Hydroxyurea Therapy May Affect Fertility in Sickle Cell Disease
HCPLive
JUNE 13, 2024
Hydroxyurea treatment may impact seminal fluid levels and ovarian reserves in male and female patients with sickle cell disease.
Sickle Cell Disease Related Topics 
Safety of a potential new treatment to manage complications from sickle cell disease
Science Daily - Heart Disease
APRIL 11, 2024
A drug approved to treat pulmonary arterial hypertension may be effective at managing hypertension and end-organ damage in patients with sickle cell disease, according to a new study.
Researchers identify safety of a potential new treatment to manage complications from sickle cell disease
Medical Xpress - Cardiology
APRIL 11, 2024
A drug approved to treat pulmonary arterial hypertension may be effective at managing hypertension and end-organ damage in patients with sickle cell disease, according to a new study published in Lancet Haematology.
Elna Saah, MD: Unraveling the Current Landscape in Sickle Cell Disease
HCPLive
APRIL 18, 2024
Elna Saah, MD joins HCPLive to discuss the current landscape in sickle cell disease and recent advancements benefiting clinical care.
Presence of CKD in Sickle Cell Disease Worsens In-Hospital Outcomes
HCPLive
MARCH 25, 2024
Chronic kidney disease was linked to increased mortality, higher costs, and the need for mechanical ventilation among hospitalized patients with sickle cell disease.
CDC Opioid Guidelines Linked to Negative Consequences in Sickle Cell Disease
HCPLive
MARCH 12, 2024
The 2016 CDC guidelines led to significant decreases in opioid prescriptions and an increase in pain-related healthcare utilization for people with sickle cell disease.
Study Addresses Menstrual Pain in Sickle Cell Disease, Role of Reproductive Health Specialists
HCPLive
DECEMBER 10, 2023
Although more than half of female patients with sickle cell disease reported sickle cell pain associated with their menstrual cycles, only 12.5% had used ≥1 hormonal therapies within the past 3 months.
Substance Use Disorder of Nitrous Oxide Uncommon in Sickle Cell Disease
HCPLive
MARCH 20, 2024
Results from the PHEDRE study show nitrous oxide in a gas mixture for pain was not problematic for most patients with sickle cell disease in France.
Clinical Pain Screening Proves Feasible in Pediatric Sickle Cell Disease
HCPLive
FEBRUARY 16, 2024
Over the study period, pain screening procedures were integrated within routine clinical visits and providers’ workflow in sickle cell disease care.
Hearing Loss Prevalence High in Children, Adults with Sickle Cell Disease
HCPLive
FEBRUARY 18, 2024
Hearing loss was more prevalent among children and adults with sickle cell disease and its traits compared to matched controls with normal hemoglobin.
Sickle Cell Disease with Venous Thromboembolism Linked to Higher Mortality
HCPLive
DECEMBER 12, 2023
Presented at ASH 2023, findings of a new study showed patients with sickle cell disease and venous thromboembolism have longitudinal worsening of left ventricular diastolic and right-sided cardiac function.
Study Reveals Higher Prevalence of STIs Among Adolescents, Young Adults with Sickle Cell Disease
HCPLive
DECEMBER 11, 2023
A higher prevalence of STI diagnosis is observed in adolescents and young adults with sickle cell disease compared with controls.
Hydroxyurea Therapy Shown Not to Impact Onset of Puberty in Male Sickle Cell Disease Patients
HCPLive
DECEMBER 9, 2023
This new data on a European sickle cell disease cohort expands upon existing knowledge of the effects of HU on fertility, with the findings showing the benefits of cryopreservation.
Abstract TP147: Assessment of Inter-Rater Reliability of Fazekas Scoring on Magnetic Resonance Imaging in Patients With Sickle Cell Disease
Stroke Journal
FEBRUARY 1, 2024
Background:White matter disease is a common phenomenon in patients with sickle cell disease, that has been linked to cognitive impairment. However, there is no standardized approach for quantification of the cerebral disease burden. However, its utility in sickle cell disease has not yet been established.
Children with Sickle Cell Disease Experience Severe COVID-19 Infection
HCPLive
MARCH 13, 2024
In a registry-based analysis, more hospitalized children with SCD and COVID-19 had severe infection requiring supplemental oxygen, compared with the general population.
COVID-19 
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Mortality in U.S. Youth; Gene Therapy for Sickle Cell Disease
Med Page Today
MAY 11, 2024
(MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center.
Allogenic HSCT May Improve Sickle Cell Disease-Related Organ Dysfunction
HCPLive
MARCH 27, 2024
A new analysis summarized evidence on the effects of allogeneic HSCT on SCD-related organ dysfunction in pediatric and adult patients with SCD.
Abnormal ECG Findings Prevalent Among People with Sickle Cell Disease
HCPLive
FEBRUARY 21, 2024
A meta-analysis revealed a higher prevalence of abnormal ECG findings in individuals with SCD compared to those without the disease.
Universal Newborn Screening Pivotal for Sickle Cell Disease Outcomes
HCPLive
JUNE 20, 2024
Early detection from a universal newborn screening program in Canada significantly reduced disease-related burden in children with SCD.
Children with Sickle Cell Disease Show No Alarming Trends After Opioid Use
HCPLive
FEBRUARY 19, 2024
No concerning patterns of long-term or increasing opioid use were observed within 3 years after first opioid prescription in opioid-naive children with SCD.
Pain Scores, Opioid Receipt Predict Hospitalization in Children with Sickle Cell Disease
HCPLive
DECEMBER 12, 2023
Final emergency department pain scores, opioid doses in the emergency department, and receipt of an opioid prescription at discharge predicted hospitalization and return visits.
RUBY: Reni-Cel Displays Promising Efficacy, Safety for Sickle Cell Disease
HCPLive
JUNE 14, 2024
Phase 1/2/3 trial data show the investigational gene-editing medicine has been well-tolerated, with encouraging efficacy, for people living with SCD.
Patients with SCD Face Early Death Despite Improved Survival Rates
HCPLive
APRIL 15, 2024
A recent multi-center study identified risk factors linked to premature mortality in sickle cell disease, including male gender and hematologic and biochemical parameters.
Exa-Cel Shows Long-Term Clinical Benefit in Sickle Cell Disease, TDT
HCPLive
JUNE 17, 2024
The CRISPR-based gene therapy demonstrated durable effects on SCD and TDT, with the longest follow-up extending past 5 years.
Abstract TMP7: Disruption of Blood Brain Barrier is Associated With Silent Cerebral Infarcts in Patients With Sickle Cell Disease
Stroke Journal
FEBRUARY 1, 2024
Background:Microvascular thromboinflammation is a major pathomechanism underlying vaso-occlusive crisis in patients with sickle cell disease (SCD), yet its role underlying the elevated stroke risk in SCD is unclear. Stroke, Volume 55, Issue Suppl_1 , Page ATMP7-ATMP7, February 1, 2024.
Frequent Hospitalized VOCs Worsens Mortality Risk in Sickle Cell Disease
HCPLive
APRIL 11, 2024
In a nationwide study of an adult SCD population, the risk of mortality increased with the number of HVOCs in the year before death.
SGLT2is, GLP-1s Display Reno-Protective Benefit in Sickle Cell Disease
HCPLive
APRIL 28, 2024
Preliminary findings demonstrate an improvement in eGFR slope in nearly all patients with SCD after treatment with SGLT-2 inhibitors and GLP-1 receptor agonists.
Abstract TMP12: Large Vessel Vasculopathy is Associated With Oxygen Metabolic Stress in Children and Young Adults With Sickle Cell Disease
Stroke Journal
FEBRUARY 1, 2024
Background:Large-vessel vasculopathy (LVV), such as moyamoya syndrome, increases stroke risk with sickle cell disease (SCD). Stroke, Volume 55, Issue Suppl_1 , Page ATMP12-ATMP12, February 1, 2024.
Hematology Month in Review: March 2024
HCPLive
APRIL 3, 2024
Our March 2024 month-in-review in hematology features updates to the anemia pipeline, the latest research in sickle cell disease, and the role of SGLT2 inhibition on hematologic outcomes.
COVID-19 Vaccination Shows Favorable Risk-Benefit in Sickle Cell
HCPLive
JULY 14, 2024
A study from the ASH Research Network reports positive antibody response and tolerability after mRNA vaccination in people with sickle cell disease.
Voxelotor Benefits Red Blood Cell Functionality in Pediatric Sickle Cell Disease
HCPLive
FEBRUARY 26, 2024
An ancillary study of the phase 2 HOPE-KIDS 1 trial revealed voxelotor is associated with reduced sickling and hemolysis in children with SCD.
Voxelotor Improves Cerebral Hemodynamic Parameters in Pediatric Sickle Cell Disease
HCPLive
FEBRUARY 20, 2024
Voxelotor decreases oxygen extraction fraction and cerebral blood flow towards levels observed in healthy children.
Age, Genetics Help Predict Proliferative Sickle Cell Retinopathy
HCPLive
MAY 14, 2024
Age and sickle cell disease genotype predicted individuals with sickle cell retinopathy at risk for proliferative disease.
Mitapivat Maintains Safety, Tolerability Over 2 Years in Sickle Cell Disease
HCPLive
DECEMBER 10, 2023
Extension analysis from a phase 1 trial show the investigative oral mitapivat was not associated with any discontinuations nor deaths over 2 years.
Hematology Month in Review: April 2024
HCPLive
MAY 2, 2024
Our April month in review for hematology breaks down the latest updates to the pipeline, mortality risk in people with sickle cell disease, and our newest multimedia offerings.
Hematopoietic Stem Cell Transplantation Improves Pediatric SCD Outcomes
HCPLive
APRIL 9, 2024
A systematic review and meta-analysis of HSCT in children with sickle cell disease demonstrated pooled survival rates exceeding 90%.
Opioid Use Disorder in Sickle Cell Patients with Vaso-Occlusive Crisis Linked to Greater Cost
HCPLive
DECEMBER 12, 2023
Presented at ASH 2023, opioid use disorder in sickle cell disease patients with vaso-occlusive is associated with a longer hospital stay and greater cost.
Positive Phase 2/3 Results Suggest Potential for GBT021601 As Future Treatment for Sickle Cell
HCPLive
DECEMBER 10, 2023
These findings presented at ASH show promise for future studies on GBT02601 as a potential alternative to voxelotor for sickle cell disease.
Keli Coleman, MD: Predictors of Hospitalization, Return Visits in Children with SCD
HCPLive
DECEMBER 14, 2023
Keli Coleman, MD, discusses findings from her research about the role of pain scores and opioids in predicting hospitalization and return visits in children with sickle cell disease and uncomplicated pain crises.
Abstract WP32: A Dissection of Spinal Cord Infarction: Cases With Rare Features and Innovative Treatments
Stroke Journal
FEBRUARY 1, 2024
We review the results of 9 patients who were evaluated with digital subtraction angiography (DSA), including 2 patients receiving different multiple drug regimens of acute intra-arterial therapies. One patient was also found eligible and treated with IV-thrombolysis.
Significant Fatigue Common in Adult Patients with Sickle Cell Disease
HCPLive
JUNE 6, 2024
A lower FACIT-Fatigue score, indicating higher fatigue was independently associated with female sex, a high BMI, a high stress level, and poor sleep quality.
Abstract WP218: Risk Factors for Cerebral Aneurysms in Sickle Cell Disease
Stroke Journal
FEBRUARY 1, 2024
Introduction:Cerebral aneurysm frequency in sickle cell disease (SCD) is higher than in the general population. Stroke, Volume 55, Issue Suppl_1 , Page AWP218-AWP218, February 1, 2024. Specific risk factors explaining this difference have not been previously explored.
Lantheus Announces the FDA Approval of DEFINITY as Ultrasound Enhancing Agent for Use in Certain Pediatric Cardiovascular Patients
DAIC
MARCH 6, 2024
Patients with sickle cell disease may be at higher risk of painful crisis and DEFINITY® should be administered with caution. The risk for these reactions may be increased among patients with unstable cardiopulmonary conditions and/or with pre-existing PEG hypersensitivity [see Adverse Reactions (6.2)].
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Abstract WP222: Basilar Artery Stenosis in Children With Moyamoya
Stroke Journal
FEBRUARY 1, 2024
An associated disorder was found in 11 (46%) including ACTA2, PHACE syndrome, cranial radiation, trisomy 21, sickle cell disease, neurofibromatosis type 1 and morning glory disc.Conclusion:To our knowledge we present the first study to examine prevalence of basilar artery stenosis in a large single center cohort of children with moyamoya.
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