Fri.Jun 21, 2024

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How Does Heat Kill? It Confuses the Brain, Shuts Down Organs, and Strains the Heart.

Med Page Today

(MedPage Today) -- As temperatures and humidity soar outside, what's happening inside the human body can become a life-or-death battle decided by just a few degrees. The critical danger point outdoors for illness and death from relentless heat.

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Research finds causal evidence tying cerebral small-vessel disease to Alzheimer's, dementia

Science Daily - Heart Disease

While previous studies suggested an association of the most common cerebral small-vessel disease with dementia risk, new research provides evidence of causal link, identifying it as a major vascular factor.

Dementia 109
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Tech in Diabetes: What's Going Wrong?

Med Page Today

(MedPage Today) -- ORLANDO -- Technologic advances aren't fulfilling their promise for improving diabetes or overall health outcomes in the U.S., argued FDA Commissioner Robert Califf, MD. "We are wowing the world in technology -- much of.

Diabetes 108
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Fenofibrate Markedly Lowers Progression of Diabetic Retinopathy

HCPLive

A first-time trial presented at ADA 2024 found the common cholesterol-lowering drug halts vision loss in patients with diabetic eye disease.

Diabetes 115
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Novel Tricuspid Valve Procedure Improves Patients' Quality of Life and Health Status

DAIC

milla1cf Fri, 06/21/2024 - 20:10 June 21, 2024 — UC San Francisco interventional cardiologists and interventional echocardiographers recently performed the health system’s first commercial transcatheter tricuspid valve replacement procedure using the Edwards EVOQUE system. The novel and minimally invasive cardiac procedure was recently approved for use within the U.S. by the Food and Drug Administration.

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Cardiac Shockwave Device Passes Hurdle in Ischemic Cardiomyopathy

Med Page Today

(MedPage Today) -- As an adjunct to bypass surgery for ischemic cardiomyopathy, a cardiac shockwave therapy aimed at regenerating ischemic myocardium boosted left ventricular ejection fraction (LVEF) and physical function at 1 year in a small sham.

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Analysis of INPEFA (Sotagliflozin) Cost-Effectiveness Published in JACC: Heart Failure, the Peer-Reviewed Journal of the American College of Cardiology

DAIC

milla1cf Fri, 06/21/2024 - 20:15 June 21, 2024 — Lexicon Pharmaceuticals, Inc. announced that the peer-reviewed Journal of the American College of Cardiology: Heart Failure has published a research paper concluding that INPEFA (sotagliflozin) is cost-effective for people with diabetes and recent worsening heart failure using commonly accepted willingness-to-pay thresholds.

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Donald Sutherland Dies; Can Viagra Benefit Women? Insulin Supply Affected by Wegovy

Med Page Today

(MedPage Today) -- Note that some links may require registration or subscription. Actor Donald Sutherland, who starred as surgeon Hawkeye Pierce in the film "M*A*S*H" among numerous other roles, died at age 88 of an undisclosed illness. (Variety.

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FORWARD: VX-880 Could Eliminate Need for Insulin in Patients with Type 1 Diabetes

HCPLive

New phase 1/2 data suggest VX-880 islet cell therapy may restore physiological islet function and glycemic control in patients with T1D, potentially eliminating the need for insulin use.

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Regular Wide Complex Tachycardia. What to do?

Dr. Smith's ECG Blog

A patient in the ICU with significant underlying cardiac disease [HFrEF 30%, non-ischemic cardiomyopathy, LBBB s/p CRT-D (biventricular pacer), AVNRT s/p ablation a few yrs ago, hx sinus tachycardia while on max tolerated BB therapy] went into a regular wide-complex tachycardia after intubation for severe COPD exacerbation. Here is the ECG: Regular Wide Complex Tachycardia at a rate of 166 bpm.

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Weight Loss Lowers Risk of Obesity-Related Cancer, Study Finds

HCPLive

In retrospective, observational research at ADA 2024, real-world weight loss was linked to a reduction in the risk of obesity-related cancers.

Obesity 80
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Air Pollution Shared Risk Factor For CVD, Cancer; More in SDoH Focus Issue of JACC: CardioOncology

American College of Cardiology

Air pollution can greatly increase the risk of cardiovascular disease and mortality in patients with cancer and can contribute to health disparities related to both conditions,

Cancer 74
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Atul Malhotra, MD: Tirzepatide for Obstructive Sleep Apnea and Obesity

HCPLive

Atul Malhotra, MD, discusses the results of the SURMOUNT-OSA trial and how they inform clinicians on the role of tirzepatide in OSA and obesity.

Obesity 75
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What To Do If You Have An Early Family History Of Heart Disease

Dr. Paddy Barrett

If you have an early family history of heart disease, there are specific steps you need to take to define if you have an increased risk and what to do about it. Heart disease is the leading cause of death worldwide, and the probability of someone in your family having heart disease is likely to be high. This does not mean it was genetic. Just that heart disease is common.

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Edward V Loftus, Jr, MD: Discussing FDA Approval of Risankizumab (Skyrizi) in Ulcerative Colitis

HCPLive

Loftus explains the significance of IL-23 and Th17 in IBD and key trial data supporting the FDA approval of risankizumab in ulcerative colitis.

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New Echo AI Model Could Streamline Mitral Regurgitation Diagnosis

CardiacWire

Columbia and Cornell researchers developed an echo AI model that could improve the difficult task of mitral regurgitation diagnosis, and might even represent an AI-driven step towards enhancing all valvular regurgitation assessments. Transthoracic echocardiography is the go-to modality for mitral regurgitation diagnosis, but these exams are difficult to perform and prone to high variability.

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Analysis Demonstrates Long-Term Safety Profile of Filgotinib for RA Treatment

HCPLive

The incidences of adverse events were comparable between the original and current analyses of patients with moderate to severe RA treated with filgotinib.

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Timing of P2Y12 Inhibitors in STEMI Patients Undergoing PPCI

American College of Cardiology

What is the safety and effectiveness of P2Y12 inhibitor pretreatment in patients transferred for primary percutaneous coronary intervention (PPCI) within a regional ST-segment elevation myocardial infarction (STEMI) network?

STEMI 60
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Higher Step Count Lowers Risk of Developing RA by 45%

HCPLive

Patients with the highest daily step count had a 45% lower risk of RA compared with patients in the lowest quarter (< 6818 daily steps).

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Exploring new frontiers: a rare case of catheter ablation for persistent atrial fibrillation in a patient with cor triatriatum sinister guided by intracardiac echocardiography

Journal of Cardiothoracic Surgery

Cor triatriatum sinister (CTS) is an uncommon congenital cardiac anomaly. Atrial fibrillation (AF) is commonly the initial symptom in patients with CTS, occurring in approximately 32% of the cases. The complex.

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GLP-1 Receptor Agonists Improved Psoriasis Despite Diabetes Mellitus

HCPLive

In this systematic review and meta-analysis, the clinical efficacy of glucagon-like peptide 1 receptor agonists was evaluated.

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Del Nido cardioplegia versus cold blood cardioplegia in adult cardiac surgery: a meta-analysis of randomized clinical trials

Journal of Cardiothoracic Surgery

Objective Systematic evaluation of the safety of del Nido cardioplegia compared to cold blood cardioplegia in adult cardiac surgery. Methods We systematically searched PubMed, EMbase, The Cochrane Library and ClinicalTrials.gov for randomized clinical trials (published by 14 January 2024) comparing del Nido cardioplegia to cold blood cardioplegia in adult.

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The Benefits of Earlier Diagnosis and Treatment of COPD

HCPLive

Focusing on evolving therapeutic paradigms for patients with COPD, experts discuss the importance of earlier diagnosis and treatment.

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Clinical value of measuring plasma D-dimer levels in patients with esophageal cancer

Journal of Cardiothoracic Surgery

Esophageal cancer represents a significant public health concern; however, reliable diagnostic and prognostic markers have not been established. This study aimed to investigate the clinical value of plasma D-d.

Cancer 52
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Trial of Vascular Care Team vs. Education for PAD

American College of Cardiology

What is the difference in utilization of lipid management strategies when using a vascular care team including a clinical pharmacist versus usual care with provider education for patients with peripheral artery disease (PAD)?

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Survival outcomes of segmentectomy and lobectomy for early stage non-small cell lung cancer: a systematic review and meta-analysis

Journal of Cardiothoracic Surgery

The question of whether segmentectomy and lobectomy have similar survival outcomes for patients with early-stage non-small cell lung cancer (NSCLC) is a matter of debate.

Cancer 52
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Alpha-1 Antitrypsin Therapy Does Not Improve C-Peptide in Chronic Pancreatitis

HCPLive

Although AAT therapy was found to be well-tolerable, the infusions did not improve C-peptide AUC in patients with chronic pancreatitis undergoing TP-IAT.

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Therapy Duration and Improvement of Ventricular Function in HF

American College of Cardiology

To what extent does left ventricular ejection fraction (LVEF) improve beyond 90 days in patients with de novo heart failure with reduced ejection fraction (HFrEF)?

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Resources Available for Patients with HIV Drug Resistance

HCPLive

The panel concludes its discussion by talking about resources available for providers in managing their patients with HIV who experience drug resistance.

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Partial cardiopulmonary bypass through left thoracotomy for coarctation repair in children

Journal of Cardiothoracic Surgery

A left thoracotomy approach is anatomically appropriate for childhood aortic coarctation; however, the pediatric femoral arteriovenous diameters are too small for cardiopulmonary bypass cannulation. We aimed t.

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Abiprubart Reduces Disease Activity in Refractory Rheumatoid Arthritis

HCPLive

Phase 2 data showed a significant reduction in RA disease activity at Week 12 with weekly abiprubart, compared with placebo.

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Correction to: Imbalance of Iron Availability and Demand in Patients With Acute and Chronic Heart Failure

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print.

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Switching Therapies for Patients with HIV and History of Resistance

HCPLive

Experts on HIV offer insights into switching therapies for patients with a history of resistance, highlighting ways to simplify and optimize treatment.

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Physiology Friday #223: Can a Healthy Lifestyle Increase Your Chances of Living to 100?

Physiologically Speaking

Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including Examine.com and my book “VO2 Max Essentials ” can be found at the end of the post! Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

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Illness Perception Linked to Subjective Signs of RA Disease Activity

HCPLive

A study presented at EULAR 2024 found tender joint count was linked to depression and illness perception but not anxiety.

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The Relationship Between Comorbidities in COPD

HCPLive

Clinical insights on the relationship between comorbidities in COPD and how multimorbidity plays a role in treatment decisions.

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SHR0302, A JAK1 Inhibitor, Shows Promise for Rheumatoid Arthritis in Phase 3 Study

HCPLive

Phase 3 data showed patients treated with SHR0302 4 mg or 8 mg had greater improvements in ACR20 response rates and other key secondary outcomes versus placebo.