Science Daily - Heart Disease

FEBRUARY 4, 2025

Researchers have used mathematical analysis tools to study the effect of classical music on a fetal heartbeat and identify patterns in heart rate variability. They recruited 36 pregnant women and played two classical pieces for their fetuses. By attaching external heart rate monitors, the researchers could measure the fetal heart rate response to both songs, and by employing nonlinear recurrence quantification analysis, they could identify changes in heart rate variability during and after the m

Research 121

Research 121

Open Heart

FEBRUARY 23, 2025

Background Individual cardiometabolic diseases (CMDs) increase atrial fibrillation (AF) risk; however, whether multiple CMDs exert a cumulative effect on AF risk remains unclear. Our objective was to examine the link between coexisting CMDs and AF, as well as their cumulative impact. Methods This UK Biobank-based prospective cohort study included data from participants with information related to CMDs and AF.

Atrial Fibrillation 98

Atrial Fibrillation 98

CardiacWire

FEBRUARY 12, 2025

Just a couple weeks after the full trial results of AZALEA TIMI 71 were released, Novartis agreed to acquire Anthos Therapeutics for $925M upfront and another $2.15B in milestone payments, signaling that the pharma titan may have renewed confidence in abelacimab and the Factor XI inhibition segment. Novartis spun out the testing and development of abelacimab and formed Anthos Therapeutics back in 2019.

AFIB 102

AFIB Embolism Plaque Stroke 102

Nature Reviews - Cardiology

FEBRUARY 27, 2025

Nature Reviews Cardiology, Published online: 28 February 2025; doi:10.1038/s41569-025-01143-0 Epigenetic editing holds great promise for the treatment of many diseases, including cardiovascular disease. However, realizing this potential requires more than developing robust technology and demands a steadfast focus on patient needs and inclusion, to ensure that access to epigenetic medicine will be equitable and will benefit diverse populations worldwide.

Technology 88

Technology Cardiovascular Disease 88

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

Patient Care

Heart BMJ

FEBRUARY 26, 2025

Background Menopause is a timely opportunity to screen for cardiovascular disease (CVD) and intervene with healthier lifestyles. We investigated the association between premature/early menopause and the likelihood of CVD and whether a healthy lifestyle is associated with a lower likelihood of CVD in menopausal woman. Methods The Sax Institute’s 45 and Up Study prospectively recruited participants aged ≥45 years (n=267 357) between 2005 and 2009 (New South Wales, Australia).

Cardiovascular Disease 78

Cardiovascular Disease Diet Heart Disease Stroke 78

Frontiers in Cardiovascular Medicine

FEBRUARY 4, 2025

Dyslipidemia is extensively analyzed in clinical trials investigating its role as a risk factor for coronary artery disease (CAD). However, its definition varies vastly among studies, leading to different attributions to the variable dyslipidemia. The objectives of this study are to verify the hypothesis of a lack of a consensual definition of dyslipidemia in coronary angiography studies and to propose a consensual definition of dyslipidemia, considering the influence of each serum lipid paramet

Coronary Artery Disease 94

Coronary Artery Disease Cholesterol Article Risk Factors 94

Open Heart

FEBRUARY 17, 2025

Background Hypertrophic cardiomyopathy (HCM) is commonly associated with atrial fibrillation (AF), but its impact on outcomes in real-world practice is uncertain. The aim of the study was to evaluate the clinical profile and prognosis of patients with HCM and AF. Methods Overall, 1739 adult patients with HCM (40.9% women; median age: 55.5 years) were enrolled in the EURObservational Research Programme (EORP) Cardiomyopathy/Myocarditis Registry.

Atrial Fibrillation 88

Atrial Fibrillation Cardiomyopathy Research Defibrillator 88

Circulation

FEBRUARY 20, 2025

Circulation, Ahead of Print. This American Heart Association/American College of Cardiology scientific statement on clinical considerations for competitive sports participation for athletes with cardiovascular abnormalities or diseases is organized into 11 distinct sections focused on sports-specific topics or disease processes that are relevant when considering the potential risks of adverse cardiovascular events, including sudden cardiac arrest, during competitive sports participation.

Cardiac Arrest 81

Cardiac Arrest Circulation 81

Nature Reviews - Cardiology

FEBRUARY 2, 2025

Nature Reviews Cardiology, Published online: 03 February 2025; doi:10.1038/s41569-025-01132-3 In this Clinical Outlook, we describe available multiomic studies in cardiovascular medicine, discuss the advantages and potential of multiomic techniques for clinical translation in cardiology, and highlight three promising aspects: the generation of unprecedented cellular atlases, the identification of composite diagnostic and prognostic biomarkers derived from integrative multiomic signatures, and th

Biomarkers 86

Biomarkers 86

Journal of the American Heart Association

FEBRUARY 25, 2025

Journal of the American Heart Association, Ahead of Print. Perinatal psychological health conditions (eg, perinatal depression, anxiety) are some of the leading causes of maternal mortality in the United States and are associated with adverse pregnancy outcomes, longterm cardiovascular outcomes, and intergenerational effects on offspring neurodevelopment.

Pharmacology 75

Pharmacology Outcomes 75

Science Daily - Heart Disease

FEBRUARY 26, 2025

Coronary artery disease (CAD), or the narrowing of the coronary arteries, is the leading cause of morbidity and mortality throughout the world. Atherosclerosis, or the buildup of plaque in the arteries, develops when low-density lipoprotein cholesterol (LDL-C) enters the blood vessel walls through dysfunctional endothelial cells (EC), leading to the formation of plaques.

Cholesterol 70

Cholesterol Coronary Artery Disease Plaque Heart Disease 70

Journal of Clinical Investigation - Cardiology

FEBRUARY 3, 2025

Disruptions of blood pressure (BP) circadian variation are closely associated with an increased risk of cardiovascular disease. Thus, gaining insights into the molecular mechanisms of BP circadian variation is essential for comprehending BP regulation. Human genetic analyses suggest that PR domaincontaining protein 16 (PRDM16), a transcription factor highly expressed in vascular smooth muscle cells (VSMCs), is significantly associated with BP-related traits.

Blood Pressure 72

Blood Pressure Cardiovascular Disease 72

Physiologically Speaking

FEBRUARY 14, 2025

Greetings! Welcome to the Physiology Friday newsletter. If you’re looking for a new (mess-free) way to fuel your workouts, you should check out Intra Chew—it’s a workout gummy bear made by one of my friends that has carbohydrates and electrolytes. I’ve been using them during all of my long bike rides and before runs. At the very least, it’s something you should try once, and you can get 20% off using the code BRADY20 on the site.

Physiology 85

Physiology Exercise Research Dementia 85

Circulation

FEBRUARY 13, 2025

Circulation, Ahead of Print. Critical care cardiology refers to the practice focus of and subspecialty training for the comprehensive management of life-threatening cardiovascular diseases and comorbid conditions that require advanced critical care in an intensive care unit. The development of coronary care units is often credited for a dramatic decline in mortality rates after acute myocardial infarction throughout the 1960s.

Critical Care 72

Critical Care Myocardial Infarction Research Cardiovascular Disease 72

Nature Reviews - Cardiology

FEBRUARY 11, 2025

Nature Reviews Cardiology, Published online: 12 February 2025; doi:10.1038/s41569-025-01137-y Differing definitions and questionable prognostic significance have caused confusion and controversy around the applicability of the current definitions of periprocedural and perioperative myocardial infarction in clinical practice. In this Clinical Outlook, we review the definitions and the clinical and prognostic relevance of the various entities and provide implications for clinical practice.

Myocardial Infarction 81

Myocardial Infarction 81

Journal of the American Heart Association

FEBRUARY 3, 2025

Journal of the American Heart Association, Ahead of Print. Cerebral blood flow (CBF) is vital for delivering oxygen and nutrients to the brain. Many forms of orthostatic intolerance (OI) involve impaired regulation of CBF in the upright posture, which results in disabling symptoms that decrease quality of life. Because CBF is not easy to measure, rises in heart rate or drops in blood pressure are used as proxies for abnormal CBF.

Blood Pressure 76

Blood Pressure Ultrasound Quality of Life Tachycardia 76

Cardiomatics

FEBRUARY 5, 2025

At Cardiomatics, we are committed to advancing cardiac research with AI-driven ECG analysis. We are proud to share our latest study, conducted with University Hospital Basel, and published in Diabetes Care. This marks our fourth collaboration, and we are eager to do more! The study explores how metformin can protect against the harmful effects of glucocorticoids (GCs).

Research 93

Research Hospital Diabetes Electrophysiology 93

Journal of Clinical Investigation - Cardiology

FEBRUARY 17, 2025

Heterozygous truncating variants in the sarcomere protein titin (TTN) are the most common genetic cause of heart failure. To understand mechanisms that regulate abundant cardiomyocyte (CM) TTN expression, we characterized highly conserved intron 1 sequences that exhibited dynamic changes in chromatin accessibility during differentiation of human CMs from induced pluripotent stem cells (hiPSC-CMs).

CMS 75

CMS Heart Failure Cardiomyopathy 75

DAIC

FEBRUARY 10, 2025

tim.hodson Mon, 02/10/2025 - 12:43 Feb. 6, 2025 Eko Health, a leader in applying artificial intelligence (AI) for the early detection of heart and lung diseases, recently announcedpublication of a peer-reviewed study evaluating its novel algorithm for the detection of pulmonary hypertension (PH). The study, which was published in the Journal of the American Heart Association (JAHA), highlighted the algorithms ability to analyze heart sounds recorded with a digital stethoscope for identifying ele

Research 64

Research Innovation Pulmonary Hypertension 64

Science Daily - Heart Disease

FEBRUARY 11, 2025

Newborns with heart complications can rely on their newly developed immune systems to regenerate cardiac tissues, but adults aren't so lucky. After a heart attack, most adults struggle to regenerate healthy heart tissue, leading to scar-tissue buildup and, often, heart failure. A new study in experimental animals reveals a critical difference in how macrophages -- a part of the immune system -- help repair the heart in newborns versus adults after a heart attack.

Heart Attack 69

Heart Attack Heart attacks Heart Failure 69

Nature Reviews - Cardiology

FEBRUARY 18, 2025

Nature Reviews Cardiology, Published online: 19 February 2025; doi:10.1038/s41569-025-01130-5 In this Roadmap, Stellos and colleagues discuss the mechanisms of cardiovascular system ageing and how the ageing of blood, vessels and heart relates to the decline in organ function, and highlight potential therapeutic interventions, challenges in ageing research and future directions for preclinical and clinical studies.

Research 75

Research 75

Heart BMJ

FEBRUARY 26, 2025

One in five women suffer from hypertension worldwide, and almost half of the mortality in women is caused by cardiovascular disease (CVD) (WHO). The timely launch of the Women’s Health Strategy for England in 2022 focuses attention on the changing health and needs of women across their life. It is ambitious—aiming to identify the critical stages where there are opportunities to promote good health during the woman’s life course.

Hypertension 59

Hypertension Cardiovascular Disease Outcomes 59

MIBHS

FEBRUARY 15, 2025

High blood pressure, also known as hypertension, is a common condition that affects millions of people worldwide. Often referred to as the silent killer, hypertension can quietly damage your heart and other vital organs over time. Understanding how high blood pressure impacts your heart and learning to manage it can significantly reduce your risk of heart disease and improve your overall health.

Blood Pressure 52

Blood Pressure Hypertension Chest Pain Aneurysm 52

Open Heart

FEBRUARY 27, 2025

Background Understanding pandemic-related reductions and subsequent recovery of cardiovascular testing in Asia is important for guiding regional public health efforts. Objectives This study sought to evaluate the recovery of cardiovascular testing in Asia 1 year into the COVID-19 pandemic. Methods In this subanalysis of a worldwide survey on the impact of COVID-19 on cardiovascular diagnostic care in April 2020 and April 2021, recovery of testing volume in Asia was compared among subregions, Wor

COVID-19 52

COVID-19 Public Health 52

Frontiers in Cardiovascular Medicine

FEBRUARY 27, 2025

BackgroundPrevious studies have shown that exercise can improve arterial stiffness (AS). However, it remains unclear which type of exercise is most effective for managing AS, particularly in individuals at high risk for cardiovascular diseases (CVD). This review aims to evaluate the effects of various exercises on AS and related variables in individuals at high risk for CVD.MethodsA comprehensive search strategy was employed to systematically explore MEDLINE (PubMed), Embase, Cochrane Library, E

Exercise 52

Exercise Cardiovascular Disease Blood Pressure Risk Factors 52

Science Daily - Heart Disease

FEBRUARY 3, 2025

Low-density lipoproteins (LDL) -- commonly known as bad cholesterol -- have long been on scientists' radar as a major contributor to heart disease. But these microscopic troublemakers have hidden their inner workings behind a maze of complexity. That is, until now. Researchers have now revealed the specific shape and structure of one of the body's most important yet complicated proteins: ApoB100.

Heart Disease 68

Heart Disease Cholesterol Research 68

CardiacWire

FEBRUARY 19, 2025

Although heart failure prognosis is grim, the ALT-FLOW trials two year results suggest that diverting blood from the left atrium to the coronary sinus using a shunt could have lasting benefits for patients with HFmrEF/HFpEF. Theres no cure for HF, so most treatments focus on extending lifespan and improving quality-of-life by reducing symptoms. Current treatments focus on improving blood flow, lowering blood pressure, and relieving kidney fluid pressure, while procedures like CABG or ICD and VAD

Quality of Life 59

Quality of Life Heart Failure Blood Pressure Hospital 59

Heart BMJ

FEBRUARY 26, 2025

A significant proportion of patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) have concomitant coronary artery disease (CAD). The best way to treat these patients is contentious. Conventional assessments of ischaemia such as fractional flow reserve (FFR) and instantaneous wave-free ratio are not validated in the context of severe AS despite having a Class I European Society of Cardiology indication in patients with isolated coronary disease.

Coronary Artery Disease 59

Coronary Artery Disease Stenosis Aortic Aortic valve 59

Physiologically Speaking

FEBRUARY 3, 2025

This week marked week 1 of my 12-week marathon training block which I’m referring to as the “Road to Boston.” Each week I’ll share details about my training, some insights, and other musings as I train for the 2025 Boston Marathon. Thanks for following along! You can also find my training on Strava. Physiologically Speaking is a reader-supported publication.

Physiology 64

Physiology 64

DAIC

FEBRUARY 18, 2025

In tricuspid valve regurgitation, a complex condition that Cedars-Sinai experts regularly treat, the valve between two heart chambers on the right side doesn't open or close properly. Image by Getty. tim.hodson Tue, 02/18/2025 - 10:08 Feb. 13, 2025 Research from Cedars-Sinai investigators and collaborators at other leading medical institutions is helping to provide more treatment options to people living with tricuspid valve disease.

Tricuspid 52

Tricuspid Open-Heart Surgery Quality of Life Anatomy 52

Frontiers in Cardiovascular Medicine

FEBRUARY 13, 2025

IntroductionThis paper aims to expose the link between occupational exposure to respirable crystalline silica (SiO2) and cardiovascular diseases (CVDs).MethodsA comprehensive review of the literature was conducted, focusing on epidemiological studies that assessed the association between silicosis or SiO2 exposure and CVDs. Specific cardiovascular diseases, such as acute myocardial infarction, arrhythmias, pulmonary hypertension and pericarditis, were also pointed.

Myocardial Infarction 52

Myocardial Infarction Biomarkers Pericarditis Cardiovascular Disease 52

Science Daily - Heart Disease

FEBRUARY 7, 2025

Women who have experienced pregnancy complications have an increased risk of cardiovascular disease. Now, a new study shows that sisters of women with complicated pregnancies are also at higher risk, even if they had uncomplicated pregnancies. The findings suggest that genes and shared environmental factors may influence the association between pregnancy complications and cardiovascular disease risk.

Cardiovascular Disease 72

Cardiovascular Disease 72

Medical Xpress - Cardiology

FEBRUARY 27, 2025

Hospital-based researchers from Denmark have reported a substantial increase in cardiovascular disease risk among male users of anabolic androgenic steroids (AAS). Long-term health outcomes for AAS users show extreme increases in heart-related health risks.

Cardiovascular Disease 139

Cardiovascular Disease Hospital Research Outcomes 139

Heart BMJ

FEBRUARY 26, 2025

Background Health inequalities in cardiovascular care have been identified in the UK. The sociodemographic characteristics of patients undergoing intervention for aortic stenosis (AS) in England, and the impact of COVID-19, is unknown. Methods National linked data sets identified all surgical aortic valve replacement (SAVR) and transcatheter aortic valve implantation (TAVI) for AS, and post-intervention cardiovascular mortality, between 2000 and 2023.

Aortic valve 52

Aortic valve Aortic COVID-19 Stenosis 52

Open Heart

FEBRUARY 27, 2025

Background Iron deficiency (ID) is a highly prevalent comorbidity in patients with chronic and acute heart failure and is associated with worse clinical outcomes. We aimed to evaluate the prevalence and clinical characteristics of ID and its association with in-hospital congestion and postdischarge outcomes. Methods FiER deficit in Insuficienta Cardiaca in Romania was a prospective, multicentric study, enrolling 163 patients hospitalised for worsening chronic heart failure (WCHF) irrespective of

Heart Failure 52

Heart Failure Hospital Outcomes 52

DAIC

FEBRUARY 3, 2025

tim.hodson Mon, 02/03/2025 - 12:30 January 29, 2025 Roche announced today that the Tina-quant Lipoprotein (a) Gen.2 Molarity assay has received 510(k) clearance from the United States Food and Drug Administration (FDA). This will be the first 510(k) cleared test of its kind available in the U.S. measuring lipoprotein (a), or Lp(a), in nanomoles per liter (nmol/L).

Cardiovascular Disease 52

Cardiovascular Disease Aortic valve Biomarkers Innovation 52