Ken Grauer, MD

MAY 17, 2025

== P lease N OTE : After today No new ECG Blog posts for 3- to -4 weeks. I will also not be prompt in replying to emails. == All material on this ECG Blog site remains open! The INDEX tab ( in the upper right of each page ) has linked Contents, listed by subject. So IF you are looking for ECG material There is plenty on this web site! And IF you look at the TOP of every page in this blog You'll see a Menu of Tabs that link to a variety of blog features, including my ECG podcasts, Audios &a

Blog 161

Blog STEMI Angina Ischemia 161

Science Daily - Heart Disease

MAY 5, 2025

People who are given a vaccine for shingles have a 23% lower risk of cardiovascular events, including stroke, heart failure, and coronary heart disease, according to a recent study of more than a million people. The protective effect of the vaccine lasts for up to eight years and is particularly pronounced for men, people under the age of 60 and those with unhealthy lifestyles.

Heart Disease 131

Heart Disease Heart Failure Stroke Strokes 131

Journal of Clinical Investigation - Cardiology

MAY 15, 2025

Sterile acute kidney injury (AKI) is common in the clinic and frequently associated with unexplained hypoxemia that does not improve with dialysis. AKI induces remote lung inflammation with neutrophil recruitment in mice and humans, but which cellular cues establish neutrophilic inflammation and how it contributes to hypoxemia is not known. Here we report that AKI induced rapid intravascular neutrophil retention in lung alveolar capillaries without extravasation into tissue or alveoli, causing h

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122

Med Page Today

MAY 27, 2025

(MedPage Today) -- Active treatment of hemodynamically significant patent ductus arteriosus (PDA) in preterm infants within the first 2 weeks of life was associated with worse outcomes than expectant management, a meta-analysis suggested. In the.

Outcomes 130

Outcomes 130

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

Patient Care

HCPLive

MAY 12, 2025

New research reveals that maternal avocado consumption during pregnancy significantly reduces the risk of infant food allergies.

Research 114

Research 114

Medical Xpress - Cardiology

MAY 17, 2025

A pharmaceutically produced cannabidiol formulation had a good overall safety profile, including cardiac safety, according to research presented at Heart Failure 2025.

Heart Failure 125

Heart Failure Research 125

Science Daily - Heart Disease

MAY 27, 2025

Taking a statin medication is an effective, safe, and low-cost way to lower cholesterol and reduce risk of cardiovascular events. Despite clinicians recommending that many patients with diabetes take statins, nearly one-fifth of them opt to delay treatment. In a new study, researchers found that patients who started statin therapy right away reduced the rate of heart attack and stroke by one third compared to those who chose to delay taking the medication.

Heart attacks 98

Heart attacks Heart Attack Diabetes Stroke 98

Journal of Clinical Investigation - Cardiology

MAY 1, 2025

CD4+FOXP3+ Treg cells maintain self tolerance, suppress the immune response to cancer, and protect against tissue injury during acute inflammation. Treg cells require mitochondrial metabolism to function, but how Treg cells adapt their metabolic programs to optimize their function during an immune response occurring in a metabolically stressed microenvironment remains unclear.

Cancer 105

Cancer 105

Med Page Today

MAY 15, 2025

(MedPage Today) -- Steak 'n Shake recently announced it plans to transition from seed oils to butter and beef tallow -- a move they referred to as "RFK'ing the fries." Many other restaurants plan to follow suit due to growing populist criticism.

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134

HCPLive

MAY 12, 2025

A study shows that many children with pollen allergies face ongoing symptoms into adulthood, highlighting the need for better management.

114

114

Medical Xpress - Cardiology

MAY 25, 2025

For patients with acute ischemic stroke due to large-vessel occlusion who present within 4.5 hours, intravenous tenecteplase before endovascular thrombectomy is associated with higher functional independence at 90 days, according to a study published online May 21 in the New England Journal of Medicine to coincide with the annual European Stroke Organisation Conference, held from May 21 to 23 in Helsinki.

Stroke 96

Stroke Strokes 96

Cardiomatics

MAY 28, 2025

In a world where rapidly developing Artificial Intelligence (AI) is entering more spheres of life, questions about its use are beginning to arise. With ongoing changes in the job market, many employees across various industriesincluding healthcareare beginning to feel the impact. One notable shift is the increasing use of AI to analyse medical data and accelerate the work of specialists.

Atrial Fibrillation 93

Atrial Fibrillation Electrocardiogram Hospital Patient Care 93

Science Daily - Heart Disease

MAY 13, 2025

Experts are urging people, especially those with existing heart or vascular conditions, to seek medical advice before attempting to lose weight using water-only fasting diets.

Diet 113

Diet 113

Journal of Clinical Investigation - Cardiology

MAY 15, 2025

Red blood cells (RBCs) induce endothelial dysfunction in type 2 diabetes (T2D), but the mechanism by which RBCs communicate with the endothelium is unknown. This study tested the hypothesis that extracellular vesicles (EVs) secreted by RBCs act as mediators of endothelial dysfunction in T2D. Despite a lower production of EVs derived from RBCs of T2D patients (T2D RBC-EVs), their uptake by endothelial cells was greater than that of EVs derived from RBCs of healthy individuals (H RBC-EVs).

Diabetes 96

Diabetes 96

Frontiers in Cardiovascular Medicine

MAY 21, 2025

IntroductionHigh-Density Lipoprotein Cholesterol (HDL-C) plays a pivotal role in cardiovascular health, acting as a key component in lipid transport and atheroprotection. While low HDL-C levels in the general population are often the result of multifactorial causes, extremely low HDL-C levels ( T, chr:9 91757308 C>A, rs375247413], LCAT [NM_000229.2(LCAT):c.349G>A p.Ala117Thr, rs28940886], and APOA1 [NM_000039.3(APOA1):c.388A>T, p.Lys130*].DiscussionEach case presented a unique spectrum of clinic

Cholesterol 98

Cholesterol Patient Care Research 98

HCPLive

MAY 28, 2025

In this episode, hosts explore technosphere inhaled insulin (Afrezza) in comparison to standard diabetes therapies in the INHALE-3 trial.

Diabetes 111

Diabetes 111

Medical Xpress - Cardiology

MAY 25, 2025

We've long known that a lack of sleep is bad for the heartbut scientists are now starting to understand exactly how it causes harm.

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95

American Heart News - Heart News

MAY 30, 2025

DALLAS, May 30, 2025 Smoke from Canada wildfires is rapidly drifting into the U.S. and the American Heart Association, a global force changing the future of health for all, warns that this wildfire smoke exposure may pose an increased risk for heart.

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106

Heart BMJ

MAY 12, 2025

Chronic kidney disease (CKD) represents a significant global health priority, affecting approximately 844 million adults (10% of the world population). 1 Beyond its implication for kidney health, CKD is inherently linked to cardiovascular disease (CVD), which is the leading cause of morbidity and mortality in this population. 2 The interplay between CKD and CVD is well documented, with mechanisms including shared risk factors, metabolic disturbances and systemic inflammation. 2 Albuminuria, a ma

Kidney Disease 92

Kidney Disease Outcomes Document Risk Factors 92

Nature Reviews - Cardiology

MAY 22, 2025

Nature Reviews Cardiology, Published online: 23 May 2025; doi:10.1038/s41569-025-01168-5 In this Review, Ackerman and colleagues describe the rationale for gene therapy to treat cardiac arrhythmias; discuss advantages and disadvantages of gene silencing, replacement and editing technologies; summarize vector modalities and delivery approaches; present examples of gene therapy strategies used for atrial and ventricular arrhythmias; and highlight the current challenges and limitations in the gene

Arrhythmia 86

Arrhythmia Technology 86

Med Page Today

MAY 7, 2025

(MedPage Today) -- Obicetrapib provided dramatic reductions in LDL cholesterol, without noticeable side effects, in a phase III trial of high-risk individuals already on maximal lipid-lowering therapy. In adults with heterozygous familial hypercholesterolemia.

Cholesterol 97

Cholesterol 97

HCPLive

MAY 14, 2025

In this analysis, investigators looked at the extent to which psoriasis severity correlates with patients risk of developing sleep disorders.

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92

Journal of Clinical Investigation - Cardiology

MAY 15, 2025

Tissue regenerative responses involve complex interactions between resident structural and immune cells. Recent reports indicate that accumulation of senescent cells during injury repair contributes to pathological tissue fibrosis. Using tissue-based spatial transcriptomics and proteomics, we identified upregulation of the immune checkpoint protein, cytotoxic T lymphocyteassociated protein 4 (CTLA4), on CD8+ T cells adjacent to regions of active fibrogenesis in human idiopathic pulmonary fibrosi

Pulmonary 82

Pulmonary 82

Medical Xpress - Cardiology

MAY 18, 2025

Waist-to-height ratio predicts heart failure incidence, according to research presented at Heart Failure 2025.

Heart Failure 87

Heart Failure Research 87

Cardiomatics

MAY 6, 2025

We are proud to announce our partnership with Arseus Medical , a leading distributor of medical technology in the Benelux region. This partnership brings innovation straight to cardiology clinics across the Netherlands and Belgium. What the Cardiomatics Arseus Medical Partnership Means Together with Arseus Medical, Cardiomatics is now part of a unified, end-to-end solution for cardiac diagnostics combining high-quality Holter recorders with AI-powered ECG interpretation in one integrated offeri

Innovation 93

Innovation Technology Outcomes Hospital 93

Science Daily - Heart Disease

MAY 19, 2025

People who were less active, with a daily average of more than 14 hours of sedentary behavior, were more than twice as likely to have another cardiac event, including heart attack, surgery to treat heart issues (coronary revascularization), or to be hospitalized again within a year after the first cardiac event.

Heart attacks 73

Heart attacks Heart Attack Hospital 73

Med Page Today

MAY 14, 2025

(MedPage Today) -- A diuretic was able to match spironolactone for blood pressure (BP) lowering in people with resistant hypertension, a small randomized trial showed. Home-measured systolic blood pressure (SBP) was similarly reduced at 12 weeks.

Hypertension 77

Hypertension Blood Pressure 77

HCPLive

MAY 12, 2025

Skin prick test showed limited symptom correlation and shrimp-specific IgE demonstrated greater diagnostic value than tropomyosin-specific IgE.

Pediatrics 98

Pediatrics 98

Journal of Clinical Investigation - Cardiology

MAY 1, 2025

Reduced kidney function is associated with increased risk of cardiovascular disease in addition to kidney disease progression. Kidney disease is considered an inflammatory state, based on elevated levels of C-reactive protein and inflammatory cytokines. A key mediator of cardiovascular and kidney disease progression in the setting of reduced kidney function is systemic and vascular inflammation.

Kidney Disease 92

Kidney Disease Biomarkers Cardiovascular Disease Research 92

American Heart News - Heart News

MAY 28, 2025

Research Highlights: An analysis of data from a national health survey conducted before the pandemic found that pizza, soup and chicken are some of the main sources of sodium (salt) intake for people in all racial and ethnic groups. The study also.

Research 82

Research 82

Science Daily - Stroke

MAY 14, 2025

A transient ischemic attack, also known as a mini-stroke, is typically defined as a temporary blockage of blood flow to the brain that causes symptoms that go away within a day, but a new study finds that people who have this type of stroke may also have prolonged fatigue lasting up to one year.

Stroke 78

Stroke Strokes 78

Heart Sisters

MAY 4, 2025

"Out of the 700+ scientific papers presented at my first national cardiology conference, only four focused specifically on women's heart disease. FOUR!? Out of HUNDREDS!?" As you might guess, hearing that appalling news became the real story behind that conference for me.

Heart Disease 86

Heart Disease 86

American College of Cardiology

MAY 14, 2025

Cardiovascular magnetic resonance (CMR) imaging was able to detect longer myocardial T2, higher extracellular volume (ECV) fraction and worse myocardial dynamics, including impaired strain, before significant decline in left ventricular (LV) systolic function in carriers of LMNA (Lamin) dilated cardiomyopathy (DCM).

Cardiomyopathy 69

Cardiomyopathy Article 69

HCPLive

MAY 28, 2025

Ehsan Rahimy, MD; David G. Miller, MD; and Michael Klufas, MD, discuss how real-world treatment strategies for neovascular age-related macular degeneration (AMD) and diabetic macular edema (DME) with next-generation anti-VEGF therapies differ from clinical trials, including individualized loading dose approaches, extension interval considerations, and the challenges of balancing durability with appropriate monitoring.

Diabetes 84

Diabetes 84

Journal of Clinical Investigation - Cardiology

MAY 15, 2025

Endothelial dysfunction remains a cornerstone of diabetic vascular complications. RBCs emerge as pivotal players in endothelial dysfunction, yet the underlying mechanisms remain elusive. In this issue of the JCI, Collado et al. show that the detrimental action of RBCs on the endothelium is mediated by extracellular vesicles (EVs). EVs derived from RBCs (RBC-EVs) of patients with diabetes were taken up by the endothelium and were able to impair endothelium-dependent relaxation via an EV-mediated

Diabetes 75

Diabetes 75

Science Daily - Heart Disease

MAY 9, 2025

New research shows that the gum disease bacterium P. gingivalis can slip into the bloodstream and infiltrate the heart. There, it quietly drives scar tissue buildup -- distorting the heart's architecture, disrupting electrical signals, and raising the risk of atrial fibrillation.

Heart Rhythm 128

Heart Rhythm Atrial Fibrillation Research 128