Sun.Nov 24, 2024

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Muvalaplin Aces Phase 2 Lp(a) Test

CardiacWire

Impressive results from the Phase 2 KRAKEN trial presented at the AHA 2024 Scientific Sessions showed that Eli Lilly’s muvalaplin greatly reduces Lp(a) blood levels, adding an attractive oral option to its Lp(a) pipeline. High Lp(a) is an inherited CVD risk factor that impacts one out of every five people and currently has no approved drug therapies.

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LUNA, OPTIC Data Support Long-Term Benefit of Ixo-Vec for Wet AMD

HCPLive

New 52-week LUNA and 4-year OPTIC data demonstrate Ixo-vec’s potential to reduce injection burden, maintain vision, and achieve lifelong benefits for wet AMD.

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Evaluation value of ultrasound on gastrointestinal function in patients with acute heart failure

Frontiers in Cardiovascular Medicine

ObjectiveTo study the changes in gastrointestinal wall thickness, blood flow, motility, and symptoms in patients with acute heart failure, and to assess gastrointestinal function by ultrasound.MethodsIn this study, patients diagnosed with acute heart failure were selected as the study group, and healthy individuals were selected as the control group.

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Jack Arnold, MBBS: Honing in on ANA-RMD Classifications to Improve Research

HCPLive

Arnold discussed his research in analyzing and improving current classifications of ANA-RMDs and how it could help improve research in the field.

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Summary of the best evidence for risk stratification of exercise rehabilitation in patients with a cardiac implantable electronic device

Frontiers in Cardiovascular Medicine

BackgroundHierarchical management of sports risk is highly critical to ensure the safety of sports rehabilitation. Early identification, timely prevention and control of sports-related risk factors, and enhanced supervision and guidance can provide a basis for the formulation of sports programmes and the setting of sports monitoring levels.ObjectiveThis study aimed to retrieve, evaluate, and integrate evidence for the stratified management of motor risk in patients with a cardiac implantable ele

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Direct Oral Anticoagulants versus Warfarin for the Treatment of Left Ventricular Thrombus: A Multicenter Retrospective Observational Study

The American Journal of Cardiology

Publication date: Available online 24 November 2024 Source: The American Journal of Cardiology Author(s): Abdullah Al-Abcha, Shannon Clay, Ling Wang, Rohan Madhu Prasad, Mohammad Fahad Salam, Shaurya Srivastava, Manel Boumegouas, George S Abela, Yehia Saleh, Essa M Essa

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Correlation between remnant cholesterol and premature coronary artery disease and the severity of coronary artery lesions in men: a retrospective study

Frontiers in Cardiovascular Medicine

ObjectiveTo investigate the correlation between remnant cholesterol (RC) and premature coronary artery disease (PCAD) and the severity of coronary artery lesions in men.MethodsA total of 630 male subjects who underwent coronary angiography were included in the study. The general data, laboratory tests, and coronary angiography data of each group were statistically analyzed, and RC levels were calculated.

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Bidirectional two-sample Mendelian randomization study of atrial fibrillation and breast cancer

Frontiers in Cardiovascular Medicine

BackgroundObservational studies have shown an association between Breast Cancer (BC) and Atrial Fibrillation (AF). However, due to confounding factors and reverse causality, the causal role between BC and AF remains unclear. In this study, bidirectional two-sample Mendelian randomization (MR) combined with meta-analysis was used to evaluate the causal association between BC and AF.MethodsBased on the Genome-Wide Association Studies (GWAS) summary data sets, the Inverse variance weighted (IVW) me

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Letter by Zhang et al Regarding Article, “Positive Vasoreactivity Testing in Pulmonary Arterial Hypertension: Therapeutic Consequences, Treatment Patterns, and Outcomes in the Modern Management Era”

Circulation

Circulation, Volume 150, Issue 22 , Page e467-e467, November 26, 2024.

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Genetics architecture of spontaneous coronary artery dissection in an Italian cohort

Frontiers in Cardiovascular Medicine

Spontaneous coronary artery dissection (SCAD) is a relevant non-atherosclerotic cause of acute coronary syndrome with a complex genetic architecture. Recent discoveries have highlighted the potential role of miRNAs and protein-coding genes involved in the processing of small RNAs in the pathogenesis of SCAD. Furthermore, there may be a connection between SCAD and the increased cardiovascular risk observed in fragile X premutation carriers as well as a correlation with pathogenetic variants in ge

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Technologic Advances in Cardiac Electrophysiology

Circulation

Circulation, Volume 150, Issue 22 , Page 1745-1746, November 26, 2024.

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Safety and efficacy of outpatient intravenous diuresis in decompensated heart failure: a systematic review

Frontiers in Cardiovascular Medicine

IntroductionHeart failure (HF) burdens the US healthcare system, with annual costs exceeding $30 billion. Outpatient intravenous (OP IV) diuresis in clinic or home settings may potentially improve outcomes and reduce costs, though limited data exists. This systematic review evaluates the safety, efficacy, and outcomes of OP IV diuresis in managing decompensated HF as a hospitalization alternative.MethodsFollowing PRISMA 2020 guidelines, this systematic review used MeSH terms in MEDLINE, SCOPUS,

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Stroke Literature Synopses (Preclinical)

Stroke Journal

Stroke, Volume 55, Issue 12 , Page e330-e331, December 1, 2024.

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Ethanol marshall bundle elimination, pulmonary vein isolation, and linear ablation for atrial fibrillation with or without heart failure

Frontiers in Cardiovascular Medicine

BackgroundIn medical practice, atrial fibrillation (AF) is intricately associated with heart failure (HF). Currently, ethanol infusion of vein of Marshall (EIVOM) for AF ablation in HF patients remains significantly limited.MethodThis was a non-randomized, single-center, retrospective observational study. AF patients received 4-step ablation composed of EIVOM, pulmonary vein isolation (PVI) and linear ablation.

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December 2024 Stroke Highlights

Stroke Journal

Stroke, Volume 55, Issue 12 , Page 2773-2773, December 1, 2024.

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Correction to: 2024 Guideline for the Primary Prevention of Stroke: A Guideline From the American Heart Association/American Stroke Association

Stroke Journal

Stroke, Volume 55, Issue 12 , Page e439-e439, December 1, 2024.

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