Journal of Clinical Investigation - Cardiology

MAY 15, 2025

Sterile acute kidney injury (AKI) is common in the clinic and frequently associated with unexplained hypoxemia that does not improve with dialysis. AKI induces remote lung inflammation with neutrophil recruitment in mice and humans, but which cellular cues establish neutrophilic inflammation and how it contributes to hypoxemia is not known. Here we report that AKI induced rapid intravascular neutrophil retention in lung alveolar capillaries without extravasation into tissue or alveoli, causing h

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122

HCPLive

MAY 12, 2025

New research reveals that maternal avocado consumption during pregnancy significantly reduces the risk of infant food allergies.

Research 114

Research 114

Med Page Today

MAY 15, 2025

(MedPage Today) -- Steak 'n Shake recently announced it plans to transition from seed oils to butter and beef tallow -- a move they referred to as "RFK'ing the fries." Many other restaurants plan to follow suit due to growing populist criticism.

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Science Daily - Heart Disease

MAY 13, 2025

Experts are urging people, especially those with existing heart or vascular conditions, to seek medical advice before attempting to lose weight using water-only fasting diets.

Diet 113

Diet 113

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

Patient Care

Journal of Clinical Investigation - Cardiology

MAY 15, 2025

Red blood cells (RBCs) induce endothelial dysfunction in type 2 diabetes (T2D), but the mechanism by which RBCs communicate with the endothelium is unknown. This study tested the hypothesis that extracellular vesicles (EVs) secreted by RBCs act as mediators of endothelial dysfunction in T2D. Despite a lower production of EVs derived from RBCs of T2D patients (T2D RBC-EVs), their uptake by endothelial cells was greater than that of EVs derived from RBCs of healthy individuals (H RBC-EVs).

Diabetes 96

Diabetes 96

HCPLive

MAY 12, 2025

A study shows that many children with pollen allergies face ongoing symptoms into adulthood, highlighting the need for better management.

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114

Heart BMJ

MAY 12, 2025

Chronic kidney disease (CKD) represents a significant global health priority, affecting approximately 844 million adults (10% of the world population). 1 Beyond its implication for kidney health, CKD is inherently linked to cardiovascular disease (CVD), which is the leading cause of morbidity and mortality in this population. 2 The interplay between CKD and CVD is well documented, with mechanisms including shared risk factors, metabolic disturbances and systemic inflammation. 2 Albuminuria, a ma

Kidney Disease 92

Kidney Disease Outcomes Document Risk Factors 92

Journal of Clinical Investigation - Cardiology

MAY 15, 2025

Tissue regenerative responses involve complex interactions between resident structural and immune cells. Recent reports indicate that accumulation of senescent cells during injury repair contributes to pathological tissue fibrosis. Using tissue-based spatial transcriptomics and proteomics, we identified upregulation of the immune checkpoint protein, cytotoxic T lymphocyteassociated protein 4 (CTLA4), on CD8+ T cells adjacent to regions of active fibrogenesis in human idiopathic pulmonary fibrosi

Pulmonary 82

Pulmonary 82

HCPLive

MAY 14, 2025

In this analysis, investigators looked at the extent to which psoriasis severity correlates with patients risk of developing sleep disorders.

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92

Med Page Today

MAY 14, 2025

(MedPage Today) -- A diuretic was able to match spironolactone for blood pressure (BP) lowering in people with resistant hypertension, a small randomized trial showed. Home-measured systolic blood pressure (SBP) was similarly reduced at 12 weeks.

Hypertension 77

Hypertension Blood Pressure 77

Science Daily - Stroke

MAY 14, 2025

A transient ischemic attack, also known as a mini-stroke, is typically defined as a temporary blockage of blood flow to the brain that causes symptoms that go away within a day, but a new study finds that people who have this type of stroke may also have prolonged fatigue lasting up to one year.

Stroke 78

Stroke Strokes 78

Journal of Clinical Investigation - Cardiology

MAY 15, 2025

Endothelial dysfunction remains a cornerstone of diabetic vascular complications. RBCs emerge as pivotal players in endothelial dysfunction, yet the underlying mechanisms remain elusive. In this issue of the JCI, Collado et al. show that the detrimental action of RBCs on the endothelium is mediated by extracellular vesicles (EVs). EVs derived from RBCs (RBC-EVs) of patients with diabetes were taken up by the endothelium and were able to impair endothelium-dependent relaxation via an EV-mediated

Diabetes 75

Diabetes 75

HCPLive

MAY 12, 2025

Skin prick test showed limited symptom correlation and shrimp-specific IgE demonstrated greater diagnostic value than tropomyosin-specific IgE.

Pediatrics 98

Pediatrics 98

American College of Cardiology

MAY 14, 2025

Cardiovascular magnetic resonance (CMR) imaging was able to detect longer myocardial T2, higher extracellular volume (ECV) fraction and worse myocardial dynamics, including impaired strain, before significant decline in left ventricular (LV) systolic function in carriers of LMNA (Lamin) dilated cardiomyopathy (DCM).

Cardiomyopathy 69

Cardiomyopathy Article 69

Medical Xpress - Cardiology

MAY 10, 2025

Women who experience infertility are more likely to develop heart and blood vessel conditions later in life, with younger women and those who undergo fertility treatments at a greater risk. The findings, presented at the first Joint Congress between the European Society of Pediatric Endocrinology (ESPE) and the European Society of Endocrinology (ESE), highlight the importance of considering a woman's reproductive history when assessing her long-term heart health.

Cardiovascular Disease 66

Cardiovascular Disease Pediatrics 66

Science Daily - Heart Disease

MAY 13, 2025

Researchers have identified the origin of cardiac cells using 3D images of a heart forming in real-time, inside a living mouse embryo.

Research 74

Research 74

HCPLive

MAY 15, 2025

Elevated lipoprotein(a) levels significantly increase the risk of recurrent cardiovascular events, highlighting the need for effective LDL-C-lowering therapies.

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Journal of Clinical Investigation - Cardiology

MAY 15, 2025

BACKGROUND Bacterial vaginosis (BV) is a dysbiosis of the vaginal microbiome that is prevalent among reproductive-age females worldwide. Adverse health outcomes associated with BV include an increased risk of sexually acquired HIV, yet the immunological mechanisms underlying this association are not well understood.METHODS To investigate BV-driven changes to cervicovaginal tract (CVT) and circulating T cell phenotypes, Kinga Study participants with or without BV provided vaginal tract (VT) and e

Circulation 63

Circulation Outcomes 63

American College of Cardiology

MAY 12, 2025

Assessment of mitral regurgitation (MR) has traditionally been performed with echocardiography. However, echocardiography has known limitations including the lack of a single reliable parameter of severity, high inter- and intraobserver variability, and discordance between echocardiographic parameters in a given patient.

Bicuspid/Mitral 66

Bicuspid/Mitral Article 66

Cardiovascular Ultrasound

MAY 16, 2025

Conduction system pacing (CSP), encompassing His-bundle pacing (HBP) and left bundle branch area pacing (LBBAP), revolutionizes cardiac pacing, allowing a more physiological left ventricular activation than co.

Physiology 72

Physiology 72

HCPLive

MAY 13, 2025

A study reveals a significant link between iron deficiency anemia and increased ischemic stroke risk in young adults, highlighting urgent screening needs.

Stroke 82

Stroke Strokes 82

Journal of Clinical Investigation - Cardiology

MAY 15, 2025

Metabolic dysfunctionassociated steatotic liver disease (MASLD) diagnosis and management have evolved rapidly alongside the increasing prevalence of obesity and related complications. Hepatology has expanded its focus beyond late-stage cirrhosis and portal hypertension to earlier, complex MASLD cases in younger patients, necessitating closer collaboration with endocrinology.

Obesity 61

Obesity Technology Patient Care Hypertension 61

Heart BMJ

MAY 12, 2025

Background The upper reference limit of normal (ULN) of cardiac troponin (cTn) for older adults can be higher than for young adults, while the same ULN is used for both older and young adults in the current clinical practice. Methods In this multicentre longitudinal cohort study, non-acute myocardial infarction (non-AMI) inpatients with at least two cTn concentrations hospitalised between 2013 and 2022 in the Tianjin Health and Medical Data Platform were included.

Myocardial Infarction 59

Myocardial Infarction Inpatient Hospital 59

Open Heart

MAY 14, 2025

Introduction Cardiac MRI (CMRI) is an important investigation in cases of unclear cause of sudden cardiac arrest (SCA). It demonstrates diagnostic utility in assessing reversibility and tissue scar burden and ultimately aids in further treatment planning. Methods A retrospective analysis of all adult patients referred for CMRI after SCA between 2007 and 2022 by local intensive care units in our institution was performed.

Cardiac Arrest 52

Cardiac Arrest Myocardial Infarction Cardiomyopathy Hospital 52

HCPLive

MAY 13, 2025

This months Lungcast features a discussion on the ALAs State of the Air report and how worsening air conditions affect people across the nation.

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Journal of Clinical Investigation - Cardiology

MAY 15, 2025

Neuronal hyperexcitability precedes synapse loss in certain neurodegenerative diseases, yet the synaptic membrane interactions and downstream signaling events remain unclear. The disordered amino terminus of the prion protein (PrPC) has been implicated in aberrant signaling in prion and Alzheimers disease. To disrupt neuronal interactions and signaling linked to the amino terminus, we CRISPR-engineered a knockin mouse expressing mutant PrPC (G92N), generating an N-linked glycosylation site betwe

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52

Heart BMJ

MAY 12, 2025

Background The impact of early-stage chronic kidney disease (CKD) on cardiovascular outcomes, particularly when albuminuria is present, remains unclear. This study examined the associations between early CKD (stages 1 and 2) with and without albuminuria and the incidence of major adverse cardiovascular events (MACEs), heart failure (HF) and all-cause mortality.

Kidney Disease 52

Kidney Disease Outcomes Heart Failure 52

Frontiers in Cardiovascular Medicine

MAY 14, 2025

Background and aimsAnemia has been implicated in prognosis across ischemic heart diseases. This study aimed to investigate the association between time-weighted average hemoglobin (TWA-Hb) and all-cause mortality in patients with acute myocardial infarction-related cardiogenic shock (AMI-CS).Methods and resultsWe conducted a retrospective analysis of 765 patients diagnosed with AMI-CS using data from the MIMIC-IV database (20082019).

Cardiogenic Shock 52

Cardiogenic Shock Myocardial Infarction BMI Heart Disease 52

HCPLive

MAY 16, 2025

Zirwas outlines a 4-visit approach to diagnosing spongiotic dermatitis, helping dermatologists manage uncertain rashes more effectively.

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Journal of Clinical Investigation - Cardiology

MAY 15, 2025

Tumor-associated macrophages (TAMs) are the most prominent immune cell population in the glioblastoma (GBM) tumor microenvironment and play critical roles in promoting tumor progression and immunosuppression. Here we identified that TAM-derived legumain (LGMN) exhibited a dual role in regulating the biology of TAMs and GBM cells. LGMN promoted macrophage infiltration in a cell-autonomous manner by activating the GSK3/STAT3 pathway.

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Physiologically Speaking

MAY 12, 2025

Thank you all for following this journey through to the end. It still blows my mind that tens of thousands of people (some strangers, some friends) returned weekly to read about my training for the Boston Marathon. I sincerely hope something I shared has helped you train smarter or harder—whether for Boston or otherwise. That’s really the goal!

Physiology 59

Physiology 59

Frontiers in Cardiovascular Medicine

MAY 12, 2025

BackgroundStent failure (SF) is a complication of percutaneous coronary intervention (PCI).ObjectivesThis study aimed to assess the relationship of the optical coherence tomography (OCT) determined cause of SF with time since stent implantation, treatment, and outcome.MethodsThis retrospective study included patients who underwent an OCT evaluation for SF from January 2013 to July 2023.

Stent 52

Stent Stents Outcomes Research 52

HCPLive

MAY 13, 2025

These data compare the characteristics and trends of anaphylaxis caused by goat and sheeps milk allergies with those of cows milk and peanut allergy.

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Journal of Clinical Investigation - Cardiology

MAY 15, 2025

Atherosclerosis is a slowly progressing inflammatory disease characterized with cholesterol disorder and intimal plaques. Asparagine endopeptidase (AEP) is an endolysosomal protease that is activated under acidic conditions and is elevated substantially in both plasma and plaques of patients with atherosclerosis. However, how AEP accelerates atherosclerosis development remains incompletely understood, especially from the view of cholesterol metabolism.

Atherosclerosis 52

Atherosclerosis Cholesterol Plaque 52

Circulation

MAY 13, 2025

Circulation, Ahead of Print. The open vein hypothesis postulates that early thrombus clearance and restoration of venous blood flow may prevent postthrombotic syndrome after proximal deep vein thrombosis. Since its proposal several decades ago, new insights from basic and clinical studies have motivated a re-evaluation and refinement of this hypothesis.

Research 49

Research Thrombosis Risk Factors Circulation 49

Frontiers in Cardiovascular Medicine

MAY 14, 2025

BackgroundThe rising incidence of cardiovascular diseases (CVD) in the elderly highlights the need for effective preventive strategies. Recent studies suggest that obesity, through metabolic factors, contributes to the development of CVD. This study aims to explore how body roundness index (BRI) levels affect the occurrence of CVD using data from the National Health and Nutrition Examination Survey (NHANES) (20032016), to better understand the role of obesity in CVD prevention and management.Met

Obesity 52

Obesity Education Risk Factors Cardiovascular Disease 52