Journal of Clinical Investigation - Cardiology

SEPTEMBER 3, 2024

Obesity is a known driver of endometrial cancer. In this issue of the JCI, Gómez-Banoy and colleagues investigated a cohort of patients with advanced endometrial cancer treated with immune checkpoint inhibitors targeting the interaction between programmed cell death receptor-1 (PD-1) and its ligand (PD-L1).

Cancer 78

Cancer BMI Obesity Biomarkers 78

Heart BMJ

JULY 25, 2024

Background Data on the management of patients with cancer presenting with sudden cardiac arrest (SCA) are scarce. We aimed to assess the characteristics and outcomes of SCA according to cancer history. Results Out of 4069 patients who had SCA admitted alive in hospital, 207 (5.1%) had current or past medical history of cancer.

Cardiac Arrest 52

Cardiac Arrest Cancer Hospital Embolism 52

Stroke Journal

FEBRUARY 1, 2024

Introduction:Atrial fibrillation (AF) and cancer are both independently associated with worse outcomes in patients with acute ischemic stroke. Few studies have evaluated the impact of AF on outcomes of cancer-related stroke. The primary outcome was in-hospital mortality. The primary exposure was a diagnosis of AF.

Cancer 40

Cancer Atrial Fibrillation Stroke Strokes 40

DAIC

FEBRUARY 28, 2024

The findings – published this week in the Journal of the American College of Cardiology — could fuel advocacy for a paradigm shift in clinical heart health guidelines to address cardiovascular risk factors at an earlier age in childhood cancer survivors. “We Wendy Bottinor, MD.

Risk Factors 105

Risk Factors Cancer Cardio Oncology Blood Pressure 105

Medical Xpress - Cardiology

JULY 11, 2024

New research from the University of Alberta offers the hope of better long-term outcomes for survivors of childhood cancer—and the path to those better outcomes is exercise.

Cancer 40

Cancer Research Exercise Outcomes 40

Journal of Clinical Investigation - Cardiology

JULY 1, 2024

Crosstalk between different types of ubiquitination results in distinct biological outcomes for proteins. Using high-throughput sequencing, we found that ubiquitin-conjugating enzyme E2 C (UBE2C) was overexpressed in bladder cancer (BCa) and was strongly associated with an unfavorable prognosis.

Cancer 96

Cancer Outcomes 96

Journal of Cardiovascular Pharmacology

JUNE 24, 2024

Their impact on the prognostic outcomes among cancer patients has been subject to scrutiny and debate. The aim of this study is to evaluate the effect of RASi on survival in cancer patients. Their impact on the prognostic outcomes among cancer patients has been subject to scrutiny and debate.

Cancer 40

Cancer Hypertension Outcomes Article 40

Journal of Clinical Investigation - Cardiology

MARCH 1, 2024

Chemotherapy, which primarily acts on cancer cells, can influence the tumor microenvironment and the recruitment and behavior of stromal cells. explored the potent anticancer effect of the combination of a glutaminase inhibitor (CB-839) and 5-FU against PIK3CA-mutant colorectal cancer tumors. In this issue of the JCI, Li et al.

Cancer 40

Cancer Outcomes 40

Journal of the American Heart Association

JANUARY 19, 2024

BackgroundPatients with acute ischemic stroke and active cancer have more severe neurological symptoms, elevated risks of stroke recurrence, and death compared with the general population. 30.78];P<0.05).ConclusionsElevated

Cancer 40

Cancer Stroke Strokes Outcomes 40

HeartRhythm

APRIL 30, 2024

Atrial arrhythmias (AA) are common in patients with pulmonary disease and various cancers. However, the association between AA and non-small cell lung cancer (NSCLC), and the impact of AA on overall clinical outcome in patients with NSCLC are not well-known.

Cancer 40

Cancer Arrhythmia Pulmonary Outcomes 40

HeartRhythm

APRIL 30, 2024

Furthermore the outcomes among patients with known cancer is not well documented. Transvenous lead extraction (TLE) is a revered procedure among Cardiologist.

Cancer 40

Cancer Document Outcomes 40

Heart BMJ

NOVEMBER 27, 2023

The number of patients at the intersection of cancer and cardiovascular disease (CVD) is increasing, reflecting ageing global populations, rising burden of shared cardiometabolic risk factors, and improved cancer survival. Many cancer treatments carry a risk of cardiotoxicity.

Cardio Oncology 40

Cardio Oncology Cancer Cardiovascular Disease Risk Factors 40

HCPLive

JANUARY 5, 2024

Patients with lean NAFLD had fewer metabolic comorbidities but maintained similar risk of NASH, cirrhosis, nonliver cancer, and mortality compared to their overweight and obese counterparts.

BMI 105

BMI Obesity Cancer Outcomes 105

Society of Thoracic Surgeons - Surgeon

NOVEMBER 3, 2023

While both trials showed similar results, there are important differences in design, demographics, and patients’ outcomes. The presenters will debate the nuances of the trials and their potential applications in clinical practice.

Cancer 52

Cancer Webinar Biomarkers Hospital 52

ECG Cases

JULY 30, 2024

A cultural shift emphasizing the importance of compassion in patient care needs to occur to improve outcomes of our patients and our job satisfaction; as such, compassion should be part of our training and CME. The post Compassionate Care to Improve Patient Outcomes and Your Career from EMU 2024 appeared first on Emergency Medicine Cases.

CME 52

CME Outcomes Cancer Patient Care 52

Open Heart

APRIL 13, 2023

Objective Patients with cancer are at increased bleeding risk, and anticoagulants increase this risk even more. Yet, validated bleeding risk models for prediction of bleeding risk in patients with cancer are lacking. The aim of this study is to predict bleeding risk in anticoagulated patients with cancer.

Cancer 52

Cancer Outcomes 52

HCPLive

MAY 17, 2024

This analysis may help bring to light more specific skin cancer-related data on the underserved population of non-Hispanic Black, or NHB, patients.

Cancer 52

Cancer Outcomes 52

Open Heart

DECEMBER 8, 2022

Background Cancer treatment with vascular endothelial growth factor signalling pathway (VSP) inhibitors frequently causes hypertension. Objectives The study aims to clarify whether RASIs exhibit clinical benefits for patients with cancer with hypertension. to 1.06, p=0.386).

Cancer 40

Cancer Hypertension Outcomes 40

Dr. Paddy Barrett

OCTOBER 11, 2024

Obesity is the second leading cause of preventable cancers after smoking 9. Anything that reduces obesity has the potential to reduce future risks of any associated cancers. Colorectal Cancer - 46% reduction. Kidney Cancer - 24% reduction. Liver Cancer - 53% reduction. Pancreatic Cancer - 59% reduction.

Obesity 52

Obesity Cancer Dementia Coronary Artery Disease 52

DAIC

APRIL 9, 2024

Anthracyclines are a well-established class of cancer drugs that are used to treat several types of cancer. While they are effective at eradicating cancer, they are known to carry a risk of causing damage to the heart muscle. The PROACT study will continue to track outcomes in the study participants for at least 12 months.

ACE Inhibitor 105

ACE Inhibitor Cancer Biomarkers Heart Failure 105

DAIC

JANUARY 29, 2024

The researchers found that Medicare patients undergoing esophagectomy for cancer exhibit identifiable predictors for long-term survival and readmission. These findings suggest opportunities to enhance clinical practice and improve outcomes for Medicare patients undergoing esophagectomy for cancer.

Research 111

Research TAVR Aortic valve Atrial Fibrillation 111

DAIC

APRIL 30, 2024

Tricuspid Valve Repair Existing literature on national surgical outcomes of isolated tricuspid valve repair or replacement is based on data from over a decade ago and may not reflect current practice results. Outcomes were worse with increasing surgical urgency, older age, dialysis dependence, and multiple reoperations.

TAVR 111

TAVR Aortic valve Tricuspid Coronary Artery Bypass Graft 111

Journal of Clinical Investigation - Cardiology

JANUARY 16, 2024

Cancer remains a leading cause of mortality on a global scale. Lung cancer, specifically non–small cell lung cancer (NSCLC), is a prominent contributor to this burden. Although generally well tolerated, the administration of ICIs can result in unique side effects known as immune-related adverse events (irAEs).

Pulmonary 79

Pulmonary Cancer Outcomes 79

Journal of Clinical Investigation - Cardiology

JULY 15, 2024

These circadian mechanisms represent potential pathophysiological pathways linking circadian disruption to adverse metabolic health outcomes, including obesity, metabolic syndrome, and type 2 diabetes.

Diabetes 145

Diabetes Obesity Cancer Risk Factors 145

The American Journal of Cardiology

FEBRUARY 18, 2024

Publication date: Available online 17 February 2024 Source: The American Journal of Cardiology Author(s): Siddharth Agarwal, Usama Qamar, Yu Fujiwara, Avirup Guha, Abdul Rafeh Naqash, Eric H. Yang, Daniel Addison, Ana Barac, Zain Ul Abideen Asad

Cancer 52

Cancer Outcomes 52

Frontiers in Cardiovascular Medicine

OCTOBER 7, 2024

BackgroundPrimary pericardial mesothelioma (PMPM) is a rare, aggressive, and lethal form of cancer. Due to its rarity, low incidence and poor prognosis, PMPM has no accepted standard-of-care treatment options with management and outcomes often extrapolated from diffuse pleural mesothelioma.

Chest Pain 52

Chest Pain Ultrasound Cancer Outcomes 52

Stroke Journal

FEBRUARY 1, 2024

vs 63.38, p<0.001) and had fewer comorbidities such as cancer and chronic kidney disease, atrial fibrillation, hypertension, hyperlipidemia. We observed an increasing trend of ICH among pregnant individuals. Pregnant patients were notably younger (30.63 vs 16.2%, p<0.001). vs 23.2%, p<0.001).

Hemorrhage 40

Hemorrhage Outcomes Kidney Disease Atrial Fibrillation 40

Journal of Clinical Investigation - Cardiology

MAY 1, 2024

Moreover, the approach was generalizable to tumor cells with different oncogenic pathways, opening the door to precision oncology–based rationale combination therapies that have the potential to improve outcomes for patients with oncogene-driven lung cancers and likely other cancer types.

Cancer 73

Cancer Innovation Outcomes 73

Journal of Cardiothoracic Surgery

DECEMBER 7, 2023

Frailty develops as a result of age-related decline in many physiological systems and is associated with increased vulnerability to adverse outcomes following thoracic surgery. We prospectively tested our hypo.

Cancer 40

Cancer Physiology Pulmonary Outcomes 40

Journal of Cardiovascular Pharmacology

AUGUST 6, 2024

Patients undergoing anthracycline-based cancer treatments have an increased risk of heart failure (HF) and adverse metabolic outcomes such as malnutrition and cachexia. Patients undergoing anthracycline-based cancer treatments have an increased risk of heart failure (HF) and adverse metabolic outcomes such as malnutrition and cachexia.

Heart Failure 40

Heart Failure Cancer Research Outcomes 40

Frontiers in Cardiovascular Medicine

FEBRUARY 18, 2024

Introduction Immune checkpoint inhibitors have advanced the outcomes of many different types of cancer. Case report A 57-year-old woman had uneventfully received pembrolizumab for metastatic non-small cell lung cancer for over 2.5 years and was admitted after an out-of-hospital cardiac arrest due to ventricular fibrillation.

Cardiac Arrest 72

Cardiac Arrest Hospital Cancer Cardiac Function 72

Dr. Paddy Barrett

JANUARY 16, 2024

Cardiovascular disease, cancer and dementia account for 60% of all deaths in the US. Let’s start with Cancer. Compared to those who had ‘Low’ lifestyle scores, those with ‘Ideal’ scores were 27% less likely to be diagnosed with cancer in the next ten years. The leading causes of death are clear.

Cancer 75

Cancer Dementia Diabetes Cardiovascular Disease 75

Journal of Clinical Investigation - Cardiology

MAY 15, 2024

Immune checkpoint blockade (ICB) is an approach to treat inoperable, undruggable cancers like MPNST, but successful outcomes require an immune cell–rich tumor microenvironment. MPNSTs are difficult to resect and refractory to chemo- and radiotherapy, and no molecular therapies currently exist.

Cancer 64

Cancer Outcomes 64

Society of Thoracic Surgeons - Research

FEBRUARY 5, 2024

Priorities Preserve and support healthcare research funding for federal agencies : including, but not limited to, Agency for Healthcare Research and Quality (AHRQ), Patient-Centered Outcomes Research Institute (PCORI), and the National Institutes of Health (NIH).

Research 40

Research Cancer Cardiothoracic Innovation 40

Journal of Clinical Investigation - Cardiology

APRIL 1, 2024

There is unmet need for additional biomarkers to better select patients with non–small cell lung cancer (NSCLC) that are likely to benefit from immunotherapy in order to improve patient outcomes, reduce patient toxicity, and relieve the growing burden of healthcare costs.

Biomarkers 70

Biomarkers Cancer Outcomes 70

Frontiers in Cardiovascular Medicine

JUNE 25, 2024

Among the leading causes of natural death are cardiovascular diseases, cancer, and respiratory diseases. Inconclusive clinical outcomes of vitamin D supplements in cardiovascular diseases demonstrate the need to identify cause-effect relationships without bias.

Cardiovascular Disease 52

Cardiovascular Disease Genetic predisposition Pharmacology Cancer 52

Journal of the American Heart Association

JANUARY 31, 2024

Arrests involving patients <18 years, health care facility residents, patients with cancer diagnoses, and patients with select missing data were excluded. Our main outcome of interest was survival with good neurological outcome, defined as Cerebral Performance Category score 1 or 2. versus non‐OD: 23.5%,P=0.087)

Cardiac Arrest 80

Cardiac Arrest Public Health Cancer Hospital 80