

Heart Failure Cardiac Function 40

HeartRhythm

APRIL 30, 2024

Einthoven's and Goldberger's lead systems are the basis of electrocardiography, providing insights into cardiac function and heart health. Despite their long-standing use, the new landscape of technology and lack of current validation of these systems require a re-evaluation.

Cardiac Function 40

Cardiac Function Technology 40

Frontiers in Cardiovascular Medicine

APRIL 7, 2024

In these patients, congenital defects themselves, surgical operations and remaining lesions may alter cardiac anatomy and impact the mechanical performance of both ventricles. Cardiac function significantly influences outcomes in CHDs, necessitating regular patient follow-up to detect clinical changes and relevant risk factors.

Congenital Heart Disease 40

Congenital Heart Disease Congenital Heart Disease Anatomy 40

Frontiers in Cardiovascular Medicine

MARCH 7, 2024

The patient required prolonged catecholamine support owing to poor cardiac function, and heart transplantation was considered. Case presentation A 43-year-old man with a body mass index of 41 kg/m 2 was admitted to our hospital for acute heart failure due to dilated cardiomyopathy.

Heart Failure 124

Heart Failure Obesity Heart Transplant Transplant 124

HCPLive

DECEMBER 12, 2023

Presented at ASH 2023, findings of a new study showed patients with sickle cell disease and venous thromboembolism have longitudinal worsening of left ventricular diastolic and right-sided cardiac function.

Sickle Cell Disease 52

Sickle Cell Disease Cardiac Function 52

Clinical Trial Results

APRIL 7, 2024

Loading… Taking too long? Reload document | Open in new tab Download [958.21 KB] Disclosures: TBD

Download 40

Download Cardiac Function Document Cardiomyopathy 40

Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

At baseline, cKO mice exhibited a reduced cardiac function, elevated stress markers and a decrease in FAO and GO gene expression compared to WT mice. LVH resulted in increased cardiac remodeling and a decreased expression of FAO and GO genes, but a comparable decline in cardiac function in cKO compared to WT mice.

Heart Failure 59

Heart Failure Cardiac Function Aortic 59

Journal of Cardiovascular Pharmacology

FEBRUARY 11, 2024

Myocardial fibrosis, a common complication of myocardial infarction (MI), is characterized by excessive collagen deposition and can result in impaired cardiac function. Remarkably, CD137 knockout mice exhibited improved cardiac function and reduced fibrosis compared to wild-type mice at day 28 post-MI.

Cardiac Function 40

Cardiac Function Myocardial Infarction Article 40

Frontiers in Cardiovascular Medicine

DECEMBER 20, 2023

The secondary outcomes were changes in hemodynamic and cardiac function. As adjuvants to etomidate induction, they do not impair cardiac function (ChiCTR1900028030). Results The incidence of the response to cardiovascular stress was 23.1%, 30.8%, and 65.4% in groups A, B, and C, respectively. Discussion Esketamine 0.5 mg/kg

Cardiac Function 64

Cardiac Function Outcomes Stroke Strokes 64

HeartRhythm

JANUARY 29, 2024

Mitochondria control cardiac function by regulating adenosine triphosphate synthesis, reactive oxygen species (ROS) generation, intracellular calcium (Ca2+), and the cellular redox state. Yet, their role in the pathophysiology of arrhythmias remains massively underappreciated.

Arrhythmia 40

Arrhythmia Cardiac Function Article 40

Frontiers in Cardiovascular Medicine

JANUARY 3, 2024

Cardiac function was measured by echocardiography during hospitalization and follow-up. Major adverse cardiac events (MACEs) were recorded for prognostic analysis. Results At the 6-month follow-up, AMI patients who received TPE after primary PCI had significantly lower levels of CTCF (24.27 ± 2.40

Myocardial Infarction 59

Myocardial Infarction Cardiac Function Outcomes Thrombolysis 59

CardiacWire

JANUARY 7, 2024

Far fewer participants in the AT-001 group experienced “clinically significant worsening in cardiac functional capacity” than the placebo group (32.7% The post Applied Therapeutics’ AT-001 Trial Misses Mark appeared first on Cardiac Wire. ml/kg/min Peak VO2).

Cardiomyopathy 59

Cardiomyopathy Diabetes Cardiac Function Heart Failure 59

Circulation: Heart Failure

FEBRUARY 27, 2024

After swimming training, echocardiography was used to evaluate cardiac function in mice, and histopathologic staining was used to detect cardiac hypertrophy, myocardial fibrosis, and cardiac inflammation.

Exercise 40

Exercise Cardiac Rehabilitation Cardiac Function Heart Failure 40

Frontiers in Cardiovascular Medicine

FEBRUARY 18, 2024

Despite cardiac MRI being unsuggestive of myocarditis, myocardial biopsies were obtained and histologically confirmed anti-PD-1 antibody-associated myocarditis. After the initiation of prednisone at 1 mg/kg body weight, the patient gradually recovered and was discharged three weeks later with markedly improved cardiac function.

Cardiac Arrest 72

Cardiac Arrest Hospital Cancer Cardiac Function 72

BMH Medical Journal

MARCH 23, 2024

Earlier experimental studies had suggested that MNPs promote oxidative stress, inflammation and apoptosis in endothe-lial and other vascular cells which could eventually lead to impairment in cardiac function, myocar-dial fibrosis and endothelial dysfunction.

Cardiac Function 40

Cardiac Function 40

Open Heart

OCTOBER 12, 2023

Cardiac function is characterised by haemodynamic parameters in the clinical scenario. Due to recent development in imaging techniques, the clinicians focus on the quantitative assessment of left ventricular size, shape and motion patterns mostly analysed by echocardiography and cardiac magnetic resonance.

Cardiac Function 52

Cardiac Function Physiology 52

Journal of the American Heart Association

JANUARY 11, 2024

Blood pressure and measures of cardiac geometry and function were obtained in 2001 to 2003 and 2006 to 2009. We used generalized estimating equations to evaluate the association of declines in blood lead with changes in blood pressure; cardiac function and geometry measures were considered secondary. μg/dL at baseline.

Blood Pressure 81

Blood Pressure Cardiac Function Cardiovascular Disease 81

Frontiers in Cardiovascular Medicine

FEBRUARY 6, 2024

Objectives The aim of this retrospective study was to explore the diagnostic potential of various cardiac parameters in differentiating between heart failure with preserved ejection fraction (HFpEF) and heart failure with mid-ranged and reduced ejection fraction (HFm + rEF), and to discern their relationship with normal cardiac function.

Heart Failure 64

Heart Failure Preserved Ejection Fraction Cardiac Function Research 64

Journal of the American Heart Association

FEBRUARY 29, 2024

Our purpose is to investigate the effect of MYPT2 on cardiac function and fibrosis in mineralocorticoid receptor‐related hypertension.Methods and ResultsHL‐1 murine cardiomyocytes were incubated with different concentrations or durations of aldosterone.

Hypertension 75

Hypertension Blood Pressure Cardiac Function 75

Frontiers in Cardiovascular Medicine

FEBRUARY 21, 2024

It is unclear to what extent the reduced arrhythmia burden is due to direct effects of the SGLT2 inhibitors or is solely a marker of improved cardiac function. Evidence suggests a reduced incidence of ventricular and atrial arrhythmias in patients with dapagliflozin or empagliflozin treatment.

Electrophysiology 59

Electrophysiology Atrial Fibrillation Arrhythmia Cardiac Function 59

Journal of Cardiovascular Pharmacology

MARCH 24, 2024

We found that RUS effectively alleviated myocardial pathological damage, normalized cardiac function, and increased survival in septic mice. We found that RUS effectively alleviated myocardial pathological damage, normalized cardiac function, and increased survival in septic mice.

Cardiac Function 40

Cardiac Function Article 40

Journal of Cardiovascular Pharmacology

FEBRUARY 28, 2024

Here, we performed transcriptome analysis of SNPiP-treated mice ventricles to elucidate how SNPiP exerts beneficial effects on cardiac function. Here, we performed transcriptome analysis of SNPiP-treated mice ventricles to elucidate how SNPiP exerts beneficial effects on cardiac function.

Cardiac Function 40

Cardiac Function Ischemia Article 40

Frontiers in Cardiovascular Medicine

FEBRUARY 20, 2024

The objective of the review was to compare the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on the exercise capacity, cardiac function, quality of life (QoL) and heart rate among patients with heart failure with reduced ejection fraction.

Heart Failure 64

Heart Failure Exercise Quality of Life Cardiac Function 64

Journal of Cardiovascular Pharmacology

APRIL 4, 2024

PTE administration promoted protective effects in terms of oxidative stress in two experimental models of cardiac diseases: MI and PAH. PTE also improved cardiac function in infarcted rats and pulmonary artery flow in animals with PAH. In the PAH model, PTE improved pulmonary artery flow and decreased ROS levels in the lung.

Myocardial Infarction 40

Myocardial Infarction Cardiovascular Disease Pulmonary Hypertension 40

Hypertension Journal

DECEMBER 12, 2023

The current evidence indicates that in patients with HHD, pathological lesions in the myocardium lead to maladaptive structural remodeling and subsequent alterations in cardiac function, electrical activity, and perfusion, all contributing to poor outcomes.

Heart Disease 45

Heart Disease Hypertension Cardiac Function Research 45

Heart BMJ

FEBRUARY 23, 2024

Objective Left ventricular ejection fraction (LVEF) is measured to assess haemodynamic status and cardiac function. It may be difficult to accurately measure in patients with heart failure (HF) as they are often poorly echogenic.

Heart Failure 52

Heart Failure Cardiac Function Technology 52

Frontiers in Cardiovascular Medicine

APRIL 18, 2024

Improvements in exercise tolerance, lipid metabolism, cardiac function, and psychological aspects of the patients were evident with appropriate exercise interventions based on a comprehensive assessment. Aerobic exercise, resistance training, flexibility training, and other forms of exercise are recommended by many experts.

Cardiac Rehabilitation 40

Cardiac Rehabilitation Research Quality of Life Exercise 40

DAIC

APRIL 18, 2024

Enhancement of cardiac function and suppression of heart failure progression by inhibition of protein phosphatase 1. I-1c delivered via direct coronary infusion in a porcine model of heart failure improves contractility and mitigates adverse remodeling. Circ Heart Fail. 2013;6(2):310-317. [2] 2] Pathak A, del Monte F, Zhao W, et al.

Heart Failure 97

Heart Failure Public Health Cardiac Function Research 97

Journal of Cardiovascular Pharmacology

NOVEMBER 16, 2023

Overexpression of ALKBH5 inhibited H/R-induced cardiomyocyte apoptosis and oxidative stress in vitro, and inhibited I/R-induced collagen deposition, cardiac function, and apoptosis in vivo. We observed that ALKBH5 and MG53 were highly expressed in MI. We observed that ALKBH5 and MG53 were highly expressed in MI.

Myocardial Infarction 40

Myocardial Infarction Cardiac Function Ischemia Article 40

DAIC

MAY 2, 2024

The team of investigators built a dataset of 1,032,975 cardiac ultrasound videos and corresponding expert interpretations to develop EchoCLIP. Key takeaways from the study include: EchoCLIP displayed strong performance when assessing cardiac function using heart images.

Echocardiogram 66

Echocardiogram Aortic valve Ultrasound Bicuspid/Mitral 66

Journal of Cardiovascular Electrophysiology

MARCH 3, 2024

Abstract Introduction Cardiac contractility modulation (CCM) is a medical device-based therapy delivering non-excitatory electrical stimulations to the heart to enhance cardiac function in heart failure (HF) patients. The lack of human in vitro tools to assess CCM hinders our understanding of CCM mechanisms of action.

Electrophysiology 40

Electrophysiology Cardiac Function Physiology Heart Failure 40

Frontiers in Cardiovascular Medicine

DECEMBER 13, 2023

The individual relationship between fatal arrhythmias and cardiac function abnormalities in predicting cardiac death risk has rarely been explored. Primary preventive therapies, such as implantable cardioverter defibrillators, are not personalized and not predictive.

Chest Pain 64

Chest Pain Cardiac Arrest Public Health Defibrillator 64