Sat.Apr 27, 2024 - Fri.May 03, 2024

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Alzheimer's Biomarkers Linked With Plasma Leptin Levels

Med Page Today

(MedPage Today) -- Plasma leptin levels were linked with Alzheimer's disease PET pathology in cognitively unimpaired older adults, a longitudinal cohort study in Korea showed. Over 2 years, lower baseline plasma leptin was associated with a greater.

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Insulin sensitivity estimates and their longitudinal association with coronary artery disease in type 1 diabetes. Does it matter?

Cardiovascular Diabetology

Insulin resistance and chronic kidney disease are both associated with increased coronary artery disease risk. Many formulae estimating glucose disposal rate in type 1 diabetes infer insulin sensitivity from c.

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Brief anger may impair blood vessel function

American Heart News - Heart News

Research Highlights: When adults became angry after remembering past experiences, the function of cells lining the blood vessels was negatively impaired, which may restrict blood flow. Previous research has found that this may increase the risk of.

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Recognizing Stigma's Impact on Care for Alcohol-Related Liver Disease

HCPLive

In the first segment of this HCPLive special report, experts discuss the stigma surrounding alcohol use disorder and alcohol-associated liver disease.

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CDC: Premature Mortality for Top Causes of Death Higher in Rural Areas

Med Page Today

(MedPage Today) -- Americans living in rural areas had higher rates of preventable premature mortality from the five leading causes of death than those living in urban areas during the years 2010-2022, and the divide only appears to be growing.

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Researchers identify over 2,000 genetic signals linked to blood pressure in study of over one million people

Science Daily - Heart Disease

Researchers have discovered over a hundred new regions of the human genome, also known as genomic loci, that appear to influence a person's blood pressure. In total, over 2,000 independent genetic signals for blood pressure are now reported, demonstrating that blood pressure is a highly complex trait influenced by thousands of different genetic variants.

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Dietary carbohydrates regulate intestinal colonization and dissemination of Klebsiella pneumoniae

Journal of Clinical Investigation - Cardiology

Bacterial translocation from the gut microbiota is a source of sepsis in susceptible patients. Previous work suggests that overgrowth of gut pathobionts, including Klebsiella pneumoniae, increases the risk of disseminated infection. Our data from a human dietary intervention study found that, in the absence of fiber, K. pneumoniae bloomed during microbiota recovery from antibiotic treatment.

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'Evil Personified': Nurse Gets Life Sentence for Murdering Patients With Insulin

Med Page Today

(MedPage Today) -- A Pennsylvania nurse who purposely administered lethal doses of insulin to more than 20 patients at skilled nursing facilities received a life sentence after pleading guilty to three counts of murder and other charges, the state.

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Dietary changes may treat pulmonary hypertension

Science Daily - Heart Disease

Blood vessels in the lungs aren't like the others in the body. This difference becomes clear in pulmonary hypertension, in which only the lungs' blood vessels stiffen progressively, leading to chronic lung disease, heart failure and death. The underlying reasons for this organ-specific vessel stiffening remained a mystery until researchers made a surprising discovery about these blood vessel cells in patients with pulmonary hypertension -- they're hungry.

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CV Societies Propel Plans Forward for a New Board of Cardiovascular Medicine

DAIC

Getty Images milla1cf Mon, 04/29/2024 - 13:11 April 29, 2024 — Efforts by the American College of Cardiology , the American Heart Association , the Heart Failure Society of America , the Heart Rhythm Society and The Society for Cardiovascular Angiography & Interventions to create a new, independent Board of Cardiovascular Medicine under the American Board of Medical Specialties ( ABMS ) are closer to becoming a reality with the creation of a formal Board of Directors and the announcement by th

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Mobile Health App Improves Treatment Compliance, Health Knowledge in Gout

HCPLive

Patients placed in the intervention group reported significant improvements in gout knowledge levels over time compared with controls throughout the 24-week study period.

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Dissolving Stent Approved for Peripheral Artery Disease Below the Knee

Med Page Today

(MedPage Today) -- The FDA approved the Esprit BTK everolimus-eluting scaffold system for chronic limb-threatening ischemia (CLTI) below the knee, Abbott announced on Monday. This system represents the first drug-eluting resorbable scaffold with.

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Stress and cardiovascular disease: an update

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 02 May 2024; doi:10.1038/s41569-024-01024-y Physiological responses to stress are thought to increase the risk of cardiovascular disease via haemodynamic, vascular and immune perturbations. In this Review, Vaccarino and Bremner focus on issues with the measurement of psychological stress and the underlying pathobiology connecting stress to the risk of cardiovascular disease.

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STINGing away the pain: the role of interferon-stimulated genes

Journal of Clinical Investigation - Cardiology

Pain and inflammation are biologically intertwined responses that warn the body of potential danger. In this issue of the JCI, Defaye, Bradaia, and colleagues identified a functional link between inflammation and pain, demonstrating that inflammation-induced activation of stimulator of IFN genes (STING) in dorsal root ganglia nociceptors reduced pain-like behaviors in a rodent model of inflammatory pain.

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Jonathan Barratt, MD: Atacicept Could ‘Transform How We Think About Treating IgA Nephropathy’

HCPLive

Barratt explained findings from the phase 2b ORIGIN trial of atacicept and how it compares to current standard therapies in IgAN and other agents in the pipeline.

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Nationwide, 6 stroke advocates selected to receive 2024 Stroke Hero Awards

American Heart News - Stroke News

DALLAS, May 1, 2024 – Each year, approximately 800,000 people in the U.S. have a stroke.[1] Six local stroke heroes from across the country are being recognized by the American Stroke Association, a division of the American Heart Association, for.

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Age-Related Somatic Mutations Implicated in Cardiovascular Death

Med Page Today

(MedPage Today) -- Cardiovascular death had a strong tie to the somatic mutations that often accrue with aging in people with subclinical atherosclerosis, an observational study found. For asymptomatic people who had atherosclerosis detected by.

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How Much Does a CT Scanner Cost?

Cassling

Your healthcare facility has decided to invest in a new computed tomography (CT) scanner; now you’re in the process of evaluating your options. While considering variables like imaging capabilities, workflow efficiency, and patient experience, you’re also crunching numbers tied to cost. If you’re asking the question ‘how much does a CT scanner cost?

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FDA Approves Abbott's Novel Dissolvable Stent Therapy for Peripheral Artery Disease

HCPLive

Abbott's Esprit BTK System was shown to significantly reduce risk of ischemic events in patients with PAD versus angioplasty over 1 year.

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A step closer to understanding how a diet high in simple carbohydrates may cause dysbiosis

Journal of Clinical Investigation - Cardiology

The gut microbiota is an integral part of the human metaorganism that is required to shape physiologic host immune responses including host defense against pathogens. Disease-associated gut dysbiosis has been characterized by blooms of pathobionts, which are bacterial species that can drive disease under certain conditions. Pathobionts like Enterobacteriaceae often bloom during flares of inflammatory bowel disease (IBD) and are causally linked with IBD in murine models.

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Cardio-fitness cuts death and disease by nearly 20%

Science Daily - Heart Disease

Groundbreaking new research finds that an increased cardio fitness level will reduce your risk of death from any cause by nearly 20%.

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New Study Published in JACC: Heart Failure Reveals that Despite Significant Efforts to Improve Acute Heart Failure Treatment Over the Past 20 Years, Management Remains Unchanged

DAIC

Getty Images milla1cf Thu, 05/02/2024 - 10:17 May 2, 2024 — Reprieve Cardiovascular, Inc. (‘Reprieve’), a development stage company focused on pioneering an intelligent approach to acute decompensated heart failure (ADHF) treatment, today highlighted the publication of TREAT-AHF study results in JACC: Heart Failure. Heart failure (HF) is a leading cause of hospitalization in the United States.

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Urinary Inflammatory Biomarkers Show Prognostic Value for IgA Nephropathy

HCPLive

Urinary cytokines GDF-15, IL-6, and EGF significantly strengthened the predictability of IgAN prognosis and may be viable biomarker candidates for disease progression.

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Study finds ChatGPT fails at heart risk assessment

Medical Xpress - Cardiology

Despite ChatGPT's reported ability to pass medical exams, new research indicates it would be unwise to rely on it for some health assessments, such as whether a patient with chest pain needs to be hospitalized.

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A blood test for stroke risk? Biomarker for risk of future cerebrovascular disease

Science Daily - Heart Disease

A simple blood test could allow doctors to determine whether a person may be at higher risk for stroke or cognitive decline during their lifetime, according to a new study.

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The Society of Thoracic Surgeons Launches New Valve Surgery Risk Calculators

DAIC

milla1cf Tue, 04/30/2024 - 13:03 April 30, 2024 — The expanding use of transcatheter technologies has changed the landscape in the treatment of valvular disease in adult cardiac patients, with valve surgery rapidly shifting to more complex interventions frequently involving other concomitant procedures. To inform heart team and patient decision-making on valve surgery, The Society of Thoracic Surgeons (STS) has launched new risk calculators for isolated tricuspid valve repair and replacement ;

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FDA Approves Voclosporin Label Update in Lupus Nephritis to Reflect Long-Term Data

HCPLive

FDA approves label update for voclosporin (Lupkynis) in lupus nephritis, reflecting long-term AURORA data and new kidney function monitoring guidance.

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An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis

Journal of Clinical Investigation - Cardiology

The appearance of senescent cells in age-related diseases has spurred the search for compounds that can target senescent cells in tissues, termed senolytics. However, a major caveat with current senolytic screens is the use of cell lines as targets where senescence is induced in vitro, which does not necessarily reflect the identity and function of pathogenic senescent cells in vivo.

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Study finds network of inflammatory molecules may act as biomarker for risk of future cerebrovascular disease

Medical Xpress - Cardiology

A simple blood test could allow doctors to determine whether a person may be at higher risk for stroke or cognitive decline during their lifetime, according to a new UCLA Health study.

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ChatGPT Extracts Data for Ischaemic Stroke Almost Perfectly

DAIC

Dr Nils Lehnen, Senior Physician at the Clinic for Diagnostic and Interventional Neuroradiology and Paediatric Neuroradiology at the UKB. Image courtesy of University Hospital Bonn (UKB) / R. Müller milla1cf Wed, 05/01/2024 - 12:07 May 1, 2024 — In an ischemic stroke, an artery in the brain is blocked by blood clots and the brain cells can no longer be supplied with blood as a result.

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Young Adults More Likely to Believe Myths Related to Tanning, Sun Protection, Skin Cancer

HCPLive

These survey results indicate that young adults tended to embrace misconceptions regarding sun protection and positive views of tanning.

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Consequences of Afib; Autism Heritability in Males and Females

Med Page Today

(MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center.

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Deep Learning–Based Assessment of Built Environment From Satellite Images and Cardiometabolic Disease Prevalence

JAMA Cardiology

This cross-sectional study investigates the association between cardiometabolic disease prevalence in the US and deep learning–based assessment of the built environment from satellite imagery.

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Fujifilm Introduces First-of-its-Kind Transducer for On-Pump Intracardiac Echocardiography Imaging (OPIE) for Septal Myectomy

DAIC

milla1cf Mon, 04/29/2024 - 13:17 April 29, 2024 — FUJIFILM Healthcare Americas Corporation, a leading provider of diagnostic and enterprise imaging solutions, announced the launch of its first-of-kind OPIE Transducer for on-pump intracardiac echocardiography (OPIE) for septal myectomy. Early clinical users of the OPIE transducer will discuss how the technology helps to evaluate the ventricular septal thickness during septal myectomy surgery by providing real-time imaging visualization during t

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Clinic Days with Telemedicine, In-Person Visits Increases EHR Work for PCPs

HCPLive

A combination of telemedicine and in-person visits led to a nearly 6% increase in electronic health record work for primary care physicians.

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QT-Prolonging Meds Commonly Doled Out to Dialysis Patients

Med Page Today

(MedPage Today) -- Non-nephrologists frequently prescribed QT-prolonging medications with known torsades de pointes (TdP) risk to older dialysis-dependent patients, and often these prescriptions came from nonacute settings, a cross-sectional study.

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Scientists identify new treatment target for leading cause of blindness

Science Daily - Stroke

Scientists report that a gene previously implicated in the development of atherosclerotic lesions in coronary arteries could be key to understanding why many people don't benefit from the most used therapy for neovascular age-related macular degeneration (AMD), a leading cause of blindness.

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