Mon.Apr 15, 2024

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Cardiac Events Common in Older, Hospitalized RSV Patients

Med Page Today

(MedPage Today) -- More than one in five older adults hospitalized for respiratory syncytial virus (RSV) infection experienced an acute cardiac event, an observational study found. Among 6,248 hospitalized patients 50 or older with laboratory.

Hospital 126
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Small molecules that disrupt RAD54-BLM interaction hamper tumor proliferation in colon cancer chemoresistance models

Journal of Clinical Investigation - Cardiology

RAD54 and BLM helicase play pivotal roles during homologous recombination repair (HRR) to ensure genome maintenance. BLM amino acids (aa 181–212) interact with RAD54 and enhance its chromatin remodeling activity. Functionally, this interaction heightens HRR, leading to a decrease in residual DNA damage in colon cancer cells. This contributes to chemoresistance in colon cancer cells against cisplatin, camptothecin, and oxaliplatin, eventually promoting tumorigenesis in preclinical colon cancer mo

Cancer 118
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After Adverse Pregnancy Outcomes, Mortality Risk Lingers for Decades

Med Page Today

(MedPage Today) -- Women who experienced major adverse pregnancy outcomes still had increased mortality risks decades later, a population-based cohort study of Swedish data found. Adverse pregnancy outcomes independently associated with increased.

Outcomes 108
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Evolution of nasal and olfactory infection characteristics of SARS-CoV-2 variants

Journal of Clinical Investigation - Cardiology

SARS-CoV-2 infection of the upper airway and the subsequent immune response are early, critical factors in COVID-19 pathogenesis. By studying infection of human biopsies in vitro and in a hamster model in vivo, we demonstrated a transition in nasal tropism from olfactory to respiratory epithelium as the virus evolved. Analyzing each variant revealed that SARS-CoV-2 WA1 or Delta infect a proportion of olfactory neurons in addition to the primary target sustentacular cells.

COVID-19 103
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Patients with SCD Face Early Death Despite Improved Survival Rates

HCPLive

A recent multi-center study identified risk factors linked to premature mortality in sickle cell disease, including male gender and hematologic and biochemical parameters.

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Ectopic expression of the transcription factor ONECUT3 drives a complex karyotype in myelodysplastic syndromes

Journal of Clinical Investigation - Cardiology

Chromosomal instability is a prominent biological feature of myelodysplastic syndromes (MDS), with over 50% of patients with MDS harboring chromosomal abnormalities or a complex karyotype (CK). Despite this observation, the mechanisms underlying mitotic and chromosomal defects in MDS remain elusive. In this study, we identified ectopic expression of the transcription factor ONECUT3, which is associated with CKs and poorer survival outcomes in MDS.

Outcomes 102
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The role of COVID-19 vaccines in preventing post-COVID-19 thromboembolic and cardiovascular complications

Heart BMJ

Objective To study the association between COVID-19 vaccination and the risk of post-COVID-19 cardiac and thromboembolic complications. Methods We conducted a staggered cohort study based on national vaccination campaigns using electronic health records from the UK, Spain and Estonia. Vaccine rollout was grouped into four stages with predefined enrolment periods.

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Circulating biomolecules identify patients with atrial fibrillation at high risk of cardiovascular events

Medical Xpress - Cardiology

An analysis of the biomolecule substudy of the EAST–AFNET 4 trial has revealed that biomolecule concentrations in the blood of patients with atrial fibrillation can be used to identify patients at high and low cardiovascular risk. The findings were published in Cardiovascular Research.

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Protein aggregates containing wild-type and mutant NOTCH3 are major drivers of arterial pathology in CADASIL

Journal of Clinical Investigation - Cardiology

Loss of arterial smooth muscle cells (SMCs) and abnormal accumulation of the extracellular domain of the NOTCH3 receptor (Notch3ECD) are the 2 core features of CADASIL, a common cerebral small vessel disease caused by highly stereotyped dominant mutations in NOTCH3. Yet the relationship between NOTCH3 receptor activity, Notch3ECD accumulation, and arterial SMC loss has remained elusive, hampering the development of disease-modifying therapies.

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Colchicine in atherosclerotic cardiovascular disease

Heart BMJ

Inflammation has a direct role in the development of atherosclerotic vascular disease, and oral colchicine displays broad anti-inflammatory properties. Several large, randomised controlled trials (RCTs) have evaluated colchicine’s impact on cardiovascular outcomes. Results from a meta-analysis of these trials demonstrate that colchicine reduces the risk of recurrent major adverse cardiovascular events (MACEs) by 25%, leading to its recent approval by the Food and Drug Administration for th

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FDA Announces Recalls of Abbott/Thoratec Corp. Heartmate II and Heartmate 3 Left Ventricular Assist System (LVAS) Due to Long-term Buildup of biological material Causing an Obstruction

DAIC

Image courtesy of Abbott mtaschetta-millane Mon, 04/15/2024 - 09:54 April 15, 2024 — The U.S. Food and Drug Administration ( FDA ) announced A bbott/Thoratec Corp. is recalling HeartMate II and HeartMate 3 Left Ventricular Assist System (LVAS) due to an issue called Extrinsic Outflow Graft Obstruction , (EOGO). This occurs when biological material builds up between certain parts of the device, causing a blockage that makes it harder for the heart to pump blood.

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ACC 2024 Highlights

Cardiology Update

Dr. Chadi Alraies discusses the top impactful trials presented at the 2024 American College of Cardiology conference. Learn more about the highlights from ACC 2024. For more cardiology research news join our newsletter or follow us on Twitter , Facebook , LinkedIn or Instagram. The post ACC 2024 Highlights appeared first on Cardiology Update.

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Jonathan Barratt, MD: Targeting the Alternative Complement Pathway in IgAN with Iptacopan

HCPLive

Barratt discusses the potential of targeting the alternative pathway for controlling inflammation and the significance of the new APPLAUSE-IgAN data.

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17% of cardiologists may leave medicine due to burnout

Becker's Hospital Review - Cardiology

Seventeen percent of cardiologists said their burnout was so severe that they may leave medicine, according to a Medscape report.

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Multidisciplinary Team Intervention Flops for Improving CKD Outcomes

Med Page Today

(MedPage Today) -- A multi-pronged electronic health record-based population health management intervention failed to move the needle for slowing chronic kidney disease (CKD) progression, a cluster randomized trial showed. Over a median follow.

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CD8+ T cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione/GPX4

Journal of Clinical Investigation - Cardiology

Antitumor responses of CD8+ T cells are tightly regulated by distinct metabolic fitness. High levels of glutathione (GSH) are observed in the majority of tumors, contributing to cancer progression and treatment resistance in part by preventing glutathione peroxidase 4–dependent (GPX4-dependent) ferroptosis. Here, we show the necessity of adenosine A2A receptor (A2AR) signaling and the GSH/GPX4 axis in orchestrating metabolic fitness and survival of functionally competent CD8+ T cells.

Cancer 79
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Clinical Quiz: EULAR Guidelines for the Treatment of Fibromyalgia

HCPLive

EULAR’s fibromyalgia guidelines provide comprehensive recommendations for managing active fibromyalgia to assist clinicians in making informed decisions. Test your knowledge with this quiz.

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T antigen–specific CD8+ T cells associate with PD-1 blockade response in virus-positive Merkel cell carcinoma

Journal of Clinical Investigation - Cardiology

Merkel cell carcinoma (MCC) is a highly immunogenic skin cancer primarily induced by Merkel cell polyomavirus, which is driven by the expression of the oncogenic T antigens (T-Ags). Blockade of the programmed cell death protein-1 (PD-1) pathway has shown remarkable response rates, but evidence for therapy-associated T-Ag–specific immune response and therapeutic strategies for the nonresponding fraction are both limited.

Cancer 75
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GLP1RAs in Clinical Practice: Therapeutic Advances and Safety Perspectives

American College of Cardiology

Glucagon-like peptide-1 is an incretin (gut-derived hormone) that plays a crucial role in glucose homeostasis, linking nutrient absorption to pancreatic hormone secretion.

Article 71
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An EBV-related CD4 TCR immunotherapy inhibits tumor growth in an HLA-DP5+ nasopharyngeal cancer mouse model

Journal of Clinical Investigation - Cardiology

Adoptive transfer of T cell receptor–engineered T cells (TCR-T) is a promising strategy for immunotherapy against solid tumors. However, the potential of CD4+ T cells in mediating tumor regression has been neglected. Nasopharyngeal cancer is consistently associated with EBV. Here, to evaluate the therapeutic potential of CD4 TCR-T in nasopharyngeal cancer, we screened for CD4 TCRs recognizing EBV nuclear antigen 1 (EBNA1) presented by HLA-DP5.

Cancer 74
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Low-Dose Colchicine for Atherosclerosis: Key Points

American College of Cardiology

The following are key points to remember from a state-of-the-art review on the long-term safety of low-dose colchicine for atherosclerosis.

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Electronic Health Record-Based Population Health Management Strategy May Improve CKD Care

HCPLive

Although the intervention did not reduce risk of CKD progression versus standard care, it addressed barriers to care and increased patients’ exposure to ACEi/ARBs.

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Correlation of Extent of Left Ventricular Endocardial Unipolar Low Voltage Zones with Ventricular Tachycardia in Non-ischemic Cardiomyopathy

HeartRhythm

Endocardial electrogram (EGM) characteristics in non-ischemic cardiomyopathy (NICM) have not been explored adequately for prognostication.

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HCPLive Five at ACC 2024

HCPLive

Counting down the most impactful news at major medical meetings, it’s the HCPLive Five! This edition focuses on 5 updates from the American College of Cardiology 2024 (ACC.24) Annual Scientific Sessions.

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No link between cardiac deaths in young people, COVID-19 vaccine: CDC

Becker's Hospital Review - Cardiology

COVID-19 vaccination is not linked with sudden cardiac death among previously healthy young people, an April 11 CDC report found.

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Guselkumab Led to Improvements Over Several Psoriatic Arthritis Disease Domains

HCPLive

This post-hoc analysis of phase 3 data, using GRAPPA-recognized PsA domains, highlighted disease improvements following treatment with guselkumab.

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Gut bacteria can break down cholesterol

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 16 April 2024; doi:10.1038/s41569-024-01026-w A new study identifies a group of gut bacteria that can metabolize cholesterol and are associated with lower plasma cholesterol levels.

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Delayed Appendicitis Diagnosis Linked to Increased Hospital Care Costs

HCPLive

Patients with a delayed appendicitis diagnosis had 1.23 times increased hospital care costs, and Black patients had a greater increased cost than White patients.

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Different anatomical variations in the anterior segment of the right upper lung

Journal of Cardiothoracic Surgery

During a routine physical examination three years ago, a 47-year-old woman received a diagnosis of a nodule in her right upper lung. Since then, she has been regularly attending outpatient clinic appointments.

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Need High Awareness of Symptoms of Heart Attack

All About Cardiovascular System and Disorders

High degree of awareness of heart attack symptoms in the community will go a long way in seeking early treatment. For life threatening diseases like heart attack, early recognition of symptoms and prompt reporting to the emergency department is highly desirable. But a study from United States showed that 47% were not able to recognize some heart attack symptoms while 6% were not able to recognize any heart attack symptoms.

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Thoracoscopic resection of paraesophageal ectopic mediastinal parathyroid adenoma in the superior posterior mediastinum: a case report

Journal of Cardiothoracic Surgery

The ectopic superior parathyroid in the tracheoesophageal groove and paraesophageal region is rare. Hyperparathyroidism results when these glands become hyperfunctioning. That may necessitate surgical interven.

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Review of codelists used to define hypertension in electronic health records and development of a codelist for research

Open Heart

Background and aims Hypertension is a leading risk factor for cardiovascular disease. Electronic health records (EHRs) are routinely collected throughout a person’s care, recording all aspects of health status, including current and past conditions, prescriptions and test results. EHRs can be used for epidemiological research. However, there are nuances in the way conditions are recorded using clinical coding; it is important to understand the methods which have been applied to define expo

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A surgical resection case of myxoma arising from the posterior wall of the left atrium complicated with complete atrioventricular block

Journal of Cardiothoracic Surgery

An 80-year-old female was referred to our institution due to transient right upper limb weakness. Transthoracic and transesophageal echocardiography revealed a tumor in the left atrium. The tumor was attached.

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Assessment and management of asymptomatic atrial fibrillation

Heart BMJ

Atrial fibrillation (AF) is the most common sustained cardiac dysrhythmia encountered in practice. It is currently estimated that AF affects approximately 2% of the general population; however, the true prevalence of AF is likely to be at least 3%–4% when asymptomatic AF is considered. For clinically apparent AF, the investigations and management are relatively well established.

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Cardiac herniation post left upper lobectomy and thymectomy: a case report

Journal of Cardiothoracic Surgery

Cardiac herniation occurs when there is a residual pericardial defect post thoracic surgery and is recognised as a rare but fatal complication. It confers a high mortality and requires immediate surgical corre.

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Aortic valve perivascular adipose tissue computed tomography attenuation in patients with aortic stenosis

Heart BMJ

Objective Aortic stenosis (AS) shares pathophysiological similarities with atherosclerosis including active inflammation. CT attenuation of perivascular adipose tissue provides a measure of vascular inflammation that is linked to prognosis and has the potential to be applied to the aortic valve. We investigated perivascular adipose tissue attenuation around the aortic valve in patients with AS.

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Repair of a fistula between the aorta and right ventricular outflow tract secondary to infective endocarditis of a unicuspid aortic valve and previously repaired ventricular septal defect

Journal of Cardiothoracic Surgery

Infective endocarditis of the aortic valve can result in a wide range of destructive pathology beyond the valve leaflets and annulus which require careful surgical planning to provide appropriate debridement a.