Medical Xpress - Cardiology

NOVEMBER 18, 2024

Polygenic risk scores (PRSs) are a cutting-edge tool in genetics, combining information from genetic markers across the genome to estimate a person's risk of developing certain diseases, such as coronary artery disease (CAD).

Genetic Markers 47

Genetic Markers Genetic predisposition Heart Disease Coronary Artery Disease 47

American College of Cardiology

MAY 6, 2024

What is the prevalence, what is the genetic predisposition, and what are the clinical consequences of reduced left (LVEF) and/or right ventricular ejection fraction (RVEF) among endurance athletes?

Genetic predisposition 64

Genetic predisposition Article 64

HeartRhythm

APRIL 30, 2024

Atrial fibrillation is the most prevalent sustained cardiac arrhythmia and an important risk factor for ischemic stroke resulting in a fivefold increased stroke risk. The clinical utility of polygenic risk scores for ischemic stroke prediction among atrial fibrillation patients has not yet been established.

Atrial Fibrillation 40

Atrial Fibrillation Genetic predisposition Stroke Strokes 40

HeartRhythm

NOVEMBER 5, 2024

Data pertaining to the American Heart Association Life’s Simple 7 (LS7) health metrics show that Black Americans have suboptimal LS7 scores compared to White Americans on average despite lower genetic predisposition to AF.

Atrial Fibrillation 40

Atrial Fibrillation Risk Factors Genetic predisposition Outcomes 40

HeartRhythm

APRIL 30, 2024

Genetic predisposition to ventricular scarring is associated with heart failure and ventricular arrhythmia. Although many pathogenic variants have been shown to predispose patients to poor outcomes, the impact of many VUS remains uncharacterized.

Genetic predisposition 40

Genetic predisposition Heart Failure Arrhythmia Cardiomyopathy 40

HeartRhythm

APRIL 30, 2024

Genetic predisposition to septal scarring can result in ventricular arrhythmia and poorer ablation outcomes. There is a need to better define these genetic variants to understand clinical implications. Many commonly occurring variants continue to be described as variants of uncertain significance (VUS).

Genetic predisposition 40

Genetic predisposition Ablation Arrhythmia Outcomes 40

Physiologically Speaking

NOVEMBER 22, 2024

dementia and Alzheimer’s) can be assessed using polygenic risk scores, which aggregate the effects of numerous genetic variants to estimate genetic predisposition. Offsetting a high genetic predisposition might require a bit more focus and attention to optimizing your cardiorespiratory fitness.

Physiology 108

Physiology Dementia Genetic predisposition Exercise 108

Frontiers in Cardiovascular Medicine

JUNE 25, 2024

Factors causing illness include genetic predisposition, aging, stress, chronic inflammation, environmental factors, declining autophagy, and endocrine abnormalities including insufficient vitamin D levels. Among the leading causes of natural death are cardiovascular diseases, cancer, and respiratory diseases.

Cardiovascular Disease 52

Cardiovascular Disease Genetic predisposition Pharmacology Cancer 52

Frontiers in Cardiovascular Medicine

APRIL 29, 2024

mediation effect.DiscussionThe results underscore the genetic predisposition of ICP to elevate CVD risk and the critical mediating role of lipid levels, emphasizing the need for vigilant lipid monitoring and early intervention in individuals with ICP.

Cardiovascular Disease 52

Cardiovascular Disease Genetic predisposition Coronary Artery Disease Hypertension 52

Circulation

NOVEMBER 11, 2024

The SRPS is hypothesised to facilitate early detection and inform targeted interventions.Aim:The primary aim is to conceptualise and outline the SRPS, which categorises individuals into risk categories based on a point system reflecting genetic predispositions, clinical symptoms, dietary habits, and response to treatments.

Genetic predisposition 40

Genetic predisposition Lipid disorders Innovation Risk Factors 40

AMS Cardiology

OCTOBER 11, 2023

While lifestyle factors such as diet, exercise and smoking play a significant role in the development of heart disease, genetics also contribute substantially. Genetic Predisposition Genetic predisposition to heart disease is a reality for many individuals.

Heart Disease 52

Heart Disease Genetic predisposition Diet Genetic Markers 52

Stroke Journal

FEBRUARY 1, 2024

Cervical artery dissection occurs as a result of the interplay among risk factors, minor trauma, anatomic and congenital abnormalities, and genetic predisposition. The writing group chair and vice chair compiled the manuscript and obtained writing group members’ approval.

Genetic predisposition 75

Genetic predisposition Outcomes Thrombolysis Congenital 75

Heart BMJ

APRIL 15, 2024

Background The relationship between combined genetic predisposition and lifestyle and the risk of incident atrial fibrillation (AF) is unclear. Therefore, we aimed to assess a possible interaction between lifestyle and genetics on AF risk.

Atrial Fibrillation 52

Atrial Fibrillation Genetic predisposition Risk Factors Diet 52

Circulation

FEBRUARY 22, 2024

It also includes an updated algorithm for referral, evaluation, and management of individuals at high risk.

Congenital Heart Disease 75

Congenital Heart Disease Congenital Heart Disease Genetic predisposition 75

Frontiers in Cardiovascular Medicine

FEBRUARY 14, 2024

Results Our study identified a genetic predisposition associated with an additional 3.6 Causality was assessed using the inverse-variance weighted (IVW), ME-Egger regression, and weighted median methods. Sensitivity analyses, including heterogeneity and pleiotropy tests, were conducted to ensure the robustness of our findings.

Education 64

Education Cardiovascular Disease Peripheral Arterial Disease Genetic predisposition 64

Circulation: Arrhythmia and Electrophysiology

MARCH 5, 2024

The highest HRs (95% CIs) of AF were observed for participants at high genetic risk who consumed >2 L/wk of ASB (HR, 3.51 [95% CI, 2.94–4.19]), 4.19]), and the lowest HR were observed for those at low genetic risk who consumed ≤1 L/wk of PJ (HR, 0.77 [95% CI, 0.65–0.92]).

Atrial Fibrillation 40

Atrial Fibrillation Genetic predisposition Electrophysiology Diet 40

Stroke Journal

FEBRUARY 1, 2024

Background:Diabetes is a highly heritable stroke risk factor with numerous known genetic risk variants. However, the role of these genetic risk variants in the development of cerebrovascular disease in Native Hawaiians remains unknown. Genetic predisposition to diabetes was associated with a 23% higher risk of diabetes (OR 1.23, CI 1.01-1.51;

Genetic predisposition 40

Genetic predisposition Diabetes Stroke Strokes 40

Physiologically Speaking

DECEMBER 2, 2024

This study examined the relationship between cardiorespiratory fitness and the risk of developing neurodegenerative diseases, such as dementia and Alzheimer’s, particularly in individuals with a high genetic predisposition.

Physiology 57

Physiology Exercise Dementia Genetic predisposition 57

Wellnest

AUGUST 24, 2023

By adopting a heart-healthy diet, engaging in regular physical activity, managing stress, avoiding smoking, and controlling blood pressure and cholesterol levels, we can mitigate genetic predispositions' impact and reduce our overall risk of cardiovascular disease. Myth #3: Heart diseases only affect men.

Heart Disease 52

Heart Disease Blood Pressure Cholesterol Genetic predisposition 52

Dr. Paddy Barrett

APRIL 26, 2024

Yes, there is a genetic predisposition at play. But I am saying that even if you have developed type 2 diabetes, which is a major driver of risk, there is still a huge amount that can be done to reduce future risk. But why wait? For sure. ( I know because I have some of those genes ). They set the odds.

Heart Disease 93

Heart Disease Coronary Artery Disease Diabetes Genetic predisposition 93

GEMMS

SEPTEMBER 27, 2024

Personalized treatment plans consider genetic predispositions, lifestyle, and comorbidities, ensuring that each patient receives the most effective care. The Need for Personalization in Cardiology Cardiovascular health is inherently complex, with conditions ranging from hypertension to heart failure requiring specific treatment plans.

Technology 52

Technology Genetic predisposition Patient Care Education 52

Circulation

DECEMBER 17, 2023

The aim is to assess the prevalence, clinical consequences, and genetic predisposition of reduced EF in athletes.METHODS:Young endurance athletes were recruited from elite training programs and underwent cardiac phenotyping, genetic analyses and clinical events were recorded over a mean of 4.4

Genetic predisposition 77

Genetic predisposition Cardiomyopathy Sudden Cardiac Death Heart Failure 77

Stroke Journal

FEBRUARY 1, 2024

We used multivariate logistic and Cox Proportional Hazards regressions, as appropriate, to assess the relationship between genetic predisposition to hypertension and both uncontrolled BP and incident stroke.Results:The discovery stage included 110,892 participants (mean age 58, female sex 58%). 1.18) and 30% (OR 1.30, 95%CI 1.24-1.36)

Blood Pressure 40

Blood Pressure Genetic predisposition Stroke Strokes 40

Frontiers in Cardiovascular Medicine

DECEMBER 18, 2023

In recent years, the genetic predisposition for SCAD is also recognized as a predisposing factor. The precipitating factors are also different in women (emotional stress) compared with those in men (physical stress).

SCAD 88

SCAD Genetic predisposition Risk Factors Chest Pain 88