Sat.Feb 10, 2024 - Fri.Feb 16, 2024

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Dementia Predicted 10 Years Before Diagnosis

Med Page Today

(MedPage Today) -- Blood protein profiles predicted future dementia in healthy adults, a large longitudinal study showed. Blood samples from over 50,000 people in the U.K. Biobank showed that four proteins -- glial fibrillary acidic protein.

Dementia 145
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CTRP4/interleukin-6 receptor signaling ameliorates autoimmune encephalomyelitis by suppressing Th17 cell differentiation

Journal of Clinical Investigation - Cardiology

C1q/TNF-related protein 4 (CTRP4) is generally thought to be released extracellularly and plays a critical role in energy metabolism and protecting against sepsis. However, its physiological functions in autoimmune diseases have not been thoroughly explored. In this study, we demonstrate that Th17 cell–associated experimental autoimmune encephalomyelitis was greatly exacerbated in Ctrp4–/– mice compared with WT mice due to increased Th17 cell infiltration.

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AI tools better at predicting heart transplant rejection than standard clinical method, finds study

Medical Xpress - Cardiology

More than 4,500 heart transplants were performed in the U.S. in 2023. While the lifesaving operation improves the quality of life and longevity for most recipients, organ rejection remains a risk, with acute rejection occurring in up to 32% of recipients within the first year.

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A young man with persistent palpitations

Dr. Smith's ECG Blog

Written by Pendell Meyers A teenager was playing basketball when he suddenly developed palpitations and lightheadedness. He presented soon afterward at the Emergency Department with ongoing symptoms. Mentation and blood pressure were normal. He had no chest pain or shortness of breath. Heart rates on the monitor fluctuated from 180-250 bpm. Here is his triage ECG: What do you think?

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DNA methylation risk score for type 2 diabetes is associated with gestational diabetes

Cardiovascular Diabetology

Gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) share many pathophysiological factors including genetics, but whether epigenetic marks are shared is unknown. We aimed to test whether a.

Diabetes 122
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Piezo1 agonist restores meningeal lymphatic vessels, drainage, and brain-CSF perfusion in craniosynostosis and aged mice

Journal of Clinical Investigation - Cardiology

Skull development coincides with the onset of cerebrospinal fluid (CSF) circulation, brain-CSF perfusion, and meningeal lymphangiogenesis, processes essential for brain waste clearance. How these processes are affected by craniofacial disorders such as craniosynostosis are poorly understood. We report that raised intracranial pressure and diminished CSF flow in craniosynostosis mouse models associate with pathological changes to meningeal lymphatic vessels that affect their sprouting, expansion,

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Can hydrogels help mend a broken heart?

Science Daily - Heart Disease

You can mend a broken heart this valentine s day now that researchers invented a new hydrogel that can be used to heal damaged heart tissue and improve cancer treatments.

Cancer 123

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Diabetes Dialogue: Tirzepatide in Type 1 Diabetes, with Viral Shah, MD

HCPLive

Viral Shah, MD, of Indiana University, joins Diabetes Dialogue to discuss a recent proof-of-concept study examining use of tirzepatide in type 1 diabetes.

Diabetes 125
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Dynamic metabolism of endothelial triglycerides protects against atherosclerosis in mice

Journal of Clinical Investigation - Cardiology

Blood vessels are continually exposed to circulating lipids, and elevation of ApoB-containing lipoproteins causes atherosclerosis. Lipoprotein metabolism is highly regulated by lipolysis, largely at the level of the capillary endothelium lining metabolically active tissues. How large blood vessels, the site of atherosclerotic vascular disease, regulate the flux of fatty acids (FAs) into triglyceride-rich (TG-rich) lipid droplets (LDs) is not known.

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Rapid Weight Loss a Diabetic Retinopathy Risk?

Med Page Today

(MedPage Today) -- While rapid weight-loss with bariatric surgery or drugs might temporarily worsen diabetic retinopathy as blood sugar levels are rapidly corrected, the low overall risk likely doesn't outweigh the benefits of weight loss, according.

Diabetes 117
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New study analyzes link between digit ratio and oxygen consumption in footballers

Science Daily - Heart Disease

The efficiency of oxygen supply to tissues is a factor in the severity of important diseases such as Covid-19 and heart conditions. Scientists already know that the relationship between the length of a person's index and ring fingers, known as the 2D:4D ratio is correlated with performance in distance running, age at heart attack and severity of Covid-19.

COVID-19 114
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Atlantic Health System Breaks New Ground with CAR-T Cell Therapy for Lupus Treatment

HCPLive

A groundbreaking phase 1 study using CAR-T cells to treat severe lupus highlights a collaborative effort between the Cellular Therapy Program and rheumatology programs to pioneer innovative patient care.

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p53 suppresses lipid droplet–fueled tumorigenesis through phosphatidylcholine

Journal of Clinical Investigation - Cardiology

Choline deficiency causes disorders including hepatic abnormalities and is associated with an increased risk of multiple types of cancer. Here, by choline-free diet–associated RNA-Seq analyses, we found that the tumor suppressor p53 drives the Kennedy pathway via PCYT1B to control the growth of lipid droplets (LDs) and their fueling role in tumorigenesis.

Diet 122
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Hypertension, Diabetes in Pregnancy Affects Offspring's Heart Health in Adolescence

Med Page Today

(MedPage Today) -- NATIONAL HARBOR, Md. -- Moms who had hypertensive disorders of pregnancy (HDP) or gestational diabetes mellitus (GDM) were more likely to have kids with worse cardiovascular health (CVH) in adolescence, a secondary analysis.

Diabetes 114
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Menopause and migraines: New findings point to power of prevention

Science Daily - Heart Disease

Women who have both migraines and a long-term history of hot flashes and/or night sweats have a slightly higher risk of heart disease and stroke, and young women who have migraines have a higher risk of later persistent menopause symptoms, according to two new papers based on a data from a long-term study of the same group of women from their young adult to middle-age years.

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Big systems have a responsibility to reach rural patients, pediatric heart leader says

Becker's Hospital Review - Cardiology

For Shelley Miyamoto, MD, there were two reasons to become a cardiologist: The mentors she encountered during residency who inspired her and the physiology of the heart.

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Microbiota-dependent indole production stimulates the development of collagen-induced arthritis in mice

Journal of Clinical Investigation - Cardiology

Altered tryptophan catabolism has been identified in inflammatory diseases like rheumatoid arthritis (RA) and spondyloarthritis (SpA), but the causal mechanisms linking tryptophan metabolites to disease are unknown. Using the collagen-induced arthritis (CIA) model, we identified alterations in tryptophan metabolism, and specifically indole, that correlated with disease.

Diet 111
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Hot Flashes, Migraine Tied to Higher Risk of Stroke, Heart Disease

Med Page Today

(MedPage Today) -- History of migraine combined with persistent hot flashes was associated with higher risks for cardiovascular disease and stroke, according to an analysis of women in the Coronary Artery Risk Development in Young Adults (CARDIA.

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The double burden: type 1 diabetes and heart failure—a comprehensive review

Cardiovascular Diabetology

Heart failure (HF) is increasing at an alarming rate, primary due to the rising in aging, obesity and diabetes. Notably, individuals with type 1 diabetes (T1D) face a significantly elevated risk of HF, leading.

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Top 50 cardiovascular hospitals, per Fortune, PINC

Becker's Hospital Review - Cardiology

Fortune and PINC AI named the top cardiovascular hospitals, including teaching hospitals with and without cardiovascular residency programs, and community hospitals.

Hospital 113
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Gastric Bypass Surgery’s Durable Hypertension Impact

CardiacWire

The associations between obesity and hypertension are widely known, but a new JACC study reveals that weight-reducing gastric bypass surgery has a significant and lasting impact on patients’ need for antihypertensives. The GATEWAY trial assigned 100 participants (76% women, 43.8 avg. age, 36.9 BMI) to receive Roux-en-Y gastric bypass and medical therapy or only receive medical therapy, finding that after five years… Far more gastric bypass patients cut their BP medication use by at least 30% (80

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Electroacupuncture Effectively Treats Gouty Arthritis

HCPLive

Electroacupuncture demonstrates superior analgesic effects and the ability to lower serum uric acid in patients with acute gouty arthritis when compared to conventional medication options.

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Targeting the microenvironment rather than a specific cell type could be the key to healing injured hearts

Science Daily - Heart Disease

A groundbreaking scientific study has unveiled a remarkable discovery that may have far-reaching implications for the treatment of heart disease. The implications are immense offering glimpses of a future where heart disease may no longer be an irreversible condition but a challenge that can be overcome through medical intervention. The potential for developing novel therapies that leverage the body's innate regenerative capacity holds great promise for millions of individuals affected by heart

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Heart disease risk factors in women highlight need for increased awareness, prevention

American Heart News - Heart News

Statement Highlights: The new scientific statement highlights heart disease as the leading cause of death for women and emerging evidence that has identified several gender-specific risk factors for heart disease in women, including complications.

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ECG Cases 48 – ECG Interpretation in Cardiac Arrest

ECG Cases

In this month's ECG Cases blog Dr. Jesse McLaren reviews interpretation of the pre-arrest ECG: identifying high risk ECGs requiring empiric treatment like calcium for hyperkalemia, magnesium for long QT, or reperfusion for Occlusion MI; the intra-arrest ECG: identifying pseudo-PEA; and post-arrest ECG: the importance of serial ECGs to reduce false positive STEMI, role of POCUS to help with the differential of diffuse ST depression with reciprocal ST elevation in aVR, and identifying signs of Occ

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Marla Dubinsky, MD: Using Off-Label Treatments to Address the Unmet Need in Pediatric IBD

HCPLive

Marla Dubinsky, MD, discusses the use of off-label upadacitinib in pediatric IBD patients and the importance of this research due to delays in pediatric drug approvals.

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What high triglycerides mean and why it matters to your heart

Medical Xpress - Cardiology

You may be familiar with high-density, or good cholesterol; low-density lipoproteins (LDL), or bad cholesterol; and their connections to heart health. But what about triglycerides? Often that word gets skimmed over when talking about cholesterol levels.

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RNA Silencer Zilebesiran: Infrequent Injections Bring Down BP

Med Page Today

(MedPage Today) -- In people with mild to moderate hypertension taken off antihypertensive treatment, quarterly and biannual injections of novel RNA silencer zilebesiran showed promise for safely reducing systolic blood pressure (BP), the phase.

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Association of plasma angiogenin with risk of major cardiovascular events in type 2 diabetes

Cardiovascular Diabetology

Angiogenin, an enzyme belonging to the ribonucleases A superfamily, plays an important role in vascular biology. Here, we sought to study the association of plasma angiogenin and major adverse cardiovascular e.

Diabetes 102
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FDA Approves Budesonide Oral Suspension (Eohilia) for Eosinophilic Esophagitis

HCPLive

The decision makes budesonide oral suspension (Eohilia) the first and only FDA-approved oral therapy for patients ≥ 11 years of age with eosinophilic esophagitis.

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Heterozygous mutations in the C-terminal domain of COPA underlie a complex autoin?ammatory syndrome

Journal of Clinical Investigation - Cardiology

Mutations in the N-terminal WD40 domain of coatomer protein complex subunit α (COPA) cause a type I interferonopathy, typically characterized by alveolar hemorrhage, arthritis, and nephritis. We described 3 heterozygous mutations in the C-terminal domain (CTD) of COPA (p.C1013S, p.R1058C, and p.R1142X) in 6 children from 3 unrelated families with a similar syndrome of autoinflammation and autoimmunity.

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I Never Expected to Run a Code While Running the NYC Marathon

Med Page Today

(MedPage Today) -- I'd seen a 78-year-old in cardiac arrest before. In fact, I've resuscitated thousands, and run countless codes in 30-plus years as an emergency medicine nurse and doctor. I'm trained to take charge, make the most of staffing.

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AI Measures Fat Around the Heart, a Key to Predicting Heart Attacks

DAIC

milla1cf Wed, 02/14/2024 - 18:21 February 14, 2024 — Efemoral Medical , developer of advanced interventional bioresorbable therapies, today announced that the United States Food & Drug Administration ( FDA ) has granted its novel Efemoral Vascular Scaffold System (EVSS) Breakthrough Device status for the treatment of de novo or restenotic lesions of the infrapopliteal arteries in patients with Chronic Limb Threatening Ischemia (CLTI).

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Abrocitinib Effective for Eczema Patients with Inadequate Response to Upadacitinib, Dupilumab

HCPLive

This research also included results from a sub-analysis of non-responders with hand eczema to dupilumab and upadacitinib.

Research 128
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TAVI Matches SAVR in Lower Risk Aortic Valve Patients: 10 year outcomes

Cardiology Update

The NOTION trial, a pioneering study, sought to compare the long-term clinical and bioprosthesis outcomes of Transcatheter Aortic Valve Implantation (TAVI) versus Surgical Aortic Valve Replacement (SAVR) in patients with severe aortic valve stenosis (AS) at lower surgical risk. The study, spanning a decade, enrolled 280 patients, randomly assigned to either TAVI with the CoreValve bioprosthesis or SAVR.

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Denosumab Protective Against Diabetes?

Med Page Today

(MedPage Today) -- Continued treatment with the osteoporosis drug denosumab (Prolia) was tied to a lower risk of developing diabetes in a Taiwanese cohort study. In a propensity score-matched analysis, adherence to denosumab for osteoporosis was.

Diabetes 104
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ZODIAC Clinical Trial Led by UT Health Science Center Professor Likely to Make Major Impact on Stroke Care

DAIC

Dr. Anne Alexandrov. Image courtesy of the UT Health Science Center milla1cf Thu, 02/15/2024 - 13:16 February 15, 2024 — Research findings in a clinical trial led by a professor at the University of Tennessee Health Science Center ’s College of Nursing are likely to dramatically change care and improve outcomes for patients suffering from acute stroke.

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