Wed.Jun 19, 2024

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Women who experience depression during pregnancy or after birth have higher risk of cardiovascular disease

Science Daily - Heart Disease

Women diagnosed with perinatal depression are more likely to develop cardiovascular disease in the following 20 years compared to women who have given birth without experiencing perinatal depression. The study is the first of its kind to look at cardiovascular health after perinatal depression and included data on around 600,000 women. It found the strongest links with risks of high blood pressure, ischemic heart disease and heart failure.

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Robert Gish, MD: Advancements in Therapeutic Development, Combination Therapy in PBC

HCPLive

Gish explains recent developments in the treatment of PBC, highlighting the FDA approval of elafibranor, the anticipated decision for seladelpar, and the growing role of combination therapy.

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Exploring Potential New Treatment for Ventricular Tachycardia

DAIC

Eugenio Cingolani, MD. Photo by Cedars-Sinai. milla1cf Wed, 06/19/2024 - 20:57 June 19, 2024 — When electrophysiologist Eugenio Cingolani, MD , isn’t seeing patients, he can usually be found in his laboratory, investigating improved treatments for heart rhythm disorders. Cingolani, director of Cardiogenetics and Preclinical Research in the Department of Cardiology in the Smidt Heart Institute at Cedars-Sinai, is exploring new ways to help patients with ventricular tachycardia (VT), a recurrin

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Reducing Dose of Belimumab in Patients with Lupus

HCPLive

A recent study provides some evidence of the ability to potentially reduce belimumab dose in a subset of patients with SLE.

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Study Finds Air Pollution Can Increase Cardiovascular Risk for Cancer Patients

DAIC

Getty Images milla1cf Wed, 06/19/2024 - 20:54 June 19, 2024 — Modern therapies have extended the lives of many cancer patients; however, survivors often live with chronic health conditions, including cardiovascular disease. New research published in JACC: CardioOncology shows that air pollution plays a significant role in increasing cardiovascular disease and mortality in cancer patients and contributes to health disparities related to these conditions.

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Unlocking heart health: Advancing noninvasive monitoring in chimpanzees

Science Daily - Heart Disease

Measuring the heart rate of great apes in captivity is essential for both health management and animal studies. However, existing most methods are either invasive or inaccurate. Now, researchers have investigated the potential of using millimeter-wave radar technology to estimate heart rate from subtle body movements in chimpanzees. Their efforts will hopefully pave the way to better practices and techniques for monitoring heart rates in wild and captive primates.

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Stereotaxis Receives CE Mark Recertification Under EU’s MDR Regulatory Framework

DAIC

milla1cf Wed, 06/19/2024 - 20:50 June 19, 2024 — Stereotaxis , a pioneer and global leader in surgical robotics for minimally invasive endovascular intervention, today announced that it has received CE Mark recertification under the European Union’s new Medical Device Regulation (MDR) regulatory framework. The recertification under MDR covers all Stereotaxis devices currently available in Europe.

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In Memoriam: Former DAIC Editor Cristen Bolan

DAIC

Cristen Bolan mtaschetta-millane Wed, 06/19/2024 - 12:57 It is with great sadness that the DAIC/ITN team learned of the sudden passing of former Editor Cristen Bolan on June 17. Cristen worked on the brands from 2005-2010, before moving on to other industry related ventures. Our team extends its sincere sympathy to her family and friends. More information on her memorial service can be found here.

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Comparative study on the predictive value of TG/HDL-C, TyG and TyG-BMI indices for 5-year mortality in critically ill patients with chronic heart failure: a retrospective study

Cardiovascular Diabetology

The triglyceride glucose (TyG) index, TyG-body mass index (TyG-BMI), and triglyceride-density lipoprotein cholesterol ratio (TG/HDL-C) are substitute indicators for insulin resistance (IR). This study aimed to.

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Abrocitinib Effective for Atopic Dermatitis Patients Unresponsive to Biologics

HCPLive

This analysis highlights the potential for abrocitinib as an alternative to biologics in the eczema treatment armamentarium.

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What would you do with acute chest pain and this ECG? You might see what the Queen thinks.

Dr. Smith's ECG Blog

This is another case sent by the undergraduate (who is applying to med school) who works as an EKG tech. Case An 82 year old man with a history of hypertension presented to the ED with chest pain at 1211. He described his chest pain as pleuritic and reported that it started the day prior while swinging a golf club. An EKG for chest pain was obtained right away: For an 82 year old, this is a good looking EKG, with sinus rhythm at a rate of 70 BPM.

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Marea Therapeutics’ Cardiometabolic Mission

CardiacWire

Marea Therapeutics emerged this week , announcing $190M in Series A/B funding and a mission to develop “a new generation of medicines for cardiometabolic diseases” – starting with their drug candidate targeting remnant cholesterol. Marea got its start from a tweet by UCSF cardiologist Ethan J. Weiss, MD, regarding his interest in metabolism and a protein (Angptl4) that blocks lipoprotein lipase (LPL) and regulates how the body stores fat.

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Did Covid come to save the vaccine?

Dr. S. Venkatesan MD

June 2020 Let me go back … 4 years in time-line, to the dark COVID duty days in 2020 at one of the largest COVID facilities, Madras Medical College, Chennai.India.I still feel a sense of unease when I reflect on those harsh days, with bed-less patients gasping for breath and waiting in the long ambulance queues in our esteemed hospital. I can’t recall how many times I was disrupted by the silent, final journey of body bags being transported to the mortuary ward.

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ELA026 Shows Promise for Secondary HLH in Phase 1b Study

HCPLive

Late-breaking data from EHA 2024 demonstrated a high overall response rate and favorable safety across a range of sHLH patients treated with ELA026.

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Additive effect of admission hyperglycemia on left ventricular stiffness in patients following acute myocardial infarction verified by CMR tissue tracking

Cardiovascular Diabetology

Stress hyperglycemia occurs frequently in patients following acute myocardial infarction (AMI) and may aggravate myocardial stiffness, but relevant evidence is still lacking. Accordingly, this study aimed to e.

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Brian LaMoreaux, MD: Defining and Achieving Remission in Gout with Pegloticase

HCPLive

A post hoc analysis of the MIRROR trial suggests comprehensive gout management should aim for remission, incorporating both uric acid lowering and broader symptom improvements.

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Is systemic inflammation a missing link between cardiometabolic index with mortality? Evidence from a large population-based study

Cardiovascular Diabetology

This study sought to elucidate the associations of cardiometabolic index (CMI), as a metabolism-related index, with all-cause and cardiovascular mortality among the older population. Utilizing data from the Na.

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Endothelial-derived microvesicles promote pro-migratory cross-talk with smooth muscle cells by a mechanism requiring tissue factor and PAR2 activation

Frontiers in Cardiovascular Medicine

IntroductionMicrovesicles (MV) released by endothelial cells (EC) following injury or inflammation contain tissue factor (TF) and mediate communication with the underlying smooth muscle cells (SMC). Ser253-phosphorylated TF co-localizes with filamin A at the leading edge of migrating SMC. In this study, the influence of endothelial-derived TF-MV, on human coronary artery SMC (HCASMC) migration was examined.Methods and ResultsMV derived from human coronary artery EC (HCAEC) expressing TFWt accele

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Clinical Quiz: Risk Assessment from 2019 ESC/EAS Guidelines on Dyslipidemia

HCPLive

Check out the second quiz in our series testing your knowledge of the ESC/EAS 2019 guidelines on dyslipidemia. This quiz focuses on risk assessment and stratification!

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Rothia dentocariosa endocarditis with brain abscess and splenic abscess: case report and brief review

Frontiers in Cardiovascular Medicine

Rothia dentocariosa is a conditionally pathogenic bacterium that may cause infective endocarditis (IE) in selected patients and give rise to a variety of clinical complications, albeit it is not a common IE pathogen. We present the case of a patient diagnosed with Rothia dentocariosa-associated IE secondary to influenza B and thrombocytopenic purpura.

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Achilles Tendon Structure, Function Differs Depending on Pain or No Pain

HCPLive

A study describes the structure and function differences of the Achilles tendon for PsA patients who self-report pain and those who don’t.

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Rationale For the Third Dimension in Preoperative Assessments of Atrioventricular Septal Defects

American College of Cardiology

Although surgical death during atrioventricular septal defect (AVSD) repair has declined in the past decades, significant postoperative left atrioventricular valve regurgitation (LAVVR) remains in up to 25% of patients.

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Iron Deficiency Anemia Associated with High Risk of Asthma

HCPLive

Genetically predicted anemia may be casually linked to an increased risk of asthma, suggesting its role in the chronic lung disease's development.

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Fifteen years of subcutaneous implantable cardioverter-defibrillator therapy: Where do we stand, and what will the future hold?

HeartRhythm

The subcutaneous implantable cardioverter-defibrillator (S-ICD) has emerged as a feasible alternative for the transvenous ICD in the treatment of ventricular tachyarrhythmias in patients without pacing or cardiac resynchronization therapy indications. Since its introduction, numerous innovations have been made and clinical experience was gained leading to its adoption in current practice and preference in certain populations.

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Survey Reveals Reasons Why Respondents Avoid AATD Trial Participation

HCPLive

A survey found individuals may avoid participating in AATD trials because a trial may require them to go off augmentation therapy.

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Outcomes with Physiologic His Bundle Pacing in Patients with Narrow QRS Complex

HeartRhythm

In patients with narrow QRS complex, both ventricular and biventricular pacing is associated with increased cardiac morbidity and mortality. This risk is not decreased by ventricular pacing avoidance algorithms which cause non-physiologic atrioventricular delays. Objective: To report outcomes in patients with narrow QRS complex, when paced complex is in normal range and physiologic atrioventricular delays are programmed.

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Study Highlights Prevalence of Lichen Planopilaris, Patterns in Treatment in the US

HCPLive

These data highlight the patterns of treatment as well as prevalence of LPP within the US.

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Supercharging the ECG: AI set to Revolutionize the Diagnostic Cardiology Market

DAIC

While the spotlight in 2023 shone on developments around Generative Artificial Intelligence (AI), away from the limelight a quiet revolution in AI was taking place, which promises to transform the way we diagnose, manage, and treat cardiovascular diseases, the world’s leading cause of death. Signify Research has just released a deep-dive qualitative analysis of developments around the use of AI to analyze and interpret electrocardiograms (ECGs), one of the world’s most ubiquitous diagnostic test

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Dapagliflozin’s Association with LCN2, AGER Suggest Therapeutic Effect in IgA Nephropathy

HCPLive

A Mendelian randomization analysis found co-localization between the target genes of SGLT2 inhibitors and the pathogenesis genes of membranous nephropathy and IgAN.

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FIRST Questionnaire Can Help Detect Fibromyalgia in RA Patients

HCPLive

A study from EULAR details the ability of the FIRST self-questionnaire to identify fibromyalgia in patients with rheumatoid arthritis.

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