Mon.Jun 09, 2025

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Polypill Approved for Hypertension, Including as Initial Therapy

Med Page Today

(MedPage Today) -- The FDA approved a polypill containing telmisartan, amlodipine, and indapamide, known as Widaplik, for the treatment of hypertension in adults, including as initial treatment. This marks the first time that a triple combination.

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Leveraging SGLT2 Inhibitors, GLP-1 RAs in Heart Failure, with Jose Lopez, MD

HCPLive

News Media Podcasts State Of Sciences - Presentations Videos Webinars Multimedia Series CURE Connections® Insights Medcast Peer Exchange Peers & Perspectives Special Report Conferences Conference Coverage Conference Listing Partners CME/CE Resources Digital Supplements Interactive Tools Live Events Press Release Publications Sponsored Advisory Board Subscribe Choose Specialty Allergy Allergy Allergy Allergy Biosimilars Cardiology Cardiology Cardiology Cardiology Cardiology Cardiology Cardiol

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Cycling in Midlife Tied to Lower Risk of Dementia

Med Page Today

(MedPage Today) -- Using physically active transportation modes in midlife -- particularly cycling -- was tied to lower dementia risk and greater hippocampal volume, a large U.K. Biobank study suggested. Compared with non-active travel like.

Dementia 137
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Enlicitide Reduces LDL-C in People With Hyperlipidemia, HeFH, Against Placebo and Non-Statins

HCPLive

Phase 3 trials show enlicitide decanoate significantly lowers LDL cholesterol, offering a promising oral treatment for hyperlipidemia and cardiovascular risk.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Modest Blood Pressure Reductions With DASH-Like Diet in Type 2 Diabetes

Med Page Today

(MedPage Today) -- A modified DASH-style diet modestly reduced blood pressure (BP) for patients with type 2 diabetes and hypertension, the DASH4D randomized trial showed. With low-sodium DASH4D meals featuring lower carbs, higher unsaturated fats.

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19 Trial Meta-Analysis Finds GLP-1 RAs Have Substantial Kidney Benefits

HCPLive

A recent meta-analysis reveals GLP-1 RAs significantly reduce adverse kidney outcomes, highlighting their potential in chronic kidney disease management.

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Association of plasma homocysteine with cardiovascular disease in American adults: a study based on the national health and nutrition examination survey database

Frontiers in Cardiovascular Medicine

ObjectiveThe purpose of this study was to investigate the correlation between plasma homocysteine (Hcy) levels and cardiovascular disease (CVD) in United States adults based on the National Health and Examination Survey (NHANES) database of the United States.MethodsData from two survey periods (2003–2006) in the NHANES database were used as the research data set.

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How to Customize Your EHR for Subspecialties in Cardiology: Tailoring Technology for Better Cardiac Care

GEMMS

When you run a cardiology practice that includes diverse subspecialties, like electrophysiology, heart failure, or interventional procedures, you quickly realize that a generic electronic health record (EHR) isn’t enough. Subspecialists manage complex cases that require highly specific documentation, imaging, and diagnostic procedures. Without an EHR tailored to these workflows, efficiency drops, documentation errors rise, and patient outcomes may suffer.

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Analysis of risk factors and the predictive value of a nomogram model for coronary heart disease in patients with rheumatoid arthritis

Frontiers in Cardiovascular Medicine

BackgroundRheumatoid arthritis (RA) is associated with an elevated risk of coronary heart disease (CHD) due to a complex interplay of traditional cardiovascular risk factors and RA-specific mechanisms. This study aimed to identify key risk factors for CHD in RA patients and develop a nomogram model for individualized risk prediction.MethodsA retrospective study was conducted involving 258 RA patients, including 32 with CHD and 226 without CHD, admitted between January 2021 and August 2024.

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Primary Prevention of Cardiovascular Disease Important in People With HIV

Med Page Today

(MedPage Today) -- People living with HIV have a significantly increased risk of cardiovascular disease that requires a different level of preventive management than in the general population. Last year, an HHS panel released recommendations for.

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Moving the Needle on Cardiovascular Disease, with Seth Martin, MD, MHS

HCPLive

Martin reviews recent trends in cardiovascular disease and contributing underlying risk factors, describing them as a “call to action” for cardiovascular care.

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How to Maximize Your Workout Recovery

Physiologically Speaking

What you do after your workout can be just as important as the workout itself. That’s where the 4R Framework of Sports Nutrition comes in—it’s a scientifically grounded guide for optimizing post-exercise recovery and promoting long-term performance. Originally proposed in 2020 and updated with new research, this model emphasizes four crucial strategies: Rehydrate, Refuel, Repair, and Recuperate (or Rest).

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Improving Incidental Lung Nodule Follow-up, with Javier Zulueta, MD

HCPLive

Zulueta discussed Mount Sinai's incidental lung nodule program using AI tools to improve follow-up and recent findings from the program presented at ATS.

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Automated Vessel Occlusion Software in Acute Ischemic Stroke: Pearls and Pitfalls

Stroke Journal

Stroke, Ahead of Print. Software programs leveraging artificial intelligence to detect vessel occlusions are now widely available to aid in stroke triage. Given their proprietary use, there is a surprising lack of information regarding how the software works, who is using the software, and their performance in an unbiased real-world setting. In this educational review of automated vessel occlusion software, we discuss emerging evidence of their utility, underlying algorithms, real-world diagnost

Stroke 40
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Dr. Ron Witteles and Dr. C. Michael Gibson discuss: Atrial fibrillation, arrythmias, and other cardiac manifestations in patients with ATTR-CM

Clinical Trial Results

Skip to main content Clinical Trial Results Close Navigation Primary Navigation Home Slide Library This Week in Medicine® Past Videos About Contact Toggle Menu Search Dr. Ron Witteles and Dr. C. Michael Gibson discuss: Atrial fibrillation, arrythmias, and other cardiac manifestations in patients with ATTR-CM Search for: Search Search archived content (2018 and prior) Search June 9, 2025 Uncategorized Disclosures: Sponsored by BridgeBio Pharma, Inc.

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Familial hypercholesterolaemia with early-onset coronary artery disease and recurrent in-stent restenosis associated with the LDLR gene c.428G>A mutation: a case report

Frontiers in Cardiovascular Medicine

BackgroundFamilial hypercholesterolaemia (FH) is characterised by significantly elevated low-density lipoprotein cholesterol (LDL-C) levels and early-onset coronary artery disease. Additionally, clopidogrel resistance is observed in approximately 30%–50% of individuals globally. Among FH patients with early-onset coronary artery disease, inadequate LDL-C management and suboptimal antiplatelet therapy after stent implantation are key factors contributing to recurrent in-stent restenosis (ISR).Cas

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Correction of the Murine Model of Congenital Heart Disease Associated With the Nkx2-5 Mutation Using Prime Editing

Circulation: Genomic and Precision Medicine

Circulation: Genomic and Precision Medicine, Ahead of Print.

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Long‐term efficacy of tafamidis in patients with transthyretin amyloid cardiomyopathy by National Amyloidosis Centre stage

European Journal of Heart Failure

Long-term efficacy of tafamidis in patients with ATTR-CM in ATTR-ACT and its LTE by NAC stage at ATTR-ACT baseline. ATTR-ACT, Tafamidis in Transthyretin Cardiomyopathy Clinical Trial; ATTR-CM, transthyretin amyloid cardiomyopathy; NAC, National Amyloidosis Centre. Abstract Aims Tafamidis is an approved treatment for patients with transthyretin amyloid cardiomyopathy (ATTR-CM) based on the 30-month Tafamidis in Transthyretin Cardiomyopathy Clinical Trial (ATTR-ACT).

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Hypertension in Pregnancy Linked to Cerebral Small Vessel Disease 15 Years Later

Hypertension Journal

Hypertension, Ahead of Print. BACKGROUND:Substantial evidence suggests an association between hypertensive disorders of pregnancy and long-term cerebrovascular health. We aimed to determine the associations between hypertensive disorders of pregnancy and markers of cerebral small vessel disease 15 years after pregnancy.METHODS:This was a nested cohort study embedded in a population-based prospective cohort followed from early pregnancy.

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Minimal Hemolytic Profile of the Monopolar Lattice-Tip Pulse Field Ablation System: An In Vivo Preclinical Porcine Assessment

Circulation: Arrhythmia and Electrophysiology

Circulation: Arrhythmia and Electrophysiology, Ahead of Print.

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Employment of artificial intelligence for an unbiased evaluation regarding the recovery of right ventricular function after mitral valve transcatheter edge‐to‐edge repair

European Journal of Heart Failure

Impact of mitral transcatheter edge-to-edge repair (M-TEER) on left and right heart function. IQR, interquartile range; LA, left atrial; RVEF, right ventricular ejection fraction; sPAP, systolic pulmonary artery pressure; TAPSE, tricuspid annular plane systolic excursion. Abstract Aims Long-standing severe mitral regurgitation (MR) leads to left atrial (LA) enlargement, elevated pulmonary artery pressures, and ultimately right heart failure.

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Discussing Chronic Hand Eczema and Delgocitinib’s Potential Approval, with Jeff Yu, MD

HCPLive

News Media Podcasts State Of Sciences - Presentations Videos Webinars Multimedia Series CURE Connections® Insights Medcast Peer Exchange Peers & Perspectives Special Report Conferences Conference Coverage Conference Listing Partners CME/CE Resources Digital Supplements Interactive Tools Live Events Press Release Publications Sponsored Advisory Board Subscribe Choose Specialty Allergy Allergy Allergy Allergy Biosimilars Cardiology Cardiology Cardiology Cardiology Cardiology Cardiology Cardiol

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Erratum to “PO-01-189 SILENT MISPLACEMENT: LEADLESS PACEMAKER IN THE LEFT VENTRICLE DISCOVERED OVER A YEAR LATER—HOW DID IT END UP THERE? COULD IT EXPLAIN THE STROKE?”, Heart Rhythm, Volume 22, Issue 4S, pS211-S212, April 2025

HeartRhythm

In the abstract “PO-01-189 SILENT MISPLACEMENT: LEADLESS PACEMAKER IN THE LEFT VENTRICLE DISCOVERED OVER A YEAR LATER—HOW DID IT END UP THERE? COULD IT EXPLAIN THE STROKE?,” published in the supplement to the April 2025 issue of Heart Rhythm (2025;22: S211-S212), there was an error in the author listing. A comma was mistakenly placed in the middle of author Qutaiba Basheer Mohammad Qafisheh’s name.

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Deuvacratinib Found to Concurrently Improve Psoriasis and Arthritis

HCPLive

New research highlights deucravacitinib's effectiveness in alleviating both skin and joint symptoms in people with both psoriasis and psoriatic arthritis.

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Alcohol Use and Cardiovascular Disease: A Scientific Statement From the American Heart Association

Circulation

Circulation, Ahead of Print. Alcohol is one of the most commonly consumed substances in the world, exhibiting complex relationships with multiple aspects of cardiovascular health and disease. The majority of the research on the topic is observational and therefore prone to bias and confounding. The available evidence suggests no risk to possible risk reduction when alcohol is consumed in low amounts (such as no more than 1 to 2 drinks a day) in regard to coronary artery disease, stroke, sudden d

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Bedtime Procrastination Linked to Extraversion But Not Excitement-Seeking

HCPLive

A recent study reveals how personality traits like neuroticism and extraversion influence bedtime procrastination in young adults, impacting sleep health.

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Red blood cell rupture, not clotting, drives vessel blockage in COVID-19, study finds

Medical Xpress - Cardiology

A team led by the University of Sydney has identified red blood cell rupture at dying endothelial sites as a primary driver of microvascular obstruction in COVID-19, bypassing the expected role of fibrin and platelet clots.

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Navigating Lupus Nephritis Pipeline Updates, with Sayna Norouzi, MD

HCPLive

News Media Podcasts State Of Sciences - Presentations Videos Webinars Multimedia Series CURE Connections® Insights Medcast Peer Exchange Peers & Perspectives Special Report Conferences Conference Coverage Conference Listing Partners CME/CE Resources Digital Supplements Interactive Tools Live Events Press Release Publications Sponsored Advisory Board Subscribe Choose Specialty Allergy Allergy Allergy Allergy Biosimilars Cardiology Cardiology Cardiology Cardiology Cardiology Cardiology Cardiol

CME 52
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Efficacy of different polypill combinations for primary and secondary cardiovascular disease prevention: a systematic review and meta-analysis

Frontiers in Cardiovascular Medicine

BackgroundCardiovascular disease is the leading cause of mortality and morbidity worldwide, and polypills have established efficacy in preventing poor outcomes. However, evidence on the optimal polypill combination is lacking. The objective of the study is to estimate the optimal polypill combination that maximizes cardiovascular outcomes.MethodsMEDLINE/PubMed, Scopus, and Cochrane Database of Systematic Reviews databases were searched from January 1, 1960, to March 30, 2025.

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Precision Medicine in Today’s Atopic Dermatitis Landscape, with Peter Lio, MD

HCPLive

In this interview at RAD 2025, Peter Lio, MD, highlighted whether precision medicine is a possibility in the near future in the atopic dermatitis management space.

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The correlation between lipoprotein(a) and major adverse cardiovascular events in patients with acute myocardial infarction combined with heart failure with preserved ejection fraction

Frontiers in Cardiovascular Medicine

AimsThis study aimed to confirm the correlation between lipoprotein(a) [Lp(a)] and major adverse cardiovascular events (MACE) in patients with acute myocardial infarction (AMI) combined with heart failure with preserved ejection fraction (HFpEF).MethodsThis retrospective study was conducted at the First Affiliated Hospital of Dalian Medical University and included 399 patients who were diagnosed with AMI combined with HFpEF and who were hospitalised and underwent percutaneous coronary interventi

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Understanding Topical Steroid Withdrawal Versus Atopic Dermatitis, with Brad Glick, MD

HCPLive

News Media Podcasts State Of Sciences - Presentations Videos Webinars Multimedia Series CURE Connections® Insights Medcast Peer Exchange Peers & Perspectives Special Report Conferences Conference Coverage Conference Listing Partners CME/CE Resources Digital Supplements Interactive Tools Live Events Press Release Publications Sponsored Advisory Board Subscribe Choose Specialty Allergy Allergy Allergy Allergy Biosimilars Cardiology Cardiology Cardiology Cardiology Cardiology Cardiology Cardiol

CME 69
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Application of a transthyretin amyloid cardiomyopathy score to heart failure with mildly reduced or preserved ejection fraction

European Journal of Heart Failure

Abstract Aims The safety and efficacy of heart failure (HF)-directed medical therapy among patients who might be considered for further diagnostic evaluation to rule out transthyretin amyloid cardiomyopathy (ATTR-CM) is largely unknown. Methods and results We applied a previously validated ATTR-CM screening score in patients with HF and mildly reduced or preserved ejection fraction (HFmrEF/HFpEF) and assessed treatment effect of sodium–glucose cotransporter 2 inhibitors (SGLT2i), angiotensin rec

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Predictors of disease burden in patients with untreated transthyretin amyloid cardiomyopathy and their caregivers: a post hoc analysis of an international survey

Frontiers in Cardiovascular Medicine

IntroductionTransthyretin amyloid cardiomyopathy (ATTR-CM) is a progressive condition with debilitating symptoms. The self-reported burden of ATTR-CM on patients and their caregivers was previously evaluated in an international, multicenter, real-world survey study.MethodsThis post hoc analysis used univariate and multivariate models to evaluate survey items as predictors of ATTR-CM burden.

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Long-Term Upadacitinib for Atopic Dermatitis Safe Regardless of Oral Contraceptive Use

HCPLive

News Media Podcasts State Of Sciences - Presentations Videos Webinars Multimedia Series CURE Connections® Insights Medcast Peer Exchange Peers & Perspectives Special Report Conferences Conference Coverage Conference Listing Partners CME/CE Resources Digital Supplements Interactive Tools Live Events Press Release Publications Sponsored Advisory Board Subscribe Choose Specialty Allergy Allergy Allergy Allergy Biosimilars Cardiology Cardiology Cardiology Cardiology Cardiology Cardiology Cardiol

Cancer 64
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Lipid accumulation product index is inversely U-shaped associated with abdominal aortic calcification based on NHANES 2013–2014

Frontiers in Cardiovascular Medicine

BackgroundIn this study, we explored the correlation between lipid accumulation product (LAP) and abdominal aortic calcification (AAC).MethodsData collected from 2013–2014 were obtained from the National Health and Nutrition Examination Survey (NHANES) database. We utilized weighted univariate and multivariate regression analyses to assess the correlation between ln-LAP (LAP was transformed using a natural logarithm) and AAC.

Aortic 40