Fri.Jun 06, 2025

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Type 2 diabetes worsens the outcome of ischemia/reperfusion in female STEMI patients and female db/db mice with HFpEF cardiometabolic phenotype

Cardiovascular Diabetology

Heart failure with preserved ejection fraction (HFpEF) poses a significant global health challenge, disproportionately affecting women. Diabetic women with HFpEF represent a high-risk subgroup, particularly af.

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GLP-1 Drug Can Cause Rare, Potentially Blinding Side Effect, EMA Warns

Med Page Today

(MedPage Today) -- A potentially blinding condition is a very rare side effect of the GLP-1 receptor agonist semaglutide (Ozempic, Wegovy, Rybelsus), the European Medicines Agency (EMA) concluded. Following a review of all available data, the.

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Women with Premature Menopause Face Greater Cardiovascular Risks, Study Finds

HCPLive

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Over-the-counter supplement could prevent heart disease in type 2 diabetes patients

Medical Xpress - Cardiology

A cheap over-the-counter supplement could hold the key to preventing heart failure in people with Type 2 diabetes, according to research presented Tuesday at the British Cardiovascular Society conference in Manchester.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Don’t Miss a Beat: CONFIDENCE Trial and Combination T2D, CKD Therapy at Heart in Diabetes 2025

HCPLive

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ACC CardiaCast: Conversations in Heart Failure: Extrapolate With Caution: A STEMI Shock Reality Check

American College of Cardiology

In this episode, Drs. Jenna Skowronski, Francesco Castagna and Saraschandra Vallabhajosyula unpack how assumptions drawn from ST-segment elevation myocardial infarction (STEMI) data may be leading us astray in broader shock management.

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Cardiac Injury Detected by Smartwatch

The New England Journal of Medicine

A 76-year-old retired cardiovascular nurse presented to the ED with 2 hours of chest pain triggered by severe emotional distress and associated with changes in the electrocardiogram on her smartwatch.

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Contrast Use During PCI on the Decline

CardiacWire

New ACC registry data suggests interventional cardiologists are using less contrast for PCI procedures in the cath lab which helps reduce post-PCI acute kidney injury risks, but a deeper look tells us there’s still room for improvement. Iodinated contrast agents are commonly used for PCI with gadolinium-based contrast serving as an alternative but both can cause complications like acute kidney injury.

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Study Highlights Cardiopulmonary Benefits of GLP-1 RAs in Patients with Diabetes, OSA

HCPLive

New research has indicated that glucagon-like peptide-1 receptor agonists result in lower all-cause mortality and risk of cardiovascular events in patients with concurrent sleep apnea and type 2 diabetes.

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Cardiac contractility modulation to enhance optimized medical therapy and improve cardiac remodeling in advanced heart failure: a case report

Frontiers in Cardiovascular Medicine

BackgroundGuideline-directed medical therapy (GDMT) for heart failure (HF) with reduced ejection fraction (HFrEF) has been demonstrated to significantly reduce morbidity and mortality. However, many patients, especially those with advanced HFrEF, are unable to tolerate optimal GDMT due to hypotension. Cardiac contractility modulation (CCM) is a novel therapeutic approach that enhances myocardial contractility and reverses cardiac remodeling, thereby improving cardiac function and quality of life

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New Study: GLP-1 Medications Decrease Risk of Major Cardiovascular Events

DAIC

tim.hodson Fri, 06/06/2025 - 14:01 June 6, 2025 – A large retrospective review of more than 100,000 patients found the use of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) in moderate peripheral artery disease (PAD) is associated with a decreased rate of cardiovascular events, major limb events and inpatient admissions. This is the first retrospective trial to evaluate the clinical impact of GLP-1 RAs for patients with moderate PAD.

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A retrospective cross-sectional study of association between triglyceride-glucose index and carotid atherosclerosis

Frontiers in Cardiovascular Medicine

BackgroundThe triglyceride-glucose (TyG) index, a simple surrogate marker of insulin resistance (IR), has been associated with cardiovascular risk factors and atherosclerosis. However, its relationship with carotid atherosclerosis (CA), including carotid intima thickening (CMT), plaques, and stenosis, remains inadequately studied in the general population.PurposeThis study aimed to evaluate the association between the TyG index and CA.MethodsA retrospective cross-sectional study was conducted am

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ERA 2025: Sibeprenlimab Halves Proteinuria in IgAN in Phase 3 VISIONARY Trial

HCPLive

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Left atrial pressure and significant tricuspid regurgitation in persistent atrial fibrillation

Frontiers in Cardiovascular Medicine

IntroductionAtrial fibrillation (AF) is a well-established contributing factor to isolated tricuspid regurgitation (TR), with elevated left atrial pressure (LAP) playing a crucial role in disease progression and patient outcomes. We investigated the relationship between LAP and TR in patients with AF.MethodsWe enrolled individuals diagnosed with AF who underwent LA appendage closure at two centers in China, between January 2015 and December 2023.

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ERA 25: Data Underscore Iptacopan’s Effect on Proteinuria and Complement Activation in IgAN

HCPLive

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A novel model describing blood pressure profiles

Frontiers in Cardiovascular Medicine

IntroductionBlood pressure follows a circadian rhythm and is influenced by various factors. Blood pressure rises in the morning and decreases at night. It is known that deviations from this pattern are associated with an increased cardiovascular risk. Therefore, it is important to analyze blood pressure profiles and blood pressure variability.MethodsA blood pressure model was developed based on data from cuffless blood pressure measurements of six healthy volunteers over a 14-day period.

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Obicetrapib Treats Hypercholesterolemia, Phase 3 Trail Results Suggest

HCPLive

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Dynamic change in maternal cardiac function during pregnancy

Frontiers in Cardiovascular Medicine

BackgroundPregnant women experience various physiological changes that, if uncompensated, may result in varying degrees of cardiac dysfunction, and adverse pregnancy outcomes. Left ventricular (LV) global longitudinal strain (GLS) and P-wave to A' duration on tissue Doppler imaging (PA-TDI) have been shown to be able to detect subtle cardiac dysfunction.MethodsThe present study was a prospective cross-sectional study.

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Treatment Strategies for Resistant Hypertension

HCPLive

A panelist discusses how successful treatment requires selecting the right three to five medications with minimal side effects, using once-daily combination pills to maximize adherence, and engaging patients as active participants through structured home blood pressure monitoring protocols.

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Impact of steatotic liver diseases on diabetes mellitus risk in patients with atrial fibrillation: a nationwide population study

Cardiovascular Diabetology

Atrial fibrillation (AF) frequently coexists with diabetes mellitus (DM), leading to a worse prognosis if both are present. Steatotic liver disease (SLD) may also predispose to DM, but its impact among AF pati.

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Barriers in the Treatment Landscape of Resistant Hypertension

HCPLive

A panelist discusses how patient compliance remains the primary obstacle to blood pressure control despite effective medications being available, while clinical inertia among healthcare providers and medication side effects affecting electrolytes and kidney function add additional complexity to resistant hypertension management.

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Drug-Coated Balloon Versus Newer-Generation Drug-Eluting Stent Following Directional Coronary Atherectomy for Left Main Bifurcation Lesions

The American Journal of Cardiology

Publication date: Available online 5 June 2025 Source: The American Journal of Cardiology Author(s): Kota Murai, Kensuke Takagi, Fumiyuki Otsuka, Yoshiyuki Tomishima, Takamasa Iwai, Kenichiro Sawada, Hideo Matama, Satoshi Honda, Masashi Fujino, Shuichi Yoneda, Kazuhiro Nakao, Yu Kataoka, Yasuhide Asaumi, Kisaki Amemiya, Manabu Matsumoto, Keiko Ohta-Ogo, Yoshihiko Ikeda, Hatsue Ishibashi-Ueda, Kinta Hatakeyama, Teruo Noguchi

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Kidney Compass: CONFIDENCE Trial at ERA 2025, with Rajiv Agarwal, MD, MS

HCPLive

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Impact of Bifurcation Angle on Side Branch Occlusion in Provisional Bifurcation Percutaneous Coronary Intervention: Analysis from the PROGRESS-BIFURCATION registry

The American Journal of Cardiology

Publication date: Available online 6 June 2025 Source: The American Journal of Cardiology Author(s): Deniz Mutlu, Ozgur Selim Ser, Dimitrios Strepkos, Pedro E.P. Carvalho, Michaella Alexandrou, Barkin Kultursay, Ali Karagoz, Oleg Krestyaninov, Dmitrii Khelimskii, Mahmut Uluganyan, Korhan Soylu, Ufuk Yildirim, Mehmet Semih Belpinar, Olga Mastrodemos, Bavana V.

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Semaglutide Significantly Reduces Blood Pressure in Patients with Type 2 Diabetes

HCPLive

Semaglutide’s reduction in systolic blood pressure could indicate more potential for cardiovascular protection than simply its well-known glycemic benefits.

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Real-World Safety Profile of the Extravascular (EV) Implantable Defibrillator System: Insights From the MAUDE Database

Circulation: Arrhythmia and Electrophysiology

Circulation: Arrhythmia and Electrophysiology, Ahead of Print.

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Clinical Perspectives on DORAs for Insomnia Management

HCPLive

A panelist discusses how dual orexin receptor antagonists (DORAs) are considered a first-line treatment for chronic insomnia, particularly for sleep maintenance issues, due to their superior tolerability, lack of withdrawal symptoms, and positive impact on daytime functioning.

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Case Report: Paracentral acute middle maculopathy following carotid artery dissection

Frontiers in Cardiovascular Medicine

BackgroundParacentral acute middle maculopathy (PAMM) is a rare, presumed ischemic maculopathy. While primarily associated with retinal vascular pathologies, several case studies have documented PAMM diagnoses following systemic cardiovascular events or interventions. Here, we discuss a case of PAMM development after carotid artery dissection (CAD).Case presentationA woman in her late 30 s presented to the emergency department with transient right-side weakness and amaurosis in her left eye last

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Daridorexant and Next-Day Function: What Patients Are Reporting

HCPLive

A panelist discusses how dual orexin receptor antagonists (DORAs) are ideal for patients with chronic insomnia who require long-term sleep support, emphasizing their safety, tolerability, and effectiveness, while cautioning against use in patients with narcolepsy, parasomnia history, or severe kidney or liver disease.

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5 Scientifically Proven Ways To Reverse Coronary Artery Disease.

Dr. Paddy Barrett

Over a long enough time horizon, everyone will develop coronary artery disease. It is not a matter of if but when. The ultimate goal, even when doing everything right, is to die at an old age having lived a long and healthy life ‘ with ’, but not ‘ from ’ coronary artery disease. In general, heart disease doesn’t kill people.

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Addressing JAK Inhibitor Concerns in Atopic Dermatitis, with Leon H. Kircik, MD

HCPLive

News Media Podcasts State Of Sciences - Presentations Videos Webinars Multimedia Series CURE Connections® Insights Medcast Peer Exchange Peers & Perspectives Special Report Conferences Conference Coverage Conference Listing Partners CME/CE Resources Digital Supplements Interactive Tools Live Events Press Release Publications Sponsored Advisory Board Subscribe Choose Specialty Allergy Allergy Allergy Allergy Biosimilars Cardiology Cardiology Cardiology Cardiology Cardiology Cardiology Cardiol

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Observed and expected overall mortality for acute myocardial infarction during the COVID-19 pandemic in Italy: an analysis of nationwide institutional databases

Frontiers in Cardiovascular Medicine

AimTo carry out a nationwide evaluation of both in- and out-of-hospital mortality for acute myocardial infarction (AMI) during the COVID-19 pandemic period in Italy.MethodsThis was a retrospective cohort study analysing overall mortality for AMI in Italy during the COVID-19 pandemic (March 1st, 2020–December 31st, 2021) and the previous 5 years (January 1st, 2015–February 29th, 2020).

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Pulmonology Month in Review: May 2025

HCPLive

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MRI-based method identifies high-risk cardiac sarcoidosis patients who would benefit from implantable defibrillators

Medical Xpress - Cardiology

New research from the University of Minnesota Medical School demonstrates that using cardiovascular magnetic resonance imaging—known as CMR phenotyping—can help identify patients with suspected cardiac sarcoidosis who are at increased risk of sudden cardiac death.

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Abrocitinib Advantages Among Patients with Atopic Dermatitis, with Leon H. Kircik, MD

HCPLive

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Global Stroke Deaths Still a Concern, and It's Not Just About Developing Countries

Med Page Today

(MedPage Today) -- Though stroke mortality has decreased over the last few decades, there is still room for improvement, researchers said. Using global data on stroke mortality and risk factors as recent as 2021, age-standardized death rates were.

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