Med Page Today
FEBRUARY 12, 2024
(MedPage Today) -- Blood protein profiles predicted future dementia in healthy adults, a large longitudinal study showed. Blood samples from over 50,000 people in the U.K. Biobank showed that four proteins -- glial fibrillary acidic protein.
Dr. Smith's ECG Blog
FEBRUARY 16, 2024
Written by Pendell Meyers A teenager was playing basketball when he suddenly developed palpitations and lightheadedness. He presented soon afterward at the Emergency Department with ongoing symptoms. Mentation and blood pressure were normal. He had no chest pain or shortness of breath. Heart rates on the monitor fluctuated from 180-250 bpm. Here is his triage ECG: What do you think?
Journal of Clinical Investigation - Cardiology
FEBRUARY 15, 2024
C1q/TNF-related protein 4 (CTRP4) is generally thought to be released extracellularly and plays a critical role in energy metabolism and protecting against sepsis. However, its physiological functions in autoimmune diseases have not been thoroughly explored. In this study, we demonstrate that Th17 cell–associated experimental autoimmune encephalomyelitis was greatly exacerbated in Ctrp4–/– mice compared with WT mice due to increased Th17 cell infiltration.
Medical Xpress - Cardiology
FEBRUARY 15, 2024
More than 4,500 heart transplants were performed in the U.S. in 2023. While the lifesaving operation improves the quality of life and longevity for most recipients, organ rejection remains a risk, with acute rejection occurring in up to 32% of recipients within the first year.
Cardiology Update
FEBRUARY 11, 2024
The NOTION trial, a pioneering study, sought to compare the long-term clinical and bioprosthesis outcomes of Transcatheter Aortic Valve Implantation (TAVI) versus Surgical Aortic Valve Replacement (SAVR) in patients with severe aortic valve stenosis (AS) at lower surgical risk. The study, spanning a decade, enrolled 280 patients, randomly assigned to either TAVI with the CoreValve bioprosthesis or SAVR.
Cardiovascular Diabetology
FEBRUARY 12, 2024
Gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) share many pathophysiological factors including genetics, but whether epigenetic marks are shared is unknown. We aimed to test whether a.
Journal of Clinical Investigation - Cardiology
FEBRUARY 15, 2024
Skull development coincides with the onset of cerebrospinal fluid (CSF) circulation, brain-CSF perfusion, and meningeal lymphangiogenesis, processes essential for brain waste clearance. How these processes are affected by craniofacial disorders such as craniosynostosis are poorly understood. We report that raised intracranial pressure and diminished CSF flow in craniosynostosis mouse models associate with pathological changes to meningeal lymphatic vessels that affect their sprouting, expansion,
Cardiovascular Update brings together the best content for cardiovascular medicine professionals from the widest variety of industry thought leaders.
American Heart News - Heart News
FEBRUARY 12, 2024
Embargoed until 4 a.m. CT/5 a.m. ET Monday, Feb. 12, 2024 DALLAS, Feb. 12, 2024 — Dramatic advances in the understanding and treatment of cardiovascular diseases have saved millions of lives in the 100 years since the founding in 1924 of the American.
HCPLive
FEBRUARY 15, 2024
Viral Shah, MD, of Indiana University, joins Diabetes Dialogue to discuss a recent proof-of-concept study examining use of tirzepatide in type 1 diabetes.
Journal of Clinical Investigation - Cardiology
FEBRUARY 15, 2024
Blood vessels are continually exposed to circulating lipids, and elevation of ApoB-containing lipoproteins causes atherosclerosis. Lipoprotein metabolism is highly regulated by lipolysis, largely at the level of the capillary endothelium lining metabolically active tissues. How large blood vessels, the site of atherosclerotic vascular disease, regulate the flux of fatty acids (FAs) into triglyceride-rich (TG-rich) lipid droplets (LDs) is not known.
Medical Xpress - Cardiology
FEBRUARY 16, 2024
You may be familiar with high-density, or good cholesterol; low-density lipoproteins (LDL), or bad cholesterol; and their connections to heart health. But what about triglycerides? Often that word gets skimmed over when talking about cholesterol levels.
Science Daily - Heart Disease
FEBRUARY 14, 2024
Women who have both migraines and a long-term history of hot flashes and/or night sweats have a slightly higher risk of heart disease and stroke, and young women who have migraines have a higher risk of later persistent menopause symptoms, according to two new papers based on a data from a long-term study of the same group of women from their young adult to middle-age years.
Becker's Hospital Review - Cardiology
FEBRUARY 13, 2024
For Shelley Miyamoto, MD, there were two reasons to become a cardiologist: The mentors she encountered during residency who inspired her and the physiology of the heart.
Journal of Clinical Investigation - Cardiology
FEBRUARY 15, 2024
Choline deficiency causes disorders including hepatic abnormalities and is associated with an increased risk of multiple types of cancer. Here, by choline-free diet–associated RNA-Seq analyses, we found that the tumor suppressor p53 drives the Kennedy pathway via PCYT1B to control the growth of lipid droplets (LDs) and their fueling role in tumorigenesis.
HCPLive
FEBRUARY 16, 2024
A groundbreaking phase 1 study using CAR-T cells to treat severe lupus highlights a collaborative effort between the Cellular Therapy Program and rheumatology programs to pioneer innovative patient care.
Science Daily - Heart Disease
FEBRUARY 16, 2024
The efficiency of oxygen supply to tissues is a factor in the severity of important diseases such as Covid-19 and heart conditions. Scientists already know that the relationship between the length of a person's index and ring fingers, known as the 2D:4D ratio is correlated with performance in distance running, age at heart attack and severity of Covid-19.
Becker's Hospital Review - Cardiology
FEBRUARY 15, 2024
Fortune and PINC AI named the top cardiovascular hospitals, including teaching hospitals with and without cardiovascular residency programs, and community hospitals.
Cardiovascular Diabetology
FEBRUARY 11, 2024
Heart failure (HF) is increasing at an alarming rate, primary due to the rising in aging, obesity and diabetes. Notably, individuals with type 1 diabetes (T1D) face a significantly elevated risk of HF, leading.
CardiacWire
FEBRUARY 11, 2024
The associations between obesity and hypertension are widely known, but a new JACC study reveals that weight-reducing gastric bypass surgery has a significant and lasting impact on patients’ need for antihypertensives. The GATEWAY trial assigned 100 participants (76% women, 43.8 avg. age, 36.9 BMI) to receive Roux-en-Y gastric bypass and medical therapy or only receive medical therapy, finding that after five years… Far more gastric bypass patients cut their BP medication use by at least 30% (80
HCPLive
FEBRUARY 12, 2024
Electroacupuncture demonstrates superior analgesic effects and the ability to lower serum uric acid in patients with acute gouty arthritis when compared to conventional medication options.
Journal of Clinical Investigation - Cardiology
FEBRUARY 15, 2024
Altered tryptophan catabolism has been identified in inflammatory diseases like rheumatoid arthritis (RA) and spondyloarthritis (SpA), but the causal mechanisms linking tryptophan metabolites to disease are unknown. Using the collagen-induced arthritis (CIA) model, we identified alterations in tryptophan metabolism, and specifically indole, that correlated with disease.
Science Daily - Heart Disease
FEBRUARY 14, 2024
A groundbreaking scientific study has unveiled a remarkable discovery that may have far-reaching implications for the treatment of heart disease. The implications are immense offering glimpses of a future where heart disease may no longer be an irreversible condition but a challenge that can be overcome through medical intervention. The potential for developing novel therapies that leverage the body's innate regenerative capacity holds great promise for millions of individuals affected by heart
ECG Cases
FEBRUARY 13, 2024
In this month's ECG Cases blog Dr. Jesse McLaren reviews interpretation of the pre-arrest ECG: identifying high risk ECGs requiring empiric treatment like calcium for hyperkalemia, magnesium for long QT, or reperfusion for Occlusion MI; the intra-arrest ECG: identifying pseudo-PEA; and post-arrest ECG: the importance of serial ECGs to reduce false positive STEMI, role of POCUS to help with the differential of diffuse ST depression with reciprocal ST elevation in aVR, and identifying signs of Occ
HCPLive
FEBRUARY 15, 2024
Marla Dubinsky, MD, discusses the use of off-label upadacitinib in pediatric IBD patients and the importance of this research due to delays in pediatric drug approvals.
Med Page Today
FEBRUARY 12, 2024
(MedPage Today) -- While rapid weight-loss with bariatric surgery or drugs might temporarily worsen diabetic retinopathy as blood sugar levels are rapidly corrected, the low overall risk likely doesn't outweigh the benefits of weight loss, according.
American Heart News - Heart News
FEBRUARY 12, 2024
Statement Highlights: The new scientific statement highlights heart disease as the leading cause of death for women and emerging evidence that has identified several gender-specific risk factors for heart disease in women, including complications.
Cardiovascular Diabetology
FEBRUARY 14, 2024
Angiogenin, an enzyme belonging to the ribonucleases A superfamily, plays an important role in vascular biology. Here, we sought to study the association of plasma angiogenin and major adverse cardiovascular e.
HCPLive
FEBRUARY 12, 2024
The decision makes budesonide oral suspension (Eohilia) the first and only FDA-approved oral therapy for patients ≥ 11 years of age with eosinophilic esophagitis.
Med Page Today
FEBRUARY 16, 2024
(MedPage Today) -- NATIONAL HARBOR, Md. -- Moms who had hypertensive disorders of pregnancy (HDP) or gestational diabetes mellitus (GDM) were more likely to have kids with worse cardiovascular health (CVH) in adolescence, a secondary analysis.
Medical Xpress - Cardiology
FEBRUARY 16, 2024
Having a heart attack significantly increases the risk of developing other serious long-term health conditions, a major new study shows.
Journal of Clinical Investigation - Cardiology
FEBRUARY 15, 2024
Mutations in the N-terminal WD40 domain of coatomer protein complex subunit α (COPA) cause a type I interferonopathy, typically characterized by alveolar hemorrhage, arthritis, and nephritis. We described 3 heterozygous mutations in the C-terminal domain (CTD) of COPA (p.C1013S, p.R1058C, and p.R1142X) in 6 children from 3 unrelated families with a similar syndrome of autoinflammation and autoimmunity.
HCPLive
FEBRUARY 12, 2024
HCPLive is a comprehensive clinical news and information portal that provides physicians with up-to-date specialty and disease-specific resources designed to help them provide better care to patients. At HCPLive, you will find breaking news, video interviews with physician experts, in-depth conference coverage, finance and practice management updates, insight and analysis from physician contributors, and more.
Med Page Today
FEBRUARY 13, 2024
(MedPage Today) -- I'd seen a 78-year-old in cardiac arrest before. In fact, I've resuscitated thousands, and run countless codes in 30-plus years as an emergency medicine nurse and doctor. I'm trained to take charge, make the most of staffing.
Medical Xpress - Cardiology
FEBRUARY 15, 2024
Healthy gums are imperative to a healthy mouth, but what about your cardiovascular health? In honor of Heart Month, Dr. Frank Nichols, professor of periodontics at the UConn School of Dental Medicine, unravels the underlying connection between gum health and heart health.
Journal of Clinical Investigation - Cardiology
FEBRUARY 15, 2024
Effective immunity requires a large, diverse naive T cell repertoire circulating among lymphoid organs in search of antigen. Sphingosine 1-phosphate (S1P) and its receptor S1PR1 contribute by both directing T cell migration and supporting T cell survival. Here, we addressed how S1P enables T cell survival and the implications for patients treated with S1PR1 antagonists.
HCPLive
FEBRUARY 15, 2024
This research also included results from a sub-analysis of non-responders with hand eczema to dupilumab and upadacitinib.
Med Page Today
FEBRUARY 15, 2024
(MedPage Today) -- History of migraine combined with persistent hot flashes was associated with higher risks for cardiovascular disease and stroke, according to an analysis of women in the Coronary Artery Risk Development in Young Adults (CARDIA.
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