Open Heart

FEBRUARY 17, 2025

Background Hypertrophic cardiomyopathy (HCM) is commonly associated with atrial fibrillation (AF), but its impact on outcomes in real-world practice is uncertain. The aim of the study was to evaluate the clinical profile and prognosis of patients with HCM and AF. Methods Overall, 1739 adult patients with HCM (40.9% women; median age: 55.5 years) were enrolled in the EURObservational Research Programme (EORP) Cardiomyopathy/Myocarditis Registry.

Atrial Fibrillation 88

Atrial Fibrillation Cardiomyopathy Research Defibrillator 88

Circulation

FEBRUARY 20, 2025

Circulation, Ahead of Print. This American Heart Association/American College of Cardiology scientific statement on clinical considerations for competitive sports participation for athletes with cardiovascular abnormalities or diseases is organized into 11 distinct sections focused on sports-specific topics or disease processes that are relevant when considering the potential risks of adverse cardiovascular events, including sudden cardiac arrest, during competitive sports participation.

Cardiac Arrest 81

Cardiac Arrest Circulation 81

Nature Reviews - Cardiology

FEBRUARY 18, 2025

Nature Reviews Cardiology, Published online: 19 February 2025; doi:10.1038/s41569-025-01130-5 In this Roadmap, Stellos and colleagues discuss the mechanisms of cardiovascular system ageing and how the ageing of blood, vessels and heart relates to the decline in organ function, and highlight potential therapeutic interventions, challenges in ageing research and future directions for preclinical and clinical studies.

Research 75

Research 75

Journal of Clinical Investigation - Cardiology

FEBRUARY 17, 2025

Heterozygous truncating variants in the sarcomere protein titin (TTN) are the most common genetic cause of heart failure. To understand mechanisms that regulate abundant cardiomyocyte (CM) TTN expression, we characterized highly conserved intron 1 sequences that exhibited dynamic changes in chromatin accessibility during differentiation of human CMs from induced pluripotent stem cells (hiPSC-CMs).

CMS 75

CMS Heart Failure Cardiomyopathy 75

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

Patient Care

MIBHS

FEBRUARY 15, 2025

High blood pressure, also known as hypertension, is a common condition that affects millions of people worldwide. Often referred to as the silent killer, hypertension can quietly damage your heart and other vital organs over time. Understanding how high blood pressure impacts your heart and learning to manage it can significantly reduce your risk of heart disease and improve your overall health.

Blood Pressure 52

Blood Pressure Hypertension Chest Pain Aneurysm 52

CardiacWire

FEBRUARY 19, 2025

Although heart failure prognosis is grim, the ALT-FLOW trials two year results suggest that diverting blood from the left atrium to the coronary sinus using a shunt could have lasting benefits for patients with HFmrEF/HFpEF. Theres no cure for HF, so most treatments focus on extending lifespan and improving quality-of-life by reducing symptoms. Current treatments focus on improving blood flow, lowering blood pressure, and relieving kidney fluid pressure, while procedures like CABG or ICD and VAD

Quality of Life 59

Quality of Life Heart Failure Blood Pressure Hospital 59

Frontiers in Cardiovascular Medicine

FEBRUARY 17, 2025

IntroductionSince TAVR was approved for lower-risk aortic stenosis (AS) patients, managing post-implantation conduction disturbances has become crucial, especially with self-expanding heart valves (SEV). This study aims to identify risk factors for conduction disturbances in such patients using a specific fluoroscopic cusp overlap (COL) technique.MethodsThis retrospective study analyzed AS patients who underwent TAVR with SEV from 2019 to 2022, excluding those needing pacemakers or valve-in-valv

Pacemaker 52

Pacemaker Aortic Stenosis Aortic valve 52

Open Heart

FEBRUARY 17, 2025

Background Despite limited beneficial evidence, mechanical circulatory support (MCS) is commonly used in patients with acute myocardial infarction-related cardiogenic shock (AMI-CS). In this Dutch registry, we investigated MCS usage, associated patient characteristics and clinical outcomes. Methods This real-world, multicentre registry included CS patients undergoing percutaneous coronary intervention between 2017 and 2021 in 14 Dutch hospitals.

Cardiogenic Shock 52

Cardiogenic Shock Myocardial Infarction Aortic Outcomes 52

CardiacWire

FEBRUARY 17, 2025

With 85% of cardiologists now employed by health systems, it may seem like the days of independent cardiology practice are long gone, but Atria Health is looking to reverse this trend with the help of a unique private equity model. The shift towards corporate and hospital-owned cardiology groups stems from a long list of factors like falling reimbursements, rising costs, and partners who want an exit.

Reimbursement 59

Reimbursement Hospital Outcomes 59

Hypertension Journal

FEBRUARY 21, 2025

Hypertension, Ahead of Print. BACKGROUND:A hypertensive disorder of pregnancy is associated with a higher risk of cardiovascular disease later in life, but the potential mechanistic links are unknown.METHODS:We recruited 2 groups of women, 1 during pregnancy and another at least 2 years after delivery. Cases had a hypertensive disorder of pregnancy, and controls had a normotensive pregnancy.

Hypertension 45

Hypertension Cardiovascular Disease 45

Frontiers in Cardiovascular Medicine

FEBRUARY 19, 2025

BackgroundAtrial fibrillation (AF) is the most common arrhythmia worldwide. Data regarding AF screening in conflict countries emergency departments (ED) is lacking.MethodsWe included consecutive patients >40 years old who reported to the ED of a Syrian tertiary centre between July 2024 and September 2024. Patients had routine 12-lead electrocardiograms (ECGs) regardless of presenting complaints.

Atrial Fibrillation 52

Atrial Fibrillation Electrocardiogram Tachycardia Arrhythmia 52

Open Heart

FEBRUARY 17, 2025

Objective Out-of-hospital cardiac arrest (OHCA) is a major public health challenge across Europe, with a survival rate of only 8.5% to hospital discharge. Implementing a community first responder (CFR) system, including earlier Basic Life Support and defibrillation, can enhance survival rates and neurological outcomes. This study assesses the cost-effectiveness of two scenarios for implementing such a system in Belgium.

Cardiac Arrest 52

Cardiac Arrest Hospital Defibrillator Quality of Life 52

Circulation

FEBRUARY 20, 2025

Circulation, Ahead of Print. BACKGROUND:Circular RNAs derived from both nuclear and mitochondrial genomes are identified in animal cells. Mitochondria-encoded circular RNAs (mecciRNAs) are attracting more attention, and several members of mecciRNAs have already been recognized in regulating mitochondrial functions. Mitochondria dysfunctions are well-known to participate in heart failure (HF).

Heart Failure 45

Heart Failure Circulation 45

DAIC

FEBRUARY 18, 2025

tim.hodson Tue, 02/18/2025 - 16:17 Feb. 11, 2025 UltraSight, a company committed to enhancing the efficiency and productivity of cardiac ultrasound,recentlyannounced support from Bristol Myers Squibb (BMS) for a study that aims to improve access to echocardiographic assessments for patients with obstructive hypertrophic cardiomyopathy (oHCM). Cardiac ultrasound is routinely used as an essential tool in the diagnosis and management of oHCM.

Ultrasound 52

Ultrasound Echocardiogram Innovation Cardiomyopathy 52

Frontiers in Cardiovascular Medicine

FEBRUARY 17, 2025

IntroductionSecundum Atrial septal defect (ASD) is the most common type of ASD. When it is large and hemodynamically significant, it can cause symptoms such as dyspnea, exercise intolerance, and palpitations. Following diagnosis confirmation, an ASD with hemodynamic significance should be closed electively. Percutaneous closure (PC) is an effective treatment option for ostium secundum ASD with adequate rims, despite the potential for several complications.

Hospital 52

Hospital Exercise Tachycardia Pulmonary 52

Open Heart

FEBRUARY 17, 2025

Background Infants with congenital heart disease (CHD) are clinically vulnerable to cardiac deteriorations and intercurrent infections. We aimed to quantify the impact of health system disruptions during the COVID-19 pandemic, on their clinical outcomes and whether these differed by socioeconomic and ethnic subgroups. Methods In this population-based cohort study, we used linked electronic healthcare datasets from England and Wales to identify infants with nine sentinel CHDs born and undergoing

Congenital Heart Disease 52

Congenital Heart Disease Congenital Heart Disease Outcomes 52

Journal of Clinical Investigation - Cardiology

FEBRUARY 17, 2025

Red blood cells (RBCs), traditionally recognized for their role in transporting oxygen, play a pivotal role in the bodys immune response by expressing TLR9 and scavenging excess host cell-free DNA. DNA capture by RBCs leads to accelerated RBC clearance and triggers inflammation. Whether RBCs can also acquire microbial DNA during infections is unknown.

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Med Page Today

FEBRUARY 21, 2025

(MedPage Today) -- The shortage of semaglutide injections (Ozempic, Wegovy) is over, the FDA announced on Friday. The agency, along with maker Novo Nordisk, confirmed that supply now meets or exceeds both the current and projected U.S. demand.

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Frontiers in Cardiovascular Medicine

FEBRUARY 18, 2025

BackgroundLimited evidence exists regarding the association between oxidative stress induced by dietary and lifestyle factors and cardiovascular diseases (CVDs).MethodsWe conducted a weighted analysis using data from 13,530 adults in the National Health and Nutrition Examination Survey (NHANES), covering the period from 2003 to 2018. The total oxidative balance score (OBS) was derived from 20 oxidative stress-related exposures, including dietary and lifestyle factors.

Cardiovascular Disease 52

Cardiovascular Disease Research 52

Open Heart

FEBRUARY 17, 2025

Background Percutaneous coronary intervention (PCI) is a well-established treatment for coronary artery disease, one of the most significant causes of morbidity and mortality worldwide. Intracoronary imaging, including intravascular ultrasound (IVUS) and optical coherence tomography (OCT), has been shown to improve outcomes for patients following PCI by reducing complications and the need for repeat procedures.

Coronary Artery Disease 52

Coronary Artery Disease Ultrasound Hospital Outcomes 52

American Heart News - Heart News

FEBRUARY 18, 2025

DALLAS, Feb. 18, 2025 About 90% of U.S. adults meet the criteria for a newly recognized syndrome that comes from a combination of heart disease, kidney disease, type 2 diabetes and obesity.[1] This cluster of chronic health conditions is called.

Kidney Disease 117

Kidney Disease Obesity Heart Disease Diabetes 117

HCPLive

FEBRUARY 15, 2025

In this episode, hosts offer perspective on recent studies assessing insulin delivery systems in adults with type 2 diabetes.

Diabetes 114

Diabetes 114

Frontiers in Cardiovascular Medicine

FEBRUARY 18, 2025

IntroductionCellular senescence can cause heart failure. However, studies on diagnostic markers related to cellular senescence in acute myocardial infarction (AMI) have not been reported. Therefore, this study explores the mechanism of key genes related to cellular senescence in acute myocardial infarction (AMI) through a bioinformatics approach.MethodsAMI related datasets were obtained from gene expression omnibus (GEO) database, and 3,058 cellular senescence related genes (CSRGs) were extracte

Myocardial Infarction 52

Myocardial Infarction Heart Failure Research 52

European Journal of Cardiovascular Nursing

FEBRUARY 16, 2025

Abstract Aim Delirium is common in patients aged over 70 years after cardiac surgery. Screening to detect delirium in high-risk patients is important, yet hypoactive delirium is often missed in nurse-reported screening. Polymorphic delta waves are associated with delirium, and can be detected with single-channel electroencephalography (SC-EEG). The aim of the study is to assess whether SC-EEG as a screening instrument for delirium will increase the detection rate of postoperative delirium and re

Nursing 40

Nursing Hospital 40

Medical Xpress - Cardiology

FEBRUARY 19, 2025

From diet soda to zero-sugar ice cream, artificial sweeteners have been touted as a guilt-free way to indulge our sweet tooth. However, new research published in Cell Metabolism shows that aspartame, one of the most common sugar substitutes, may impact vascular health.

Diet 111

Diet Research 111

HCPLive

FEBRUARY 19, 2025

Chemomab completed an end-of-phase 2 meeting with the FDA and has aligned on the design of a phase 3 registration study for nebokitug (CM-101) in PSC.

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Frontiers in Cardiovascular Medicine

FEBRUARY 17, 2025

Ischemia with no obstructive coronary arteries (INOCA) is an increasingly recognized condition in patients presenting with angina and positive stress tests but without significant coronary artery stenosis. This review addresses the pathophysiology, diagnostic approaches, and management strategies associated with INOCA, emphasizing epicardial coronary spasms and coronary microvascular dysfunction (CMD) as underlying mechanisms and myocardial bridging (MB) as a risk factor.

Ischemia 52

Ischemia Angina Pharmacology Stenosis 52

Science Daily - Heart Disease

FEBRUARY 17, 2025

In a surprising discovery, scientists have found that the heart possesses 'sweet taste' receptors, similar to those on our tongues, and that stimulating these receptors with sweet substances can modulate the heartbeat. This research opens new avenues for understanding heart function and potentially for developing novel treatments for heart failure.

Heart Failure 109

Heart Failure Research 109

Medical Xpress - Cardiology

FEBRUARY 21, 2025

A positive patient-doctor relationship is an ingredient to a healthy life, and new research has zeroed in on the impact common language in the relationship can have by decreasing cardiovascular disease for the benefit of a longer life.

Cardiovascular Disease 98

Cardiovascular Disease Research 98

HCPLive

FEBRUARY 18, 2025

Dual SGLT1/2 inhibition with sotagliflozin significantly reduced both heart attacks and stroke in a prespecified secondary analysis of the SCORED trial.

Heart attacks 101

Heart attacks Heart Attack Diabetes Stroke 101

Frontiers in Cardiovascular Medicine

FEBRUARY 20, 2025

IntroductionERAS protocols have revolutionized perioperative care by optimizing patient outcomes after major surgeries. Despite widespread recognition in various surgical specialties, the implementation of ERAS in cardiac surgery remains relatively novel.MethodsThis qualitative study employed semi-structured interviews to explore the perspectives and experiences of healthcare professionals involved in ERAS implementation, focusing on identifying facilitators and barriers.

Heart Valves 52

Heart Valves Outcomes Research 52

European Journal of Heart Failure

FEBRUARY 16, 2025

Baseline characteristics for the vericiguat global study in participants with chronic heart failure (VICTOR) trial. ARNI, angiotensin receptor/neprilysin inhibitor; CRT, cardiac resynchronization therapy; eGFR, estimated glomerular filtration rate; GDMT, guideline-directed medical therapy; HF, heart failure; HFrEF, heart failure with reduced ejection fraction; HHF, hospitalization for heart failure; ICD, implantable cardioverter-defibrillator; IV, intravenous; LVEF, left ventricular ejection fra

Heart Failure 40

Heart Failure Defibrillator Hospital Outcomes 40

Medical Xpress - Cardiology

FEBRUARY 20, 2025

A new study shows how the brain reorganizes itself in the first few months after a stroke to improve the ability to speak again. The findings will help researchers understand how functional networks work in the brain. They also have the potential to be used in the future for personalized treatment of stroke patients.

Stroke 98

Stroke Strokes Research 98

HCPLive

FEBRUARY 18, 2025

Younger age, low knowledge of HBV sequelae, and high perceived HBV stigma were linked to lower medication adherence in Korean American patients.

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Frontiers in Cardiovascular Medicine

FEBRUARY 17, 2025

IntroductionSepsis, a life-threatening condition arising from an uncontrolled immune response to infection, can lead to organ dysfunction, with severe inflammation potentially causing multiple organ failures. Sepsis-induced cardiac dysfunction (SIMD) is a common and severe complication of sepsis, significantly increasing patient mortality. Understanding the pathogenesis of SIMD is crucial for improving treatment, and microRNAs (miRNAs) have emerged as important regulators in this process.Methods

Article 52

Article Research Biomarkers 52

The American Journal of Cardiology

FEBRUARY 19, 2025

Publication date: Available online 18 February 2025 Source: The American Journal of Cardiology Author(s): Sean Gilhooley, David Power, Anastasios Roumeliotis, Richard Tanner, Anton Camaj, Samantha Sartori, Kenneth Smith, Johny Nicolas, Rakhee R. Makhija, Pier Pasquale Leone, Keisuke Yasumura, Manish Vinayak, Amit Hooda, Parasuram Melarcode Krishnamoorthy, Serdar Farhan, Joseph Michael Sweeny, George D.

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