Sat.May 11, 2024 - Fri.May 17, 2024

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Transcutaneous Pacing: Part 2

EMS 12-Lead

TCP in the ROSC Patient: False Electrical Capture at 75mA Josh Kimbrell, NRP @joshkimbre Judah Kreinbrook, EMT-P @JMedic2JDoc This is the second installment of a blog series showing how transcutaneous pacing (TCP) can be difficult and how you can improve your skills. We will be using redacted information from different cases where paramedics attempted TCP in the field.

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Evaluating Safety of Novel LDL Management Mechanism

HCPLive

Deepak Bhatt, MD, MPH, MBA, reviews the efficacy and safety data of inclisiran, highlighting its long-term effects and noting that injection site reactions are among the most prominent adverse reactions associated with this medication.

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The mechanosensory channel PIEZO1 functions upstream of angiopoietin/TIE/FOXO1 signaling in lymphatic development

Journal of Clinical Investigation - Cardiology

Lymphedema is a debilitating disease with no effective cure and affects an estimated 250 million individuals worldwide. Prior studies have identified mutations in piezo-type mechanosensitive ion channel component 1 (PIEZO1), angiopoietin 2 (ANGPT2), and tyrosine kinase with Ig-like and EGF-like domains 1 (TIE1) in patients with primary lymphedema. Here, we identified crosstalk between these molecules and showed that activation of the mechanosensory channel PIEZO1 in lymphatic endothelial cells (

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Low Testosterone Linked With Mortality Risk in Aging Men

Med Page Today

(MedPage Today) -- A low serum testosterone level at baseline was associated with higher risk for all-cause and cardiovascular disease (CVD) mortality, a meta-analysis of 11 prospective cohort studies found. In age-adjusted analyses, men in the.

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New Treatment in Pipeline for Patients with Hypertrophic Cardiomyopathy

DAIC

Getty Images milla1cf Tue, 05/14/2024 - 13:00 May 14, 2024 — One of the most common genetic heart diseases worldwide, hypertrophic cardiomyopathy (HCM) causes the walls of the left ventricle to become thick and stiff. In about 70 percent of cases, patients with HCM experience obstruction to blood flow, which increases pressures in the heart and can lead to chest pain, shortness of breath and reduced exercise capacity.

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Two decades of studies suggest health benefits associated with plant-based diets

Science Daily - Heart Disease

Vegetarian and vegan diets are generally associated with better status on various medical factors linked to cardiovascular health and cancer risk, as well as lower risk of cardiovascular diseases, cancer, and death, according to a new review of 49 previously published papers.

Diet 107
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RNF4 sustains Myc-driven tumorigenesis by facilitating DNA replication

Journal of Clinical Investigation - Cardiology

The mammalian SUMO-targeted E3 ubiquitin ligase Rnf4 has been reported to act as a regulator of DNA repair, but the importance of RNF4 as a tumor suppressor has not been tested. Using a conditional-knockout mouse model, we deleted Rnf4 in the B cell lineage to test the importance of RNF4 for growth of somatic cells. Although Rnf4–conditional-knockout B cells exhibited substantial genomic instability, Rnf4 deletion caused no increase in tumor susceptibility.

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Therapeutic strategies targeting mechanisms of macrophages in diabetic heart disease

Cardiovascular Diabetology

Diabetic heart disease (DHD) is a serious complication in patients with diabetes. Despite numerous studies on the pathogenic mechanisms and therapeutic targets of DHD, effective means of prevention and treatme.

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Trends Shaping the Cardiovascular Information Systems Market

DAIC

In the dynamic realm of healthcare technology, cardiovascular information systems (CVIS) stand at the forefront, facilitating streamlined operations, enhanced patient care and efficient data management within cardiovascular departments. According to a recent market report from Credence Research, the CVIS market is projected to surge from $1,197 M in 2023 to $2,387 by 2023 — a compound annual growth rate of 7.7%.

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The alanyl-tRNA synthetase AARS1 moonlights as a lactyltransferase to promote YAP signaling in gastric cancer

Journal of Clinical Investigation - Cardiology

Lactylation has been recently identified as a new type of posttranslational modification occurring widely on lysine residues of both histone and nonhistone proteins. The acetyltransferase p300 is thought to mediate protein lactylation, yet the cellular concentration of the proposed lactyl-donor, lactyl-coenzyme A, is about 1,000 times lower than that of acetyl-CoA, raising the question of whether p300 is a genuine lactyltransferase.

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Draw Between Two Diuretics for Renal Prevention in Hypertension

Med Page Today

(MedPage Today) -- LONG BEACH, Calif. -- Chlorthalidone was no better than hydrochlorothiazide for reducing the incidence of major renal outcomes in patients with hypertension, a secondary analysis of the randomized Diuretic Comparison Project.

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New STS Mentorship Program Introduces Medical Students to the Specialty

Society of Thoracic Surgeons - Early Career

In a bid to foster professional development and guidance for aspiring cardiothoracic surgeons, The Society of Thoracic Surgeons has unveiled a unique mentorship program tailored for medical students and residents.

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Franklin King, MD: Psychedelic Therapy History, Advances, and Hurdles

HCPLive

In an interview, King provided an overview of the history of psychedelic research for psychiatric conditions, where we are now, and what hurdles investigators must address.

Research 105
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Excess glucocorticoids inhibit murine bone turnover via modulating the immunometabolism of the skeletal microenvironment

Journal of Clinical Investigation - Cardiology

Elevated bone resorption and diminished bone formation have been recognized as the primary features of glucocorticoid-associated skeletal disorders. However, the direct effects of excess glucocorticoids on bone turnover remain unclear. Here, we explored the outcomes of exogenous glucocorticoid treatment on bone loss and delayed fracture healing in mice and found that reduced bone turnover was a dominant feature, resulting in a net loss of bone mass.

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Yet Another Benefit for Metformin?

Med Page Today

(MedPage Today) -- Metformin started for pre-diabetes also appeared to reduce patients' risk of developing gout, researchers found. Among 1,154 people with elevated hemoglobin A1c (HbA1c) just short of the threshold for type 2 diabetes who began.

Diabetes 106
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New postpartum care recommendations target CVD risk

American Heart News - Heart News

DALLAS, May 16, 2024 — Pregnancy-related deaths in the U.S. have risen 140% over the past three decades and cardiovascular disease is the leading cause.[1] Despite existing medical guidance on pregnancy and cardiovascular health, current trends in health.

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New drug makes exercise, everyday tasks easier for people with common heart condition

Science Daily - Heart Disease

People with the heart condition obstructive cardiomyopathy were able to use significantly more oxygen while exercising after taking the investigational drug aficamten, according to a new study.

Exercise 101
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Ep 194 Subarachnoid Hemorrhage – Recognition, Workup and Diagnosis Deep Dive

ECG Cases

Anton is joined by the world's leading EM researcher in subarachnoid hemorrhage diagnosis Dr. Jeff Perry and EM-Stroke team clinician Dr. Katie Lin for a deep dive into why we still miss this life-threatening diagnosis, the key clinical clues, proper use of decision tools, indications for CT, indications for CTA, indications for LP and CSF interpretation for the sometimes elusive diagnosis of subarachnoid hemorrhage.

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MAMMOMAT B.brilliant Mammography System Cleared by FDA

Cassling

First completely redesigned mammography platform in over a decade New features reduce patient discomfort and improve user ergonomics Premarket approval application filed for PlatinumTomo 3D portion with new technology Siemens Healthineers has announced the Food and Drug Administration 510(k) clearance of the MAMMOMAT B.brilliant — the first completely redesigned mammography platform in more than 10 years.

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Endeavor Health opens $170M cardiovascular institute

Becker's Hospital Review - Cardiology

Discover the new state-of-the-art Cardiovascular Institute at Glenbrook Hospital in Evanston, IL, offering advanced heart care and future expansion plans.

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GE HealthCare and Medis Medical Imaging Announce Collaboration Focused on Non-Invasive Coronary Assessments to Help Advance Precision Care in Treatment of Coronary Artery Disease

DAIC

milla1cf Tue, 05/14/2024 - 12:53 May 14, 2024 — GE HealthCare , a leading global medical technology, pharmaceutical diagnostics and digital solutions innovator, and Medis Medical Imaging , a leading cardiac imaging software company, announced their collaboration aimed at helping advance precision care in the diagnosis and treatment of coronary artery disease ( CAD ).

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Mortality in U.S. Youth; Gene Therapy for Sickle Cell Disease

Med Page Today

(MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center.

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Clinical Quiz: Protein and Energy Intake in Chronic Kidney Disease from KDOQI Guidelines

HCPLive

Check out this quiz on the NKF's KDOQI recommendations on nutrition in chronic kidney disease, with a focus on their guidance for protein and energy intake!

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New cardiac research will save women's lives by improving detection of heart failure

Science Daily - Heart Disease

An important new study has advanced how heart failure is detected in women -- meaning more female patients can be diagnosed and at an earlier stage.

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SHINE Trial Sheds Light on Deadly Stroke Complication

DAIC

UVA Health's Karen Johnston, MD, the SHINE trial leader, was pleased to see the new insights into best practices for stroke care. “These data from the SHINE trial continue to inform the national stroke community about potential approaches to treating hyperglycemic stroke patients to assure better outcomes,” she said. Dan Addison | UVA Communications milla1cf Tue, 05/14/2024 - 12:57 May 14, 2024 — An ambitious, nationwide clinical trial led by UVA Health ’s Karen Johnston , MD, has provided docto

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Which Patients With Diabetes and Ketoacidosis Face Higher Death Risk?

Med Page Today

(MedPage Today) -- NEW ORLEANS -- Patients with type 2 diabetes (T2D) hospitalized for ketoacidosis had a higher mortality rate versus patients with type 1 diabetes (T1D), according to a study of national data. In the retrospective study, the.

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MaineHealth to open $580M heart hospital

Becker's Hospital Review - Cardiology

MaineHealth's new $580 million Malone Family Tower in Portland offers state-of-the-art cardiac care with 96 rooms, 10 operating rooms, and more.

Hospital 105
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Normothermic perfusion system extends life of organs waiting for transplant

Science Daily - Heart Disease

In the United States, about 30-40% of donor hearts aren't considered for transplant due to inadequate function in the donor. This leads to a drop in the number of donated hearts that are available to be matched with someone who needs a heart transplant.

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Transcatheter Valve Replacement Outcomes Similar to Surgery in Long-Term Analysis

DAIC

Getty Images milla1cf Wed, 05/15/2024 - 19:10 May 15, 2024 — A new study demonstrated parity between a minimally invasive procedure to replace the aortic valve in the heart— transcatheter aortic valve replacement (TAVR)—and surgical aortic valve replacement (SAVR). In the meta-analysis of seven randomized trials, published in JSCAI and presented at the 2024 EuroPCR conference in Paris, France, researchers compared the outcomes of 7,785 patients undergoing TAVR (a procedure that delivers a n

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Physical Activity and Progression of Coronary Artery Calcification

JAMA Cardiology

This cohort study examines data for men and women 40 years and older to determine the association between high-volume leisure-time aerobic physical activity and the progression of coronary artery calcium over time.

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Singing repairs the language network of the brain after a cerebrovascular accident

Science Daily - Stroke

Singing rehabilitates speech production in post-stroke aphasia. Researchers investigated the rehabilitative effect of singing on the brain.

Research 107
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Liver Disease, High Lipoprotein(a) Tied to Higher MI Risk in Diabetes Patients

Med Page Today

(MedPage Today) -- NEW ORLEANS -- Individuals with diabetes were more likely to report a history of myocardial infarction (MI) if they also had high levels of serum lipoprotein(a), or Lp(a), or advanced liver fibrosis, a retrospective study using.

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New Guidelines on Peripheral Artery Disease Issued by American Heart Association, American College of Cardiology and Leading Medical Societies

DAIC

A new joint guideline from the American Heart Association (AHA), the American College of Cardiology (ACC) and nine other medical societies reports early diagnosis and treatment of peripheral artery disease is essential to improve outcomes and reduce amputation risk, heart attack, stroke and death for people with Peripheral Artery Disease (PAD). Image courtesy: Getty Images christine.book Thu, 05/16/2024 - 11:23 May 16, 2024 — Timely diagnosis and proper management of peripheral artery disease (P

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Hidradenitits Suppurativa Linked to Increased Risk of Cardiovascular Diseases

HCPLive

Patients with hidradenitis suppurativa had the greatest risk of developing various CVS, with heart failure being the most common one.

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An astrocytic pH regulator that can repair the blood-brain barrier and reverse brain damage caused by ischemic stroke

Science Daily - Stroke

A recent study has found that an ion transporter protein that regulates the pH of specific brain cells can repair the blood-brain barrier and restore normal brain function after ischemic stroke. The study has revealed novel and specific therapeutic targets for ischemic stroke and related brain conditions for which no targeted treatments exist currently.

Stroke 93
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Early repol or anterior OMI?

Dr. Smith's ECG Blog

Chest Pain – Benign Early Repol or OMI? Written by Destiny Folk, MD, Adam Engberg, MD, and Vitaliy Belyshev MD A man in his early 60s with a past medical history of hypertension, type 2 diabetes, obesity, and hyperlipidemia presented to the emergency department for evaluation of chest pain. He reported substernal chest pressure with radiation to his left arm that started at work several hours prior to arrival and had somewhat improved since onset.

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Gender-affirming hormone therapy preserves skeletal maturation in young mice via the gut microbiome

Journal of Clinical Investigation - Cardiology

Gender-affirming hormone therapy (GAHT) is often prescribed to transgender (TG) adolescents to alleviate gender dysphoria, but the effect of GAHT on the growing skeleton is unclear. We found GAHT to improve trabecular bone structure via increased bone formation in young male mice and not to affect trabecular structure in female mice. GAHT modified gut microbiome composition in both male and female mice.