Mon.Apr 01, 2024

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5 Dead and Over 100 Hospitalized From Recalled Japanese Health Supplements

Med Page Today

(MedPage Today) -- TOKYO (AP) -- Five people who took a Japanese health supplement have died and more than 100 have been hospitalized as of Friday, a week after a pharmaceutical company issued a recall of the products, officials said. Osaka.

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COPD, IPF Linked to More Severe COVID-19 Outcomes, Mortality Risk

HCPLive

New data show COPD and IPF, among other interstitial lung diseases, are more significantly associated with poor 30-day outcomes from COVID-19 than asthma.

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New Technology Promises to Revolutionize Valvular Heart Disease Care

DAIC

Getty Images milla1cf Mon, 04/01/2024 - 08:21 April 1, 2024 — Roughly 25,000 Americans die each year from valvular heart disease, but researchers from Rutgers Health and other institutions conclude that new technology could soon help doctors slash that number. “We are witnessing a paradigm shift in how valvular heart diseases are diagnosed and treated,” said Partho Sengupta , Henry Rutgers Professor of Cardiology and chief of the Division of Cardiovascular Disease and Hypertension at Rutgers Ro

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Virtual Reality Protocol Improves Fibromyalgia Symptoms

HCPLive

Results offer important guidance for healthcare providers to develop tailored treatment strategies that align with the unique needs and preferences of individual patients.

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New gene discovery leads advance against a form of heart failure prevalent in men

Medical Xpress - Cardiology

University of Virginia School of Medicine researchers have discovered a gene on the Y chromosome that contributes to the greater incidence of heart failure in men. The work is published in the journal Nature Cardiovascular Research.

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Isolated Tricuspid Valve Surgery Risk Calculator

Society of Thoracic Surgeons - Congenital

Resource Isolated Tricuspid Valve Surgery Risk Calculator kchalko Mon, 04/01/2024 - 13:31 Isolated Tricuspid Valve Surgery Risk Calculator Existing literature on national surgical outcomes of isolated tricuspid valve repair or replacement is based on data from over a decade ago and may not reflect current practice results. Real-world contemporary data from the STS Adult Cardiac Surgery Database demonstrate increased overall volumes compared to prior years, and improved outcomes for both isolated

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mTORC1 controls murine postprandial hepatic glycogen synthesis via Ppp1r3b

Journal of Clinical Investigation - Cardiology

In response to a meal, insulin drives hepatic glycogen synthesis to help regulate systemic glucose homeostasis. The mechanistic target of rapamycin complex 1 (mTORC1) is a well-established insulin target and contributes to the postprandial control of liver lipid metabolism, autophagy, and protein synthesis. However, its role in hepatic glucose metabolism is less understood.

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Increasing histone acetylation improves sociability and restores learning and memory in KAT6B-haploinsufficient mice

Journal of Clinical Investigation - Cardiology

Mutations in genes encoding chromatin modifiers are enriched among mutations causing intellectual disability. The continuing development of the brain postnatally, coupled with the inherent reversibility of chromatin modifications, may afford an opportunity for therapeutic intervention following a genetic diagnosis. Development of treatments requires an understanding of protein function and models of the disease.

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Little guidance exists for treating inpatients with asymptomatic high blood pressure, review finds

Medical Xpress - Cardiology

A systematic review of 14 clinical practice guidelines found that guidance on inpatient management of elevated blood pressure (BP) without symptoms is lacking. According to the authors, this lack of guidance may contribute to variable practice patterns. The review is published in Annals of Internal Medicine.

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The integrated stress response pathway and neuromodulator signaling in the brain: lessons learned from dystonia

Journal of Clinical Investigation - Cardiology

The integrated stress response (ISR) is a highly conserved biochemical pathway involved in maintaining proteostasis and cell health in the face of diverse stressors. In this Review, we discuss a relatively noncanonical role for the ISR in neuromodulatory neurons and its implications for synaptic plasticity, learning, and memory. Beyond its roles in stress response, the ISR has been extensively studied in the brain, where it potently influences learning and memory, and in the process of synaptic

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The neutrophil-to-lymphocyte ratio is associated with all-cause and cardiovascular mortality among individuals with hypertension

Cardiovascular Diabetology

Identifying reliable prognostic markers is crucial for the effective management of hypertension. The neutrophil-to-lymphocyte ratio (NLR) has emerged as a potential inflammatory marker linked to cardiovascular.

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Small extracellular vesicles from the infarcted heart can promote tumour growth

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 02 April 2024; doi:10.1038/s41569-024-01022-0 After myocardial infarction, the heart secretes small extracellular vesicles with pro-neoplastic properties that can accelerate tumour growth when taken up by cancer cells.

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New advance against a form of heart failure prevalent in men

Science Daily - Heart Disease

Researchers have discovered a gene on the Y chromosome that contributes to the greater incidence of heart failure in men, opening the door to new treatments.

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Take steps towards a longer, healthier life on National Walking Day

Medical Xpress - Cardiology

Physical activity is one of the best ways to improve overall health and manage stress. Unfortunately, 1 in 4 adults in the U.S. are sedentary for more than eight hours each day, according to the U.S. Centers for Disease Control & Prevention (CDC). This can have negative consequences on physical and mental health. The American Heart Association established National Walking Day in 2007.

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Los Rams de la NFL continúan apoyando a la cadena de supervivencia en Los Angeles

American Heart News - Heart News

Dallas, 1 de abril de 2024 - La American Heart Association (la Asociación Americana del Corazón) y Los Angeles Rams brindaron educación que salva vidas a 200 jóvenes futbolistas, entrenadores y educadores en un evento de entrenamiento sobre reanimación.

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Exploring the Inclusion of Person-Centered Care Domains in Stroke Transitions of Care Interventions: A Scientific Statement From the American Heart Association

Stroke Journal

Stroke, Ahead of Print. BACKGROUND:Health care teams along the stroke recovery continuum have a responsibility to support care transitions and return to the community. Ideally, individualized care will consider patient and family preferences, best available evidence, and health care professional input. Person-centered care can improve patient-practitioner interactions through shared decision-making in which health professionals and institutions are sensitive to those for whom they provide care.

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Scientific researchers: Win up to $20K studying effectiveness of cardiovascular, stroke research funding

American Heart News - Stroke News

DALLAS, April 1, 2024 — The Global Cardiovascular Research Funders Forum invite scientific researchers to compete in a new data challenge, hosted on the American Heart Association’s Precision Medicine Platform. The challenge is designed to better.

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Dermatology Month in Review: March 2024

HCPLive

In this review of the top stories in dermatology in March, several were highlighted such as the recent report on benzene in skincare products and the FDA’s approval of spesolimab for generalized pustular psoriasis.

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Researchers find heart patients live longer in a 'greener' environment

Medical Xpress - Cardiology

In a long-term study published in the journal Epidemiology, researchers from Tel Aviv University (TAU) examined the association between a greener environment, which is most likely saturated with vegetation, and the mortality rate of coronary heart patients after undergoing bypass surgery—which is considered a traumatic event from both the physical and mental aspects.

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SZN-043 Demonstrates Safety, Pharmacodynamic Effect for Cirrhosis in Phase 1a Trial

HCPLive

SZN-043 showed evidence of target engagement, Wnt signal activation, and effects on liver function, supporting its advancement to a phase 1b trial in severe alcohol-associated hepatitis.

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The NFL’s Rams continue support of the chain of survival in Los Angeles

American Heart News - Heart News

DALLAS, April 1, 2024 — The American Heart Association and the Los Angeles Rams brought lifesaving education to 200 youth football participants, coaches and educators at a cardiopulmonary resuscitation (CPR) and automated external defibrillator (AED).

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The Expert's Approach to Managing Cardiovascular Risk Among Athletes Using Anabolic-Androgenic Steroids

American College of Cardiology

The use of anabolic-androgenic steroids (AAS) has become widespread, with an estimated tens of millions of people worldwide using these drugs.

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Bitopertin Meets Primary Phase 2 Endpoint in Erythropoietic Protoporphyria

HCPLive

Topline results from AURORA indicate that while bitopertin significantly reduced PPIX levels, improvements in light tolerance were not statistically significant.

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Stratifying Disease Progression in Cardiac ATTR Amyloidosis

American College of Cardiology

What is the prognostic importance of an increase in N-terminal pro–B-type natriuretic peptide (NT-proBNP) and outpatient diuretic intensification (ODI) as markers of disease progression in a cohort of patients with transthyretin cardiac amyloidosis (ATTR-CA)?

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Investigadores científicos: Ganen hasta $20,000 estudiando la eficacia del financiamiento de la investigación de ataques o derrames cerebrales y enfermedades cardiovasculares

American Heart News - Stroke News

DALLAS, 1er avril 2024 — Le Global Cardiovascular Research Funders Forum invite les chercheurs à participer à un nouveau défi d’analyse de données, sur la Precision Medicine Platform de l’American Heart Association (Association américaine du cœur). Ce.

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Soluble immune-checkpoint factors: a potential immunotherapy biomarker

Journal of Clinical Investigation - Cardiology

There is unmet need for additional biomarkers to better select patients with non–small cell lung cancer (NSCLC) that are likely to benefit from immunotherapy in order to improve patient outcomes, reduce patient toxicity, and relieve the growing burden of healthcare costs. In this issue of the JCI, Hayashi and colleagues evaluated soluble forms of the immune checkpoint molecules PD-L1, PD-1, and CTLA-4 in the plasma of patients with advanced NSCLC who had been treated with anti-PD-1/L1 therapy.

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Sodium-glucose cotransporter 2 inhibitors, inflammation, and heart failure: a two-sample Mendelian randomization study

Cardiovascular Diabetology

Sodium-glucose cotransporter 2 (SGLT-2) inhibitors are increasingly recognized for their role in reducing the risk and improving the prognosis of heart failure (HF). However, the precise mechanisms involved re.

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Short- and Long-term survival prediction in patients with acute type A aortic dissection undergoing open surgery

Journal of Cardiothoracic Surgery

Acute Type A aortic dissection (ATAAD) is a life-threatening cardiovascular disease associated with high mortality rates, where surgical intervention remains the primary life-saving treatment. However, the mor.

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The association of atherogenic index of plasma with cardiovascular outcomes in patients with coronary artery disease: A systematic review and meta-analysis

Cardiovascular Diabetology

Atherogenic index of plasma (AIP) represents a novel marker in the current era of cardiovascular diseases. In this meta-analysis, we aimed to evaluate the association of AIP with cardiovascular prognosis in pa.

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Hemodynamic Vise

All About Cardiovascular System and Disorders

Transcript of the video: Hemodynamic vise is the term given to compression of a vertical vein, which ascends to the brachiocephalic vein, between a bronchus and pulmonary artery. This produces a vicious cycle and that is why it is known as hemodynamic vise in certain types of congenital heart diseases which have a vertical vein. This is the typical location of the hemodynamic vise, between the pulmonary artery and left bronchus.

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Psychiatry Month in Review: March 2024

HCPLive

This March 2024 psychiatry month in review highlights positive phase 2b and phase 2a data for drugs targeting treatment-resistant depression, generalized anxiety disorder, and PTSD.

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The Importance of Endurance Training and Other Health Questions

Physiologically Speaking

Today, I’m sharing an interview that I did with for his Substack Shortcut U. We discuss endurance training, why it's important for health, and how to approach it. I also answer some questions like: Do we really need to be doing endurance training if we're already lifting weights? Is sauna actually useful for health and performance? Are coffee and energy drinks negatively impacting your cardiovascular health?

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Arterial Switch Operation

All About Cardiovascular System and Disorders

Transcript of the video: Arterial switch operation is the ideal corrective surgery for D-Transposition or dextro transposition of great arteries, if it can be detected early in life. As the left ventricle is facing the pulmonary artery in dextro transposition of great arteries, if there is a delay beyond two to three weeks of life, there is possibility that the muscle mass of the left ventricle can regress, so that, later if arterial switch operation is done, it will not be able to face the syst

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Clinical Quiz: Nonstatin Therapies for LDL-C Lowering in Special Populations

HCPLive

This clinical quiz will test your knowledge on management of LDL-C special populations with nonstatin therapies based on the ACC's 2022 expert clinical decision pathway.

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New PREVENT Equations for CVD Risk Assessment: Key Takeaways

American College of Cardiology

The following are five takeaways from a perspective article on the new PREVENT equations for cardiovascular disease (CVD) risk assessment.

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Analysis Supports Role of Lotilaner Ophthalmic Solution for Demodex Blepharitis

HCPLive

In a systematic review and meta-analysis of available data, lotilaner ophthalmic solutions outperformed placebo, with few side effects, in treating Demodex blepharitis.

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The D84G mutation in STIM1 causes nuclear envelope dysfunction and myopathy in mice

Journal of Clinical Investigation - Cardiology

Stromal interaction molecule 1 (STIM1) is a Ca2+ sensor located in the sarcoplasmic reticulum (SR) of skeletal muscle, where it is best known for its role in store-operated Ca2+ entry (SOCE). Genetic syndromes resulting from STIM1 mutations are recognized as a cause of muscle weakness and atrophy. Here, we focused on a gain-of-function mutation that occurs in humans and mice (STIM1+/D84G mice), in which muscles exhibited constitutive SOCE.

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