American Heart News - Stroke News
FEBRUARY 1, 2024
Research Highlights: In a large population study conducted in Canada, the risk of dementia was nearly 3 times higher in the first year after a stroke, then fell to a 1.5-times increased risk by the 5-year mark and remained elevated 20 years later.
Journal of Clinical Investigation - Cardiology
FEBRUARY 1, 2024
While the poor prognosis of glioblastoma arises from the invasion of a subset of tumor cells, little is known of the metabolic alterations within these cells that fuel invasion. We integrated spatially addressable hydrogel biomaterial platforms, patient site–directed biopsies, and multiomics analyses to define metabolic drivers of invasive glioblastoma cells.
HCPLive
FEBRUARY 1, 2024
In the wake of Vera Therapeutics announcing positive 72-week data from the phase 2b ORIGIN trial, we sat down with lead investigator Richard Lafayette, MD, to learn more about how he interprets the latest data from the atacicept program in IgA nephropathy.
Journal of Clinical Investigation - Cardiology
FEBRUARY 1, 2024
Synaptic plasticity is obstructed by pathogenic tau in the brain, representing a key mechanism that underlies memory loss in Alzheimer’s disease (AD) and related tauopathies. Here, we found that reduced levels of the memory-associated protein KIdney/BRAin (KIBRA) in the brain and increased KIBRA protein levels in cerebrospinal fluid are associated with cognitive impairment and pathological tau levels in disease.
DAIC
FEBRUARY 1, 2024
Getty Images milla1cf Thu, 02/01/2024 - 17:03 February 1, 2024 — Genomics plc (Genomics), a healthcare company aiming to transform health through the power of genomics, today announced that the results of its HEART study (Healthcare Evaluation of Absolute Risk Testing) have been published in the European Journal of Preventive Cardiology. The HEART Study is the world's first clinical trial investigating the use of genomic 'polygenic risk score (PRS) testing' to support the prevention of
Journal of Clinical Investigation - Cardiology
FEBRUARY 1, 2024
This study investigates a mechanistic link of bacterial biofilm–mediated host-pathogen interaction leading to immunological complications associated with breast implant illness (BII). Over 10 million women worldwide have breast implants. In recent years, women have described a constellation of immunological symptoms believed to be related to their breast implants.
American Heart News - Stroke News
FEBRUARY 1, 2024
Research Highlights: In a study conducted in China, adults treated with 14 days of intravenous injections of ginkgo diterpene lactone meglumine (GDLM) — a combination of biologically active components of ginkgo biloba — after an ischemic (clot-caused).
Cardiovascular Update brings together the best content for cardiovascular medicine professionals from the widest variety of industry thought leaders.
American Heart News - Stroke News
FEBRUARY 1, 2024
Research Highlights: Stimulating a nerve that runs between various organs and the brain with intense physical rehabilitation improved arm and hand function in people with stroke. The improved motor function remained at the end of the one-year.
Cardiometabolic Health Congress
FEBRUARY 1, 2024
The profound link between the heart and mind has been the subject of much research for some time, with newer studies reinforcing the existing evidence as well as offering deeper insights. A large number of studies have shown that individuals coping with conditions like depression, anxiety, or stress face an elevated risk of cardiovascular problems. Past studies have often attributed this association to behavioral aspects, such as a person coping with emotional distress through smoking or drinkin
DAIC
FEBRUARY 1, 2024
It is a new year with lots of new content! Here is a look at the most-read content during the month of January on dicardiology.com. 1. A Dietary Supplement Leads to Remarkable Regression in Atherosclerotic Lesions 2. iRhythm Technologies Receives European Union’s CE Marking Under Medical Device Regulation (EU MDR) for its Zio monitor and ZEUS System 3.
Journal of Clinical Investigation - Cardiology
FEBRUARY 1, 2024
Nonalcoholic fatty liver disease (NAFLD) is prevalent in the majority of individuals with obesity, but in a subset of these individuals, it progresses to nonalcoholic steatohepatitis (0NASH) and fibrosis. The mechanisms that prevent NASH and fibrosis in the majority of patients with NAFLD remain unclear. Here, we report that NAD(P)H oxidase 4 (NOX4) and nuclear factor erythroid 2–related factor 2 (NFE2L2) were elevated in hepatocytes early in disease progression to prevent NASH and fibrosis.
American Heart News - Stroke News
FEBRUARY 1, 2024
Research Highlights: Compared with the standard medication alteplase, the newer clot-busting medication tenecteplase may offer a safe, effective and simpler way to treat clot-caused stroke in special ambulances called mobile stroke units. Tenecteplase.
DAIC
FEBRUARY 1, 2024
February 1, 2024 — As cardiologists, heart disease patients and the organizations that serve them across the country embark on American Heart Month, DAIC has compiled a snapshot of significant cardiovascular disease (CVD) and stroke statistics, along with a review of the atherosclerosis drug market. Each year, the American Heart Association (AHA) gathers a Statistical Update, described as a major source for monitoring cardiovascular health, risk factors and disease in the United States and globa
HCPLive
FEBRUARY 1, 2024
In a survey, 1 in 6 cisgender men and women reported unmet mental health needs at their latest visit with a healthcare professional. Mental health needs for other gender identities ranged from 1 in 5 and 1 in 4.
Journal of Clinical Investigation - Cardiology
FEBRUARY 1, 2024
Microscopic hemorrhage is a common aspect of cancers, yet its potential role as an independent factor influencing both cancer progression and therapeutic response is largely ignored. Recognizing the essential function of macrophages in red blood cell disposal, we explored a pathway that connects intratumoral hemorrhage with the formation of cancer-promoting tumor-associated macrophages (TAMs).
Conquering CHD
FEBRUARY 1, 2024
Today, U.S. Representatives Gus Bilirakis (R-FL) and Adam Schiff (D-CA), along with original cosponsors Representatives Tony Cardenas (D-CA), Buddy Carter (R-GA), María Elvira Salazar (R-FL), and Darren Soto (D-FL), introduced the Congenital Heart Futures Reauthorization Act of 2024 – a bipartisan bill that will authorize continued funding for congenital heart disease research and surveillance programs at the Centers for Disease Control and Prevention (CDC).
Journal of Clinical Investigation - Cardiology
FEBRUARY 1, 2024
Itaconate has emerged as a critical immunoregulatory metabolite. Here, we examined the therapeutic potential of itaconate in atherosclerosis. We found that both itaconate and the enzyme that synthesizes it, aconitate decarboxylase 1 (Acod1, also known as immune-responsive gene 1 [IRG1]), are upregulated during atherogenesis in mice. Deletion of Acod1 in myeloid cells exacerbated inflammation and atherosclerosis in vivo and resulted in an elevated frequency of a specific subset of M1-polarized pr
American Heart News - Heart News
FEBRUARY 1, 2024
Research Highlights: The risk of a heart attack among adults after a clot-caused stroke or a stroke plus a tear in the wall of a neck artery (carotid or vertebral artery dissection) was almost double within the first year compared to the heart attack.
Journal of Clinical Investigation - Cardiology
FEBRUARY 1, 2024
Pulmonary arterial hypertension (PAH) is a devastating and progressive disease with limited treatment options. Endothelial dysfunction plays a central role in the development and progression of PAH, yet the underlying mechanisms are incompletely understood. The endosome-lysosome system is important to maintain cellular health, and the small GTPase RAB7 regulates many functions of this system.
Science Daily - Heart Disease
FEBRUARY 1, 2024
Scientists have developed a new approach to machine learning -- a form of artificial intelligence -- to identify drugs that help minimize harmful scarring after a heart attack or other injuries.
Journal of Clinical Investigation - Cardiology
FEBRUARY 1, 2024
Oxygen and nutrient deprivation are common features of solid tumors. Although abnormal alternative splicing (AS) has been found to be an important driving force in tumor pathogenesis and progression, the regulatory mechanisms of AS that underly the adaptation of cancer cells to harsh microenvironments remain unclear. Here, we found that hypoxia- and nutrient deprivation–induced asparagine endopeptidase (AEP) specifically cleaved DDX3X in a HIF1A-dependent manner.
Science Daily - Heart Disease
FEBRUARY 1, 2024
Adults treated with 14 days of intravenous injections of ginkgo diterpene lactone meglumine (GDLM) -- a combination of biologically active components of ginkgo biloba -- after an ischemic (clot-caused) stroke had better cognitive recovery at 14 days and 90 days.
HCPLive
FEBRUARY 1, 2024
The Xist ribonucleoprotein (RNP) complex, linked to the XX sex chromosome complement, influences the susceptibility to autoimmunity.
American Heart News - Stroke News
FEBRUARY 1, 2024
Research Highlights: One month after hospital evaluation for stroke-like symptoms, people whose symptoms were attributed to another condition were 3 times more likely to have increased risk of post-traumatic stress disorder (PTSD) than people.
Medical Xpress - Cardiology
FEBRUARY 1, 2024
In a new study published in iScience, Mayo Clinic researchers found that a novel 4D echo imaging method that measures cardiac strain may detect subtle changes in the heart's dysfunction during acute myocarditis, a deadly heart disease.
Journal of Clinical Investigation - Cardiology
FEBRUARY 1, 2024
Pancreatic β cells are specialized for coupling glucose metabolism to insulin peptide production and secretion. Acute glucose exposure robustly and coordinately increases translation of proinsulin and proteins required for secretion of mature insulin peptide. By contrast, chronically elevated glucose levels that occur during diabetes impair β cell insulin secretion and have been shown experimentally to suppress insulin translation.
American Heart News - Stroke News
FEBRUARY 1, 2024
Research Highlights: Black women who develop high blood pressure before age 35 may have triple the odds of having a stroke, and those who develop high blood pressure before age 45 may have twice the risk of suffering a subsequent stroke.
Journal of Clinical Investigation - Cardiology
FEBRUARY 1, 2024
AIOLOS, also known as IKZF3, is a transcription factor that is highly expressed in the lymphoid lineage and is critical for lymphocyte differentiation and development. Here, we report on 9 individuals from 3 unrelated families carrying AIOLOS variants Q402* or E82K, which led to AIOLOS haploinsufficiency through different mechanisms of action. Nonsense mutant Q402* displayed abnormal DNA binding, pericentromeric targeting, posttranscriptional modification, and transcriptome regulation.
American Heart News - Stroke News
FEBRUARY 1, 2024
Research Highlights: Living in neighborhoods with more recreational and fitness centers may influence people’s engagement in physical activity during the first year after a stroke. A small study found that people in New York City who survived a mild.
Journal of Clinical Investigation - Cardiology
FEBRUARY 1, 2024
Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized by abscesses, nodules, dissecting/draining tunnels, and extensive fibrosis. Here, we integrate single-cell RNA sequencing, spatial transcriptomics, and immunostaining to provide an unprecedented view of the pathogenesis of chronic HS, characterizing the main cellular players and defining their interactions.
Medical Xpress - Cardiology
FEBRUARY 1, 2024
A team of obstetricians, gynecologists and data analysts from West Virginia University School of Medicine and the West Virginia University School of Public Health, working with colleagues from WHOOP Inc., has found evidence that wrist-based heart rate monitors could predict a premature birth.
American Heart News - Stroke News
FEBRUARY 1, 2024
Research Highlights: Stroke survivors living in areas with high levels of unemployment, low income, low education levels and poor housing quality had twice the risk of poor recovery after a stroke compared to those living in areas with better.
Medical Xpress - Cardiology
FEBRUARY 1, 2024
People with so-called stroke mimics may be even more likely to develop post-traumatic stress disorder (PTSD) than those with a confirmed stroke, according to preliminary research to be presented at the American Stroke Association's International Stroke Conference 2024. The meeting will be held in Phoenix, Feb. 7-9.
American Heart News - Stroke News
FEBRUARY 1, 2024
Research Highlights: Among most ischemic (clot-caused) stroke survivors including those taking anticoagulant medications, use of antidepressants in the SSRI or SNRI class did not increase the risk of hemorrhagic (bleeds) stroke or other serious.
Journal of Clinical Investigation - Cardiology
FEBRUARY 1, 2024
Challenging skeletal repairs are frequently seen in patients experiencing systemic inflammation. To tackle the complexity and heterogeneity of the skeletal repair process, we performed single-cell RNA sequencing and revealed that progenitor cells were one of the major lineages responsive to elevated inflammation and this response adversely affected progenitor differentiation by upregulation of Rbpjk in fracture nonunion.
Stroke Journal
FEBRUARY 1, 2024
Stroke, Ahead of Print. Cervical artery dissection is an important cause of stroke, particularly in young adults. Data conflict on the diagnostic evaluation and treatment of patients with suspected cervical artery dissection, leading to variability in practice. We aim to provide an overview of cervical artery dissection in the setting of minor or no reported mechanical trigger with a focus on summarizing the available evidence and providing suggestions on the diagnostic evaluation, treatment app
Journal of Clinical Investigation - Cardiology
FEBRUARY 1, 2024
Alcohol-associated liver disease (ALD) is a major cause of chronic liver disease worldwide, and comprises a spectrum of several different disorders, including simple steatosis, steatohepatitis, cirrhosis, and superimposed hepatocellular carcinoma. Although tremendous progress has been made in the field of ALD over the last 20 years, the pathogenesis of ALD remains obscure, and there are currently no FDA-approved drugs for the treatment of ALD.
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