Sat.Nov 16, 2024 - Fri.Nov 22, 2024

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Weight-loss drug found to shrink heart muscle in mice and human cells

Medical Xpress - Cardiology

Trendy weight-loss drugs making headlines for shrinking waistlines may also be shrinking the human heart and other muscles, according to a new University of Alberta study in JACC: Basic to Translational Science. The authors say the research should serve as a "cautionary tale" about possible long-term health effects of these drugs.

Research 143
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Instructor Collection ECG: Anterior M.I. and Left Ventricular Hypertrophy

ECG Guru

The Patient: Sixty-year-old man with a complaint of severe substernal chest pain. Denies hx of M.I., but reports feeling short of breath on exertion for about a year. Hx of hypertension, but admits he is non-compliant with his medication. Appears pale and diaphoretic, BP 110/68. The ECG: The rhythm is sinus at 62 bpm. The QRS is slightly wide at 110 ms (.11 seconds), but still within normal limits.

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GLP-1 Use Prior to Surgery: Analyzing the Updated Guidance

Med Page Today

(MedPage Today) -- Since the modern practice of anesthesia has evolved, providers have been concerned about pulmonary aspiration -- when gastric contents enter the lung, resulting in severe complications including pneumonitis, and aspiration.

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Finding a Role for GLP-1 RAs, Incretin Therapies in Heart Failure, with Muthiah Vaduganathan, MD, MPH

HCPLive

Muthiah Vaduganathan, MD, MPH, discusses the need for cardiology to embrace a role for GLP-1 receptor agonists and incretin therapies, with a focus on obesity-related HFpEF.

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In a small international trial, novel oral medication muvalaplin lowered Lp(a)

American Heart News - Heart News

Research Highlights: The oral medication muvalaplin may safely lower high levels of lipoprotein(a), also known as Lp(a), an independent, inherited risk factor for cardiovascular disease. Muvalaplin is a small molecule inhibitor that prevents the.

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Physiology Friday #245: Fitness Protects against Neurodegenerative Diseases—Even in Those at the Greatest Risk

Physiologically Speaking

Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

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Fitness Level May Offset Genetic Dementia Risk

Med Page Today

(MedPage Today) -- Genetic risk for Alzheimer's disease and dementia appeared to be partly offset by high levels of cardiorespiratory fitness, U.K. Biobank data suggested. Overall, high cardiorespiratory fitness was associated with better global.

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The human heart may have a hidden ability to repair itself

Science Daily - Heart Disease

After severe heart failure, the ability of the heart to heal by forming new cells is very low. However, after receiving treatment with a supportive heart pump, the capacity of a damaged heart to repair itself with new muscle cells becomes significantly higher, even higher than in a healthy heart.

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New genetic explanation for heart condition revealed

Medical Xpress - Cardiology

A potentially life-changing heart condition, dilated cardiomyopathy, can be caused by the cumulative influence of hundreds or thousands of genes and not just by a single "aberrant" genetic variant, as was previously thought, finds a new study led by researchers at UCL (University College London), Imperial College London and the MRC Laboratory of Medical Sciences.

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Over 50% of U.S. Adults Qualify for Ozempic, Wegovy

Med Page Today

(MedPage Today) -- More than half of all adults in the U.S. are eligible for semaglutide (Ozempic, Wegovy, Rybelsus), researchers estimated. Among 25,531 participants in the National Health and Nutrition Examination Survey (NHANES) from 2015 to.

Research 122
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Lipoxin A4 improves cardiac remodeling and function in diabetes-associated cardiac dysfunction

Cardiovascular Diabetology

Diabetic heart disease may eventually lead to heart failure, a leading cause of mortality in diabetic individuals. The lack of effective treatments for diabetes-induced heart failure may result from a failure.

Diabetes 105
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LDL Cholesterol–Lowering Strategy in ASCVD

JAMA Cardiology

This systematic review and individual patient data meta-analysis investigates the association of an alternative low-density lipoprotein (LDL) strategy with differences in long-term efficacy and safety in patients with atherosclerotic cardiovascular disease (ASCVD) compared with a high-intensity statin strategy.

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Discovery explains kidney damage caused by blood pressure drugs

Science Daily - Heart Disease

Scientists have discovered how long-term treatment of high blood pressure with commonly prescribed drugs can destroy the kidney's ability to filter and purify blood. The finding could open the door to better ways to manage high blood pressure and other vascular diseases.

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Electronic Nudges Improved Flu Shot Uptake in Patients With Acute MI History

Med Page Today

(MedPage Today) -- CHICAGO -- Electronic nudges increased uptake of flu vaccines among patients with a history of acute myocardial infarction (MI), results from three Danish randomized trials showed. Among over 2 million patients, a letter explaining.

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Mapping the intersection of sudden cardiac death and COVID-19: a comprehensive bibliometric analysis (2020–2024)

Frontiers in Cardiovascular Medicine

IntroductionA direct causal link between Sudden Cardiac Death (SCD) and COVID-19 is unproven, although current data suggest a plausible association.AimThis study aims to map and analyze the intersection of research on sudden cardiac death and COVID-19 through a comprehensive bibliometric analysis.MethodologyThis study searched the literature by applying the keywords “COVID-19” AND “Sudden Cardiac Death (SCD)”.

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Marcelo Kugelmas, MD: Elafibranor (Iqirvo) Does Not Impact Renal Function in PBC

HCPLive

Kugelmas reviews findings from a secondary analysis of the phase 3 ELATIVE trial suggesting elafibranor is associated with stable kidney function.

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New hope for diabetic heart disease treatment

Science Daily - Heart Disease

Drug discovery researchers have found that a natural fat molecule called 'lipoxin A4' (LXA4) could significantly reduce inflammation and improve function for diabetic hearts.

Diabetes 101
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Lack of Clinical Benefit of Andexanet Flummoxes FDA Panel

Med Page Today

(MedPage Today) -- FDA advisors pushed for nuance in discussing whether andexanet alfa (Andexxa) should gain full approval, citing uncertainties about which dose and in which patients it could be best used to stop bleeding. Members of the Cellular.

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Cardiology collaboration advances machine learning predictions for AFib after stroke

Medical Xpress - Cardiology

Researchers at Penn State are using machine learning and existing electrocardiogram (ECG) data to help doctors make more accurate predictions. A team of artificial intelligence engineers, in collaboration with a team of physicians from Penn State Heart and Vascular Institute, is working to develop novel algorithms for point-of-care, in-house use and for technology licensing.

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Tirzepatide lowered risk of worsening heart failure and CVD death for obese adults

American Heart News - Heart News

Research Highlights: In an international trial of 713 adults in nine countries including the U.S. called SUMMIT, participants with heart failure with preserved ejection fraction (HFpEF) and obesity taking tirzepatide for an average of 2 years had.

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AASM Updates Clinical Guidelines for Restless Legs Syndrome

HCPLive

Following the publication of the new RLS recommendations, HCPLive spoke with John Winkelman, MD, PhD, chair of the AASM committee that revised the guidelines.

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CGM Uptake Very Low for Vulnerable Diabetes Populations

Med Page Today

(MedPage Today) -- Uptake of continuous glucose monitoring (CGM) was relatively low among vulnerable diabetes patients in the largest national system of safety-net primary care clinics, a retrospective cross-sectional study found. In patients.

Diabetes 111
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The human heart may have a hidden ability to repair itself

Medical Xpress - Cardiology

After severe heart failure, the ability of the heart to heal by forming new cells is very low. However, after receiving treatment with a supportive heart pump, the capacity of a damaged heart to repair itself with new muscle cells becomes significantly higher, even higher than in a healthy heart. This is according to a new study from Karolinska Institutet published in the journal Circulation.

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Ablation may be better than medication for those with dangerous heartbeat after heart attack

American Heart News - Heart News

Research Highlights: A new, multicenter study demonstrated that ablation treatment may be a better first option than medication for many heart attack survivors who develop abnormal electrical short circuits in their heart, which are episodes of.

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Semaglutide Eligibility Across All Current Indications for US Adults

JAMA Cardiology

This cross-sectional study uses National Health and Nutrition Examination Survey data to examine the number of US adults eligible for semaglutide across all current indications.

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Tirzepatide Officially Puts GLP-1 Meds on the Map for Obesity-Related Heart Failure

Med Page Today

(MedPage Today) -- CHICAGO -- A long-acting GIP/GLP-1 receptor agonist conferred significant clinical benefit for people with obesity and accompanying heart failure with preserved ejection fraction (HFpEF), according to the SUMMIT trial. Incident.

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Is this OMI reperfused or active?

Dr. Smith's ECG Blog

These ECGs were texted to me by one of our previous ultrasound fellows, Will Smoot An elderly male arrived via EMS for acute substernal chest pain with radiation to left shoulder and arm that awakened him from sleep at 0030. He took two full strength aspirin prior to EMS arrival. The pain was relieved by one prehospital NTG spray. He arrived at the ED just shy of two hours after onset, pain free.

STEMI 101
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Giving pharmacists feedback improved care for veterans with heart failure

American Heart News - Heart News

Research Highlights: Pharmacists in the Veterans Health Administration System who received feedback on their patients' heart failure medication rates, along with educational tools and targeted information, had a significant increase in the frequency.

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Fast Fourier transform analysis of intraoperative transit-time flow measurement during coronary artery bypass grafting

Journal of Cardiothoracic Surgery

As the current guidelines on myocardial revascularization recommend, transit-time flow measurement (TTFM) is increasingly used for intraoperative graft flow analysis during coronary artery bypass grafting (CAB.

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Opioids Tied to Higher Dementia Risk, but Only After a Point

Med Page Today

(MedPage Today) -- After a certain threshold, cumulative opioid use was associated with higher dementia risk, a study of adults over age 60 in Denmark showed. In a nested case-control study, opioid use above 90 total standardized doses (TSDs.

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Study Highlights Wound Closure Techniques Following Wide Excision for HS

HCPLive

This meta-analysis showed that both secondary closure techniques substantially reduce the risk of hidradenitis suppurativa recurrence compared to primary direct closure.

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Finerenone in Women and Men With Heart Failure With Mildly Reduced or Preserved Ejection Fraction

JAMA Cardiology

This prespecified secondary analysis of a randomized clinical trial examines the efficacy and safety of finerenone in women and men with heart failure with mildly reduced ejection fraction and heart failure with preserved ejection fraction.

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Anthos Presents New Analysis from P2 AZALEA-TIMI 71 Study

DAIC

tim.hodson Mon, 11/18/2024 - 10:55 Nov. 16, 2024 Anthos Therapeutics, Inc.recently presented new data at the American Heart Association (AHA) Scientific Sessions from its AZALEA-TIMI 71 study that demonstrated the novel factor XI inhibitor abelacimab led to consistent and substantial reductions in bleeding for patients on or off antiplatelet (APT) therapy, as compared to rivaroxaban.

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Spironolactone Misses the Mark in Acute MI Without HF

Med Page Today

(MedPage Today) -- CHICAGO -- A mineralocorticoid receptor antagonist (MRA) was unable to further improve 3-year outcomes of acute myocardial infarction (MI) in the modern era, based on the CLEAR OASIS 9 trial. Among heart attack survivors without.

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Spironolactone, a blood pressure medication, may help reduce risk of new heart failure

American Heart News - Heart News

Research Highlights: The CLEAR SYNERGY trial found that spironolactone may reduce the risk of new or worsening heart failure; however, it did not significantly impact the rate of death, new heart attack or stroke. More research is needed to further.

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Obesity-Related Heart Disease Deaths Rose Roughly 180% Since 1999

HCPLive

Obesity-related ischemic heart disease deaths rose from 1999 to 2020, particularly in middle-aged men and Black adults, per CDC WONDER data.

Obesity 111
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Weight-loss drug reduces risk of early death for patients with heart failure, trial finds

Science Daily - Heart Disease

Weight-loss and diabetes drug tirzepatide can reduce the risk of death or worsening heart failure for patients with obesity and heart failure with preserved pump function, new research reveals.