HeartRhythm

MAY 21, 2025

Catheter ablation of atrial fibrillation (AFCA) improves clinical outcomes in patients with heart failure with preserved ejection fraction (HFpEF).

Preserved Ejection Fraction 45

Preserved Ejection Fraction Atrial Fibrillation Heart Failure Ablation 45

Cardiovascular Diabetology

JULY 22, 2024

Heart failure with preserved ejection fraction (HFpEF) is a mortal clinical syndrome without effective therapies. Empagliflozin (EMPA) improves cardiovascular outcomes in HFpEF patients, but the underlying mec.

Preserved Ejection Fraction 105

Preserved Ejection Fraction Heart Failure Outcomes Research 105

JAMA Cardiology

NOVEMBER 16, 2024

This prespecified secondary analysis of a randomized clinical trial examines the efficacy and safety of finerenone in women and men with heart failure with mildly reduced ejection fraction and heart failure with preserved ejection fraction.

Preserved Ejection Fraction 100

Preserved Ejection Fraction Heart Failure 100

American College of Cardiology

JUNE 13, 2025

A new ACC Scientific Statement addresses the management of obesity in adults with heart failure (HF), with a specific focus on those with stage 2 HF with preserved ejection fraction (HFpEF).

Preserved Ejection Fraction 75

Preserved Ejection Fraction Obesity Heart Failure Article 75

JAMA Cardiology

MARCH 26, 2024

This prognostic study investigates if models that incorporate routinely collected clinical and laboratory information can predict morbidity and mortality in patients with heart failure and preserved ejection fraction.

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Preserved Ejection Fraction Heart Failure Laboratory 104

Medical Xpress - Cardiology

DECEMBER 20, 2023

Mild and moderate kidney dysfunction are associated with left ventricular diastolic dysfunction and heart failure with preserved ejection fraction (HFpEF), according to a study published online Nov. 27 in ESC Heart Failure.

Preserved Ejection Fraction 97

Preserved Ejection Fraction Heart Failure 97

Cardiovascular Diabetology

AUGUST 13, 2024

Heart failure with preserved ejection fraction (HFpEF) is associated with systemic inflammation, obesity, metabolic syndrome, and gut microbiome changes. Increased trimethylamine-N-oxide (TMAO) levels are pred.

Preserved Ejection Fraction 103

Preserved Ejection Fraction Heart Failure Obesity Research 103

Journal of the American Heart Association

JUNE 5, 2025

m2/kg2(LVEF/LVM/BSA) suggested a higher cardiac event risk.ConclusionsLVEF indexed to LVM provides better cardiac event risk stratification than LVEF alone in individuals with mildly reduced or preserved ejection fraction. While the high groups showed nonsignificant differences (LVEF/LVM: HR, 1.41 [95% CI, 0.68–2.95];

Preserved Ejection Fraction 45

Preserved Ejection Fraction 45

European Journal of Heart Failure

MAY 22, 2025

ABSTRACT Aims Overactivity of the sympathetic nervous system is a common underlying mechanism in development and progression of several heart failure with preserved ejection fraction (HFpEF) comorbidities.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Cardiac Function Exercise Heart Failure 40

The New England Journal of Medicine

JANUARY 8, 2025

Heart failure with preserved ejection fraction is noted for symptoms of heart failure, LVEF of at least 50%, and cardiac or structural abnormalities. Treatment includes diuretics and SGLT2 inhibitors.

Preserved Ejection Fraction 75

Preserved Ejection Fraction Heart Failure 75

JAMA Cardiology

DECEMBER 17, 2024

This study assesses the impact of chronic inorganic nitrate administration on exercise tolerance in a larger trial of participants with heart failure with preserved ejection fraction.

Preserved Ejection Fraction 79

Preserved Ejection Fraction Heart Failure Exercise 79

Journal of Cardiovascular Electrophysiology

MARCH 10, 2025

It highlights the confluence of two major cardiovascular epidemics, atrial fibrillation and heart failure, with preserved ejection fraction. ABSTRACT This state-of-the-art review is based on the Philippe Coumel Lecture in 2024 (Figure 1).

Preserved Ejection Fraction 40

Preserved Ejection Fraction Atrial Fibrillation Heart Failure Pharmacology 40

Cardiovascular Diabetology

FEBRUARY 6, 2025

The rising prevalence of obesity and its association with heart failure with preserved ejection fraction (HFpEF) highlight an urgent need for a diagnostic approach tailored to this population. Diagnosing HFpEF.

Preserved Ejection Fraction 83

Preserved Ejection Fraction Heart Failure Obesity 83

DAIC

MAY 6, 2024

Results of Tenax Therapeutics’ Phase 2 HELP study of levosimendan in patients with pulmonary hypertension (PH) with heart failure with preserved ejection fraction (HFpEF) demonstrated that I.V. Getty Images milla1cf Mon, 05/06/2024 - 10:48 May 6, 2024 — Tenax Therapeutics, Inc. ,

Preserved Ejection Fraction 105

Preserved Ejection Fraction Heart Failure Pulmonary Hypertension 105

Heart BMJ

MARCH 26, 2025

Background Heart failure with preserved ejection fraction is a recognised outcome in patients with myocardial infarction, although heart failure with reduced ejection fraction is more common. fold higher risk of heart failure with preserved ejection fraction (95% CI 1.30 m/s had a 2.10-fold

Aortic valve 52

Aortic valve Myocardial Infarction Preserved Ejection Fraction Heart Failure 52

Cardiovascular Ultrasound

MARCH 3, 2024

Heart failure with preserved ejection fraction (HFpEF) represents a significant proportion of heart failure cases. Accurate diagnosis is challenging due to the heterogeneous nature of the disease and limitatio.

Preserved Ejection Fraction 95

Preserved Ejection Fraction Heart Failure 95

The New England Journal of Medicine

JANUARY 29, 2025

Treatment options for heart failure with preserved ejection fraction have historically been limited. In a 2016 review of this condition in the Journal, treatment recommendations focused on diuretics, exercise training, and management of coexisting conditions.1

Preserved Ejection Fraction 62

Preserved Ejection Fraction Heart Failure Exercise 62

American College of Cardiology

NOVEMBER 7, 2024

The goal of the EMPEROR-Preserved trial was to assess the safety and efficacy of empagliflozin in patients with symptomatic heart failure with preserved ejection fraction (HFpEF), irrespective of diabetes status.

Preserved Ejection Fraction 61

Preserved Ejection Fraction Heart Failure Diabetes Outcomes 61

Circulation: Heart Failure

MAY 19, 2025

Circulation: Heart Failure, Ahead of Print.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Circulation 40

Frontiers in Cardiovascular Medicine

DECEMBER 16, 2024

To assess left atrial function and evaluate the relationship between LASI and exercise capacity in hypertension-related heart failure with preserved ejection fraction (HT-HFpEF).MethodsThe ObjectiveThe left atrial stiffness index (LASI) holds significance in the atrioventricular coupling function and heart failure progression.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Exercise Heart Failure Hypertension 40

American College of Cardiology

APRIL 6, 2024

The goal of the STEP-HFpEF DM trial was to compare the safety and efficacy of semaglutide among patients with obesity-related heart failure with preserved ejection fraction (HFpEF) and type 2 diabetes mellitus (DM).

Preserved Ejection Fraction 69

Preserved Ejection Fraction Heart Failure Obesity Diabetes 69

Journal of Clinical Investigation - Cardiology

DECEMBER 15, 2023

Heart failure with preserved ejection fraction (HFpEF) is a widespread syndrome with limited therapeutic options and poorly understood immune pathophysiology.

Preserved Ejection Fraction 75

Preserved Ejection Fraction Heart Failure Obesity Ablation 75

American College of Cardiology

JULY 29, 2024

The goal of the CAMEO-DAPA trial was to assess whether dapagliflozin, a sodium-glucose cotransporter-2 inhibitor (SGLT2i), affects rest and exercise pulmonary capillary wedge pressure (PCWP) in patients with heart failure with preserved ejection fraction (HFpEF).

Preserved Ejection Fraction 58

Preserved Ejection Fraction Heart Failure Exercise Pulmonary 58

Science Daily - Heart Disease

AUGUST 1, 2024

A new small study has revealed the impact of obesity on muscle structure in patients having a form of heart failure called heart failure with a preserved ejection fraction (HFpEF).

Heart Failure 124

Heart Failure Preserved Ejection Fraction Obesity 124

Medical Xpress - Cardiology

JULY 29, 2024

A novel study co-authored by a heart failure cardiologist at University Hospitals Harrington Heart & Vascular Institute demonstrates the effectiveness of a newly developed scoring system in identifying patients with Heart Failure with Preserved Ejection Fraction (HFpEF).

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Preserved Ejection Fraction Heart Failure Research Hospital 111

Science Daily - Heart Disease

JULY 24, 2024

In mice with heart failure with preserved ejection fraction (HFpEF), increasing ketone supply to the heart allowed their hearts to utilize more ketones and produce more energy.

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Preserved Ejection Fraction Diabetes Heart Failure 120

Frontiers in Cardiovascular Medicine

NOVEMBER 17, 2024

However, its role in right ventricular (RV) function has not been evaluated.MethodsWe retrospectively analyzed the electronic medical data of 1,014 Heart Failure with Preserved Ejection Fraction (HFpEF) patients to evaluate the relationship between anemia and RV dysfunction in patients with HFpEF and whether this relationship is influenced by classical (..)

Preserved Ejection Fraction 59

Preserved Ejection Fraction Heart Failure Tricuspid Risk Factors 59

American College of Cardiology

JULY 8, 2024

The goal of the PARAGON-HF trial was to evaluate the neprilysin-angiotension receptor inhibitor sacubitril/valsartan among patients with heart failure with preserved ejection fraction (HFpEF).

Preserved Ejection Fraction 52

Preserved Ejection Fraction Heart Failure Outcomes Article 52

Circulation: Heart Failure

MAY 12, 2025

BACKGROUND:Exercise intolerance is a hallmark of heart failure with preserved ejection fraction (HFpEF) and is characterized by skeletal muscle (SkM) dysfunction with impaired oxidative capacity. Circulation: Heart Failure, Ahead of Print.

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Preserved Ejection Fraction Heart Failure Exercise Blood Pressure 66

American Heart News - Heart News

JULY 24, 2024

Research Highlights: In mice with heart failure with preserved ejection fraction (HFpEF), increasing ketone supply to the heart allowed their hearts to utilize more ketones and produce more energy. Researchers hope this study may help to improve our.

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Preserved Ejection Fraction Heart Failure Research 122

Cardiovascular Diabetology

NOVEMBER 4, 2024

Aging is influenced by genetic determinants and comorbidities, among which diabetes increases the risk for heart failure with preserved ejection fraction. There is no therapy to prevent heart dysfunction in ag.

Preserved Ejection Fraction 52

Preserved Ejection Fraction Cardiac Function Heart Dysfunction Heart Failure 52

Science Daily - Heart Disease

JULY 29, 2024

A novel study co-authored by a heart failure cardiologist demonstrates the effectiveness of a newly developed scoring system in identifying patients with Heart Failure with Preserved Ejection Fraction (HFpEF).

Preserved Ejection Fraction 115

Preserved Ejection Fraction Heart Failure 115

Cardiovascular Diabetology

APRIL 24, 2025

Empagliflozin is an effective treatment for heart failure with preserved ejection fraction (HFpEF), but its definite mechanism of action is unclear. Systemic microvascular dysfunction strongly relates to HFpEF.

Preserved Ejection Fraction 52

Preserved Ejection Fraction Heart Failure Research 52

Cardiovascular Diabetology

MARCH 21, 2025

Heart failure (HF) with preserved ejection fraction (HFpEF) is increasingly prevalent worldwide due to aging and comorbidities. Epicardial adipose tissue (EAT), favored by diabetes and obesity, was shown to co.

Preserved Ejection Fraction 52

Preserved Ejection Fraction Heart Failure Obesity Diabetes 52

American College of Cardiology

MARCH 31, 2025

25 in Chicago and simultaneously published in JACC.

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Preserved Ejection Fraction Kidney Disease Heart Failure Obesity 61

Cardiovascular Diabetology

AUGUST 30, 2024

Heart failure with preserved ejection fraction (HFpEF) is common in type 2 diabetes mellitus (T2D), leading to high morbidity and mortality. Managing HFpEF in diabetic patients is challenging with limited trea.

Preserved Ejection Fraction 59

Preserved Ejection Fraction Heart Failure Diabetes Research 59

JAMA Cardiology

JULY 23, 2024

This randomized clinical trial investigates the effect of dapagliflozin on right ventricular performance and vascular load during exertion in heart failure with preserved ejection fraction (HFpEF).

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Preserved Ejection Fraction Pulmonary Heart Failure 108