July, 2024

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ECG Blog #437 — A 2-Part Answer.

Ken Grauer, MD

I was sent the ECG in Figure-1 — but without the benefit of any history. QUESTIONS: How would YOU interpret this tracing? WHY do I say there is, "A 2-Part Answer?" Figure-1: The initial ECG in today's case. ( To improve visualization — I've digitized the original ECG using PMcardio ). MY Thoughts on Today's CASE: As important as providing a brief, relevant history is for optimal clinical ECG interpretation — Cases like the one today often prove even more educational, because we are not given any

Blog 143
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Data-independent LC-MS/MS analysis of ME/CFS plasma reveals a dysregulated coagulation system, endothelial dysfunction, downregulation of complement machinery

Cardiovascular Diabetology

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic condition that is characterized by unresolved fatigue, post-exertion symptom exacerbation (PESE), cognitive dysfunction, or.

Research 145
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COVID May Affect Type 1 Diabetes in Kids, and Not in a Good Way

Med Page Today

(MedPage Today) -- COVID-19 may accelerate progression of presymptomatic type 1 diabetes in youth, a German study suggested. Incidence of clinical type 1 diabetes nearly doubled after the pandemic started among 591 youth ages 1 to 16 known to.

COVID-19 145
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Study identifies 18 proteins linked to heart failure, frailty

Medical Xpress - Cardiology

An analysis of blood samples from thousands of study participants, led by researchers at UT Southwestern Medical Center, revealed 18 proteins associated with both heart failure and frailty, conditions that commonly develop in late life. Their findings, published in JAMA Cardiology, could lead to new strategies to jointly predict risk, administer preventive approaches, or treat these conditions, which often occur together.

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White adipocytes in subcutaneous fat depots require KLF15 for maintenance in preclinical models

Journal of Clinical Investigation - Cardiology

Healthy adipose tissue is essential for normal physiology. There are 2 broad types of adipose tissue depots: brown adipose tissue (BAT), which contains adipocytes poised to burn energy through thermogenesis, and white adipose tissue (WAT), which contains adipocytes that store lipids. However, within those types of adipose, adipocytes possess depot and cell-specific properties that have important implications.

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Survey Details General Public's Eroding Trust Level with Healthcare After COVID-19

HCPLive

Trust in physicians and hospitals dropped from over 70% in 2020 to under 50% in 2024, with declines seen across all demographics, a new survey shows.

COVID-19 140
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New research explores alcohol’s impact on the heart

American Heart News - Heart News

Research Highlights: Two new, basic research studies in rodents (mice and rats) analyzed the impacts that alcohol may have on the heart. In a mouse study, abnormal heart rhythms that can occur after a pattern of repeated simulation of binge drinking.

Research 121

More Trending

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New Alzheimer's Mimic Identified

Med Page Today

(MedPage Today) -- A new memory-loss syndrome that mimics the clinical features of Alzheimer's disease was identified, researchers said. "We propose a set of clinical criteria for a limbic-predominant amnestic neurodegenerative syndrome [LANS.

Research 138
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Study discovers connection between between heart and brain in KBG syndrome

Medical Xpress - Cardiology

A new study sheds light on a medical question scientists have long wondered: why do 40% of children with the rare neurodevelopmental disorder KBG syndrome have heart defects? The research now points to a critical link between the heart and the brain. The research is published in the journal Nature Communications.

Research 132
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Early surgery to prevent embolic events in patients with infective endocarditis: a comprehensive review

Journal of Cardiothoracic Surgery

Infective endocarditis (IE) is a dangerous and lethal illness with high mortality rates. One of the main indications for surgery according to the guidelines is prevention of embolic events. However, uncertaint.

Embolism 119
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Top Gene Therapy News at ASRS 2024

HCPLive

A recap of the 5 most popular topics related to gene therapy in ophthalmology coming from the 42nd American Society of Retina Specialists meeting.

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Consequences of ionizing radiation exposure to the cardiovascular system

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 10 July 2024; doi:10.1038/s41569-024-01056-4 In this Review, Wu and co-workers describe the consequences of radiation exposure on the cardiovascular system, drawing insights from individuals exposed to whole-body radiation (including nuclear and medical workers) and from patients with cancer undergoing radiation therapy.

Cancer 116
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Rapid and Accurate Prediction Model for Cardiac Arrest Treatment

DAIC

R-EDByUS score features variables using only prehospital resuscitation data. Image courtesy of Takenobu Shimada, Osaka Metropolitan University (CC BY 4.0, [link] mtaschetta-millane Mon, 07/29/2024 - 09:09 July 29, 2024 — When it comes to treating cardiac arrest, acting quickly can mean the difference between life and death. Researchers from Osaka Metropolitan University have developed a new scoring model, using only prehospital resuscitation data, that accurately predicts neurological outcomes o

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Persistent Anxiety Tied to Future Dementia

Med Page Today

(MedPage Today) -- Persistent anxiety raised the risk of all-cause dementia in older adults, a longitudinal study showed. Both chronic anxiety (HR 2.80, 95% CI 1.35-5.72, P=0.01) and new-onset anxiety (HR 3.20, 95% CI 1.40-7.45, P=0.01) were tied.

Dementia 137
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Why skipping breakfast can be bad for your heart

Medical Xpress - Cardiology

Some say that breakfast is the most important meal of the day. Is it really? That's up for debate. However, skipping the first meal is not the healthiest choice and can even put someone at risk for health issues. In this Mayo Clinic Minute, Dr. Francisco Lopez-Jimenez, a Mayo Clinic cardiologist, explains why.

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The Case for Keto for Type 1 Diabetes with Andrew Koutnik, Ph.D.

Physiologically Speaking

Greetings! Today’s interview is with Andrew Koutnik, Ph.D. Andrew is a research scientist at Sansum Diabetes Research Institute, where he’s investigating metabolic therapies for health and disease. His mission is to optimize metabolic health and patient outcomes for people living with type 1 diabetes. Andrew is unique because he himself has type 1 diabetes.

Diabetes 113
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30-year risk of cardiovascular disease may help inform blood pressure treatment decisions

Science Daily - Heart Disease

According to a new study, both 30-year risk for cardiovascular disease in addition to 10-year risk may be considered in making decisions about when to initiate high blood pressure medication.

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Vaping Low Nicotine (<5%) Linked to Acute Compensatory Puffing

HCPLive

A new study found using e-cigarettes with partial nicotine reduction was linked to greater puffing time, puff duration, and total inhaled volume than 5% nicotine concentration.

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University Hospitals Researcher Develops New Score System to Better Screen and Treat HFpEF Heart Failure Patients

DAIC

mtaschetta-millane Wed, 07/31/2024 - 06:00 July 31, 2024 — A novel study co-authored by a heart failure cardiologist at University Hospitals Harrington Heart & Vascular Institute, demonstrates the effectiveness of a newly developed scoring system in identifying patients with Heart Failure with Preserved Ejection Fraction (HFpEF). The study, “ An Evidence-Based Screening Tool for Heart Failure with Preserved Ejection Fraction: The HFpEF-ABA Score ," was published in the July 12 issue of Natur

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Dementia Risk Drops With Shingrix Vaccine

Med Page Today

(MedPage Today) -- The recombinant shingles vaccine (Shingrix) was associated with a larger reduction in dementia than the live shingles vaccine (Zostavax), an analysis of more than 200,000 U.S. older adults showed. Over a 6-year follow-up period.

Dementia 133
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AI speeds up heart scans, saves time, and could lead to better treatment for heart conditions

Medical Xpress - Cardiology

Researchers have developed a method for analyzing heart MRI scans with the help of artificial intelligence, which could save valuable NHS time and resources, as well as improve care for patients.

Research 115
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The potential anti-arrhythmic effect of SGLT2 inhibitors

Cardiovascular Diabetology

Sodium-glucose cotransporter type 2 inhibitors (SGLT2i) were initially recommended as oral anti-diabetic drugs to treat type 2 diabetes (T2D), by inhibiting SGLT2 in proximal tubule and reduce renal reabsorpti.

Diabetes 111
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Artificial intelligence speeds up heart scans, saving doctors' time, and could lead to better treatment for heart conditions

Science Daily - Heart Disease

Researchers have developed a groundbreaking method for analysing heart MRI scans with the help of artificial intelligence, which could save valuable time and resources, as well as improve care for patients.

Research 112
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Empowering Patients with Educational Resources for Kidney Disease, with Mike Spigler

HCPLive

Spigler provides insight into the development of new patient-focused guidelines for managing hyperkalemia in CKD and the importance of providing patients with such resources.

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Kidney Dysfunction May Predict Sudden Cardiac Death in Patients with Heart Failure

DAIC

This study by Fujita Health University researchers revealed that kidney function, considered in terms of estimated glomerular filtration rate (eGFR), can be used as a predictor for SCD in patients with congestive heart failure. Image courtesy of Yoshihiro Sobue from Fujita Health University mtaschetta-millane Tue, 07/30/2024 - 09:18 July 30, 2024 — Patients with congestive heart failure (CHF) having a compromised blood supply, are at greater risk of sudden cardiac death (SCD).

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Semaglutide May Be Linked to Condition That Causes Blindness

Med Page Today

(MedPage Today) -- Use of the GLP-1 receptor agonist semaglutide (Ozempic, Wegovy) may be linked with an increased risk of the second most common form of optic neuropathy, a retrospective study suggested. Over a mean follow-up of nearly 3 years.

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Mediterranean diet linked to lower risk of mortality, especially from cardiovascular disease, in cancer survivors

Medical Xpress - Cardiology

The Mediterranean diet is a powerful ally for health even after a cancer diagnosis. This is the key result of an Italian study carried out as part of the UMBERTO Project, conducted by the Joint Research Platform Umberto Veronesi Foundation—Department of Epidemiology and Prevention of the I.R.C.C.S. Neuromed of Pozzilli, in collaboration with the LUM "Giuseppe Degennaro" University of Casamassima (BA).

Diet 116
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Two researchers to receive first-ever Ralph L. Sacco Scholarships for Brain Health

American Heart News - Stroke News

DALLAS and MINNEAPOLIS, July 2, 2024 — The American Academy of Neurology and the American Heart Association have awarded the first-ever Ralph L. Sacco Scholarships for Brain Health to two researchers, Patrick Devlin, Ph.D., of Houston, Texas, and Cyprien.

Research 111
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Stroke recovery: It's in the genes

Science Daily - Stroke

New research has found that specific genes may be related to the trajectory of recovery for stroke survivors, providing doctors insights useful for developing targeted therapies.

Stroke 107
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People Aged > 30 Years Report Inadequate Knowledge Towards Gouty Arthritis

HCPLive

Although half of participants strongly agreed that gouty arthritis is painful and can cause anxiety, only 15.28% agreed on the importance of dietary intake as a means for prevention.

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Patient Enrollment Commenced in Pivotal Phase 3 Trial of CardiAMP Cell Therapy for the Treatment of Ischemic Heart Failure

DAIC

mtaschetta-millane Thu, 07/25/2024 - 09:08 July 25, 2024 — BioCardia, Inc. , a global leader in cellular and cell-derived therapeutics for the treatment of cardiovascular and pulmonary diseases, announced today that the confirmatory Phase 3 trial of its autologous CardiAMP cell therapy product candidate for patients with ischemic heart failure of reduced ejection fraction (HFrEF) has commenced enrollment in the United States.

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Mediterranean Diet Good for Kids, Teens Too

Med Page Today

(MedPage Today) -- The Mediterranean diet improved cardiometabolic health among kids and teens, a meta-analysis of randomized clinical trials affirmed. Interventions following the diet's characteristic emphasis on fruit, vegetables, olive oil.

Diet 131
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Researcher develops new score system to better screen and treat HFpEF heart failure patients

Medical Xpress - Cardiology

A novel study co-authored by a heart failure cardiologist at University Hospitals Harrington Heart & Vascular Institute demonstrates the effectiveness of a newly developed scoring system in identifying patients with Heart Failure with Preserved Ejection Fraction (HFpEF). The study, titled "An Evidence-Based Screening Tool for Heart Failure with Preserved Ejection Fraction: The HFpEF-ABA Score," was published in Nature Medicine.

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Baylor St. Luke’s Settles Concurrent Cardiac Surgery Case

CardiacWire

Cardiac surgeon compensation is generally a numbers game – the more procedures you do, the more you make. However, a Medicare fraud settlement featuring some of Houston’s most prominent institutions and cardiac surgeons reveals the pitfalls of this incentive structure. Allegations claim that between 2013 to 2020 three decorated Baylor St. Luke’s heart surgeons regularly operated in two to three rooms simultaneously, while “delegating key aspects of extremely complicated and risky heart sur

Medicare 109
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What are treatment options for this rhythm, when all else fails?

Dr. Smith's ECG Blog

Written By Magnus Nossen — with edits by Ken Grauer and Smith. The patient in today’s case is a previously healthy 40-something male who contacted EMS due to acute onset crushing chest pain. The pain was 10/10 in intensity radiating bilaterally to the shoulders and also to the left arm and neck. The below ECG was recorded. The ECG shows obvious STEMI(+) OMI due to probable proximal LAD occlusion.

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FDA Accepts sNDA for Furosemide (Furoscix) in Chronic Kidney Disease

HCPLive

The sNDA for furosemide seeks to expand the indication to include the treatment of edema due to fluid overload in patients with CKD, with a PDUFA date of March 6, 2025.

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Study Calls for Targeted Strategies for Managing Diabetic Cardiomyopathy Across Racial, Ethnic Groups

DAIC

Findings from an observational analysis of ARISE-HF trial participants, newly-published in the Journal of the American College of Cardiology, JACC, shed light on the racial and ethnic disparities in diabetic cardiomyopathy (DbCM), which researchers note may have the potential to inform clinical practice, interventions, and policies. Image courtesy: Getty Images christine.book Wed, 07/10/2024 - 12:02 July 10, 2024 — Findings from an observational analysis of ARISE-HF trial participants, newly-pub