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Continuous Peripheral Electrical Nerve Stimulation Improves Cardiac Function via Autonomic Nerve Regulation in MI Rats

HeartRhythm

Peripheral electrical nerve stimulation (PENS) reportedly improves cardiac function after myocardial ischemia (MI) by rebalancing the cardiac autonomic nervous system. The dynamic and continuous influence of the PENS on autonomic and cardiac functioning based on cardiac self-repair is not well understood.

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Efficacy of physical exercise on the physical ability, cardiac function and cardiopulmonary fitness of patients with atrial fibrillation: a systematic review and meta-analysis

Frontiers in Cardiovascular Medicine

The purpose of the current study was to measure the efficacy of exercise on the physical ability, cardiac function and cardiopulmonary fitness of patients with AF. Meanwhile, we also do not exclude the positive effect of exercise on the improvement of cardiac function (LVEF) in patients with AF.

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Study discovers how a magnesium cellular transport 'pump' plays a vital role in cardiac function

Medical Xpress - Cardiology

Magnesium is a mineral critical to a wide range of biological functions, and a new study takes aim at how it's transported to address cardiac dysfunction and other diseases, opening new possibilities for treatment.

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Effect of Tafamidis on Cardiac Function in Patients With Transthyretin Amyloid Cardiomyopathy

JAMA Cardiology

This post hoc analysis of the randomized Tafamidis in Transthyretin Cardiomyopathy Clinical Trial examines the effect of tafamidis vs placebo on 30-month changes in cardiac function in patients with transthyretin amyloid cardiomyopathy.

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CRISPR-Cas9 base editing of pathogenic CaMKII? improves cardiac function in a humanized mouse model

Journal of Clinical Investigation - Cardiology

CAMK2D-edited mice recovered cardiac function, showed improved exercise performance, and were protected from myocardial fibrosis, which was otherwise observed in injured control mice after IR. Our findings identify a potentially effective strategy for cardioprotection in response to oxidative damage.

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Evaluation of vascular aging on measures of cardiac function and mechanical efficiency: insights from in-silico modeling

Frontiers in Cardiovascular Medicine

Introduction This study evaluated the hypothesis that vascular aging (VA) reduces ventricular contractile function and mechanical efficiency (ME) using the left ventricular pressure-volume (PV) construct. Methods A previously published in-silico computational model (CM) was modified to evaluate the hypothesis in two phases.

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Inflammation of the heart muscle following viral infection can impede long-term cardiac function

Medical Xpress - Cardiology

Inflammation of the heart muscle, also known as myocarditis, is a serious consequence of a viral infection. This can impede the heart's ability to pump blood in the long term. In a recent study, researchers of the Faculty of Medicine of the University of Freiburg have discovered a new approach for treating myocarditis.