Journal of Clinical Investigation - Cardiology

APRIL 15, 2024

RAD54 and BLM helicase play pivotal roles during homologous recombination repair (HRR) to ensure genome maintenance. BLM amino acids (aa 181–212) interact with RAD54 and enhance its chromatin remodeling activity. Functionally, this interaction heightens HRR, leading to a decrease in residual DNA damage in colon cancer cells. This contributes to chemoresistance in colon cancer cells against cisplatin, camptothecin, and oxaliplatin, eventually promoting tumorigenesis in preclinical colon cancer mo

Cancer 122

Cancer 122

Med Page Today

APRIL 15, 2024

(MedPage Today) -- More than one in five older adults hospitalized for respiratory syncytial virus (RSV) infection experienced an acute cardiac event, an observational study found. Among 6,248 hospitalized patients 50 or older with laboratory.

Hospital 116

Hospital Laboratory 116

Medical Xpress - Cardiology

APRIL 15, 2024

An analysis of the biomolecule substudy of the EAST–AFNET 4 trial has revealed that biomolecule concentrations in the blood of patients with atrial fibrillation can be used to identify patients at high and low cardiovascular risk. The findings were published in Cardiovascular Research.

Atrial Fibrillation 111

Atrial Fibrillation Circulation Research 111

Journal of Clinical Investigation - Cardiology

APRIL 15, 2024

SARS-CoV-2 infection of the upper airway and the subsequent immune response are early, critical factors in COVID-19 pathogenesis. By studying infection of human biopsies in vitro and in a hamster model in vivo, we demonstrated a transition in nasal tropism from olfactory to respiratory epithelium as the virus evolved. Analyzing each variant revealed that SARS-CoV-2 WA1 or Delta infect a proportion of olfactory neurons in addition to the primary target sustentacular cells.

COVID-19 104

COVID-19 104

HCPLive

APRIL 15, 2024

A recent multi-center study identified risk factors linked to premature mortality in sickle cell disease, including male gender and hematologic and biochemical parameters.

Sickle Cell Disease 102

Sickle Cell Disease Risk Factors 102

Journal of Clinical Investigation - Cardiology

APRIL 15, 2024

Chromosomal instability is a prominent biological feature of myelodysplastic syndromes (MDS), with over 50% of patients with MDS harboring chromosomal abnormalities or a complex karyotype (CK). Despite this observation, the mechanisms underlying mitotic and chromosomal defects in MDS remain elusive. In this study, we identified ectopic expression of the transcription factor ONECUT3, which is associated with CKs and poorer survival outcomes in MDS.

Outcomes 104

Outcomes 104

Heart BMJ

APRIL 15, 2024

Objective To study the association between COVID-19 vaccination and the risk of post-COVID-19 cardiac and thromboembolic complications. Methods We conducted a staggered cohort study based on national vaccination campaigns using electronic health records from the UK, Spain and Estonia. Vaccine rollout was grouped into four stages with predefined enrolment periods.

COVID-19 98

COVID-19 Thrombosis Heart Failure Outcomes 98

Cardiology Update

APRIL 15, 2024

Dr. Chadi Alraies discusses the top impactful trials presented at the 2024 American College of Cardiology conference. Learn more about the highlights from ACC 2024. For more cardiology research news join our newsletter or follow us on Twitter , Facebook , LinkedIn or Instagram. The post ACC 2024 Highlights appeared first on Cardiology Update.

Research 98

Research Heart Failure Interventional Cardiology General Cardiology 98

Journal of Clinical Investigation - Cardiology

APRIL 15, 2024

Loss of arterial smooth muscle cells (SMCs) and abnormal accumulation of the extracellular domain of the NOTCH3 receptor (Notch3ECD) are the 2 core features of CADASIL, a common cerebral small vessel disease caused by highly stereotyped dominant mutations in NOTCH3. Yet the relationship between NOTCH3 receptor activity, Notch3ECD accumulation, and arterial SMC loss has remained elusive, hampering the development of disease-modifying therapies.

97

97

Heart BMJ

APRIL 15, 2024

Inflammation has a direct role in the development of atherosclerotic vascular disease, and oral colchicine displays broad anti-inflammatory properties. Several large, randomised controlled trials (RCTs) have evaluated colchicine’s impact on cardiovascular outcomes. Results from a meta-analysis of these trials demonstrate that colchicine reduces the risk of recurrent major adverse cardiovascular events (MACEs) by 25%, leading to its recent approval by the Food and Drug Administration for th

Cardiovascular Disease 97

Cardiovascular Disease Biomarkers Heart Failure Outcomes 97

Becker's Hospital Review - Cardiology

APRIL 15, 2024

Seventeen percent of cardiologists said their burnout was so severe that they may leave medicine, according to a Medscape report.

108

108

DAIC

APRIL 15, 2024

Image courtesy of Abbott mtaschetta-millane Mon, 04/15/2024 - 09:54 April 15, 2024 — The U.S. Food and Drug Administration ( FDA ) announced A bbott/Thoratec Corp. is recalling HeartMate II and HeartMate 3 Left Ventricular Assist System (LVAS) due to an issue called Extrinsic Outflow Graft Obstruction , (EOGO). This occurs when biological material builds up between certain parts of the device, causing a blockage that makes it harder for the heart to pump blood.

Transplant 90

Transplant Heart Transplant Pediatrics Heart Failure 90

Med Page Today

APRIL 15, 2024

(MedPage Today) -- Women who experienced major adverse pregnancy outcomes still had increased mortality risks decades later, a population-based cohort study of Swedish data found. Adverse pregnancy outcomes independently associated with increased.

Outcomes 90

Outcomes 90

HCPLive

APRIL 15, 2024

Barratt discusses the potential of targeting the alternative pathway for controlling inflammation and the significance of the new APPLAUSE-IgAN data.

98

98

Journal of Clinical Investigation - Cardiology

APRIL 15, 2024

Antitumor responses of CD8+ T cells are tightly regulated by distinct metabolic fitness. High levels of glutathione (GSH) are observed in the majority of tumors, contributing to cancer progression and treatment resistance in part by preventing glutathione peroxidase 4–dependent (GPX4-dependent) ferroptosis. Here, we show the necessity of adenosine A2A receptor (A2AR) signaling and the GSH/GPX4 axis in orchestrating metabolic fitness and survival of functionally competent CD8+ T cells.

Cancer 81

Cancer 81

HCPLive

APRIL 15, 2024

EULAR’s fibromyalgia guidelines provide comprehensive recommendations for managing active fibromyalgia to assist clinicians in making informed decisions. Test your knowledge with this quiz.

69

69

Journal of Clinical Investigation - Cardiology

APRIL 15, 2024

Merkel cell carcinoma (MCC) is a highly immunogenic skin cancer primarily induced by Merkel cell polyomavirus, which is driven by the expression of the oncogenic T antigens (T-Ags). Blockade of the programmed cell death protein-1 (PD-1) pathway has shown remarkable response rates, but evidence for therapy-associated T-Ag–specific immune response and therapeutic strategies for the nonresponding fraction are both limited.

Cancer 75

Cancer Outcomes 75

Med Page Today

APRIL 15, 2024

(MedPage Today) -- A multi-pronged electronic health record-based population health management intervention failed to move the needle for slowing chronic kidney disease (CKD) progression, a cluster randomized trial showed. Over a median follow.

Kidney Disease 69

Kidney Disease Outcomes 69

Journal of Clinical Investigation - Cardiology

APRIL 15, 2024

Adoptive transfer of T cell receptor–engineered T cells (TCR-T) is a promising strategy for immunotherapy against solid tumors. However, the potential of CD4+ T cells in mediating tumor regression has been neglected. Nasopharyngeal cancer is consistently associated with EBV. Here, to evaluate the therapeutic potential of CD4 TCR-T in nasopharyngeal cancer, we screened for CD4 TCRs recognizing EBV nuclear antigen 1 (EBNA1) presented by HLA-DP5.

Cancer 74

Cancer 74

American College of Cardiology

APRIL 15, 2024

Glucagon-like peptide-1 is an incretin (gut-derived hormone) that plays a crucial role in glucose homeostasis, linking nutrient absorption to pancreatic hormone secretion.

Article 70

Article 70

HCPLive

APRIL 15, 2024

Although the intervention did not reduce risk of CKD progression versus standard care, it addressed barriers to care and increased patients’ exposure to ACEi/ARBs.

64

64

American College of Cardiology

APRIL 15, 2024

The following are key points to remember from a state-of-the-art review on the long-term safety of low-dose colchicine for atherosclerosis.

Atherosclerosis 75

Atherosclerosis Article 75

Becker's Hospital Review - Cardiology

APRIL 15, 2024

COVID-19 vaccination is not linked with sudden cardiac death among previously healthy young people, an April 11 CDC report found.

COVID-19 72

COVID-19 Sudden Cardiac Death 72

HeartRhythm

APRIL 15, 2024

Endocardial electrogram (EGM) characteristics in non-ischemic cardiomyopathy (NICM) have not been explored adequately for prognostication.

Cardiomyopathy 75

Cardiomyopathy Tachycardia 75

HCPLive

APRIL 15, 2024

Counting down the most impactful news at major medical meetings, it’s the HCPLive Five! This edition focuses on 5 updates from the American College of Cardiology 2024 (ACC.24) Annual Scientific Sessions.

59

59

Nature Reviews - Cardiology

APRIL 15, 2024

Nature Reviews Cardiology, Published online: 16 April 2024; doi:10.1038/s41569-024-01026-w A new study identifies a group of gut bacteria that can metabolize cholesterol and are associated with lower plasma cholesterol levels.

Cholesterol 52

Cholesterol 52

HCPLive

APRIL 15, 2024

This post-hoc analysis of phase 3 data, using GRAPPA-recognized PsA domains, highlighted disease improvements following treatment with guselkumab.

64

64

Journal of Cardiothoracic Surgery

APRIL 15, 2024

During a routine physical examination three years ago, a 47-year-old woman received a diagnosis of a nodule in her right upper lung. Since then, she has been regularly attending outpatient clinic appointments.

Outpatient 52

Outpatient 52

HCPLive

APRIL 15, 2024

Patients with a delayed appendicitis diagnosis had 1.23 times increased hospital care costs, and Black patients had a greater increased cost than White patients.

Hospital 59

Hospital 59

Journal of Cardiothoracic Surgery

APRIL 15, 2024

The ectopic superior parathyroid in the tracheoesophageal groove and paraesophageal region is rare. Hyperparathyroidism results when these glands become hyperfunctioning. That may necessitate surgical interven.

52

52

All About Cardiovascular System and Disorders

APRIL 15, 2024

High degree of awareness of heart attack symptoms in the community will go a long way in seeking early treatment. For life threatening diseases like heart attack, early recognition of symptoms and prompt reporting to the emergency department is highly desirable. But a study from United States showed that 47% were not able to recognize some heart attack symptoms while 6% were not able to recognize any heart attack symptoms.

Heart Attack 52

Heart Attack Heart attacks Chest Pain Myocardial Infarction 52

Journal of Cardiothoracic Surgery

APRIL 15, 2024

An 80-year-old female was referred to our institution due to transient right upper limb weakness. Transthoracic and transesophageal echocardiography revealed a tumor in the left atrium. The tumor was attached.

52

52

Open Heart

APRIL 15, 2024

Background and aims Hypertension is a leading risk factor for cardiovascular disease. Electronic health records (EHRs) are routinely collected throughout a person’s care, recording all aspects of health status, including current and past conditions, prescriptions and test results. EHRs can be used for epidemiological research. However, there are nuances in the way conditions are recorded using clinical coding; it is important to understand the methods which have been applied to define expo

Hypertension 52

Hypertension Research Risk Factors Cardiovascular Disease 52

Journal of Cardiothoracic Surgery

APRIL 15, 2024

Cardiac herniation occurs when there is a residual pericardial defect post thoracic surgery and is recognised as a rare but fatal complication. It confers a high mortality and requires immediate surgical corre.

52

52

Heart BMJ

APRIL 15, 2024

Atrial fibrillation (AF) is the most common sustained cardiac dysrhythmia encountered in practice. It is currently estimated that AF affects approximately 2% of the general population; however, the true prevalence of AF is likely to be at least 3%–4% when asymptomatic AF is considered. For clinically apparent AF, the investigations and management are relatively well established.

Atrial Fibrillation 52

Atrial Fibrillation Dysrhythmia Risk Factors 52

Journal of Cardiothoracic Surgery

APRIL 15, 2024

Infective endocarditis of the aortic valve can result in a wide range of destructive pathology beyond the valve leaflets and annulus which require careful surgical planning to provide appropriate debridement a.

Aortic valve 52

Aortic valve Aortic 52

Heart BMJ

APRIL 15, 2024

Objective Aortic stenosis (AS) shares pathophysiological similarities with atherosclerosis including active inflammation. CT attenuation of perivascular adipose tissue provides a measure of vascular inflammation that is linked to prognosis and has the potential to be applied to the aortic valve. We investigated perivascular adipose tissue attenuation around the aortic valve in patients with AS.

Aortic valve 52

Aortic valve Aortic Stenosis Atherosclerosis 52