Tue.May 07, 2024

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SGLT2i for Mitral Regurgitation; Mining Angiograms With AI; Melatonin and CVD Risk?

Med Page Today

(MedPage Today) -- The Apple Watch atrial fibrillation feature got added to FDA's list of qualified devices for use in clinical studies. (Mashable) The SGLT2 inhibitor ertugliflozin (Steglatro) showed promise for the reduction of functional mitral.

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Documentary Led by HonorHealth Research Institute Focuses on Injuries to Doctors and Nurses Working in Cardiology

DAIC

milla1cf Tue, 05/07/2024 - 12:54 May 7, 2024 — HonorHealth Research Institute ’s David G. Rizik , M.D., narrates and is a co-producer of a documentary focused on radiation and orthopedic injuries suffered by doctors and nurses who work in cardiac catheterization laboratories where they apply the very latest non-surgical technologies to treat the world’s leading cause of death, heart disease.

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Role of Tyrosine Kinase Inhibitors and Gene Therapy in Retinal Diseases

HCPLive

Experts discuss challenges in integrating gene therapy and port delivery systems early in treating common retinal diseases while emphasizing historical challenges and safety considerations.

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New Study Reveals Age-related Brain Changes Influence Recovery After Stroke

DAIC

An example of white matter hyperintensities (WMHs) on a FLAIR MRI scan in an older adult. FLAIR MRI is a technique that is particularly good at detecting fluid in the brain. It helps researchers see areas of the brain that might be damaged by making the cerebrospinal fluid appear dark while the surrounding tissue remains light and detailed. This contrast makes it easier to identify abnormalities or injuries; WMHs appear as bright, patchy regions in the brain tissue.

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Sedentary lifestyle puts strain on young hearts

Science Daily - Heart Disease

According to a recent study, high levels of sedentary behavior and physical inactivity from childhood strain the heart in adolescence. High cardiac workload predicts heart failure and other heart diseases. In light of the findings, increasing moderate and vigorous physical activity from childhood onwards is particularly important in preventing heart diseases.

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RapidAI Secures FDA Clearance for Perfusion Imaging in the Angiography Suite

DAIC

milla1cf Tue, 05/07/2024 - 12:59 May 7, 2024 — RapidAI , the global leader in developing clinically deep Artificial Intelligence ( AI ) and technology workflow solutions to combat life-threatening neurovascular, cardiac, and vascular diseases, today announced that the Food and Drug Administration ( FDA ) has granted 510(k) clearance for its AngioFlow by RapidAI solution.

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Small pump for kids awaiting heart transplant shows promise

Science Daily - Heart Disease

A new type of surgically implanted pump that can support a child's failing heart has passed the first stage of human testing in a recent trial.

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Biomarker found to help identify cells that can repair damaged blood vessels

Science Daily - Heart Disease

Researchers have discovered a protein marker to help identify cells able to repopulate in patients with damaged blood vessels. Their findings could lead to new therapies for people with endothelial dysfunction, a type of disorder that contributes to coronary artery disease that may occlude with plaque and lack ability to carry sufficient blood into the heart tissue causing a heart attack.

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Study Calls for Reevaluation of Proteinuria Treatment Target in IgA Nephropathy

HCPLive

Proteinuria < 1 g/d is the current treatment target, but findings suggest patients with uACR between 0.3 and 1.0 g/g face a substantial risk of adverse kidney outcomes.

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Continuous heart monitoring to evaluate treatment effects in pulmonary hypertension

Open Heart

Background The treatment of pulmonary hypertension (PH) has improved rapidly in recent decades. There is increasing evidence to support the role of early intervention and treatment in affecting clinical outcomes in PH. Objectives To assess treatment effects before and after the escalation of specific PH treatments using continuous heart monitoring with a Reveal LINQ loop recorder.

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Community-Based Asthma Challenges and Solutions, with Stephanie Lovinsky-Desir, MD, MS

HCPLive

Lovinsky-Desir joins Lungcast on World Asthma Day to discuss community-specific burdens of disease, and emerging strategies to manage it.

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Transesophageal echocardiogram

All About Cardiovascular System and Disorders

Echocardiogram is an image of the heart using ultrasound. An ultrasound beam is transmitted into the body using a device known as transducer. The echo received from the body is processed by the computer in the machine to give an image of the heart. Transesophageal echocardiogram or TEE test, is obtained by introducing a special type of transducer, also called a TEE probe, through the throat into the food pipe (esophagus) and stomach.

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John Browning, MD: Potential Impact of FDA Acceptance of Tapinarof on Eczema Management

HCPLive

During this interview segment, Browning highlighted the impact of a future FDA acceptance of tapinarof for atopic dermatitis as well as the next milestones in regulatory approval.

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Influence of Chest Compression Duration on Pediatric In-Hospital Cardiac Arrest Survival

Cardiology Update

The impact of chest compression (CC) pause duration on survival outcomes in pediatric in-hospital cardiac arrests remains unclear, despite the American Heart Association’s recommendation to limit pauses to less than 10 seconds for children without solid evidence. A recent study published in Circulation explored whether longer maximum CC pause durations correlate with poorer survival and neurological outcomes.

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Daniela Ferrara, MD, PhD: Machine Learning Predicts Functional Outcomes in DME

HCPLive

Daniela Ferrara, MD, PhD described the key takeaways from the machine learning model's performance in predicting outcomes for various treatment durations of faricimab in DME.

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NCDR Research at SCAI 2024: Long-Term LVEF Trajectories and PCI Outcomes; Blood Draws and Post-PCI Bleeding; More

American College of Cardiology

Several abstracts featuring data from NCDR’s family of registries – including the CathPCI Registry, the SVS VQI Registry (formerly known as the PVI Registry) and STS/ACC TVT Registry – were presented at SCAI 2024, held May 2-4 in Long Beach, CA.

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Minimal Residual Lesions, Previous Biologic Failure Linked to Poor Patient-Reported Psoriasis Outcomes

HCPLive

These data highlight the elements known to impact patient-reported outcomes among those with psoriasis and successful clinician-reported outcomes following biologic use.

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ACP Guideline on Pharmacologic Treatments for Diabetes: Key Points

American College of Cardiology

The following are key points to remember about a clinical guideline from the American College of Physicians (ACP) on newer pharmacologic treatments in adults with type 2 diabetes.

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The Future of DSM-5-TR with Nitin Gogtay, MD, Maria Oquendo, MD, PhD, and Jonathan Alpert, MD, PhD

HCPLive

At APA 2024, HCPLive interviewed APA members about how DSM-5-TR classifies psychiatric disorders differently than previous iterations.

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Efficacy of Catheter Ablation for Ventricular Tachycardia in Ischemic Cardiomyopathy Patients without an ICD Implantation

HeartRhythm

Implantable cardioverter defibrillator (ICD) prevents sudden cardiac death (SCD) in patients with ischemic cardiomyopathy (ICM). Catheter ablation has been shown to effectively reduce ventricular tachycardia (VT) recurrence, yet its efficacy in patients without an ICD implantation remains uncertain.

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Concomitant PsA, Atopic Dermatitis Could Help Predict Treatment Response

HCPLive

Those with coexisting PsA and atopic dermatitis needed to switch to a higher number of biologics to achieve disease control.

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Statin Intolerance, Inclisarin, and the VICTORION-INITIATE Trial

American College of Cardiology

In this interview, Michael J. Koren, MD, FACC, and C. Noel Bairey Merz, MD, FACC discuss results from the VICTORION-INITIATE randomized trial.

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Baseline Features in nAMD Not Predictive of Aflibercept 8 mg Intervals

HCPLive

Disease characteristics in wet AMD at baseline were not linked to aflibercept 8 mg dosing interval extensions in the phase 3 PULSAR trial at 96 weeks.

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Pulsed Field Ablation For Atrial Fibrillation: The New Kid on the Block (ADVENT Study)

American College of Cardiology

Catheter ablation is one of the most effective rhythm-control strategies for atrial fibrillation (AF). Conventional catheter ablation is performed using thermo-energy sources via either radiofrequency that burns cardiac tissue through heat or cryoablation that freezes tissue under ultralow temperature.

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FDA Approves ColoSense, a Noninvasive mt-sRNA Test, for Adults 45 or Older

HCPLive

Geneoscopy's ColoSense received FDA approval on May 06, 2024 based on data from the phase 3 CRC-PREVENT trial.

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Complete vs Culprit-Only Revascularization in Older Patients With MI and High Bleeding Risk

JAMA Cardiology

This randomized clinical trial investigates if patients with high bleeding risk and a history of myocardial infarction (MI) would benefit from complete vs culprit-only revascularization.

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Full MARCH-PFIC Data Offers Further Insight into Maralixibat in PFIC

HCPLive

Maralixibat oral solution improved pruritus and native liver survival in PFIC patients in the MARCH-PFIC trial.

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Hydroxychloroquine and Chloroquine-Induced Cardiac Arrhythmias and Sudden Cardiac Death in Patients with Systemic Autoimmune Rheumatic Diseases: A Systematic Review and Meta-Analysis

Journal of Cardiovascular Pharmacology

Hydroxychloroquine (HCQ) and chloroquine (CQ) are foundational treatments for several systemic autoimmune rheumatic diseases, including systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Concerns regarding the risk of cardiac arrhythmia and death have been raised, yet the burden of HCQ and CQ-related cardiac toxicities remains unclear.

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Perspectives on the Future of Retinal Disease Management

HCPLive

Experts conclude this series highlighting what is on the horizon of retinal disease care.

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Are sodium-glucose cotransporter-2 inhibitors fantastic for coronary plaque stabilization?

The American Journal of Cardiology

Publication date: Available online 7 May 2024 Source: The American Journal of Cardiology Author(s): Yoshiyasu Minami, Toshiyuki Iwaya

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Women and Black Patients Less Likely to Receive Catheter-based Treatment for Pulmonary Embolism According to REAL-PE Analysis Presented at SCAI 2024

DAIC

Women and black patients were less frequently treated with minimally invasive therapy compared to men or non-Black patients, according to new data from the REAL-PE analysis which investigated catheter-based pulmonary embolism (PE) treatment. Late-breaking results from the study, for which Sahil A. Parikh, MD, Associate Professor of Medicine, Columbia University Irving Medical Center was lead author, were shared during the recently-held Society for Cardiovascular Angiography & Interventions (SCA

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A young man with palpitations.

Dr. Smith's ECG Blog

A 30-something presented with chest pain, palpitations, and SOB. He has had similar symptoms for 4 years, but has never been evaluated. Here is his presenting ECG, which was sent to me real time, along with the 2nd ECG below: Regular Narrow Fast without P-waves. PSVT. It is very difficult to tell if this is: 1) AVNRT or 2) orthodromic AVRT (Orthodromic AVRT = WPW with orthograde conduction down the AV node and retrograde up an accessory pathway) See Ken Grauer's discussion below in differentiati