European Journal of Heart Failure

APRIL 17, 2024

HFpEF, heart failure with preserved ejection fraction; MR, mitral valve regurgitation. Abstract Mitral regurgitation (MR) is highly prevalent among patients with heart failure and preserved ejection fraction (HFpEF).

Preserved Ejection Fraction 40

Preserved Ejection Fraction Bicuspid/Mitral Heart Failure Pulmonary 40

Journal of Clinical Investigation - Cardiology

DECEMBER 15, 2023

Heart failure with preserved ejection fraction (HFpEF) is a widespread syndrome with limited therapeutic options and poorly understood immune pathophysiology.

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Preserved Ejection Fraction Heart Failure Obesity Ablation 75

HeartRhythm

APRIL 30, 2024

However, it is unknown whether these patterns hold for persistent AF among patients with heart failure with preserved ejection fraction (HFpEF). The majority of these studies evaluated paroxysmal AF cases.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Atrial Fibrillation Heart Failure Ablation 40

HeartRhythm

APRIL 14, 2024

The benefit of catheter ablation in patients with atrial fibrillation (AF) for patients with heart failure with preserved ejection fraction (HFpEF) remains uncertain.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Atrial Fibrillation Heart Failure Ablation 40

European Journal of Heart Failure

FEBRUARY 18, 2024

Global longitudinal strain (GLS) and clinical outcomes in heart failure with preserved ejection fraction (HFpEF). Almost 47% of patients with HFpEF had evidence of left ventricular (LV) subclinical dysfunction, defined as absolute LV GLS 0.1).

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Preserved Ejection Fraction Heart Failure Hospital Outcomes 40

Frontiers in Cardiovascular Medicine

MARCH 3, 2024

Introduction Heart failure with preserved ejection fraction (HFpEF) is a complex disease process influenced by metabolic disorders, systemic inflammation, myocardial fibrosis, and microvascular dysfunction.

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Preserved Ejection Fraction Biomarkers Heart Failure 64

HeartRhythm

APRIL 30, 2024

Patients with heart failure with preserved ejection fraction (HFpEF) have many comorbidities including SND, but the optimal treatment approach for HFpEF with SND is uncertain. Guidelines recommend permanent pacemaker (PPM) implantation in patients with sinus node dysfunction (SND) to improve quality of life.

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Preserved Ejection Fraction Heart Failure Quality of Life Medicare 40

HeartRhythm

APRIL 30, 2024

The data on comparison of parameters of diastolic dysfunction (DD) on transthoracic echocardiogram (TTE) according to the progressive stages of AF in patients with coexisting heart failure with preserved ejection fraction (HFpEF) are limited.

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Preserved Ejection Fraction Heart Failure Echocardiogram Atrial Fibrillation 40

Heart BMJ

FEBRUARY 12, 2024

Objective Heart failure with preserved ejection fraction (HFpEF) is a common heterogeneous syndrome that remains imprecisely defined and consequently has limited treatment options and poor outcomes. The study will develop a large, highly characterised cohort of patients with HFpEF.

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Preserved Ejection Fraction Heart Failure Outcomes 40

HeartRhythm

APRIL 30, 2024

Left atrial and pulmonary artery pressure (PAP) elevation can reflect severity and dynamic status of heart failure (HF) in HF with preserved ejection fraction (pEF). Atrial fibrillation (AF) worsens HFpEF progression and pump failure, but catheter ablation can restore rhythm control in this population.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Atrial Fibrillation Heart Failure Ablation 40

JAMA Cardiology

JUNE 30, 2023

This post hoc analysis of a randomized clinical trial evaluates the safety and efficacy of empagliflozin in patients with heart failure and preserved ejection fraction who are taking diuretics.

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Preserved Ejection Fraction Heart Failure 40

European Journal of Heart Failure

DECEMBER 7, 2023

ABSTRACT Background Left atrial (LA) myopathy is increasingly recognized as an important phenotypic trait in heart failure (HF) with preserved ejection fraction (HFpEF).

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Preserved Ejection Fraction Heart Failure Exercise Tricuspid 40

Frontiers in Cardiovascular Medicine

JANUARY 28, 2024

Heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) have emerged as major age-related epidemics within cardiology.

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Preserved Ejection Fraction Heart Failure Atrial Fibrillation Electrophysiology 59

Circulation: Heart Failure

OCTOBER 23, 2023

BACKGROUND:Heart failure with preserved ejection fraction is associated with significant functional limitations, yet treatments for improving exercise performance have been elusive. Circulation: Heart Failure, Volume 16, Issue 11 , Page e010633, November 1, 2023.

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Preserved Ejection Fraction Heart Failure Biomarkers Exercise 40

Journal of the American Heart Association

FEBRUARY 14, 2024

Pathological increases in renal sympathetic nerve activity contribute to the pathogenesis of heart failure with preserved ejection fraction (HFpEF).We BackgroundThe renal sympathetic nervous system modulates systemic blood pressure, cardiac performance, and renal function.

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Preserved Ejection Fraction Heart Failure Blood Pressure Obesity 40

European Journal of Heart Failure

DECEMBER 28, 2023

Abstract Aims Preventive strategies for heart failure (HF) with preserved ejection fraction (HFpEF) include pharmacotherapies and lifestyle modifications. Thus, we evaluated the association between CRF and HFpEF incidence.

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Preserved Ejection Fraction Heart Failure Myocardial Infarction Article 40

European Journal of Heart Failure

OCTOBER 30, 2023

In patients with heart failure with preserved ejection fraction (HFpEF), abnormal global longitudinal strain (GLS) is a strong predictor for clinical events and can help identity patients who are at risk for future decline in left ventricular ejection fraction (LVEF).

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Preserved Ejection Fraction Heart Failure Outcomes Hospital 40

Circulation: Heart Failure

OCTOBER 23, 2023

Heart failure with preserved ejection fraction (HFpEF) has become the leading form of heart failure worldwide, particularly among elderly patient populations. Circulation: Heart Failure, Volume 16, Issue 11 , Page e010802, November 1, 2023.

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Preserved Ejection Fraction Heart Failure Quality of Life Circulation 40

Heart BMJ

FEBRUARY 23, 2024

Objective The heterogeneous pathophysiology of the diverse heart failure with preserved ejection fraction (HFpEF) phenotypes needs to be examined. We aim to assess differences in the biomarkers among the phenotypes of HFpEF and investigate its multifactorial pathophysiology.

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Preserved Ejection Fraction Heart Failure Biomarkers Hypertension 40

JAMA Cardiology

APRIL 23, 2024

This systematic review and meta-analysis investigates the efficacy of catheter ablation compared with rate or rhythm control among patients with atrial fibrillation and heart failure.

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Preserved Ejection Fraction Atrial Fibrillation Heart Failure Ablation 69

JAMA Cardiology

MAY 31, 2023

This prespecified analysis of the DELIVER trial evaluates the effect of dapagliflozin on total (ie, first and recurrent) heart failure (HF) events and cardiovascular death among patients with HF with mildly reduced or preserved ejection fraction.

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Preserved Ejection Fraction Heart Failure 40

Journal of the American Heart Association

DECEMBER 29, 2023

BackgroundHeart failure with preserved ejection fraction ≥50% is prevalent with few evidence‐based therapies. Journal of the American Heart Association, Ahead of Print. These changes were paralleled by improvements in heart failure‐related quality of life (myPACE Minnesota Living with Heart Failure Questionnaire improved by 16.1

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Preserved Ejection Fraction Heart Failure Quality of Life Echocardiogram 40

European Journal of Heart Failure

DECEMBER 7, 2023

Increasing severity of obesity is associated with multiple characteristics that may contribute to the development or worsening of heart failure (HF) with preserved ejection fraction (HFpEF).

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Preserved Ejection Fraction Obesity Heart Failure BMI 40

European Journal of Heart Failure

DECEMBER 13, 2023

BMI, body mass index; CI, confidence interval; LVEF, left ventricular ejection fraction; NT-proBNP, N-terminal pro-B-type natriuretic peptide. ABSTRACT Aim Chronic obstructive pulmonary disease (COPD) is common in heart failure with a mildly reduced or preserved ejection fraction (HFmrEF/HFpEF) and is associated with worse outcomes.

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Preserved Ejection Fraction Heart Failure Pulmonary Quality of Life 75

European Journal of Heart Failure

DECEMBER 28, 2023

Abstract Background and aim Heart Failure with preserved Ejection Fraction (HFpEF) remains under-diagnosed in clinical practice despite accounting for nearly half of all Heart Hailure (HF) cases. Accurate and timely diagnosis of HFpEF is crucial for proper patient management and treatment.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Echocardiogram Article 40

Journal of the American Heart Association

DECEMBER 29, 2023

BackgroundPulmonary hypertension (PH) is highly prevalent in patients with heart failure with preserved ejection fraction (HFpEF), and it is a strong predictor of adverse outcomes. Journal of the American Heart Association, Ahead of Print.

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Preserved Ejection Fraction Pulmonary Heart Failure Hypertension 40

Hypertension Journal

FEBRUARY 22, 2024

Background:We tested the hypothesis that patients with heart failure with preserved ejection fraction (HFpEF) would have greater muscle sympathetic nerve activity (MSNA) at rest and sympathetic reactivity during a cold pressor test compared with non–heart failure controls. Hypertension, Ahead of Print.

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Preserved Ejection Fraction Heart Failure Blood Pressure Physiology 40

Circulation

OCTOBER 13, 2023

BACKGROUND:Apparent treatment-resistant hypertension (aTRH) is prevalent and associated with adverse outcomes in heart failure with mildly reduced or preserved ejection fraction. Less is known about the potential role of sodium-glucose co-transporter 2 inhibition in this high-risk population.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Hypertension Myocardial Infarction 40

Circulation: Heart Failure

FEBRUARY 1, 2024

Background:NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels are variably elevated in heart failure with preserved ejection fraction (HFpEF), even in the presence of increased left ventricular filling pressures. Circulation: Heart Failure, Ahead of Print.

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Preserved Ejection Fraction Heart Failure Atrial Fibrillation Cardiac Function 40

European Journal of Heart Failure

MARCH 4, 2024

Patients with heart failure and mildly reduced or preserved ejection fraction (HFmrEF/HFpEF) have a high risk of developing LRTI. CI, confidence interval; HR, hazard ratio. Aims Lower respiratory tract infections (LRTI) are common worldwide.

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Preserved Ejection Fraction Heart Failure COVID-19 Kidney Disease 40

European Journal of Heart Failure

OCTOBER 9, 2023

Impact of COVID-19 in patients with HF and mildly reduced and preserved ejection fraction. Methods and results Participants with chronic heart failure with mildly reduced or preserved ejection fraction (HFmrEF/HFpEF) were randomized to dapagliflozin or placebo across 350 sites in 20 countries.

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Preserved Ejection Fraction COVID-19 Heart Failure Hospital 40

European Journal of Heart Failure

OCTOBER 5, 2023

Abstract Aims Patients with heart failure (HF) and mildly reduced ejection fraction (HFmrEF) and preserved ejection fraction (HFpEF) are often treated with calcium channel blockers (CCBs), although the safety of CCBs in these patients is uncertain.

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Preserved Ejection Fraction Heart Failure Outcomes Hospital 40

Journal of Cardiovascular Electrophysiology

FEBRUARY 13, 2024

Contemporary classification of HF categorizes it into HF with reduced ejection fraction (HFrEF), HF with mildly reduced ejection fraction (HFmrEF), and HF with preserved ejection fraction (HFpEF). Abstract Introduction Heart failure (HF) and atrial fibrillation (AF) frequently co-exist.

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Preserved Ejection Fraction Atrial Fibrillation Heart Failure Hospital 40

Med Page Today

APRIL 7, 2024

(MedPage Today) -- ATLANTA -- Weight loss and heart failure benefits with semaglutide (Wegovy) extended to patients with obesity-related heart failure with preserved ejection fraction (HFpEF) who have type 2 diabetes, the STEP-HFpEF DM trial showed.

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Preserved Ejection Fraction Diabetes Heart Failure Obesity 96

Open Heart

NOVEMBER 4, 2022

The study population included a random sample of individuals with HF diagnostic codes (HF with reduced ejection fraction (HFrEF), HF with preserved ejection fraction (HFpEF) and non-specific HF) selected from all participants registered in the THIN database between 1 January 2015 and 30 September 2017.

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Preserved Ejection Fraction Heart Failure Echocardiogram 52

American College of Cardiology

APRIL 23, 2024

Is statin use associated with a lower risk of mortality and major adverse cardiovascular events (MACE) in patients who have heart failure with preserved ejection fraction (HFpEF)?

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Preserved Ejection Fraction Heart Failure Article 70

HeartRhythm

APRIL 30, 2024

ECG-based HF screening has been limited to determination of whether the left ventricular ejection fraction (LVEF) is greater than or less than a threshold value such as 40%. Early heart failure (HF) diagnosis would likely improve clinical outcomes, however over 60% of patients are first diagnosed with HF in the emergency department.

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Preserved Ejection Fraction Heart Failure Outcomes 40