Medical Xpress - Cardiology

NOVEMBER 27, 2024

A large population study of men over 45 indicates insulin resistance may be an important risk factor for the development of the world's most common heart valve disease—aortic stenosis (AS).

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Heart Valves Risk Factors Stenosis Aortic 98

JAMA Cardiology

FEBRUARY 27, 2024

This cohort study evaluates a novel polygenic risk score for estimating risk of aortic stenosis compared with the use of established risk factors.

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Risk Factors Stenosis Aortic 40

All About Cardiovascular System and Disorders

MAY 22, 2024

About a fifth of all ischemic strokes are attributed to embolization of ruptured atherosclerotic plaque from carotid arterial stenosis. But it has been difficult to predict which person with asymptomatic carotid artery stenosis is likely to progress to symptomatic carotid disease and stroke. J Am Coll Cardiol. doi: 10.1016/j.jacc.2024.03.389.

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Stenosis Stroke Strokes Risk Factors 52

Medical Xpress - Cardiology

SEPTEMBER 13, 2024

A review in The Lancet finds that 20% of the world population carries a genetic risk factor for cardiovascular diseases such as heart attacks, strokes, and aortic valve stenosis: Increased levels of a lipid particle called lipoprotein(a). It is the most common genetic cause of cardiovascular diseases.

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Aortic valve Heart Disease Heart attacks Heart Attack 90

American College of Cardiology

NOVEMBER 20, 2024

Which genetic and cardiovascular risk factors are aortic stenosis (AS)-specific, and which could be shared between AS and with coronary artery disease (CAD)?

Stenosis 46

Stenosis Aortic Coronary Artery Disease Risk Factors 46

Stroke Journal

JANUARY 21, 2024

This comprehensive literature review focuses on acute stroke related to intracranial atherosclerotic stenosis (ICAS), with an emphasis on ICAS-large vessel occlusion. ICAS is the leading cause of stroke globally, with high recurrence risk, especially in Asian, Black, and Hispanic populations.

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Stenosis Stent Stents Risk Factors 66

JAMA Cardiology

NOVEMBER 5, 2024

Aortic stenosis (AS) due to fibrosis and calcification of the aortic valve is a hazardous component of cardiovascular disease burden—after developing symptomatic AS, patients survive for an average of less than 2 years without treatment.

Atherosclerosis 53

Atherosclerosis Aortic Stenosis Aortic valve 53

Journal of the American Heart Association

MARCH 13, 2025

BackgroundOur previous preclinical study demonstrated thatAPOE4targeted replacement mice exhibit more severe cerebral hypoperfusion and cognitive impairment thanAPOE3targeted replacement mice with carotid artery stenosis due to neurovascular dysfunction.

Stenosis 40

Stenosis Risk Factors Circulation 40

Frontiers in Cardiovascular Medicine

APRIL 24, 2024

With this longer lifespan, calcific aortic stenosis (AS) was identified as an emerging critical risk factor for cardiac death in older patients. Three were successful and 1 patient died perioperatively due to cardiovascular disease severity, highlighting the importance of intervention timing and comparative risk stratification.

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Stenosis Aortic Peripheral Arterial Disease TAVR 52

Open Heart

FEBRUARY 17, 2025

The outcomes of cardiac intervention timing, infant mortality and hospital care utilisation, were described by birth eras, and risk factors were explored using multivariable regression. Compared with prepandemic, there was no evidence for delay in treatment procedures in transition, restrictions or postrestrictions eras.

Congenital Heart Disease 52

Congenital Heart Disease Congenital Heart Disease Outcomes 52

Stroke Journal

JUNE 26, 2024

Asymptomatic high-grade carotid stenosis is an important therapeutic target for stroke prevention. Transcarotid artery revascularization has a favorable periprocedural risk profile, but randomized trials comparing it to intensive medical management are lacking.

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Stenosis Stent Stents Atherosclerosis 40

Frontiers in Cardiovascular Medicine

AUGUST 7, 2024

Aortic Stenosis (AS) is a common condition with an estimated pooled prevalence of all AS in the elderly population at around 12.4%, with that of severe AS estimated to be around 3.4%. In the past, surgical aortic valve replacement was the primary treatment option for severe AS for decades.

Aortic valve 98

Aortic valve Aortic TAVR Peripheral Arterial Disease 98

Journal of the American Heart Association

MARCH 3, 2025

There is evidence suggesting that genetic and environmental factors may be associated with intracranial artery stenosis. The degree of intracranial artery stenosis was measured by using the Willis narrowing score (WNS), which was then dichotomized as mild and severe.

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Stenosis Risk Factors 40

Frontiers in Cardiovascular Medicine

AUGUST 2, 2024

Percutaneous coronary intervention (PCI), as a relatively rapid and effective minimally invasive treatment for coronary heart disease (CHD), can effectively relieve coronary artery stenosis and restore myocardial perfusion. However, the occurrence of major adverse cardiovascular events (MACE) is a significant challenge for post PCI care.

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Biomarkers Risk Factors Stenosis Heart Disease 97

Cardiovascular Diabetology

MARCH 4, 2025

Aortic valve calcification (AVC) is an underlying pathophysiological mechanism in aortic stenosis, which shares many risk factors with diabetes. However, the association between dysglycemia and early stages of.

Aortic valve 52

Aortic valve Aortic Risk Factors Stenosis 52

Circulation

NOVEMBER 11, 2024

However, the long-term outcomes in patient with an intermediate stenosis received FFR have not yet been investigated comprehensively.Methods:We retrospective included 558 patients underwent both coronary artery angiography (CAG) and FFR.

Coronary Artery Disease 40

Coronary Artery Disease Stenosis Risk Factors Outcomes 40

Stroke Journal

JANUARY 21, 2024

Intracranial atherosclerotic disease and resultant intracranial stenosis is a global leading cause of stroke, and poses an ongoing treatment challenge. Among patients with intracranial stenosis, those with hemodynamic compromise are at high risk for recurrent stroke despite medical therapy and risk factor modification.

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Stenosis Risk Factors Technology Stroke 40

DAIC

FEBRUARY 3, 2025

Lp(a) is emerging as an important, yet under-recognized, potential risk factor for cardiovascular disease due to its ability to promote the development of plaques within artery walls, clot formation and aortic valve calcification. The development of the Tina-quant Lipoprotein (a) Gen.2 2022 Aug, 80 (9) 934946 Kronenberg F.

Cardiovascular Disease 52

Cardiovascular Disease Aortic valve Biomarkers Innovation 52

Stroke Journal

JANUARY 30, 2025

The study was designed to investigate whether aortic arch types (AAT) was associated with the lateralization of subclavian artery stenosis (SAS).Methods:In Patients (age 18 years) with clinically manifest atherosclerotic vessel disease or risk factors for atherosclerosis and a normal branching pattern of the aortic arch were included.

Stenosis 40

Stenosis Aortic Atherosclerosis Risk Factors 40

Stroke Journal

JANUARY 21, 2024

Reducing the high risk of recurrent stroke in patients with symptomatic intracranial atherosclerotic stenosis (sICAS) has proven to be challenging, but aggressive medical management, with intensive risk factor control and antithrombotic therapy, has been shown to be beneficial.

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Stenosis Blood Pressure Diet Exercise 40

Journal of the American Heart Association

MARCH 13, 2025

BackgroundLp(a) (lipoprotein(a)) is an independent risk factor for calcific aortic valve stenosis (CAVS). Whether patients with CAVS and high Lp(a) levels are at higher risk of valvular or cardiovascular events is unknown. Journal of the American Heart Association, Ahead of Print.

Aortic valve 40

Aortic valve Coronary Artery Bypass Graft Stenosis Aortic 40

Stroke Journal

JANUARY 30, 2025

Introduction:Elevated Low-Density-Lipoprotein Cholesterol (LDL-C) blood levels are a risk factor for atherosclerosis. Lipid-lowering therapies mitigate the risk of atherothrombotic events. After adjusting for confounders, only LDL-C levels were associated with the acute symptomatic status of carotid stenosis.

Stenosis 40

Stenosis Atherosclerosis Cholesterol Ischemia 40

Stroke Journal

JANUARY 30, 2025

Ischemic stroke, a heterogeneous disease with various etiological subtypes and risk factors, places stress on the BBB. To model stenosis, a microactuator was mounted on a 3D printed platform and connected to a capillary tube (~1 mm diameter). Preliminary results show focal leaks forming immediately after stenosis (Fig.

Stenosis 40

Stenosis Physiology Risk Factors Stroke 40

Stroke Journal

JANUARY 30, 2025

Background:The uneven distribution of intracranial atherosclerotic stenosis (ICAS) along the internal carotid artery (ICA) had been described in early clinicopathological studies, yet related, large-scale data is lack despite the widespread utilization of angiography.

Stenosis 40

Stenosis Hospital Atherosclerosis Risk Factors 40

Journal of the American Heart Association

FEBRUARY 3, 2025

However, the prognostic value of malnutrition status in patients with moderatetosevere aortic stenosis is unclear. Compared with normal nutrition, malnutrition was associated with an increased risk for allcause death (adjusted hazard ratio for mild and moderatesevere malnutrition, respectively: 2.82 [95% CI, 1.694.71;P<0.001]

Stenosis 40

Stenosis Aortic Aortic valve Academic 40

Stroke Journal

JANUARY 30, 2025

We aimed to investigate the association between VAH and atherosclerotic stenosis of subclavian artery (SA), vertebral artery (VA) and basilar artery (BA) based on digital subtraction angiography (DSA).Methods:In VAH and stenosis degree of the artery (i.e., p< 0.001) and basilar artery stenosis (BAS) (left VAH: OR 2.94, 95% CI 2.15-4.04,p<

Stenosis 40

Stenosis Atherosclerosis Risk Factors Stroke 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Nontraditional lipid variables including triglycerides/high‐density lipoprotein cholesterol (HDL‐C) ratio and total cholesterol/HDL‐C ratio are linked to a vascular risk as a residual risk factor. ICAS was defined as >/=50% stenosis and quantified by presence, >/=2, and >/=3.

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Stenosis Cholesterol Stroke Strokes 40

Frontiers in Cardiovascular Medicine

DECEMBER 14, 2023

This study aimed to investigate the association between various complex indexes of blood cell types and lipid levels with the severity of coronary artery stenosis and their predictive value in coronary heart disease (CHD). Results It revealed a positive correlation between all complex indexes and the severity of coronary artery stenosis.

Heart Disease 64

Heart Disease Cholesterol Stenosis Atherosclerosis 64

DAIC

MARCH 6, 2024

The CAD Staging System is a noninvasive imaging-based investigational software device that analyzes important and actionable features of coronary atherosclerosis, stenosis and ischemia. Food and Drug Administration ( FDA ) for its Coronary Artery Disease ( CAD ) Staging System.

Heart Disease 105

Heart Disease Heart attacks Heart Attack Technology 105

Ken Grauer, MD

FEBRUARY 3, 2024

BUT — Cardiac catheterization done a little later did not reveal any significant stenosis. Despite the absence of significant coronary stenosis on her post-arrest cath — the ECG in Figure-1 is clearly diagnostic of an extensive anterolateral STEMI ( presumably from acute LAD [ L eft A nterior D escending ] coronary artery occlusion).

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Blog Cardiac Arrest STEMI Plaque 163

Journal of the American Heart Association

JANUARY 27, 2025

BackgroundRING finger protein 213 (RNF213) p.R4810K is an established risk factor for moyamoya disease and intracranial artery stenosis in East Asian people. Journal of the American Heart Association, Ahead of Print.

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Cerebrovascular Disease Pulmonary Cardiac Function Hypertension 75

Frontiers in Cardiovascular Medicine

APRIL 7, 2024

Transcatheter aortic valve replacement (TAVR) has increasingly become a safe, feasible, and widely accepted alternative surgical treatment for patients with severe symptomatic aortic stenosis.

Aortic valve 52

Aortic valve Aortic TAVR Risk Factors 52

European Journal of Heart Failure

FEBRUARY 26, 2025

This clinical consensus statement provides a comprehensive overview of low BP in HFrEF, including its definition, risk factors, and effects of HF therapies on BP. Proposed approach for clinical management and therapeutic optimization in patients with heart failure with reduced ejection fraction and low blood pressure.

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Blood Pressure Heart Failure Aortic valve TAVR 58

The British Journal of Cardiology

AUGUST 1, 2024

Genome-wide association and Mendelian randomisation studies have identified lipoprotein(a) (Lp[a]) as an emerging risk factor for calcific aortic stenosis and a causal risk factor for atherosclerotic cardiovascular disease (ASCVD) in different ethnicities.

Risk Factors 40

Risk Factors Atherosclerosis Laboratory Stenosis 40

Frontiers in Cardiovascular Medicine

DECEMBER 13, 2023

Transcatheter aortic valve replacement (TAVR) is a relatively new treatment method for aortic stenosis (AS) and has been demonstrated to be suitable for patients with varying risk levels.

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Aortic valve Cardiac Rehabilitation Aortic TAVR 64

Stroke Journal

JANUARY 30, 2025

Introduction:The middle cerebral artery (MCA) is the most common site for inrtacranial atherosclerotic stenosis. Demographic data, risk factors and the history of ischemic stroke of all patients were recorded. Stroke, Volume 56, Issue Suppl_1 , Page AWP203-AWP203, February 1, 2025. 21.35), p<0.001).Conclusions:Both

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Atherosclerosis Stenosis Risk Factors BMI 40

Dr. Smith's ECG Blog

MAY 20, 2024

Or is it a very tight stenosis that does not allow enough flow to perfuse myocardium that has a high oxygen demand from severely elevated BP? However, in light of risk factors for atherosclerotic disease and dynamic EKG changes today, we will pursue a CTCA tomorrow for further evaluation of coronaries.

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Chest Pain Blood Pressure Ischemia STEMI 127