Ken Grauer, MD

MAY 17, 2025

== P lease N OTE : After today No new ECG Blog posts for 3- to -4 weeks. I will also not be prompt in replying to emails. == All material on this ECG Blog site remains open! The INDEX tab ( in the upper right of each page ) has linked Contents, listed by subject. So IF you are looking for ECG material There is plenty on this web site! And IF you look at the TOP of every page in this blog You'll see a Menu of Tabs that link to a variety of blog features, including my ECG podcasts, Audios &a

Blog 161

Blog STEMI Angina Ischemia 161

Medical Xpress - Cardiology

MAY 17, 2025

A pharmaceutically produced cannabidiol formulation had a good overall safety profile, including cardiac safety, according to research presented at Heart Failure 2025.

Heart Failure 125

Heart Failure Research 125

Frontiers in Cardiovascular Medicine

MAY 21, 2025

IntroductionHigh-Density Lipoprotein Cholesterol (HDL-C) plays a pivotal role in cardiovascular health, acting as a key component in lipid transport and atheroprotection. While low HDL-C levels in the general population are often the result of multifactorial causes, extremely low HDL-C levels ( T, chr:9 91757308 C>A, rs375247413], LCAT [NM_000229.2(LCAT):c.349G>A p.Ala117Thr, rs28940886], and APOA1 [NM_000039.3(APOA1):c.388A>T, p.Lys130*].DiscussionEach case presented a unique spectrum of clinic

Cholesterol 98

Cholesterol Patient Care Research 98

Nature Reviews - Cardiology

MAY 22, 2025

Nature Reviews Cardiology, Published online: 23 May 2025; doi:10.1038/s41569-025-01168-5 In this Review, Ackerman and colleagues describe the rationale for gene therapy to treat cardiac arrhythmias; discuss advantages and disadvantages of gene silencing, replacement and editing technologies; summarize vector modalities and delivery approaches; present examples of gene therapy strategies used for atrial and ventricular arrhythmias; and highlight the current challenges and limitations in the gene

Arrhythmia 86

Arrhythmia Technology 86

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

Patient Care

Science Daily - Heart Disease

MAY 19, 2025

People who were less active, with a daily average of more than 14 hours of sedentary behavior, were more than twice as likely to have another cardiac event, including heart attack, surgery to treat heart issues (coronary revascularization), or to be hospitalized again within a year after the first cardiac event.

Heart attacks 73

Heart attacks Heart Attack Hospital 73

Medical Xpress - Cardiology

MAY 18, 2025

Waist-to-height ratio predicts heart failure incidence, according to research presented at Heart Failure 2025.

Heart Failure 87

Heart Failure Research 87

American College of Cardiology

MAY 20, 2025

Withdrawal of other heart failure treatment while maintaining carvedilol as a single therapy did not worsen left ventricular (LV) function compared to usual treatment at 52 weeks in patients with heart failure with improved ejection fraction (HFimpEF).

Heart Failure 75

Heart Failure Article 75

Science Daily - Heart Disease

MAY 19, 2025

A new discovery could mean more donor hearts are available for heart transplant, giving more people a second chance at life.

Heart Transplant 64

Heart Transplant Transplant 64

Physiologically Speaking

MAY 23, 2025

Greetings! Welcome to the Physiology Friday newsletter. This week I want to shoutout my new favorite protein bar— BOLD Bar. Founded by Sean Jagermann, BOLD BAR launched in April 2025 to redefine on-the-go fuel. Each bar packs 20g of protein and 100mg of caffeine, and is sweetened only with honey, for a clean, simple, and satiating snack. BOLD is the only bar on the market built on these three uncompromising pillars: high protein, a real caffeine boost, and natural sweetness with zero artif

Physiology 59

Physiology Exercise Research Outcomes 59

HCPLive

MAY 18, 2025

Pande explains findings from his research on immunosuppression in interstitial lung disease suggesting this treatment does not affect fibrosis progression.

Research 72

Research 72

American College of Cardiology

MAY 23, 2025

In this episode, Drs. Purvi Parwani and Sharonne Hayes discuss Cardiovascular Health Throughout a Woman's Lifecycle.

Article 61

Article 61

Heart BMJ

MAY 23, 2025

Non-ST-segment elevation myocardial infarction (NSTEMI) is the most common acute coronary syndrome diagnosis in older patients. In the UK, there are ~20 000 NSTEMI cases annually in patients aged ≥75 years. Despite therapeutic advances in pharmacological and invasive management, studies show that older patients with NSTEMI experience worse in-hospital and long-term outcomes than younger patients, suggesting a clear need for robust evidence in this cohort.

Myocardial Infarction 52

Myocardial Infarction Pharmacology Outcomes Hospital 52

Medical Xpress - Cardiology

MAY 17, 2025

An artificial intelligence-enabled electrocardiogram-based algorithm performed well in the early detection of heart failure among health-care-seeking individuals in Kenya, according to late-breaking research presented Heart Failure 2025.

Heart Failure 52

Heart Failure Electrocardiogram Research 52

HCPLive

MAY 23, 2025

The analysis of pooled data from BOREAS and NOTUS highlight dupilumabs sustained impact on lung function in patients with COPD and type 2 inflammation.

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American College of Cardiology

MAY 20, 2025

In September 2024, the Taiwan Society of Cardiology (TSC) published updated guidelines on the primary prevention of atherosclerotic cardiovascular disease (ASCVD).

Cardiovascular Disease 72

Cardiovascular Disease Article 72

ADN Center of Excellence

MAY 23, 2025

What a week, what a ride and what a privilege to share in EuroPCR 2025 in Paris!This year's meeting of the international interventional cardiology community was more than a date on the calendar. It was a meeting of purpose, innovation, and common vision. And right at the center of it all, at Booth 70; stood ADN CoE proudly waving the banner for hands-on learning, practical training, and the future of simulation in interventional cardiology.

Interventional Cardiology 59

Interventional Cardiology Innovation 59

DAIC

MAY 23, 2025

tim.hodson Fri, 05/23/2025 - 10:39 May 22, 2025 Auxira Health hasofficially launched the company provides a new approach to clinical support purpose-built for cardiology. Auxiras hybrid care model deploys expert clinical teams that virtually embed directly in a practice's existing workflows, freeing cardiologists to deliver care at the top of their experience while expanding access for patients.

Innovation 52

Innovation Technology Nursing 52

HCPLive

MAY 18, 2025

These data from ATS 2025 point to climate change as a potential influence on the burden associated with obstructive sleep apnea (OSA).

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Frontiers in Cardiovascular Medicine

MAY 23, 2025

Background and objectivesTranscatheter Aortic Valve Implantation (TAVI) is a minimally invasive intervention for aortic stenosis, which is associated with the potential for major vascular complications and arrhythmias. This study aims to identify primary predictors of these complications, emphasizing the roles of Decreased Platelet Count (DPC) and Acquired Von Willebrand Syndrome (AVWS).MethodsWe performed a prospective study with 80 patients planning to receive TAVI at the Heart Center, Kaplan

Aortic valve 52

Aortic valve Aortic Arrhythmia Outcomes 52

Heart BMJ

MAY 23, 2025

Clinical introduction A man in his 60s was admitted to our hospital for surgical aortic valve replacement for severe aortic stenosis due to a bicuspid aortic valve. Although left ventricular (LV) hypertrophy was noted in his childhood, the details were not clarified. The 12-lead ECG showed normal sinus rhythm with a heart rate of 100 beats per minute and complete left bundle branch block.

Bicuspid/Mitral 59

Bicuspid/Mitral Aortic valve Aortic Stenosis 59

Science Daily - Stroke

MAY 21, 2025

A study explains how age reshapes the blood system. In both humans and mice, a few stem cells out-compete their neighbors and gradually take over blood production. The loss of diversity results in a blood system that has a preference for producing myeloid cells, immune cells linked to chronic inflammation which underlies many different diseases. Using a new technique, researchers tracked naturally-occurring 'barcodes' in blood cells which can lead to new strategies that spot early warning signs

Cancer 52

Cancer Heart Disease Research 52

HCPLive

MAY 23, 2025

Researchers introduce the Fibromyalgia Quality of Life Scale (FM-QoLS), a reliable tool designed to assess the unique quality of life challenges faced by fibromyalgia patients.

Quality of Life 59

Quality of Life Research 59

Frontiers in Cardiovascular Medicine

MAY 19, 2025

Cardiac organoid is a miniature and simplified three-dimensional (3D) cellular model system grown from progenitor cells or stem cells that more accurately mimic the significant biological characteristics and functions of the normal cardiac system than conventional two-dimensional (2D) models. With continued advances in 3D culture approaches, the cardiac organoid models produced through self-organization strategy following developmental induction conditions exhibit higher metabolic similarities a

Physiology 52

Physiology Research 52

Circulation

MAY 22, 2025

Circulation, Ahead of Print. BACKGROUND:Proteomic signatures might improve disease prediction and enable targeted disease prevention and management. We explored whether a protein risk score derived from large-scale proteomics data improves risk prediction of atrial fibrillation (AF).METHODS:A total of 51 680 individuals with 1459 unique plasma protein measurements and without a history of AF were included from the UKB-PPP (UK Biobank Pharma Proteomics Project).

Atrial Fibrillation 49

Atrial Fibrillation Atherosclerosis Research Circulation 49

American College of Cardiology

MAY 23, 2025

Patients with severe aortic stenosis and predominantly noncalcific remodeling of the aortic valve (AV) were found to have worse myocardial structural alterations when evaluated for TAVR using cardiac computed tomography angiogram (CTA) and this is associated with increased myocardial fibrosis or worse filling pressures.

Aortic valve 52

Aortic valve Aortic TAVR Stenosis 52

HCPLive

MAY 23, 2025

These data from ATS 2025 highlight patients real-world outcomes related to treatment of their chronic obstructive pulmonary disease (COPD) with dupilumab.

Pulmonary 64

Pulmonary Outcomes 64

Frontiers in Cardiovascular Medicine

MAY 22, 2025

PurposeSodium glucose co-transporter-2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP-1RAs) have demonstrated cardioprotective effects in people with type 2 diabetes and atherosclerotic cardiovascular disease (ASCVD). In this patient group, there is treatment equipoise, from the standpoint of cardiovascular effect between these medication classes; however, factors associated with prescribing are poorly characterized.MethodsWe performed a retrospective real-world analysis

Diabetes 52

Diabetes BMI Cardiovascular Disease Research 52

Physiologically Speaking

MAY 18, 2025

In today’s age of social media-fueled health advice, I do my best to stay diplomatic. Most health influencers, despite the occasional exaggeration or dramatic claim, are generally well-intentioned. After all, we all say something a bit outlandish now and then. Sensationalism sells. But there’s a growing subset of figures who repeatedly push misinformation under the guise of science—and Gary Brecka has become one of the most frustrating examples.

Physiology 59

Physiology Research Education 59

Hypertension Journal

MAY 21, 2025

Hypertension, Ahead of Print. BACKGROUND:A low circulating placental growth factor (PlGF) concentration is considered a marker of placental dysfunction, the predominant cause of preeclampsia and fetal growth restriction. Besides iatrogenic delivery, there are no effective treatments, potentially due to its heterogeneity. We hypothesize that >1 subtype of placental dysfunction exists in pregnancies with a low circulating PlGF.METHODS:Matched placental villous and maternal plasma samples (l

Circulation 45

Circulation Hypertension Outcomes 45

HCPLive

MAY 18, 2025

New research sheds light on improved waitlist outcomes after new allocation guidelines for lung transplants prioritizing medical urgency were implemented.

Transplant 72

Transplant Outcomes Research 72

Frontiers in Cardiovascular Medicine

MAY 19, 2025

IntroductionPeripheral artery disease (PAD) is a common condition caused by atherosclerosis, which leads to reduced blood flow to the limbs. PAD is associated with major adverse cardiovascular events (MACE) and major adverse limb events (MALE). Surfactant protein-D (SP-D) is a defense lectin expressed in the lungs and vasculature and has been previously associated with PAD.MethodsWe aimed to examine the prognostic value of plasma SP-D in relation to MACE, MALE, and all-cause mortality in 913 men

Peripheral Arterial Disease 52

Peripheral Arterial Disease Atherosclerosis Research 52

Dr. Paddy Barrett

MAY 23, 2025

“Dad had a heart attack at 50. His Dad had a heart attack at 50. My uncle had a heart attack at 50. Am I next?” That is how the conversation usually starts. Someone is sitting in front of me with a rip-roaring early family history of heart disease, and they want to know if they are next and what they can do about it. This person usually has already done some basic testing, and nothing seems to be wrong.

Heart attacks 52

Heart attacks Heart Attack Heart Disease 52

Heart BMJ

MAY 23, 2025

The prevalence of conditions that have been identified as risk factors for the occurrence of atrial fibrillation (AF), including hypertension and diabetes mellitus, increases in the ageing population. Hence, AF has been defined as a condition of particularly the elderly population. To deliver optimal care for patient with AF, the AF-CARE framework has been suggested in the European Society of Cardiology (ESC) guidelines, which includes [C] comorbidity and risk factor assessment, [A] avoidance of

Atrial Fibrillation 52

Atrial Fibrillation Risk Factors Diabetes Hypertension 52

HCPLive

MAY 23, 2025

The FDA approves treprostinil inhalation powder, enhancing treatment options for patients with pulmonary arterial hypertension and interstitial lung disease.

Pulmonary 52

Pulmonary Hypertension 52

Frontiers in Cardiovascular Medicine

MAY 19, 2025

IntroductionCoronary heart disease is becoming more common in developing nations. Acute coronary syndrome (ACS) poses a major challenge to global health; however, access to cardiac rehabilitation and preventative measures is limited. There is an urgent need for affordable and widely accessible alternative delivery models to resolve this treatment gap.

Outpatient 52

Outpatient Quality of Life Cardiac Rehabilitation Cardiac Function 52

Nature Reviews - Cardiology

MAY 19, 2025

Nature Reviews Cardiology, Published online: 20 May 2025; doi:10.1038/s41569-025-01170-x Conference presentation skills are a crucial, yet often overlooked, element in the dissemination of cardiovascular research. In an era of information overload and digital communication, the ability to clearly and engagingly present scientific data is essential, to ensure that the findings are understood, shared and implemented into clinical practice.

Research 48

Research 48