Sat.Apr 27, 2024 - Fri.May 03, 2024

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Alzheimer's Biomarkers Linked With Plasma Leptin Levels

Med Page Today

(MedPage Today) -- Plasma leptin levels were linked with Alzheimer's disease PET pathology in cognitively unimpaired older adults, a longitudinal cohort study in Korea showed. Over 2 years, lower baseline plasma leptin was associated with a greater.

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Researchers identify over 2,000 genetic signals linked to blood pressure in study of over one million people

Science Daily - Heart Disease

Researchers have discovered over a hundred new regions of the human genome, also known as genomic loci, that appear to influence a person's blood pressure. In total, over 2,000 independent genetic signals for blood pressure are now reported, demonstrating that blood pressure is a highly complex trait influenced by thousands of different genetic variants.

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Brief anger may impair blood vessel function

American Heart News - Heart News

Research Highlights: When adults became angry after remembering past experiences, the function of cells lining the blood vessels was negatively impaired, which may restrict blood flow. Previous research has found that this may increase the risk of.

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Recognizing Stigma's Impact on Care for Alcohol-Related Liver Disease

HCPLive

In the first segment of this HCPLive special report, experts discuss the stigma surrounding alcohol use disorder and alcohol-associated liver disease.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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When female doctors treat female patients

Heart Sisters

Several theories have emerged in medicine to explain surprising differences in patient outcomes based on whether our doctor is male or female.

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Insulin sensitivity estimates and their longitudinal association with coronary artery disease in type 1 diabetes. Does it matter?

Cardiovascular Diabetology

Insulin resistance and chronic kidney disease are both associated with increased coronary artery disease risk. Many formulae estimating glucose disposal rate in type 1 diabetes infer insulin sensitivity from c.

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'Evil Personified': Nurse Gets Life Sentence for Murdering Patients With Insulin

Med Page Today

(MedPage Today) -- A Pennsylvania nurse who purposely administered lethal doses of insulin to more than 20 patients at skilled nursing facilities received a life sentence after pleading guilty to three counts of murder and other charges, the state.

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Scientists identify new treatment target for leading cause of blindness

Science Daily - Stroke

Scientists report that a gene previously implicated in the development of atherosclerotic lesions in coronary arteries could be key to understanding why many people don't benefit from the most used therapy for neovascular age-related macular degeneration (AMD), a leading cause of blindness.

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CV Societies Propel Plans Forward for a New Board of Cardiovascular Medicine

DAIC

Getty Images milla1cf Mon, 04/29/2024 - 13:11 April 29, 2024 — Efforts by the American College of Cardiology , the American Heart Association , the Heart Failure Society of America , the Heart Rhythm Society and The Society for Cardiovascular Angiography & Interventions to create a new, independent Board of Cardiovascular Medicine under the American Board of Medical Specialties ( ABMS ) are closer to becoming a reality with the creation of a formal Board of Directors and the announcement by th

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FDA Approves Abbott's Novel Dissolvable Stent Therapy for Peripheral Artery Disease

HCPLive

Abbott's Esprit BTK System was shown to significantly reduce risk of ischemic events in patients with PAD versus angioplasty over 1 year.

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Dissolving Stent Approved for Peripheral Artery Disease Below the Knee

Med Page Today

(MedPage Today) -- The FDA approved the Esprit BTK everolimus-eluting scaffold system for chronic limb-threatening ischemia (CLTI) below the knee, Abbott announced on Monday. This system represents the first drug-eluting resorbable scaffold with.

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Dietary carbohydrates regulate intestinal colonization and dissemination of Klebsiella pneumoniae

Journal of Clinical Investigation - Cardiology

Bacterial translocation from the gut microbiota is a source of sepsis in susceptible patients. Previous work suggests that overgrowth of gut pathobionts, including Klebsiella pneumoniae, increases the risk of disseminated infection. Our data from a human dietary intervention study found that, in the absence of fiber, K. pneumoniae bloomed during microbiota recovery from antibiotic treatment.

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The Society of Thoracic Surgeons Launches New Valve Surgery Risk Calculators

DAIC

milla1cf Tue, 04/30/2024 - 13:03 April 30, 2024 — The expanding use of transcatheter technologies has changed the landscape in the treatment of valvular disease in adult cardiac patients, with valve surgery rapidly shifting to more complex interventions frequently involving other concomitant procedures. To inform heart team and patient decision-making on valve surgery, The Society of Thoracic Surgeons (STS) has launched new risk calculators for isolated tricuspid valve repair and replacement ;

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Young Adults More Likely to Believe Myths Related to Tanning, Sun Protection, Skin Cancer

HCPLive

These survey results indicate that young adults tended to embrace misconceptions regarding sun protection and positive views of tanning.

Cancer 111
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Gene Therapy Allowing Heart to Grow New Blood Vessels Supported by Early Data

Med Page Today

(MedPage Today) -- LONG BEACH, Calif. -- A gene therapy for therapeutic angiogenesis showed promise for people with angina who had already exhausted their options for medical therapy and coronary revascularization, according to the single-arm.

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Nationwide, 6 stroke advocates selected to receive 2024 Stroke Hero Awards

American Heart News - Stroke News

DALLAS, May 1, 2024 – Each year, approximately 800,000 people in the U.S. have a stroke.[1] Six local stroke heroes from across the country are being recognized by the American Stroke Association, a division of the American Heart Association, for.

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Brief anger may impair blood vessel function

Science Daily - Heart Disease

When adults became angry after remembering past experiences, the function of cells lining the blood vessels was negatively impaired, which may restrict blood flow, according to a new study. Previous research has found that this may increase the risk of heart disease and stroke. In this study, episodes of anxiety and sadness did not trigger the same change in functioning of the blood vessel lining.

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Smokers with Lung Abnormalities More Likely to Report Severe Acute Respiratory Disease Events

HCPLive

This analysis indicates that quantitative interstitial abnormalities may indicate alterations in lung tissue processes that can result in short- and long-term consequences as far as symptoms.

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New Study Published in JACC: Heart Failure Reveals that Despite Significant Efforts to Improve Acute Heart Failure Treatment Over the Past 20 Years, Management Remains Unchanged

DAIC

Getty Images milla1cf Thu, 05/02/2024 - 10:17 May 2, 2024 — Reprieve Cardiovascular, Inc. (‘Reprieve’), a development stage company focused on pioneering an intelligent approach to acute decompensated heart failure (ADHF) treatment, today highlighted the publication of TREAT-AHF study results in JACC: Heart Failure. Heart failure (HF) is a leading cause of hospitalization in the United States.

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STINGing away the pain: the role of interferon-stimulated genes

Journal of Clinical Investigation - Cardiology

Pain and inflammation are biologically intertwined responses that warn the body of potential danger. In this issue of the JCI, Defaye, Bradaia, and colleagues identified a functional link between inflammation and pain, demonstrating that inflammation-induced activation of stimulator of IFN genes (STING) in dorsal root ganglia nociceptors reduced pain-like behaviors in a rodent model of inflammatory pain.

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Study finds ChatGPT fails at heart risk assessment

Medical Xpress - Cardiology

Despite ChatGPT's reported ability to pass medical exams, new research indicates it would be unwise to rely on it for some health assessments, such as whether a patient with chest pain needs to be hospitalized.

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FDA Approves Voclosporin Label Update in Lupus Nephritis to Reflect Long-Term Data

HCPLive

FDA approves label update for voclosporin (Lupkynis) in lupus nephritis, reflecting long-term AURORA data and new kidney function monitoring guidance.

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ChatGPT Extracts Data for Ischaemic Stroke Almost Perfectly

DAIC

Dr Nils Lehnen, Senior Physician at the Clinic for Diagnostic and Interventional Neuroradiology and Paediatric Neuroradiology at the UKB. Image courtesy of University Hospital Bonn (UKB) / R. Müller milla1cf Wed, 05/01/2024 - 12:07 May 1, 2024 — In an ischemic stroke, an artery in the brain is blocked by blood clots and the brain cells can no longer be supplied with blood as a result.

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Clogged arteries worsened by cells that behave like cancer cells

Science Daily - Heart Disease

Researchers have found that cells inside clogged arteries have cancer-like properties that aggravate atherosclerosis, and anticancer drugs could be a new treatment.

Cancer 102
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A step closer to understanding how a diet high in simple carbohydrates may cause dysbiosis

Journal of Clinical Investigation - Cardiology

The gut microbiota is an integral part of the human metaorganism that is required to shape physiologic host immune responses including host defense against pathogens. Disease-associated gut dysbiosis has been characterized by blooms of pathobionts, which are bacterial species that can drive disease under certain conditions. Pathobionts like Enterobacteriaceae often bloom during flares of inflammatory bowel disease (IBD) and are causally linked with IBD in murine models.

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Mobile Health App Improves Treatment Compliance, Health Knowledge in Gout

HCPLive

Patients placed in the intervention group reported significant improvements in gout knowledge levels over time compared with controls throughout the 24-week study period.

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Fujifilm Introduces First-of-its-Kind Transducer for On-Pump Intracardiac Echocardiography Imaging (OPIE) for Septal Myectomy

DAIC

milla1cf Mon, 04/29/2024 - 13:17 April 29, 2024 — FUJIFILM Healthcare Americas Corporation, a leading provider of diagnostic and enterprise imaging solutions, announced the launch of its first-of-kind OPIE Transducer for on-pump intracardiac echocardiography (OPIE) for septal myectomy. Early clinical users of the OPIE transducer will discuss how the technology helps to evaluate the ventricular septal thickness during septal myectomy surgery by providing real-time imaging visualization during t

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Stress and cardiovascular disease: an update

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 02 May 2024; doi:10.1038/s41569-024-01024-y Physiological responses to stress are thought to increase the risk of cardiovascular disease via haemodynamic, vascular and immune perturbations. In this Review, Vaccarino and Bremner focus on issues with the measurement of psychological stress and the underlying pathobiology connecting stress to the risk of cardiovascular disease.

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An in vivo screening platform identifies senolytic compounds that target p16INK4a+ fibroblasts in lung fibrosis

Journal of Clinical Investigation - Cardiology

The appearance of senescent cells in age-related diseases has spurred the search for compounds that can target senescent cells in tissues, termed senolytics. However, a major caveat with current senolytic screens is the use of cell lines as targets where senescence is induced in vitro, which does not necessarily reflect the identity and function of pathogenic senescent cells in vivo.

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Jonathan Barratt, MD: Atacicept Could ‘Transform How We Think About Treating IgA Nephropathy’

HCPLive

Barratt explained findings from the phase 2b ORIGIN trial of atacicept and how it compares to current standard therapies in IgAN and other agents in the pipeline.

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Cardiologists Train Large AI Model to Assess Heart Structure, Function

DAIC

Cedars-Sinai and Smidt Heart Institute investigators developed a novel foundation model that integrates computer vision interpretation of echocardiogram images with natural language processing to augment cardiologists’ interpretation of echocardiograms. Image by Getty. milla1cf Thu, 05/02/2024 - 10:09 May 2, 2024 — Artificial intelligence experts at Cedars-Sinai and the Smidt Heart Institute created a dataset with more than 1 million echocardiograms, or cardiac ultrasound videos, and their corre

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Consequences of Afib; Autism Heritability in Males and Females

Med Page Today

(MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center.

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Study finds network of inflammatory molecules may act as biomarker for risk of future cerebrovascular disease

Medical Xpress - Cardiology

A simple blood test could allow doctors to determine whether a person may be at higher risk for stroke or cognitive decline during their lifetime, according to a new UCLA Health study.

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Clinic Days with Telemedicine, In-Person Visits Increases EHR Work for PCPs

HCPLive

A combination of telemedicine and in-person visits led to a nearly 6% increase in electronic health record work for primary care physicians.

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How Much Does a CT Scanner Cost?

Cassling

Your healthcare facility has decided to invest in a new computed tomography (CT) scanner; now you’re in the process of evaluating your options. While considering variables like imaging capabilities, workflow efficiency, and patient experience, you’re also crunching numbers tied to cost. If you’re asking the question ‘how much does a CT scanner cost?

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QT-Prolonging Meds Commonly Doled Out to Dialysis Patients

Med Page Today

(MedPage Today) -- Non-nephrologists frequently prescribed QT-prolonging medications with known torsades de pointes (TdP) risk to older dialysis-dependent patients, and often these prescriptions came from nonacute settings, a cross-sectional study.

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