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Gene therapy for cardiac arrhythmias

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 23 May 2025; doi:10.1038/s41569-025-01168-5 In this Review, Ackerman and colleagues describe the rationale for gene therapy to treat cardiac arrhythmias; discuss advantages and disadvantages of gene silencing, replacement and editing technologies; summarize vector modalities and delivery approaches; present (..)

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Prognostic implications of stress test-induced arrhythmias: a systematic review and meta-analysis

Open Heart

Background The significance of stress-test induced arrhythmias has been examined in prior studies, but there is no clear consensus regarding its significance. Objectives To determine the significance of stress test-induced arrhythmias. Atrial arrhythmia during stress testing, on the other hand, shows no association with mortality.

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ZnO nanoparticles induce acute arrhythmia and heart failure in mice by disturbing cardiac ion channels

Frontiers in Cardiovascular Medicine

In addition, human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) were utilized for translational exploration.ResultsAcute exposure to ZnO NPs induces cardiac dysfunction and arrhythmia in mice. The downregulation of calcium transient upon ZnO NPs exposure was further confirmed in hiPSC-CMs.

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New therapeutic target for cardiac arrhythmias emerges

Science Daily - Heart Disease

Researchers identified a lipid that is involved in regulating cardiac ion channels, providing insights into possible mechanisms of cardiac arrhythmias in heart failure and a potential pathway for future therapeutic development.

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Gene-related metabolic dysfunction may be driving heart arrhythmia

Science Daily - Heart Disease

Patients with a common heart arrhythmia called Atrial Fibrillation could benefit from future treatments that target inefficiencies in heart cell metabolism, according to a new article.

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Atrial arrhythmia and heart failure in congenital heart disease: a pas de deux with consequences

Heart BMJ

In adults with congenital heart disease (ACHD patients), atrial arrhythmias (AA) and heart failure (HF) are common. Early diagnosis and ECG documentation is therefore essential for arrhythmia management. Of these, AA is one of the leading causes for hospital admissions in ACHD care.

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Redefining respiratory sinus arrhythmia as respiratory heart rate variability: an international Expert Recommendation for terminological clarity

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 06 May 2025; doi:10.1038/s41569-025-01160-z The physiological phenomenon whereby heart rate varies in phase with breathing in vertebrates has been known as respiratory sinus arrhythmia.