Sat.Dec 28, 2024 - Fri.Jan 03, 2025

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ECG Blog #462 — Why so Slow. ?

Ken Grauer, MD

I was sent the ECG in Figure-1 told only that the patient was an older adult who reported dizziness with activity. QUESTIONS: What is the rhythm? ( HINT: There are at least 4 important findings that should be noted ). Is there AV block? Figure-1: The initial ECG in today's case. ( To improve visualization I've digitized the original ECG using PMcardio ).

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Zebrafish protein unlocks dormant genes for heart repair

Science Daily - Heart Disease

Researchers have successfully repaired damaged mouse hearts using a protein from zebrafish. They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing side effects, such as heart enlargement. This study marks an important step toward regenerative therapies to prevent heart failure.

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Cellular interactions help explain vascular complications due to COVID-19 virus infection

Medical Xpress - Cardiology

COVID-19 is a respiratory disease primarily affecting the lungs. However, the SARS-CoV-2 virus that causes COVID-19 surprised doctors and scientists by causing an unusually large percentage of patients to experience vascular complicationsissues related to blood flow, such as blood clots, heart attacks, and strokes.

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Loneliness linked to higher risk of heart disease and stroke and susceptibility to infection

Science Daily - Stroke

Interactions with friends and family may keep us healthy because they boost our immune system and reduce our risk of diseases such as heart disease, stroke and type 2 diabetes, new research suggests. Researchers drew this conclusion after studying proteins from blood samples taken from over 42,000 adults recruited to the UK Biobank.

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Torsade in a patient with left bundle branch block: is there a long QT? (And: Left Bundle Pacing).

Dr. Smith's ECG Blog

By Smith with comments from our electrophysiologist, Rehan Karim. (And of course Ken's comments at the bottom) An elderly obese woman with cardiomyopathy, Left bundle branch block, and chronic hypercapnea presented hypoxic with altered mental status. She was intubated. Bedside cardiac ultrasound showed moderately decreased LV function. CT of the chest showed no pulmonary embolism but bibasilar infiltrates.

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New Guidelines Update Alzheimer's and Dementia Evaluations

Med Page Today

(MedPage Today) -- A three-step process underscores new clinical practice guidelines for primary and specialty care clinicians to evaluate patients who may have cognitive impairment or dementia due to Alzheimer's or a related disease. In broad.

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Loneliness linked to higher risk of heart disease, stroke and susceptibility to infection

Medical Xpress - Cardiology

Interactions with friends and family may keep us healthy because they boost our immune system and reduce our risk of diseases such as heart disease, stroke and type 2 diabetes, new research suggests.

More Trending

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Long-term prognostic impact of glucagon-like peptide-1 receptor agonist before ST-segment elevation myocardial infarction in patients with type 2 diabetes: a nationwide cohort study

Cardiovascular Diabetology

Glucagon-like peptide-1 receptor agonist (GLP-1RA) treatment reduces cardiovascular events in type 2 diabetes. Yet, the impact of GLP-1RA treatment before ST-segment elevation myocardial infarction (STEMI) on.

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GLP-1 Agents and Suicide: Making Sense of 2024's Mixed Data

Med Page Today

(MedPage Today) -- In January, we reported on the FDA clearing GLP-1 receptor agonists of suicidality risk following a preliminary evaluation. In this report, we follow up on what has happened since. Not long after the FDA wrapped its preliminary.

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Just two hours of exercise a week can bring you huge cardiovascular health benefits

Medical Xpress - Cardiology

There's no question that exercise is good for the heart. Regular exercise lowers blood pressure and cholesterol and reduces the chances of having a heart attack or stroke.

Exercise 115
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GLP-1 RA Discontinuations Frequent in People with Obesity Without Diabetes

HCPLive

A systematic review and meta-analysis of observational real-world data finds nearly half of patients who begin a GLP-1 RA will discontinue within a year.

Obesity 111
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Meta-analysis of MitraClip and PASCAL for transcatheter mitral edge-to-edge repair

Journal of Cardiothoracic Surgery

Despite the promising results of both MitraClip and PASCAL systems for the treatment of mitral regurgitation (MR), there is limited data on the comparison of both systems regarding their safety and efficacy. W.

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Overlooked Stories of 2024

Med Page Today

(MedPage Today) -- MedPage Today's enterprise and investigative team covers a lot of ground. We jump in when there's breaking news in healthcare. We write second-day stories on the implications of that news. We craft compelling feature stories.

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New technology 'sees' how cholesterol causes heart attacks

Medical Xpress - Cardiology

The U.S. government's premier research body has made an important discovery that could help create new drugs to lower "bad" cholesterol, and hopefully prevent heart attacks and stroke.

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Rheumatoid Arthritis Heart Failure Risk Driven by Increased HFpEF Risk

HCPLive

Other recent research presented at ACR 2024 found increased CVD risk with glucocorticosteroid use.

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Heart muscle can regenerate in some patients, study suggests

Becker's Hospital Review - Cardiology

Some heart failure patients with artificial hearts have been able to regenerate heart muscle, potentially paving the way for future heart failure treatment options, according to a study published Nov. 21 in Circulation.

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What's With All the UFH Infusions for Acute Pulmonary Embolism?

Med Page Today

(MedPage Today) -- Despite guidelines recommending other anticoagulants for people hospitalized with acute pulmonary embolism (PE), old habits and misconceptions have kept unfractionated heparin (UFH) the initial choice for many physicians in the.

Embolism 101
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Zebrafish protein unlocks dormant genes for heart repair

Medical Xpress - Cardiology

Researchers from the Bakkers group at the Hubrecht Institute have successfully repaired damaged mouse hearts using a protein from zebrafish. They discovered that the protein Hmga1 plays a key role in heart regeneration in zebrafish. In mice, this protein was able to restore the heart by activating dormant repair genes without causing side effects, such as heart enlargement.

Research 111
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Elevated HDL-C Efflux Capacity Could Protect Cognitive Function in Adults

HCPLive

Higher levels of small-particle HDL were linked with greater gray matter volume and higher cognitive capacity among middle-aged adults.

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Renal denervation for hypertension

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01104-z Endovascular renal denervation has been approved for the treatment of hypertension. In this Review, Fisher and Kirtane discuss the clinical trial data on its efficacy and safety and provide practical guidance on patient selection and clinical implementation of the procedure.

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Lupus Patients See More Vascular Risk, but It's Modifiable

Med Page Today

(MedPage Today) -- Atherosclerosis progression was more than twice as common in younger people with systemic lupus erythematosus (SLE) than in healthy controls in a prospective study from Greece, but the rate difference narrowed substantially with.

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Beware the snowstorm: Shoveling could trigger heart attacks, expert says

Medical Xpress - Cardiology

Walking in a winter wonderland may sound serene and peaceful, but shoveling your sidewalks to take that walk could quickly change delightful to deadly. According to the American Heart Association, the world's leading nonprofit organization focused on heart and brain health for all, research shows that the exertion of shoveling snow may lead to an increased risk of a heart attack or sudden cardiac arrest.

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Psychiatry Month in Review: December 2024

HCPLive

This Psychiatry Month in Review features promising phase 3 data, what is moving in the pipeline, and where the psychiatry field is heading into 2025.

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Apolipoprotein B-containing lipoproteins in atherogenesis

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01111-0 In this Review, Born and colleagues present insights into the role of apolipoprotein B-containing lipoproteins in atherogenesis, with an emphasis on the mechanisms leading to atherosclerotic plaque initiation and growth. They describe the causative role of LDL at the early stages of atherogenesis and discuss the relative atherogenicity of lipoprotein(a) and triglyceride-rich lipoproteins.

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Fairy Tales and Sleep; Cognitive Impairment in AI

Med Page Today

(MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center.

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Patients with heart disease may be at increased risk for advanced breast cancer

Medical Xpress - Cardiology

Cardiovascular disease (CVD) and cancer are the two leading causes of death in the U.S. According to researchers from The University of Texas MD Anderson Cancer Center, patients diagnosed with late-stage or metastatic breast cancer have a statistically significant increased risk of pre-diagnosis CVD compared to those with early-stage cancer at diagnosis.

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COVID-19 Infection Linked to Faster Kidney Function Decline Than Pneumonia

HCPLive

Patients hospitalized for severe COVID-19 had an accelerated eGFR decline relative to those with pneumonia due to other infections.

COVID-19 106
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Artificial Intelligence–Enhanced Electrocardiography for Hypertension

JAMA Cardiology

This prognostic study evaluates the ability of an electrocardiography-based artificial intelligence risk estimator to predict incident hypertension and stratify risk for hypertension-associated adverse events.

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Smartwatch-ECG

ECG Guru

Here we see a 30 s long strip of a 1-leadECG, recorded with a modern Smartwatch (Apple watch). The ECG has been graphically processed for better visualization. The paper speed is 25 mm/s as usual. The lead shown corresponds to ECG lead I of the limb leads.

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How do GLP-1s boost weight loss and heart health?

Medical Xpress - Cardiology

Weight loss tops many folks' list of New Year's resolutions, and lots of people are turning to cutting-edge weight-loss drugs like Ozempic to help them drop excess pounds.

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New Health Measures in CKD Management

HCPLive

Panelists discuss the new health measures relevant to chronic kidney disease (CKD) management and their significance in improving patient care and outcomes.

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Phenotyping atherosclerotic plaque and perivascular adipose tissue: signalling pathways and clinical biomarkers in atherosclerosis

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 02 January 2025; doi:10.1038/s41569-024-01110-1 In this Review, Dey and colleagues explore the pathobiology of coronary atherosclerotic plaques and perivascular adipose tissue, describe their phenotyping with computed tomography coronary angiography, and discuss potential future applications in clinical risk prediction and patient management.

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Melanocortin-4 receptor antagonist TCMCB07 alleviates chemotherapy-induced anorexia and weight loss in rats

Journal of Clinical Investigation - Cardiology

Cancer patients undergoing chemotherapy often experience anorexia and weight loss that substantially deteriorates overall health, reduces treatment tolerance and quality of life, and worsens oncologic outcomes. There are currently few effective therapeutic options to mitigate these side effects. The central melanocortin system, which plays a pivotal role in regulating appetite and energy homeostasis, presents a logical target for treating anorexia and weight loss.

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What is cardiac arrest? Why is it so deadly?

Medical Xpress - Cardiology

Cardiac arrest is when the heart stops abruptly with little or no warning. It is often fatal. According to American Heart Association data, 9 out of every 10 people who experience cardiac arrest outside of a hospital die.

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Prospective Improvements of Existing IgAN Therapies

HCPLive

Panelists discuss how current treatments for IgA nephropathy often fall short in addressing the root cause, specifically abnormal IgA production and deposition, and highlight the consequences of prioritizing symptom management, such as proteinuria reduction, over targeting the diseases underlying pathology.

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SICK-SINUS-SYNDROME

ECG Guru

This ECG is from a 65-year-old woman who had previously had no cardiac abnormalities but has now suffered several syncopes within 2 weeks. During the last syncope she suffered a fracture of the left femur.

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Physiology Friday #251: Does Our Body Have a ‘Muscle Memory’ for Aerobic Exercise?

Physiologically Speaking

Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. You can find more products I’m affiliated with on my website. Physiologically Speaking is a reader-supported publication.