Society of Thoracic Surgeons - Congenital
APRIL 25, 2025
Resource Ascending Aorta & Aortic Root Surgery Risk Calculator gmckinney Fri, 04/25/2025 - 08:08 Aortic operations accounted for about 11% of all major cardiac surgeries in the United States in 2024, up from 8.3% in 2018. In spite of this increasing frequency, surgeons have lacked a validated method to assess operative risk for ascending aorta and aortic root procedures at the bedside.
Dr. Paddy Barrett
APRIL 4, 2025
The average consultation time with a doctor is only about 15 minutes. This is not enough. If you want to get a proper heart health assessment, you will need to work smarter. Ideally, we should live in a world where doctors and healthcare professionals have infinite time to: Explain key concepts. Lay out all the pros and cons of each decision. Answer all your questions.
Heart BMJ
APRIL 10, 2025
Since the first implementation in 2002 by Alain Cribier, transcatheter aortic valve replacement (TAVR) has become a standard procedure for high-risk and elderly patients with severe aortic valve stenosis. Recently, the use of TAVR has expanded to relatively younger patients with low to moderate surgical risk. Infective endocarditis (IE) after TAVR, first reported in medical literature in 2010, is a relatively new and extremely concerning complication. 1 Its incidence, reported as 1.1% per person
Frontiers in Cardiovascular Medicine
APRIL 28, 2025
ObjectiveTo evaluate the efficacy and safety of using off-label direct oral anticoagulants (DOACs) compared to warfarin for treating left ventricular (LV) thrombi using inverse probability-of-treatment weighting (IPTW) analysis.MethodsAn observational study of 302 eligible patients with newly diagnosed LV thrombi was conducted at a tertiary referral center from January 2020 to December 2023.
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Journal of Clinical Investigation - Cardiology
APRIL 1, 2025
Chimeric antigen receptor (CAR) T cell therapy shows promise for various diseases. Our studies in humanized mice and nonhuman primates demonstrate that hematopoietic stem cells (HSCs) modified with anti-HIV CAR achieve lifelong engraftment, providing functional antiviral CAR-T cells that reduce viral rebound after antiretroviral therapy (ART) withdrawal.
Circulation
APRIL 17, 2025
Circulation, Ahead of Print. Cardiovascular disease remains a leading cause of morbidity and mortality in adults despite recent scientific advancements. Although people are living longer lives, there may be an adverse impact on quality of life, necessitating a greater need for palliative care services and support. Palliative care for adults with advanced cardiovascular disease has the potential to significantly improve quality of life for individuals living with cardiovascular disease and their
Cardiovascular Update brings together the best content for cardiovascular medicine professionals from the widest variety of industry thought leaders.
Nature Reviews - Cardiology
APRIL 6, 2025
Nature Reviews Cardiology, Published online: 07 April 2025; doi:10.1038/s41569-025-01145-y To regenerate the injured heart, cardiomyocytes must proliferate to replace lost myocardial tissue, but this capacity is largely absent in adult mammals. In this Review, Koopmans and van Rooij explore the key pathways that drive cardiomyocyte maturation after birth and how targeted manipulation might reactivate the cell cycle in adult cardiomyocytes.
Dr. Paddy Barrett
APRIL 11, 2025
More than heart disease or cancer, dementia is the primary concern for many of the patients I see. Heart disease and cancer attack your body, but dementia attacks your mind and identity. It strips away the fabric of who a person is. That is why I believe people fear dementia so much. Thankfully, 45% of all dementia is preventable 1. Many factors make up that 45%, but one factor seems to impact the risk of dementia the most.
Frontiers in Cardiovascular Medicine
APRIL 23, 2025
IntroductionThe definition of acute kidney dysfunction in patients with acute decompensated heart failure (ADHF) remains unclear. This study aimed to compare two sets of criteria for acute kidney injury (AKI), namely, the kidney disease: improving global outcomes (KDIGO) and worsening renal function (WRF) classification, in hospitalized patients with ADHF.MethodsWe utilized a multi-institutional database with 17,684 cases of hospitalizations for HF.
Journal of the American Heart Association
APRIL 17, 2025
Journal of the American Heart Association, Ahead of Print. BackgroundNonvitamin K oral anticoagulants prevent stroke and systemic embolism in patients with nonvalvular atrial fibrillation. However, potential drug interactions with concomitant medications may compromise their efficacy and escalate the risk of adverse effects.Methods and ResultsWe conducted a territorywide retrospective cohort study in Hong Kong, focusing on nonvalvular atrial fibrillation prescribed nonvitamin K oral anticoagulan
Circulation
APRIL 10, 2025
Circulation, Ahead of Print. The Physical Activity Guidelines for Americans supports sitting less and moving more. Growing evidence suggests that a waking behavior profile with less sedentary behavior and more light-intensity physical activity is associated with more favorable cardiovascular health. Remarkably, little is known about how these behaviors relate to cardiovascular health during pregnancy.
DAIC
APRIL 16, 2025
Cedars-Sinai investigators are using AI to analyze images from a common heart test to identify signs of valve disease. Photo: Getty. tim.hodson Wed, 04/16/2025 - 14:19 April 16, 2025 An artificial intelligence (AI) program trained to review images from a common medical test can detect early signs of tricuspid heart valve disease and may help doctors diagnose and treat patients sooner, according to research from the Smidt Heart Institute at Cedars-Sinai.
HCPLive
APRIL 4, 2025
A panelist discusses how dermatologists typically see patients with alopecia areata after they've already experienced significant hair loss and undergone initial treatments with primary care providers, which impacts treatment by creating potential delays in optimal intervention, heightened patient anxiety, and the need for more aggressive therapeutic approaches to address established disease patterns.
Science Daily - Heart Disease
APRIL 2, 2025
When we move, it's harder for existing wearable devices to accurately track our heart activity. But researchers found that a starfish's five-arm shape helps solve this problem. Inspired by how a starfish flips itself over -- shrinking one of its arms and using the others in a coordinated motion to right itself -- scientists have created a starfish-shaped wearable device that tracks heart health in real time.
Frontiers in Cardiovascular Medicine
APRIL 28, 2025
The pulmonary artery catheter (PAC) is widely used in cardiac surgery for monitoring hemodynamics and cardiovascular function. Complications including pulmonary artery injury causing massive intratracheal hemorrhage are rare but can be life-threatening. We report a case of intratracheal bleeding (3,000ml) caused by PAC-induced pulmonary artery injury during cardiac surgery and after weaning from cardiopulmonary bypass (CPB).
ECG Guru
APRIL 24, 2025
Sometimes a single Holter ECG can tell a whole story. Here we see a single-channel ECG, each line representing about 30 seconds. The ECG is from a 56-year-old man with severe ischemic cardiomyopathy who had an ICD implanted a few months ago due to recurrent ventricular tachycardia. The explanation of what can be seen on this ECG can be found on the 2nd image.
Circulation
APRIL 7, 2025
Circulation, Ahead of Print. Populations most affected by cardiovascular health disparities, including underrepresented populations with lower socioeconomic status, people with disabilities, and those living in underserved rural communities, are disproportionately exposed to adverse social determinants of health. Specifically, economic instability and suboptimal living conditions within the neighborhood and built environment directly determine access to resources and opportunities for healthful
Stroke Journal
APRIL 21, 2025
Stroke, Ahead of Print. Secondary stroke prevention encompasses many approaches, including antithrombotic therapy, risk factor management, and a healthy lifestyle. Recommendations are typically based on the results of randomized clinical trials that provide evidence of benefit. However, in some situations, clinicians extrapolate the results of clinical trials into everyday practice, or trials have not provided sufficient information to make treatment decisions.
HCPLive
APRIL 4, 2025
A panelist discusses how alopecia areata is clinically characterized by sudden, patchy hair loss with exclamation point hairs at the periphery and is typically diagnosed through clinical examination, dermoscopy, and sometimes scalp biopsy, noting that patients with a personal or family history of autoimmune disorders, certain genetic markers, or significant stress exposure may be at higher risk for developing this condition.
Science Daily - Heart Disease
APRIL 8, 2025
New research has uncovered a surprising culprit underlying cardiovascular diseases in obesity and diabetes -- not the presence of certain fats, but their suppression. The study challenges the conventional belief that a type of fat called ceramides accumulates in blood vessels causing inflammation and health risks. Instead, their findings reveal that when ceramides decrease in endothelial cells lining blood vessels, it can be damaging and cause chronic illnesses.
Frontiers in Cardiovascular Medicine
APRIL 28, 2025
Peripartum cardiomyopathy (PPCM) is a type of dilated cardiomyopathy that develops in women without a history of heart disease during the last trimester of pregnancy or within 6 months postpartum. It is one of the primary causes of heart failure during pregnancy, which increases peripartum morbidity and mortality. PPCM can cause significant left ventricular dysfunction, progressive heart failure, and refractory cardiogenic shock, resulting in increased maternal morbidity and mortality.
Heart BMJ
APRIL 10, 2025
Background Kuwait, one of the world’s hottest countries, faces increasing temperatures due to climate change. With a large migrant population predominantly employed in physically demanding jobs, the exact effects and burdens of temperature exposure on cardiovascular risk among this population remain unknown. This study aimed to investigate the relationship between temperature and myocardial infarction (MI) risk among migrants in Kuwait.
Nature Reviews - Cardiology
APRIL 3, 2025
Nature Reviews Cardiology, Published online: 04 April 2025; doi:10.1038/s41569-025-01146-x Heart transplantation remains the optimal long-term treatment for appropriate patients with advanced heart failure. However, the donor heart shortage is a limiting factor, and the risk profile of transplant candidates is worsening. In this landscape, the utility of conventional cold static storage for donor hearts is increasingly limited.
CardiacWire
APRIL 18, 2025
Building stronger evidence for AIs place in cardiology, this week brought several examples of how AI can improve ECG use cases and automate Echo for new disease detection methods. Starting with AI improving ECG for coronary revascularization , a deep learning ECG model outperformed both clinician-led ECG and troponin T testing in predicting which ED patients needed coronary revascularization.
Society of Thoracic Surgeons - Early Career
APRIL 28, 2025
Podcast #9, S1: Rethinking Lung Cancer Screening Eligibility In this episode of Thinking Thoracic , hear from Alexandra Potter, researcher, and Dr. Chi-Fu Jeffrey Yang, both from Massachusetts General Hospital, about a new study that reveals current lung cancer screening guidelines miss nearly half of patients who develop the disease. Alternative approaches could greatly expand accessespecially for women, minorities, and former smokers.
Journal of Clinical Investigation - Cardiology
APRIL 1, 2025
Lysyl hydroxylase 2 (LH2) is highly expressed in multiple tumor types and accelerates disease progression by hydroxylating lysine residues on fibrillar collagen telopeptides to generate stable collagen cross links in tumor stroma. Here, we show that a galactosylhydroxylysyl glucosyltransferase (GGT) domain on LH2-modified type-VI collagen (Col6) to promote lung adenocarcinoma (LUAD) growth and metastasis.
Frontiers in Cardiovascular Medicine
APRIL 1, 2025
IntroductionDepression is a significant comorbidity linked to poor subjective and objective health outcomes in cardiac patients. The paucity of data necessitates further research to elucidate the pathophysiological connection between depression and cardiac diseases in the presence of N-terminal pro-brain natriuretic peptide (NT-proBNP). Therefore, the current systematic review investigated the clinical significance of NT-proBNP as a predictive biomarker in cardiac patients with depressive sympto
Heart BMJ
APRIL 10, 2025
Background Heart failure (HF) guidelines recommend routine testing for iron deficiency (ID) and, for those with ID, intravenous iron if the left ventricular ejection fraction is <50%. Guideline adherence to these recommendations by cardiologists in China is unknown. Methods and results An independent academic web-based survey was designed and distributed via social networks to cardiologists across China.
Nature Reviews - Cardiology
APRIL 13, 2025
Nature Reviews Cardiology, Published online: 14 April 2025; doi:10.1038/s41569-025-01150-1 In this Review, Liu, Yang and He explore the diverse mechanisms by which various post-translational protein acylations, and the dynamic interactions between them, contribute to cardiac hypertrophy. The authors also discuss the therapeutic potential of targeting acylations to modulate their effects on chromatin architecture, enzyme activity and metabolic pathways.
CardiacWire
APRIL 16, 2025
Completing its pharma comeback story, Verve Therapeutics announced successful results from the Heart-2 Phase 1b Clinical Trial of its in-vivo base editing drug, VERVE-102, that targets the PCSK9 gene for reducing LDL-C. PCSK9 is a molecule that breaks down LDL receptors, so drugs that inhibit it force the bodys LDL receptors to work harder, which reduces LDL-C more efficiently.
HCPLive
APRIL 24, 2025
Panelists discuss how the SPECTREM trial (Glick, 2024) revealed guselkumabs exceptional site-specific efficacy for psoriasis in traditionally difficult-to-treat areas, achieving complete clearance (Investigators Global Assessment [IGA] 0) in remarkably high proportions of patients compared with placebowith 60% clearance in scalp (vs 9% for placebo), 76% in facial sites (vs 24%), 77% in intertriginous areas (vs 24%), and 73% in genital regions (vs 33%)while maintaining a favorable safety profile
Journal of Clinical Investigation - Cardiology
APRIL 1, 2025
Metabolic dysfunctionassociated steatotic liver disease (MASLD) is a major cause of liver disease worldwide, and our understanding of its pathogenesis continues to evolve. MASLD progresses from steatosis to steatohepatitis, fibrosis, and cirrhosis, and this Review explores how the gut microbiome and their metabolites contribute to MASLD pathogenesis.
Frontiers in Cardiovascular Medicine
APRIL 14, 2025
ObjectiveAortic dissection (AD) is a life-threatening cardiovascular emergency. Delayed diagnosis frequently leads to treatment delays, elevated mortality, and complications. This study investigates the factors contributing to the misdiagnosis of AD and proposes strategies for improving its early diagnosis.MethodsA retrospective analysis of 801 patients with AD identified 219 cases for inclusion, which were split into a training set (131 cases) and a validation set (88 cases).
ECG Guru
APRIL 23, 2025
Here is a rhythm strip from a 3-lead Holter ECG. It comes from a 56-year-old man with arterial hypertension and no other previous cardiac diseases. Recently, the patient has noticed that pulse irregularities occur during blood pressure measurement (which he performs himself at home). On the ECG, first a sinus beat, then a PVC, then an AIVR occurs, which is interrupted by another PVC, then sinus rhythm again.
DAIC
APRIL 29, 2025
tim.hodson Tue, 04/29/2025 - 13:46 April 28, 2025 The Society of Thoracic Surgeons (STS) has launched its latest surgical risk calculator designed for patients undergoing ascending aorta and aortic root surgery , with or without concomitant aortic valve replacement (AVR). This first-of-its-kind tool represents a major step forward in risk stratification and personalized surgical planning for complex aortic operations.
CardiacWire
APRIL 27, 2025
It seems like every week were discovering a new GLP-1 cardiac benefit, with the TRANSFORM-AF study now suggesting the drug could help reduce AFib burden. Up to six million people in the U.S. have AFib, making it one of the more common cardiovascular conditions. Despite significant ablation advancements, AFibs recurrence risk is ~30% at one year and rises over time, likely due to cardiometabolic factors like obesity.
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