Sat.Jan 11, 2025 - Fri.Jan 17, 2025

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Dementia Cases to Double in the U.S.

Med Page Today

(MedPage Today) -- Dementia cases in the U.S. are expected to double in the next four decades, a new analysis suggested. In a racially and geographically diverse sample, the lifetime risk of dementia was estimated at 42% (95% CI 41-43) with incidence.

Dementia 143
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Effects of respiratory sarcopenia on the postoperative course in elderly lung cancer patient: a retrospective study

Journal of Cardiothoracic Surgery

Recently, sarcopenia has been linked to unfavorable outcomes in various surgical procedures, including lung cancer surgery. This study aimed to investigate the impact of respiratory sarcopenia (RS) on postoper.

Cancer 116
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Excess weight gain in first trimester associated with fetal fat accumulation

Science Daily - Heart Disease

Fetuses of pregnant people who gained excess weight in the first trimester of pregnancy show signs of excess fat distribution in the upper arm and in the abdomen, according to a new study. These findings may inform efforts to prevent excessive weight gain early in life, a risk factor for adult obesity and related conditions, such as heart disease, high blood pressure and diabetes.

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Marla Dubinsky, MD: Ushering In a New Era of Crohn’s Disease Treatment with Mirikizumab

HCPLive

Dubinsky describes the evolution from anti-TNF therapies to IL-23 antagonists and the significance of mirikizumabs approval for Crohns disease.

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Here's What It Will Take to Grow HIV-Positive to HIV-Positive Transplant Access

Med Page Today

(MedPage Today) -- In late November, HHS issued a final rule updating transplant regulations to enable every U.S. transplant center to transplant kidneys and livers from donors with HIV into recipients with HIV -- this is a milestone to be recognized.

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Association between triglyceride-glucose (TyG) related indices and cardiovascular diseases and mortality among individuals with metabolic dysfunction-associated steatotic liver disease: a cohort study of UK Biobank

Cardiovascular Diabetology

Triglyceride-glucose (TyG) related indices, which serve as simple markers for insulin resistance, have been closely linked to metabolic dysfunction-associated steatotic liver disease (MASLD), cardiovascular di.

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Higher costs can limit attendance for life changing cardiac rehab

Medical Xpress - Cardiology

Despite the success cardiac rehabilitation has shown at reducing heart-related deaths and hospital readmissions, higher out-of-pocket costs may prevent patients from participating in the program, a Michigan Medicine study suggests.

More Trending

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Online Sellers of Compounded GLP-1s Often Don't Mention Risks

Med Page Today

(MedPage Today) -- Many online sellers of compounded GLP-1 receptor agonists may be misleading customers, a cross-sectional study suggested. Out of 79 websites that sold a compounded GLP-1 agent, 11 (13.9%) failed to mention the medications were.

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Artificial Intelligence–Guided Lung Ultrasound by Nonexperts

JAMA Cardiology

This multicenter validation study evaluates the ability of artificial intelligence to guide acquisition of diagnostic-quality lung ultrasound images by trained health care professionals.

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Some patients still taking daily aspirin to prevent heart attack: 3 notes

Becker's Hospital Review - Cardiology

Despite guideline recommendation changes, some patients are still taking a daily dose of aspirin for prevention of heart attack or stroke, according to a Jan. 13 The Washington Post report.

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Research Confirms Cold Therapy Benefits During Gout Flares

HCPLive

Heat therapy often worsened symptoms in a randomized controlled trial.

Research 111
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Experts Pitch Major Overhaul to How Obesity Is Diagnosed

Med Page Today

(MedPage Today) -- Medical experts from around the globe proposed a more nuanced approach to diagnosing obesity that does not rely exclusively on body mass index (BMI) alone. Writing in The Lancet Diabetes & Endocrinology, the global commission.

Obesity 113
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Atherosclerosis in diabetes mellitus: novel mechanisms and mechanism-based therapeutic approaches

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 13 January 2025; doi:10.1038/s41569-024-01115-w In this Review, Khan and Jandeleit-Dahm discuss pathological mechanisms involved in atherosclerosis development and progression in patients with diabetes mellitus and highlight novel therapeutic targets to treat atherosclerosis in these patients.

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Efficacy and Safety of Finerenone in Patients With Primary Aldosteronism: A Pilot Randomized Controlled Trial

Circulation

Circulation, Volume 151, Issue 2 , Page 196-198, January 14, 2025.

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Lean Steatotic Liver Disease Affects 12% of US Adults, Study Finds

HCPLive

Based on NHANES data, the age-adjusted prevalence of lean SLD was found to be 12.8%, including a 9.8% prevalence of lean MASLD.

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One Racial Group Is Less Likely to Go Through With Bariatric Surgery

Med Page Today

(MedPage Today) -- After patients with obesity discuss bariatric surgery with a clinician, racial disparities appeared to affect who moves forward with the procedure, according to 20 years of retrospective data. Among 122,487 patients with class.

Obesity 105
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Overcoming the Odds with Expert Fetal Cardiology Care: Zeke and Zane’s Story

Conquering CHD

Zane had three open heart surgeries before he turned 3. And surprisingly, he had a more routine care journey than his brother, Zeke. Zeke and Zane were both diagnosed with hypoplastic left heart syndrome (HLHS) before birth. As far as congenital heart diseases go, HLHS falls on the rarer end of the spectrum. The odds that either boy would have the condition are low roughly 1 in every 3,800 babies are born with it.

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How the brain impacts the heart: lessons from ischaemic stroke and other neurological disorders

Heart BMJ

Cardiovascular alterations are common in patients who had ischaemic stroke, haemorrhagic stroke and other acute brain disorders such as seizures. These cardiac complications are important drivers of morbidity and mortality and comprise blood-based detection of cardiomyocyte damage, ECG changes, heart failure and arrhythmia. Recently, the concept of a distinct ‘stroke-heart syndrome’ has been formulated as a pathophysiological framework for poststroke cardiac complications.

Stroke 104
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Virtual Reality Exercise Game Feasible for Patients With Fibromyalgia

HCPLive

A VR exergame may facilitate patients physical activity while promoting relaxation and positive mental states.

Exercise 111
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What Do We Know About the Pink Flame Retardants Used to Slow the Los Angeles Fires?

Med Page Today

(MedPage Today) -- Aircraft battling fires raging through the Los Angeles area are dropping more than water: Hundreds of thousands of gallons of hot-pink fire suppressant ahead of the flames in a desperate effort to stop them before they destroy.

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End-to-end deep-learning model for the detection of coronary artery stenosis on coronary CT images

Open Heart

Purpose We examined whether end-to-end deep-learning models could detect moderate (≥50%) or severe (≥70%) stenosis in the left anterior descending artery (LAD), right coronary artery (RCA) or left circumflex artery (LCX) in iodine contrast-enhanced ECG-gated coronary CT angiography (CCTA) scans. Methods From a database of 6293 CCTA scans, we used pre-existing curved multiplanar reformations (CMR) images of the LAD, RCA and LCX arteries to create end-to-end deep-learning models for th

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Right ventricles road to recovery: remodelling after chronic thromboembolic pulmonary hypertension intervention

Heart BMJ

Right heart failure is the most common cause of mortality in patients with pulmonary arterial hypertension. 1 This includes chronic thromboembolic pulmonary hypertension (CTEPH), which through obstruction of the pulmonary arteries increases afterload on the right ventricle (RV), ultimately resulting in RV failure. Histopathologically, it is also associated with microvascular changes, with smooth muscle hypertrophy, and intimal fibrosis, which cause stiffening, reduced compliance and increased re

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Emotional Resilience Linked to Better Quality of Life for Those with Acne

HCPLive

This study pointed to the abilities of patients with acne to adapt to stress and adversity as helpful in making skin-related quality of life improvements.

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Diabetes Med for Kidney Stones? Exercise and Heart Failure

Med Page Today

(MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center.

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Link between gene duplications and deletions within chromosome region and nonsyndromic bicuspid aortic valve disease

Science Daily - Heart Disease

Large and rare duplications and deletions in a chromosome region known as 22q11.2 , which involves genes that regulate cardiac development, are linked to nonsyndromic bicuspid aortic valve disease.

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Implantable cardiac defibrillator shocks vs. “careful and kind” end-of-life care

Heart Sisters

Study: Even among patients with a Do-Not-Resuscitate order, over half had their implanted cardiac defibrillators programmed ON in the final hour of life. How can this be happening?

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Critical Gaps in FSGS Treatment Highlight Need for New Therapies, with Pipeline Assets from Travere, Vertex, and Dimerix Poised to Address Unmet Needs

HCPLive

US nephrologists estimate half of all FSGS patients are not optimally managed, according to Spherix Global Insights.

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Children with congenital heart defects found to have poorer survival following cancer diagnosis

Medical Xpress - Cardiology

For children battling both congenital heart defects (CHD) and cancer, the road to recovery is far more precarious than previously understood, according to a study published in the Journal of the National Cancer Institute.

Cancer 79
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Global Rounds Afghanistan: A Critical Overview of Cardiovascular Medicine

Circulation

Circulation, Volume 151, Issue 2 , Page 129-131, January 14, 2025.

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More Data on the Cognitive Safety of Very Low LDL-C Levels

NEJM Journal Watch - Cardiology

In patients achieving a median LDL level of 35 mg/dL, neuropsychological testing found no change in cognitive function after 5 years of follow-up.

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Low Serum Vitamin D, Zinc Shown to be Risk Factor for Alopecia Areata

HCPLive

These findings suggest that zinc and vitamin D levels may function as a disease severity indicator for patients with alopecia areata.

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Mortality Patterns in Pediatric Pulmonary Vein Stenosis: Insights Into Right Ventricular Systolic Pressure Associations

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundPulmonary vein stenosis in children is associated with a poor prognosis. However, the cause and risk factors for mortality remain uncertain.MethodsThis retrospective, singlecenter study identified children with primary and secondary pulmonary vein stenosis through a cardiac catheterization database.

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State-of-the-Art Review Examines LAAO as Therapy For Stroke Prevention in Patients With AFib

American College of Cardiology

he utility of left atrial appendage occlusion (LAAO) as a therapy for stroke prevention in patients with nonvalvular atrial fibrillation (AFib) is the focus of a State-of-the-Art Review published Jan. 8 in JACC: Clinical Electrophysiology.

AFIB 75
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Stroke Mimics at 30 Years: Where We Have Been, Where We Are Now, and Where We Are Going

Stroke Journal

Stroke, Ahead of Print. Stroke mimics and chameleons remain a major challenge to the clinician and clinical investigator. Misdiagnosis of stroke can result in significant harm to our patients, as well as unnecessary financial costs to the health care systems internationally. The approach to stroke mimics and chameleons has evolved over time with the development of clinical scales and technology.

Stroke 75
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New Research Provides Insight Into Incidence, Prevalence of IgAN in the United States

HCPLive

The study leverages large US-based claims datasets and pathologist input to estimate the annual incidence and total prevalence of IgAN in the US.

Research 106
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Current and novel biomarkers in cardiogenic shock

European Journal of Heart Failure

A summary of current and novel biomarkers and their potential stages of release in cardiogenic shock. The diagram illustrates the proposed release of the biomarkers during the different stages of cardiogenic shock: progression from cardiac dysfunction/stress, through to inflammation and end-organ dysfunction. It is believed that a self-propagating spiral of events follows as a result of hypoperfusion, ischaemia and inflammation, leading to end-organ dysfunction.

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Equating Office and Ambulatory Blood Pressure

Hypertension Journal

Hypertension, Volume 82, Issue 2 , Page 161-165, February 1, 2025.