Medical Xpress - Cardiology

NOVEMBER 21, 2024

After severe heart failure, the ability of the heart to heal by forming new cells is very low. However, after receiving treatment with a supportive heart pump, the capacity of a damaged heart to repair itself with new muscle cells becomes significantly higher, even higher than in a healthy heart. This is according to a new study from Karolinska Institutet published in the journal Circulation.

Heart Failure 105

Heart Failure Circulation 105

Physiologically Speaking

NOVEMBER 22, 2024

Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

Physiology 111

Physiology Dementia Genetic predisposition Exercise 111

DAIC

NOVEMBER 18, 2024

tim.hodson Mon, 11/18/2024 - 10:55 Nov. 16, 2024 Anthos Therapeutics, Inc.recently presented new data at the American Heart Association (AHA) Scientific Sessions from its AZALEA-TIMI 71 study that demonstrated the novel factor XI inhibitor abelacimab led to consistent and substantial reductions in bleeding for patients on or off antiplatelet (APT) therapy, as compared to rivaroxaban.

Peripheral Arterial Disease 98

Peripheral Arterial Disease Blood Clot Coronary Artery Disease General Cardiology 98

Science Daily - Heart Disease

NOVEMBER 18, 2024

A study testing a new nasal spray form of the medication bumetanide, a commonly prescribed diuretic, was found to be as safe and well-tolerated (meaning with no significant nasal irritation) in healthy adults in comparison to the oral and intravenous forms of the medication. The existing oral and intravenous forms of bumetanide are commonly prescribed for people with heart failure because they ease tissue swelling, a common cause of symptoms for people with heart failure.

Heart Failure 105

Heart Failure 105

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

Patient Care

Frontiers in Cardiovascular Medicine

NOVEMBER 19, 2024

ObjectivesThe COVID-19 pandemic has challenged global health systems since December 2019, with the novel virus SARS-CoV-2 causing multi-systemic disease, including heart complications. While acute cardiac effects are well-known, long-term implications are understudied. This review hopes to fill a gap in the literature and provide valuable insights into the long-term cardiac consequences of the virus, which can inform future public health policies and clinical practices.MethodsThis systematic rev

COVID-19 98

COVID-19 Heart Disease Public Health Outcomes 98

Nature Reviews - Cardiology

NOVEMBER 18, 2024

Nature Reviews Cardiology, Published online: 19 November 2024; doi:10.1038/s41569-024-01105-y Large language models represent a transformative leap in artificial intelligence and natural language processing, offering exciting potential across cardiology, from clinical care to education and research. However, several crucial challenges limit the practical implementation of large language models in cardiology.

Education 78

Education Research 78

Circulation

NOVEMBER 21, 2024

Circulation, Ahead of Print. Right ventricular outflow dysfunction, manifesting as stenosis, regurgitation, or both, is nearly universal in patients with repaired tetralogy of Fallot, precipitating a complex pathophysiological cascade that leads to increasing rates of morbidity and mortality with advancing age. As the number of adolescent and adult patients with repaired tetralogy of Fallot continues to grow as a result of excellent survival during infancy, the need to improve late outcomes has

Quality of Life 81

Quality of Life Pulmonary Stenosis Arrhythmia 81

Frontiers in Cardiovascular Medicine

NOVEMBER 21, 2024

BackgroundIt's recognized that stress hyperglycemia ratio (SHR) is considered a significant indicator of poor prognosis in many diseases. However, its role in critically ill patients with acute heart failure (acute HF) remains underexplored.MethodsWe conducted a retrospective cohort study on patients with acute HF included in the Medical Information Mart for Intensive Care IV (MIMIC-IV) version 2.2 database.

Heart Failure 59

Heart Failure Research 59

Nature Reviews - Cardiology

NOVEMBER 17, 2024

Nature Reviews Cardiology, Published online: 18 November 2024; doi:10.1038/s41569-024-01100-3 Cholesterol crystals (CCs) have a pathogenic role in various cardiovascular diseases, particularly atherosclerosis. In this Review, Boisvert and colleagues describe the mechanisms underlying CC formation and the role of CCs in cardiovascular disease, as well as therapeutic approaches aimed at reducing CC-mediated atherosclerotic burden.

Cholesterol 57

Cholesterol Atherosclerosis Cardiovascular Disease 57

DAIC

NOVEMBER 19, 2024

tim.hodson Tue, 11/19/2024 - 15:57 Nov. 18, 2024 — Abbott recently announced new data for the Amplatzer Amulet Left Atrial Appendage (LAA) Occluder to treat people with atrial fibrillation (AFib) who are at an increased risk of stroke. The new five-year findings demonstrate that Abbott's Amplatzer Amulet helps more patients avoid long-term use of blood-thinning medication compared to the Watchman device.

AFIB 52

AFIB Stroke Strokes Atrial Fibrillation 52

Medical Xpress - Cardiology

NOVEMBER 20, 2024

Trendy weight-loss drugs making headlines for shrinking waistlines may also be shrinking the human heart and other muscles, according to a new University of Alberta study in JACC: Basic to Translational Science. The authors say the research should serve as a "cautionary tale" about possible long-term health effects of these drugs.

Research 143

Research 143

Frontiers in Cardiovascular Medicine

NOVEMBER 19, 2024

BackgroundThe mechanism underlying new-onset postoperative atrial fibrillation (POAF) in adult cardiac surgery is not well understood. However, efficient pharmacological methods to prevent and treat arrhythmic complications are still lacking. In the present study, we explored the efficacy and safety of sacubitril/valsartan (sac/val) in the control of POAF in adult cardiac surgery patients.MethodsBetween January 2021 and December 2021, 667 eligible adult patients who underwent cardiac surgery at

Atrial Fibrillation 59

Atrial Fibrillation Pharmacology Hospital Research 59

Heart BMJ

NOVEMBER 19, 2024

Background Remote monitoring (RM) is recommended for the ongoing management of patients with cardiac implantable electronic devices (CIEDs). Despite its benefits, RM adoption has increased the workload for cardiac rhythm management teams. This study used a modified Delphi method to develop a consensus on optimal RM management for adult patients with a CIED in the UK.

Best Practices 52

Best Practices Education Nursing 52

DAIC

NOVEMBER 21, 2024

tim.hodson Thu, 11/21/2024 - 13:27 Nov. 21, 2024 — Royal Philips plans to unveil its next-generation 1.5T BlueSeal MR wide-bore scanner at RSNA 2024 in Chicago, Dec. 1-4. The latest generation scanner features a 70 cm wide-bore design and integrates AI-enabled MR Smart Workflow solutions, designed to enhance access and diagnostic confidence to improve outcomes for more patients.

Technology 59

Technology Anatomy Biomarkers Cancer 59

HCPLive

NOVEMBER 21, 2024

Ahmad Masri, MD, MS, discusses a study from AHA 2024 detailing changing risk profiles and outcomes in trials among patients with ATTR-CM.

Outcomes 125

Outcomes 125

Frontiers in Cardiovascular Medicine

NOVEMBER 21, 2024

Fabry disease (FD) is a rare X-linked inherited lysosomal storage disorder. The abnormal accumulation of metabolic substrates induces inflammation and fibrosis in cells, resulting in organ dysfunction. The clinical manifestations of FD are diverse and non-specific. In the present study, we report a case initially treated as obstructive hypertrophic cardiomyopathy for several years, which was finally identified as FD through whole-exome sequencing (WES).

Cardiomyopathy 52

Cardiomyopathy Aortic valve Aortic Hospital 52

Society of Thoracic Surgeons - Early Career

NOVEMBER 19, 2024

Career Resources kgilmartin Tue, 11/19/2024 - 11:49 Search By Topics Aspiring CT Surgeons Blog Career Development Career Development Blog Early Career Leadership Image Podcast #170, S4: A Surgeon's Leadership Journey Dr. Steven Gerndt is a cardiothoracic surgeon, speaker, and leadership mentor who developed the concept “Civilitas,” a system-wide cultural transformation focused on psychological safety and fostering of leadership by example.

Cardiothoracic 52

Cardiothoracic Blog Webinar Aortic valve 52

Science Daily - Heart Disease

NOVEMBER 21, 2024

After severe heart failure, the ability of the heart to heal by forming new cells is very low. However, after receiving treatment with a supportive heart pump, the capacity of a damaged heart to repair itself with new muscle cells becomes significantly higher, even higher than in a healthy heart.

Heart Failure 122

Heart Failure 122

Med Page Today

NOVEMBER 21, 2024

(MedPage Today) -- FDA advisors pushed for nuance in discussing whether andexanet alfa (Andexxa) should gain full approval, citing uncertainties about which dose and in which patients it could be best used to stop bleeding. Members of the Cellular.

122

122

Frontiers in Cardiovascular Medicine

NOVEMBER 21, 2024

BackgroundRupture of an abdominal aortic aneurysm (AAA) is a life-threatening emergency, with untreated cases nearing a 100% mortality rate. This case presents a rare complication of AAA rupture with an infected retroperitoneal hematoma, emphasizing the importance of timely diagnosis and a multidisciplinary approach.Case presentationA 59-year-old male presented with lower back pain, fever, and difficulty moving, persisting for three weeks.

Aneurysm 59

Aneurysm Aortic Outcomes 59

HCPLive

NOVEMBER 19, 2024

Muthiah Vaduganathan, MD, MPH, discusses the need for cardiology to embrace a role for GLP-1 receptor agonists and incretin therapies, with a focus on obesity-related HFpEF.

Heart Failure 118

Heart Failure Obesity 118

Science Daily - Heart Disease

NOVEMBER 21, 2024

Scientists have discovered how long-term treatment of high blood pressure with commonly prescribed drugs can destroy the kidney's ability to filter and purify blood. The finding could open the door to better ways to manage high blood pressure and other vascular diseases.

Blood Pressure 122

Blood Pressure 122

Med Page Today

NOVEMBER 20, 2024

(MedPage Today) -- Since the modern practice of anesthesia has evolved, providers have been concerned about pulmonary aspiration -- when gastric contents enter the lung, resulting in severe complications including pneumonitis, and aspiration.

Pulmonary 122

Pulmonary 122

Frontiers in Cardiovascular Medicine

NOVEMBER 17, 2024

BackgroundAllergy to iodine contrast agents has long been a contraindication for balloon pulmonary angioplasty (BPA). We report the successful zero-contrast BPA procedure of a patient with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) and severe iodine allergy using real-time fusion of computed tomography angiography (CTA) with x-ray fluoroscopy.Case presentationA 62-year-old woman with CTEPH who developed a severe allergic reaction after the first BPA procedure.

Angioplasty 59

Angioplasty Pulmonary Technology Hypertension 59

DAIC

NOVEMBER 18, 2024

tim.hodson Mon, 11/18/2024 - 15:10 Nov. 18, 2024 — Silence Therapeutics presented end-of-treatment data from its Phase 2 ALPACAR-360 study of zerlasiran, a short interfering RNA (siRNA), in atherosclerotic cardiovascular disease (ASCVD) patients with high lipoprotein(a) [Lp(a)] levels (≥125 nmol/L). These data were presented at the American Heart Association (AHA) Scientific Sessions 2024 in Chicago, Illinois, and simultaneously published in the Journal of the American Medical Association (JAMA

Academic 52

Academic Risk Factors Cardiovascular Disease 52

Science Daily - Heart Disease

NOVEMBER 21, 2024

Drug discovery researchers have found that a natural fat molecule called 'lipoxin A4' (LXA4) could significantly reduce inflammation and improve function for diabetic hearts.

Diabetes 122

Diabetes Heart Disease Research 122

Med Page Today

NOVEMBER 19, 2024

(MedPage Today) -- Genetic risk for Alzheimer's disease and dementia appeared to be partly offset by high levels of cardiorespiratory fitness, U.K. Biobank data suggested. Overall, high cardiorespiratory fitness was associated with better global.

Dementia 122

Dementia 122

Frontiers in Cardiovascular Medicine

NOVEMBER 21, 2024

ObjectiveThis study aims to explore the effect of a case management model that breaks through the temporal and spatial characteristics on the at-home phase II exercise rehabilitation of postoperative patients treated with percutaneous coronary intervention (PCI).MethodsWe used the convenience sampling method to select 103 patients with coronary artery disease (53 in the observation group and 50 in the control group) who were admitted to the Department of Cardiovascular Internal Medicine at the J

Exercise 59

Exercise Coronary Artery Disease Cholesterol BMI 59

Dr. S. Venkatesan MD

NOVEMBER 22, 2024

Atrial fibrillation: Think locally act globally It is clear, except in specific situations like HT, LVH, HFpEF, and other left (or right )sided structural heart diseases, the bulk of the AF is part of systemic destabilization of neuro-metabolic homeostasis. Atria become a poor, jittery victim to a complex interaction of multitude of factors like obesity, systemic inflammation, fatty infiltration, anxiety, abnormal neuro-cardiac modulation, chronic oxygen deprivation. etc.

Atrial Fibrillation 52

Atrial Fibrillation Arrhythmia Risk Factors Bradycardia 52

Science Daily - Heart Disease

NOVEMBER 22, 2024

A new study found that prolonged standing at work had a negative impact on the research participants' 24-hour blood pressure. In contrast, spending more time sitting at work was associated with better blood pressure. The study suggests that activity behavior during working hours may be more relevant to 24-hour blood pressure than recreational physical activity.

Blood Pressure 117

Blood Pressure Research 117

Med Page Today

NOVEMBER 18, 2024

(MedPage Today) -- More than half of all adults in the U.S. are eligible for semaglutide (Ozempic, Wegovy, Rybelsus), researchers estimated. Among 25,531 participants in the National Health and Nutrition Examination Survey (NHANES) from 2015 to.

Research 122

Research 122

Frontiers in Cardiovascular Medicine

NOVEMBER 19, 2024

In instances where a patient with acute myocardial infarction (AMI) did not undergo immediate reperfusion therapy during the acute phase, there was a risk of the occlusion progressing to chronic and the chances of spontaneous recanalization decreasing. This case report detailed the experience of a 37-year-old male patient who, 45 days post-AMI, still had a blocked left anterior descending (LAD) artery due to the patient's refusal for intervention.

Myocardial Infarction 59

Myocardial Infarction Outcomes 59

JAMA Cardiology

NOVEMBER 19, 2024

This systematic review and individual patient data meta-analysis investigates the association of an alternative low-density lipoprotein (LDL) strategy with differences in long-term efficacy and safety in patients with atherosclerotic cardiovascular disease (ASCVD) compared with a high-intensity statin strategy.

Cholesterol 111

Cholesterol Cardiovascular Disease 111

Science Daily - Heart Disease

NOVEMBER 21, 2024

A potentially life-changing heart condition, dilated cardiomyopathy, can be caused by the cumulative influence of hundreds or thousands of genes and not just by a single 'aberrant' genetic variant, as was previously thought, finds a new study.

Cardiomyopathy 112

Cardiomyopathy 112

Med Page Today

NOVEMBER 22, 2024

(MedPage Today) -- Uptake of continuous glucose monitoring (CGM) was relatively low among vulnerable diabetes patients in the largest national system of safety-net primary care clinics, a retrospective cross-sectional study found. In patients.

Diabetes 121

Diabetes 121

Frontiers in Cardiovascular Medicine

NOVEMBER 19, 2024

ObjectiveThis review aims to summarize the salvage experience of cardiopulmonary collapse occurring as a result of absolute ethanol sclerotherapy for vascular malformations.MethodsIn total, we reviewed three cases of cardiopulmonary collapse induced by ethanol sclerotherapy for vascular malformations and described the details of the salvage procedure.

Circulation 59

Circulation Research 59