Journal of the American Heart Association

JUNE 18, 2025

Journal of the American Heart Association, Ahead of Print. BackgroundThe American Heart Association has advocated for regionalized systems of care for out‐of‐hospital cardiac arrest (OHCA), emphasizing admission to specialized centers with onsite coronary angiography. However, national data evaluating outcomes of OHCA admission to such centers remain limited.MethodsUsing the 2021 National Inpatient Sample, we identified all direct OHCA hospitalizations across US facilities.

Cardiac Arrest 40

Cardiac Arrest Hospital Cardiogenic Shock Myocardial Infarction 40

NEJM Journal Watch - Cardiology

JUNE 18, 2025

Pooled clinical trial data support P2Y12 inhibitors over aspirin as monotherapy after DAPT discontinuation.

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Frontiers in Cardiovascular Medicine

JUNE 18, 2025

BackgroundThe study aims to evaluate the efficacy of a web-based dynamic nomogram predicting the risk of heart failure (HF)-related rehospitalization within 1 year in patients with HF with preserved ejection fraction (HFpEF).MethodsThe data of patients from two centers were categorized into training and test sets. Least absolute shrinkage and selection operator and multivariate logistic regression analysis were conducted on the training set data after selecting risk factors described in previous

Preserved Ejection Fraction 52

Preserved Ejection Fraction Heart Failure Risk Factors Atrial Fibrillation 52

Journal of the American Heart Association

JUNE 18, 2025

Journal of the American Heart Association, Ahead of Print. BackgroundThe ambulance system is vital for the early management of patients with ST‐segment–elevation myocardial infarction, reducing delays in diagnosis and treatment. This study examined the impact of transport mode on reperfusion therapy and mortality among patients with ST‐segment–elevation myocardial infarction from 2000 to 2021.MethodsData from the ACSIS (Acute Coronary Syndrome Israeli Survey) registry 2000 to 2021 were analyzed.

Myocardial Infarction 40

Myocardial Infarction Outcomes Hospital 40

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

Patient Care

Cardiomatics

JUNE 18, 2025

Every day, clinics across Europe rely on ambulatory ECG recorders to detect arrhythmias and support clinical decisions. But with so many devices available, how can we tell which ones consistently deliver clean, usable signals? At Cardiomatics, we analyse ECG data from over 60 different devices, collected from hundreds of clinics. Because our platform is hardware-agnostic and powered by AI, we have a unique perspective on how these devices perform in real life.

Blog 84

Blog Arrhythmia 84

Journal of the American Heart Association

JUNE 18, 2025

Journal of the American Heart Association, Ahead of Print. Transcatheter aortic valve replacement has emerged as a valuable alternative to surgical aortic valve replacement in patients with severe aortic stenosis. Given the expansion of transcatheter aortic valve replacement to lower‐risk and younger populations with longer life expectancy, the durability of transcatheter heart valves (THVs) has become an important issue that may impact cardiovascular outcomes.

Aortic valve 40

Aortic valve Aortic Heart Valves Thrombosis 40

Journal of the American Heart Association

JUNE 18, 2025

Journal of the American Heart Association, Ahead of Print. BackgroundStandardized protocols with optimal hemodynamic targets for percutaneous ventricular assist device (PVAD) management remain undefined. We aimed to evaluate the proportion of phase‐specific hemodynamic criteria achieved during PVAD support and their association with outcomes in patients with cardiogenic shock.MethodsThis multicenter retrospective study enrolled patients with cardiogenic shock requiring PVAD (Impella).

Cardiogenic Shock 75

Cardiogenic Shock Outcomes Pulmonary 75

All About Cardiovascular System and Disorders

JUNE 18, 2025

All About Cardiovascular System and Disorders Menu Cardiology Angiography and Interventions Coronary Interventions Peripheral Interventions Structural Heart Disease Interventions Cardiac CT scan Cardiac Magnetic Resonance imaging Cardiac rehabilitation Cardiac Surgery Cardio Oncology Cardiology Basics Cardiology Basics Cardiology MCQ DM / DNB Cardiology Entrance Cardiology X-ray Cardiomyopathy Clinical Trial Review ECG / Electrophysiology ECG Library Echocardiography Echocardiogram Library Gener

Angioplasty 52

Angioplasty Stents Stent Cardio Oncology 52

Journal of the American Heart Association

JUNE 18, 2025

Journal of the American Heart Association, Ahead of Print. BackgroundEducational attainment level (EAL) is an indicator of socioeconomic status and has been shown to be inversely related with adverse health outcomes. However, the association between EAL and risk of clinical outcomes in high‐risk patients with cardiovascular disease has not been extensively investigated.MethodsIn the INVESTED (Influenza Vaccine to Effectively Stop Cardio Thoracic Events and Decompensated Heart Failure) trial, pat

Cardiovascular Disease 40

Cardiovascular Disease Education Outcomes Myocardial Infarction 40

Frontiers in Cardiovascular Medicine

JUNE 18, 2025

Artificial lungs support patients with acute or chronic lung diseases. However, complications such as the activation of blood components leading to thrombosis and inflammation limit their long-term applicability. The systematic characterization of protein adhesion events on different material parts of the oxygenators at different flow rates can shed light on the initial reaction of blood to foreign materials.

Thrombosis 52

Thrombosis Research 52

European Journal of Heart Failure

JUNE 18, 2025

Determinants of submaximal exercise intolerance in patients with heart failure with preserved ejection fraction (HFpEF). VO 2 , oxygen consumption. Abstract Aims Oxygen consumption at peak exercise is widely used to assess functional impairment in heart failure with preserved ejection fraction (HFpEF), but few patients exercise to this intensity in daily living.

Preserved Ejection Fraction 45

Preserved Ejection Fraction Exercise Heart Failure Pulmonary 45

Journal of the American Heart Association

JUNE 18, 2025

Journal of the American Heart Association, Ahead of Print. BackgroundChronotropic incompetence is common in older people and contributes to heart failure with preserved ejection fraction (HFpEF). This prospective study investigated the impact of chronotropic incompetence on cardiovascular outcomes in patients with HFpEF.Methods and ResultsFrom November 2019 to December 2022, 359 subjects undergoing invasive cardiopulmonary exercise testing for heart failure symptoms were enrolled.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Outcomes Exercise 40

European Journal of Heart Failure

JUNE 18, 2025

Seamless translation from basic concepts to new heart failure drugs. ABSTRACT A rift has opened and is widening between basic research (bench) and clinical research and patients (bed) who need their new treatments, diagnostics and preventive strategies. This problem involving the ‘translation’ of basic scientific findings into clinical applications and potential treatments or biomarkers for a condition like heart failure is widely recognized both in academia and industry.

Heart Failure 40

Heart Failure Research Biomarkers 40

Journal of the American Heart Association

JUNE 18, 2025

Journal of the American Heart Association, Ahead of Print. BackgroundCongenital heart defects affect approximately 1% of births in the United States and Europe, with >1 million children in the United States living with congenital heart defects. Many experience abnormalities in the right ventricular outflow tract, often necessitating surgical intervention early in life.

Pulmonary 40

Pulmonary Heart Valves Congenital Stents 40

Hypertension Journal

JUNE 18, 2025

Hypertension, Ahead of Print. BACKGROUND:Overweight and obesity greatly increase the risk of preeclampsia. There is a need to better risk-stratify these women in pregnancy and channel resources to those who can benefit most.METHODS:Prospective observational study of 11 962 women with singleton pregnancies attending a routine assessment at 35+0 to 36+6 weeks’ gestation at King’s College Hospital, London, United Kingdom.

Obesity 40

Obesity Aortic Hypertension Hospital 40

Journal of the American Heart Association

JUNE 18, 2025

Journal of the American Heart Association, Ahead of Print. BackgroundWhile peripheral artery disease care for claudication aims to improve health status (symptoms, physical function, and quality of life), health status trajectories remain unclear. We aimed to determine health status trajectories and explore baseline factors associated with treatment nonresponsiveness.MethodsData were derived from the PORTRAIT (Patient‐Centered Outcomes Related to Treatment Practices in Peripheral Arterial Diseas

Peripheral Arterial Disease 40

Peripheral Arterial Disease Quality of Life Outcomes 40

American College of Cardiology

JUNE 18, 2025

The timely treatment of STEMI varies substantially at the hospital level, for both primary presentation and transfers, and worse outcomes were observed in patients when the first medical contact (FMC)-to-device target was not met or who presented to low-performing hospitals.

STEMI 56

STEMI Outcomes Hospital Article 56

European Journal of Heart Failure

JUNE 18, 2025

In heart failure, sodium retention generally occurs out of proportion to water retention and may occur disproportionate to chloride retention, requiring excretion of other cations (i.e. potassium, magnesium, and hydrogen). Renal homeostatic mechanisms keep chloride levels in balance, making it the primary regulator of intravascular tonicity. Excess total body sodium stores and potassium depletion increase the vulnerability to dehydration, especially in the intracellular compartment.

Heart Failure 53

Heart Failure Article 53

American College of Cardiology

JUNE 18, 2025

Among patients undergoing PCI in the U.S., frailty is common with higher frailty status associated with increased risk of mortality, according to a brief report published June 16 in JACC. Patients categorized as severely frail were few but exhibited an exceptionally high risk.

Article 53

Article 53

Frontiers in Cardiovascular Medicine

JUNE 18, 2025

This study aimed to systematically evaluate the association between body mass index (BMI) and cardiovascular metabolic multimorbidity (CMM). Cochrane Library, CINAHL, EMBASE, Web of Science, and PubMed were searched for observational studies examining the relationship between BMI and CMM, with a search timeframe from database inception to May 16, 2024.

BMI 52

BMI Obesity Education Research 52

American College of Cardiology

JUNE 18, 2025

How does the efficacy and safety of catheter ablation as first-line therapy compare with antiarrhythmic drug (AAD) therapy for ventricular tachycardia (VT) in patients with ischemic cardiomyopathy (ICM) and implantable cardioverter-defibrillators (ICDs)?

Tachycardia 45

Tachycardia Ablation Defibrillator Cardiomyopathy 45

Circulation

JUNE 18, 2025

Circulation, Ahead of Print. Poor diet quality is a leading risk factor for cardiometabolic disease (ie, diabetes and diseases associated with metabolism and inflammation), which is present in about half of American adults. Support has grown for incorporating the provision of healthy food as a complement to or a component of clinical care. Such “Food Is Medicine” programs provide free or subsidized healthy food directly to patients in close coordination with the health care system.

Diet 85

Diet Risk Factors Outcomes Diabetes 85

HeartRhythm

JUNE 18, 2025

Cardiac sarcoidosis (CS) is a rare condition marked by granulomatous inflammation that can lead to myocardial fibrosis, heart failure, arrhythmias, and conduction defects such as complete heart block (CHB). Although CS affects about 5% of those with sarcoidosis, it often goes undiagnosed, especially in CHB cases.1 Due to the urgency of CHB treatment, patients may receive permanent pacemakers without further evaluation, as current guidelines suggest.2 However, in CS, a level IIA recommendation su

Defibrillator 40

Defibrillator Pacemaker Arrhythmia Heart Failure 40

Journal of the American Heart Association

JUNE 18, 2025

Journal of the American Heart Association, Ahead of Print. BackgroundMetabolic hyperferritinemia (MHF) is associated with the occurrence and progression of cardiovascular disease. Our aim is to investigate the prevalence of MHF, as defined by the latest consensus, and validate its association with major adverse cardiovascular events (MACEs) in heart failure with preserved ejection fraction with different glucose metabolism conditions.Methods and ResultsThis retrospective study included 7498 pati

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Diabetes Cardiovascular Disease 40

Hypertension Journal

JUNE 18, 2025

Hypertension, Ahead of Print. BACKGROUND:Indirect and direct approaches to assess sympathetic cardiovascular drive have shown that patients with essential hypertension responsive to the blood pressure–lowering effects of antihypertensive drugs are characterized by a pronounced adrenergic overactivity. Whether an emerging clinical hypertensive phenotype such as drug-resistant hypertension (RHT) is also characterized by sympathetic activation and whether its magnitude and underlying pathophysiolog

Hypertension 40

Hypertension Blood Pressure 40

Journal of the American Heart Association

JUNE 18, 2025

Journal of the American Heart Association, Ahead of Print. BackgroundTo determine the impact of tricuspid regurgitation (TR) on outcomes after transcatheter aortic valve implantation (TAVI), and to determine the evolution of TR severity after TAVI.MethodsThis was an observational study of TAVIs for aortic stenosis from November 2012 to December 2021.

Aortic valve 40

Aortic valve Tricuspid Aortic Heart Failure 40

American College of Cardiology

JUNE 18, 2025

A new multisociety expert consensus document (ECD) published in JACC addresses the evolving use of cardiac CT imaging and how to best use it to assess different types of prosthetic heart valve (PHV) dysfunction.

Document 69

Document Heart Valves Article 69

Open Heart

JUNE 18, 2025

Objectives Non-dilated left ventricular cardiomyopathy (NDLVC) is a novel cardiomyopathy characterised by normal LV size and non-ischaemic myocardial scarring or fatty tissue replacement. This study aimed to explore the clinical and cardiac magnetic resonance (CMR) characteristics of NDLVC compared with dilated cardiomyopathy (DCM) and event rates of patients with NDLVC and reduced LV ejection fraction (NDLVC-REF).

Cardiomyopathy 52

Cardiomyopathy Cardiac Function Outcomes 52

American College of Cardiology

JUNE 18, 2025

Among persons with chronic kidney disease (CKD) and type 2 diabetes (T2D), combination therapy with finerenone plus empagliflozin leads to a greater reduction in the urinary albumin-to-creatinine ratio (UACR) than either drug alone.

Kidney Disease 66

Kidney Disease Diabetes Article 66

Frontiers in Cardiovascular Medicine

JUNE 18, 2025

ObjectiveCardiac aging is a major risk factor for the development of cardiovascular diseases. Although evidence suggests an association between N6-methyladenosine (m6A) modification and numerous cardiovascular diseases, its role in cardiac aging remains unclear. This study was conducted to elucidate the role of m6A modification in cardiac aging and the molecular mechanisms involved.MethodsGlobal methylation levels and the expression of major m6A regulators were compared between young and aged he

Cardiovascular Disease 52

Cardiovascular Disease Cardiomyopathy Risk Factors Research 52

American College of Cardiology

JUNE 18, 2025

Two studies published in JACC on June 16 provide new insights on arterial events associated with heritable thoracic aortic disease (TAD) and the relative risk in patients with pathogenic variants (PVs) as well as the prevalence, characteristics and clinical outcomes of arterial aneurysms (AAs) in Loeys-Dietz Syndrome (LDS).

Aneurysm 56

Aneurysm Aortic Outcomes Article 56

Frontiers in Cardiovascular Medicine

JUNE 18, 2025

BackgroundAtrial fibrillation (AF) is the most common sustained arrhythmia in adults and is associated with significant morbidity and mortality. Mitral stenosis (MS) is common in developing countries, affecting the younger population and posing a risk of atrial fibrillation.ObjectivesThis study aims to delineate the clinical characteristics and poor outcomes in patients who have recent non-valvular AF (NVAF) compared with AF related to MS (MS-AF).

Bicuspid/Mitral 52

Bicuspid/Mitral Atrial Fibrillation Stenosis Outcomes 52

Open Heart

JUNE 18, 2025

Background There is no available information on the risk of permanent pacemaker implantation following transcatheter aortic valve implantation (TAVI) in Spain. Our objective was to investigate the incidence, temporal trends, and factors associated with this complication between 2017 and 2022, using data from the Spanish National Hospital Discharge Database (CMBD).

Aortic valve 59

Aortic valve Pacemaker Aortic Hospital 59

Frontiers in Cardiovascular Medicine

JUNE 18, 2025

BackgroundThe objective of this analysis was to assess the impact of atrial fibrillation (AF)/atrial flutter (AFL) across various European regions and countries from 1990 to 2021.MethodsUsing the global burden disease 2021 analytical tools, this study evaluated the incidence, prevalence, disability-adjusted life years (DALYs) and death associated with AF/AFL across the European Region, as defined by the World Health Organization, which includes 53 member countries (EU-53), as well as the Europea

Atrial Flutter 52

Atrial Flutter Atrial Fibrillation Public Health Research 52

HCPLive

JUNE 18, 2025

Findings highlight an increased risk of MASLD, heart failure, type 2 diabetes, and other cardiometabolic diseases following cycles of weight loss and regain.

Heart Failure 59

Heart Failure Diabetes 59

American College of Cardiology

JUNE 18, 2025

Exposure to both ozone pollution and higher ambient temperature, even when one exposure is moderate, increases the probability of an acute myocardial infarction (AMI) in younger adults, according to a large U.S. study published June 3 in Circulation.

Myocardial Infarction 49

Myocardial Infarction Circulation Article 49