April, 2024

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ECG Blog #426 — Are STEMI Criteria Met?

Ken Grauer, MD

The ECG in Figure-1 — was obtained from a 70-ish year old man with episodic CP ( C hest P ain ) over the previous 2-3 days , being awakened from sleep now for a more severe CP episode. QUESTIONS: In view of this history — How would YOU interpret this ECG? Should you activate the cath lab? Figure-1: The initial ECG in today's case. MY Initial Thoughts on Today's CASE: Although it is difficult from the brief history we are given, to determine the true onset of whatever might be happening — the pat

Blog 152
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COVID Vaccine Study Finds Small Signal of Seizure Risk in Young Kids

Med Page Today

(MedPage Today) -- Only myocarditis/pericarditis and seizures occurred at higher rates in adolescents and children vaccinated for COVID-19 when compared with historical rates of those outcomes, according to an analysis of safety data from the FDA.

COVID-19 144
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Ep 193 The Crashing Asthmatic – Recognition and Management of Life Threatening Asthma

ECG Cases

In this part 2 of our 2-part podcast on asthma with Dr. Sameer Mal and Dr. Leeor Sommer, we dig into the recognition and management of life-threatening asthma. We answer such questions as: what are the key elements in recognition of threatening asthma? What are the most time-sensitive interventions required to break the vicious cycle of asthma? What are the best options for dosing and administering magnesium sulphate, epinephrine, fentanyl and ketamine in the management of the crashing asthmatic

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Stroke incidence increases with diabetic retinopathy severity and macular edema in type 1 diabetes

Cardiovascular Diabetology

As the retina is suggested to mirror the brain, we hypothesized that diabetic retinopathy and macular edema are indicative of stroke risk in type 1 diabetes and sought to assess this association in individuals.

Diabetes 122
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Recognizing Stigma's Impact on Care for Alcohol-Related Liver Disease

HCPLive

In the first segment of this HCPLive special report, experts discuss the stigma surrounding alcohol use disorder and alcohol-associated liver disease.

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Small molecules that disrupt RAD54-BLM interaction hamper tumor proliferation in colon cancer chemoresistance models

Journal of Clinical Investigation - Cardiology

RAD54 and BLM helicase play pivotal roles during homologous recombination repair (HRR) to ensure genome maintenance. BLM amino acids (aa 181–212) interact with RAD54 and enhance its chromatin remodeling activity. Functionally, this interaction heightens HRR, leading to a decrease in residual DNA damage in colon cancer cells. This contributes to chemoresistance in colon cancer cells against cisplatin, camptothecin, and oxaliplatin, eventually promoting tumorigenesis in preclinical colon cancer mo

Cancer 122
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ECG Blog #427 — To Cath this Elderly Patient?

Ken Grauer, MD

The ECG in Figure-1 — was obtained on the scene by EMS ( E mergency M edical S ervices ). The patient was a man in his 90s, who ~1 hour earlier, noted the onset of severe CP ( C hest P ain ). He was hemodynamically stable — but clearly distressed with a sense of “impending doom” at the time ECG #1 was recorded. Despite the patient’s age — he was independent, lived alone, had good mental function — and had family support.

Blog 133

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Physical activity lowers cardiovascular disease risk by reducing stress-related brain activity, study finds

Medical Xpress - Cardiology

New research indicates that physical activity lowers cardiovascular disease risk in part by reducing stress-related signaling in the brain.

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Researchers identify over 2,000 genetic signals linked to blood pressure in study of over one million people

Science Daily - Heart Disease

Researchers have discovered over a hundred new regions of the human genome, also known as genomic loci, that appear to influence a person's blood pressure. In total, over 2,000 independent genetic signals for blood pressure are now reported, demonstrating that blood pressure is a highly complex trait influenced by thousands of different genetic variants.

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Patients with Fibromyalgia Scored Worse in Memory, Attention, Cognitive Function

HCPLive

Without controlling for the severity of symptoms, patients with either fibromyalgia or RA performed worse when compared with controls in terms of cognitive domains including verbal memory, visual memory, and strategic planning.

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More than half a million global stroke deaths may be tied to climate change

Science Daily - Stroke

A changing climate may be linked to growing death and disability from stroke in regions around the world, according to a new study. Researchers found over three decades that non-optimal temperatures, those above or below temperatures associated with the lowest death rates, were increasingly linked to death and disability due to stroke. The study does not prove that climate change causes stroke.

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ECG Cases 49 – ECG and POCUS for Dyspnea and Chest Pain

ECG Cases

In this ECG Cases blog, Jesse McLaren and Rajiv Thavanathan explore how ECG and POCUS complement each other for patients presenting to the emergency department with shortness of breath or chest pain. They explain complementary diagnostic insights into pericardial effusion and cardiac tamponade, occlusion MI and RV strain. The post ECG Cases 49 – ECG and POCUS for Dyspnea and Chest Pain appeared first on Emergency Medicine Cases.

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CDC: Premature Mortality for Top Causes of Death Higher in Rural Areas

Med Page Today

(MedPage Today) -- Americans living in rural areas had higher rates of preventable premature mortality from the five leading causes of death than those living in urban areas during the years 2010-2022, and the divide only appears to be growing.

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Cardiologist burnout rising: 7 things to know

Becker's Hospital Review - Cardiology

Burnout among cardiologists has risen by 2% since last year, with 66% reporting they have felt burned out for at least 13 months, compared to 64% in 2023, a recent Medscape report found.

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Ventricular Fibrillation, ICD, LBBB, QRS of 210 ms, Positive Smith Modified Sgarbossa Criteria, and Pacemaker-Mediated Tachycardia

Dr. Smith's ECG Blog

An elderly man collapsed. There was no bystander CPR. Medics found him in ventricular fibrillation. He was defibrillated, but they also noticed that he was being internally defibrillated and then found that he had an implantable ICD. He was unidentified and there were no records available After 7 shocks, he was successfully defibrillated and brought to the ED.

Pacemaker 118
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Around 25% of Mild Asthma Patients Not Given Guideline-Directed Therapy, Despite Updates

HCPLive

This analysis highlights trends following the significant update made to the Global Initiative for Asthma and the National Heart Lung and Blood Institute asthma guidelines.

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Elder Male with Syncope

EMS 12-Lead

David Didlake @DidlakeDW EMS personnel responded to the residence of an 81 y/o Male with syncope. His spouse had called 911 after she heard a loud “thud” in the adjacent room. He was found altered, hypotensive, and with a large hematoma to the left periorbital region. No 12 Lead ECG was captured, but telemetry did reveal the following: The spouse offers a pertinent medical history to include HTN and HLD, and furthermore states that he hasn’t previously complained of any chest discomfort, or shor

Ischemia 116
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Oral-gut microbial transmission promotes diabetic coronary heart disease

Cardiovascular Diabetology

Diabetes is a predominant driver of coronary artery disease worldwide. This study aims to unravel the distinct characteristics of oral and gut microbiota in diabetic coronary heart disease (DCHD). Simultaneous.

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Neurotechnology Development Must Be Slow and Steady

Med Page Today

(MedPage Today) -- Through my work as a neuroscientist who designs neural implants to monitor the injured brain after severe traumatic brain injuries, stroke, and brain cancers, it has become very clear to me that my field needs to communicate.

Cancer 140
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Review identifies disrupted mitochondrial metabolism as a trigger for diabetic cardiomyopathy

Medical Xpress - Cardiology

Diabetes is a global health burden. A whopping 536 million people worldwide struggle with diabetes. Diabetic cardiomyopathy (DC) is a serious condition characterized by impaired heart function due to diabetes-related metabolic abnormalities.

Diabetes 115
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Using stem cell-derived heart muscle cells to advance heart regenerative therapy

Science Daily - Heart Disease

Regenerative heart therapies involve transplanting cardiac muscle cells into damaged areas of the heart to recover lost function. However, the risk of arrhythmias following this procedure is reportedly high. In a recent study, researchers tested a novel approach that involves injecting 'cardiac spheroids,' cultured from human stem cells, directly into damaged ventricles.

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Audrey Chun, MD: Practical Recommendations to Give Older Patients for Exercise, Cognitive Health

HCPLive

In this interview, Chun discussed recommendations for internal medicine physicians to give older adults for slowing aging as well as evidence for statins.

Exercise 119
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Chest pain, resolved. Does it need emergent cath lab activation (some controversy here)? And much much more.

Dr. Smith's ECG Blog

A 50-something male with hypertension and 20- to 40-year smoking history presented with 1 week of stuttering chest pain that is worse with exertion, which takes many minutes to resolve after resting and never occurs at rest. It is a ssociated with mild dyspnea on exertion. At times the pain does go to his left neck. It was present on arrival at triage but then resolved before bed placement in the ED.

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New Study Reveals 65 and Older Population Lowered Blood Pressure, Cholesterol, and Weight Using Mobile Technology

DAIC

milla1cf Wed, 04/24/2024 - 19:01 April 24, 2024 — Hello Heart , a digital leader in preventive heart health, today announced results from its latest study observing the benefits of scalable, accessible digital health tools for a growing senior population. Presented at the American College of Cardiology 2024 Conference , study results showed an overwhelming majority of seniors aged 65 and over reduced their blood pressure (BP), cholesterol, and weight over a six month period while managing it

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5 Dead and Over 100 Hospitalized From Recalled Japanese Health Supplements

Med Page Today

(MedPage Today) -- TOKYO (AP) -- Five people who took a Japanese health supplement have died and more than 100 have been hospitalized as of Friday, a week after a pharmaceutical company issued a recall of the products, officials said. Osaka.

Hospital 145
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10 FDA panel members who voted on heart device connected to Abbott: Report

Becker's Hospital Review - Cardiology

The FDA convened a committee of advisers to assess a cardiac device made by Abbott, but the agency did not disclose that 10 of the 14 members had received payments from the company or conducted research it had funded, KFF Health News reported April 8.

Research 113
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Black and Hispanic people in the United States growing more confident learning and performing CPR

American Heart News - Heart News

DALLAS, April 22, 2024 — More Black and Hispanic people in the U.S. feel confident performing Cardiopulmonary Resuscitation (CPR). A 2023 American Heart Association survey found that 44% of Black Americans now feel confident in performing.

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Assessing Headaches in Hospitalized Patients, with Stephanie Nahas, MD, MSEd

HCPLive

Nahas reviews key highlights from her session at ACP, emphasizing the importance of reviewing patient history and considering what other factors may be causing headaches.

Hospital 111
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Circulating biomolecules identify patients with atrial fibrillation at high risk of cardiovascular events

Medical Xpress - Cardiology

An analysis of the biomolecule substudy of the EAST–AFNET 4 trial has revealed that biomolecule concentrations in the blood of patients with atrial fibrillation can be used to identify patients at high and low cardiovascular risk. The findings were published in Cardiovascular Research.

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CV Societies Propel Plans Forward for a New Board of Cardiovascular Medicine

DAIC

Getty Images milla1cf Mon, 04/29/2024 - 13:11 April 29, 2024 — Efforts by the American College of Cardiology , the American Heart Association , the Heart Failure Society of America , the Heart Rhythm Society and The Society for Cardiovascular Angiography & Interventions to create a new, independent Board of Cardiovascular Medicine under the American Board of Medical Specialties ( ABMS ) are closer to becoming a reality with the creation of a formal Board of Directors and the announcement by th

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CDC: COVID Vax Not Linked to Sudden Deaths in Young Adults

Med Page Today

(MedPage Today) -- The hunt for a signal of excess sudden cardiac deaths among young people after COVID-19 vaccination left Oregon health officials empty-handed, they reported. Investigators searched death certificates for Oregon residents 16.

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Ketone body levels and its associations with cardiac markers following an acute myocardial infarction: a post hoc analysis of the EMMY trial

Cardiovascular Diabetology

Sodium-glucose co-transporter 2 inhibitors (SGLT2i) have been suggested to exert cardioprotective effects in patients with heart failure, possibly by improving the metabolism of ketone bodies in the myocardium.

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Good heart health in middle age may preserve brain function among Black women as they age

American Heart News - Heart News

Research Highlights: Middle-aged Black women with better heart health were less likely to show a decline in mental function compared with middle-aged Black women with worse heart health. In this study, heart health was unrelated to cognitive decline.

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Melanie Jay, MD: Advancing Equitable Approaches to Improve Obesity Care

HCPLive

This interview segment featured a discussion on Jay’s ACP Internal Medicine Meeting presentation ‘Advancing Equitable Approaches to Improve Obesity Care.

Obesity 119
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Is OMI an ECG Diagnosis?

Dr. Smith's ECG Blog

Written by Jesse McLaren A 70 year old with prior MIs and stents to LAD and RCA presented to the emergency department with 2 weeks of increasing exertional chest pain radiating to the left arm, associated with nausea. The pain recurred at rest 90 minutes prior to presentation, felt like the patient’s prior MIs, and was not relieved by 6 sprays of nitro.

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Atlantic Health System’s Morristown Medical Center Treats First Patient in New Jersey with Edwards’ EVOQUE Tricuspid Valve Replacement

DAIC

milla1cf Thu, 04/25/2024 - 17:21 April 25, 2024 — Atlantic Health System ’s Morristown Medical Center treated the first patient in New Jersey using Edwards Lifesciences EVOQUE tricuspid valve replacement, the first transcatheter therapy to receive U.S. Food and Drug Administration ( FDA ) approval for the treatment of tricuspid regurgitation (TR).

Tricuspid 104
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More Cases of Asthma, COPD, Hypertension After Military Burn Pit Exposure

Med Page Today

(MedPage Today) -- Prolonged deployment to military bases with open burn pits was associated with increased risks for certain respiratory and cardiovascular diseases, according to a retrospective cohort study using Veterans Health Administration.